Download or read book HLA class II immune response genes in leprosy written by Thomas H. Ottenhoff and published by . This book was released on 1986 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recognition of M Leprae Antigens written by Tom Ottenhoff and published by Springer. This book was released on 1987-07-31 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Those who have had the privilege to visit the Sistine Chapel may remember the fres co painting of Jesus curing the leper (Marcus 1, 40-45). It seems that leprosy was not only known 2000 years ago but was also recognized as an important problem. Unfortunately, little has changed since then. Although leprosy is mainly known as an "import" disease in Europe and North America, in the greater part of the world it remains the problem it has always been, one of a stigmatizing disease comparable to the modern day pestilence, namely AIDS. Who could forget Durer's etch of a leper walking with a clapper to an nounce his presence, or the heartbreaking stories of patients, especially those with lepromatous leprosy, ousted by their own families to become social outcasts forced to beg for their food. This attitude is slowly changing and with this change the name of Mahatma Ghandi will always be connected and remembered.
Download or read book HLA and Associated Important Diseases written by Yongzhi Xi and published by BoD – Books on Demand. This book was released on 2014-03-19 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This year marks the 60th anniversary of HLA discovery by the French Nobel laureate physician Jean Dausset, as well as the 55th anniversary of the identification and naming of the first HLA. Under such circumstances, both basic HLA research and its clinical applications need a new book that comprehensively reflects the latest achievements in the field. Thus, Professor Xi as Editor has contributed to organize international experts in the areas of HLA-related basic research and clinical applications, to unite their knowledge in chapters covering various related topics, and finally to finish the book "HLA and Associated Important Diseases". The book consists of three sections which mainly include basic theoretical and technological developments, several important HLA-associated autoimmune diseases and HLA-associated infectious diseases.
Download or read book The HLA Complex in Biology and Medicine written by Narinder K Mehra and published by Boydell & Brewer Ltd. This book was released on 2010-11-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.
Download or read book HLA and Disease written by Robert Lechler and published by . This book was released on 1994 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text describes the genetics and products of the HLA region and their relationship to diseases including diabetes, rheumatoid arthritis and SLE. The statistical principles relevant to the design and interpretation of HLA and disease studies are presented in simple and accessible language.
Download or read book HLA Class II Antigens written by Soldano Ferrone and published by Springer. This book was released on 1986 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.
Download or read book Molecular Biology of HLA Class II Antigens written by Jack Silver and published by CRC Press. This book was released on 1990-02-28 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication covers the recent veritable explosion in knowledge regarding the genetic organization, structure, and function of the HLA class II region. It deals with the nature of diversity of HLA class II alleles, the molecular basis of this diversity, and the mechanisms by which HLA class II expression is regulated. Also addressed is the relationship of class II polymorphism to susceptibility to autoimmune diseases such as rheumatoid arthritis, insulin dependent diabetes mellitus, and pemphigus vulgaris. The book presents information on allele specific oligonucleotide (ASO) probes and their use in identifying susceptible individuals. It includes chapters which describe how cells transfected with HLA class II genes can be used for functional analysis. An appendix representing a compilation of all the known DR?? DQ?, DQ? sequences is included. This serves as an excellent source of comparison of newly derived sequences. This publication provides information on the enormous progress in the HLA field. It is intended for both the established investigator and the beginner.
Download or read book Immunogenetics of MHC and KIR in the Leprosy written by Jeane Eliete Laguila Visentainer and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several genetic polymorphisms in immune response genes have been associated to leprosy. This fact converges on the main hypothesis that genetic factors are involved in the disease susceptibility in two distinct steps: leprosy per se and their clinical forms. These genes play an important role in the recognition process, in the activation of the main metabolic pathway of the immune response and in the evolution of the disease. The scope of this project was to highlight the role of the immune response genes in the context of leprosy, emphasizing the participation of some of them in the signaling and targeting processes in response to bacillus infection and on disease evolution, such as HLA, KIR and MIC genes. Some environmental and genetic factors are important when the exposure to the bacillus occurs, leading to cure or not. Factors that favor a cellular or humoral immune response may influence the clinical manifestations after the infection inducting to one of extreme poles. Furthermore, some genetic factors were associated to the type of reaction that some individuals present during the disease development. Thus, it is very important to highlight the participation of some genetic factors in the immunopathogenesis of leprosy.
