Download or read book HIV 1 Infection Mucosal Immunity Pathogenesis written by Thomas F. Kresina and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HIV 1 Infection Mucosal Immunity Pathogenesis written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HIV 1 Infection Mucosal Immunity Pathogenesis written by Thomas F. Kresina and published by . This book was released on 1999 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HIV 1 Infection Mucosal Immunity and Pathogenesis written by and published by . This book was released on 1997 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Molecular Mechanisms of HIV 1 Pathogenesis in Gut Associated Lymphoid Tissue written by Sumathi Sankaran and published by . This book was released on 2006 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook on Immunosenescence written by Tamas Fulop and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 1693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.
Download or read book Mucosal Vaccines written by Hiroshi Kiyono and published by Elsevier. This book was released on 1996-10-23 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization
Download or read book Immunopathogenesis of Human Immunodefiency Virus Type 1 HIV 1 in the Gastrointestinal Mucosal Compartment written by Michael Adam Poles and published by . This book was released on 2001 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book HIV and the New Viruses written by Angus G. Dalgleish and published by Elsevier. This book was released on 1999-03-16 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: HIV and the New Viruses presents cutting-edge reviews of persistent human virus infections as a coherent collection for the first time. These cover recently discovered viruses such as HHV-6, HHV-8 and HCV, as well as the latest research on HIV. This comprehensive and updated reference includes an in-depth study of the major issues in the epidemiology, pathogenicity, molecular virology, host responses and management of conditions associated with those viruses. Information on new pharmaceuticals and vaccine developments is also included. Edited by the leading experts in the field, HIV and the New Viruses will be essential reading for postgraduates, clinicians and researchers in virology, immunology, cancer, molecular biology and the pharmaceutical industry. - Presents cutting-edge reviews of persistent human virus infections as a coherent collection for the first time - Includes an in-depth study of the major issues in the epidemiology, pathogenicity, molecular virology, host responses, and management of conditions associated with those viruses
Download or read book Diagnostics to Pathogenomics of Sexually Transmitted Infections written by Sunit Kumar Singh and published by John Wiley & Sons. This book was released on 2018-12-06 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensively explores sexually transmitted diseases, from epidemiology, causative pathogens, clinical impact, and immunology, to management strategies utilizing new strategies of genomics and next-generation diagnostic tools Sexually transmitted infections (STI) are very common worldwide. More than 20 different STIs have been identified, and about 19 million men and women are infected each year in the United States alone. This book looks at the complete picture of common STIs— how they form, evolve, and transmit, as well as how they can be treated and managed with modern techniques, medicines, and tools. Diagnostics to Pathogenomics of Sexually Transmitted Infections runs the spectrum of discussion ranging from introduction of causative pathogen, their pathogenesis to epidemiology, immunology, to anatomy and physiology of human genitalia and management strategies. The book offers in-depth chapter coverage on effect of probiotics on reproductive health; mucosal immunity in sexually transmitted infections; the role of circumcision in preventing STIs; Human Immunodeficiency Virus (HIV); genital herpes; molluscum contagiosum; genital warts; chlaymydia trachomatis; donovanosis; gonorrhoea; treponematoses; genital mycoplasms; bacterial vaginosis; vulvovaginal candidiasis; chlaymydia; scabies; chancroid, yeast infections; and more. Comprehensively compiles most of the major sexually transmitted infections Presents updated information on clinical aspects of sexually transmitted infections Examines the priorities in pathogenesis of human sexually transmitted infections and discusses new strategies of genomics and next-generation diagnostic tools used for detection of such pathogens Explores the future of rapid molecular diagnostic techniques and the challenges posed in the diagnosis of human STIs Includes bench to bedside content that will appeal to both basic and clinical researchers By offering the latest knowledge about recent advances in sexually transmitted infections in an interdisciplinary fashion, Diagnostics to Pathogenomics of Sexually Transmitted Infections is the perfect book for virologists, microbiologists, infectious disease experts, vaccinologists, biomedical researchers, clinicians, pharmacologists, and public health specialists.
Download or read book Microbial Pathogenesis written by Uday Kishore and published by Springer Nature. This book was released on 2021-10-18 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book updates in detail the microbial pathogenesis of various important pathogens, including HIV-1, MERS, SARS-CoV-2, Mycobacterium and Plasmodium. There is also a general discussion of the innate and adaptive immune responses against primary and opportunistic infections. The overall purpose of the book is to aid in the development of anti-viral and anti-microbial targets.