Download or read book The HLA System in Clinical Transplantation written by Bjarte G. Solheim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: With this book we· want to address young graduate students, clini cians involved in transplantation, and technicians in transplantation immunology laboratories. The volume should give a comprehensive but basic, up to date introduction to the structure, function, and clinical importance of the HLA system. We believe that there is a need for such a survey, and think that the present level of our knowledge is an optimal occasion for publication. A significant number of ques tions have now been resolved, and our knowledge has reached a level of sophistication that provides the basis for additional questions and answers. Although the emphasis of this book is on the role of HLA anti gens in clinical transplantation, their involvement in other clinical contexts is also discussed. The main focus is on the human MHC an tigenic system, but MHC systems in other species are described as they contribute to our understanding of the structural and functional characteristics of HLA antigens. Some important issues related to laboratory techniques are also covered. The contributors have a close affiliation to the field of transplan tation immunology. A majority have even been playing important roles in unraveling the HLA system and its functions. We believe this has contributed significantly to the quality and clinical and practical relevance of the book. As editors, we drew up the principal guidelines and took care that the chapters can be read as separate entities, although this invariably results in some overlapping.
Download or read book The Role of HLA Gene Products in the Immune Response to Environmental Antigens written by Pamela Jean Reitnauer and published by . This book was released on 1984 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Twin Study on Leprosy written by M. R. Chakravartti and published by . This book was released on 1973 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HLA Class II Antigens written by Bjarte G. Solheim and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume deals with the structure and function of molecules that have, during the last decade, turned out to have a central role in immune responses. Trans plantation antigens were discovered and characterized by Gorer about 50 years ago, and the biological basis for the unequalled complexity of their variability between individuals within a species, in spite of extreme conservation between species, was the subject of intense research and discussion for many years. During the days of belief in "immune surveillance" against spontaneously developing tumors, it was suggested that histoincompatibility between members of one species would prevent cancer from being a contagious disease and thus a threat to the species. Immunologists involved in human transplantation had to learn and care about the complexity, especially after 1967, when it was found that HLA antigens were the products of the human MHC. Rejection of HLA-identical sib kidney grafts was so rare, even in those days, that cases of rejection were described in scientific papers.
Download or read book Molecular analysis of a human immune response gene HLA DRw6 written by Marnix L. Bosch and published by . This book was released on 1987 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recognition of M leprae antigens written by Tom Ottenhoff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Those who have had the privilege to visit the Sistine Chapel may remember the fres co painting of Jesus curing the leper (Marcus 1, 40-45). It seems that leprosy was not only known 2000 years ago but was also recognized as an important problem. Unfortunately, little has changed since then. Although leprosy is mainly known as an "import" disease in Europe and North America, in the greater part of the world it remains the problem it has always been, one of a stigmatizing disease comparable to the modern day pestilence, namely AIDS. Who could forget Durer's etch of a leper walking with a clapper to an nounce his presence, or the heartbreaking stories of patients, especially those with lepromatous leprosy, ousted by their own families to become social outcasts forced to beg for their food. This attitude is slowly changing and with this change the name of Mahatma Ghandi will always be connected and remembered.
Download or read book Immunobiology of HLA written by Bo Dupont and published by Springer. This book was released on 2013-12-20 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: This set reports the results of the 10th International Histocompatibility Workshop, in which 362 laboratories collaborated over a three year period in research projects on the classification of HLA genes and their products. Volume 1 describes the experimental design of the workshop studies and their results. Volume 2 is a collection of papers on the latest developments in the molecular biology of HLA systems. Immunobiology of HLA is a valuable reference for tissue typing laboratories, blood banks, and general research programs on HLA and related diseases because it identifies common sources of HLA genes and gene products to be used as reference reagents, and because it is the only complete compilation of the latest research and results in the field.
Download or read book Analysis of HLA Class II Allele Frequencies in Leprosy Patients from Central Thailand written by Duangporn Srinak and published by . This book was released on 1996 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mycobacterial Skin Infections written by Domenico Bonamonte and published by Springer. This book was released on 2017-09-04 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-illustrated book is a comprehensive guide to the cutaneous clinical presentations of mycobacterial infections. The Mycobacterium genus includes over 170 species, nontuberculous mycobacteria (NTM) having been added to the obligate human pathogens such as M. tuberculosis and M. leprae. NTM are widely distributed in the environment with high isolation rates worldwide; the skin is a major target with variable clinical manifestations. A current resurgence in tuberculosis is aggravated by the synergy with human immunodeficiency virus, the breakdown of health care systems, and the rise in multidrug-resistant disease, as the incidence of leprosy remains stable, at around 250,000 new cases annually, regardless of effective antibiotic therapy. Presentations of various cutaneous infections caused by mycobacteria may be overlooked by clinicians owing the lack of familiarity with tuberculosis, leprosy, and the related NTM clinical features. This handy guide will help the dermatologist to spot the different clinical manifestations, make a prompt diagnosis, and apply effective treatment.