Download or read book Immunity Against Mucosal Pathogens written by Michael Vajdy and published by Springer Science & Business Media. This book was released on 2008-07-09 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surprisingly what separates us from the open environment all around us sometimes is a single layer of epithelial cells. It is at these seemingly fragile sites that most pathogens, including HIV, influenza, emerging and biodefense agents, gain access to our inside milieu. While there are major similarities between the cells and the immune responses generated at the mucosal membranes of the gastrointestinal and respiratory tracts together with the genitourinary tract, there are also important differences. Knowledge of these differences and similarities is required in order to understand the interactions between us, as the host, and the pathogens that attack through each tract, and how our immune system reacts to each of them. Whether we want to devise rational prophylactic or therapeutic vaccines or treatments to either prevent or treat mucosal infections we must acquire such knowledge. This is the rationale behind putting this book together. This book will provide the readers in the areas of vaccinology, virology, bacteriology, epidemiology, immunology and mucosal immunology within academia (undergraduate, graduate, post doctoral fellows and professors), as well as preclinical and clinical scientists in vaccine and drug industries a thorough appreciation of the mucosal immune system and its importance in protecting humans against mucosal pathogens.
Download or read book Chimpanzees in Biomedical and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2011-12-05 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.
Download or read book Idiotypes in Medicine Autoimmunity Infection and Cancer written by R.C. Kennedy and published by Elsevier. This book was released on 1997-11-19 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.
Download or read book Cofactors in HIV 1 Infection AIDS written by Ronald Ross Watson and published by CRC Press. This book was released on 1990 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the most up-to-date information available to help you better understand and identify cofactors and potential cofactors for additional study of Acquired Immunodeficiency Syndrome (AIDS). This volume is packed with reviews of AIDS research and related models and systems. It explains that infection by heterosexual contact has very different rates in distinct parts of the world and the reasons are only partially defined. Therefore, it is certain that cofactor(s), in addition to the HIV virus, are required for development of most clinical states after HIV infection. Cofactors may include race, sex, genetic differences, drug abuse, age, immunological development, and nutritional factors. This indispensable text is an absolute must for all physicians, virologists, clinical researchers, nurses, public health workers, physiologists, and anyone interested in learning more about this alarming disease.
Download or read book Mechanisms of Mucosal Dysfunction in HIV Infection and Potential Therapeutic Strategies written by Tiffany Hensley-McBain and published by . This book was released on 2017 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: HIV and pathogenic SIV infection are characterized by chronic gastrointestinal (GI) mucosal dysfunction, which contributes to morbidities and mortality. This includes damage to the epithelial barrier, loss of Th17 cells, microbial translocation and local and systemic inflammation and immune activation. The mechanisms underlying mucosal damage have not been fully elucidated. The broad purpose of this thesis was to address several unanswered questions relating to mechanisms and potential therapies for GI mucosal dysfunction in HIV infection. We aimed to address three main objectives: 1) longitudinally assess the kinetics of GI neutrophil accumulation and reduced neutrophil antimicrobial function in relation to mucosal dysfunction, immune activation, and Th17 cell depletion in acute SIV infection; 2) investigate increased neutrophil lifespan as a mechanism for GI neutrophil accumulation in chronic, treated HIV infection and a potential role for HIV altered mucosal bacteria; and 3) assess the safety and efficacy of fecal microbial transplantation (FMT) as a potential therapeutic for mucosal dysfunction in SIV infection. The role of neutrophils in HIV gastrointestinal mucosal dysfunction is one major theme of the studies described herein. Neutrophils are important for containment of pathogens, but can also contribute to tissue damage due to their release of reactive oxygen species and other potentially harmful effector molecules. Here, we demonstrate that immune alterations such as Th17 loss, prolonged intestinal neutrophil accumulation, and decreased neutrophil functionality occur after the onset of peripheral and mucosal T cell activation and evidence of microbial translocation, and are thus unlikely to be drivers of initial damage. We additionally demonstrate that neutrophils are recruited to the site of lentivirus infection, maintain antimicrobial function in acute infection, and may therefore participate in the antiviral immune response. In chronic treated HIV infection, we report that reduced homeostatic neutrophil apoptosis contributes to neutrophil accumulation in the gastrointestinal tissues, thus implicating neutrophil lifespan as a new therapeutic target for mucosal inflammation in HIV infection. Microbial dysbiosis in HIV infection is a second major underlying theme of this thesis. During HIV infection, the delicate balance of healthy bacterial communities is perturbed, and this dysbiosis associates with T cell activation and disease progression. Here, we report differential effects of HIV-altered mucosal bacteria on neutrophil survival, suggesting that dysbiosis may contribute to GI neutrophil accumulation in treated HIV. We also provide evidence that Lactobacillus species increase neutrophil apoptosis and decrease neutrophil frequency in vitro, which could have important therapeutic implications for reducing neutrophil-driven inflammation in HIV and other chronic inflammatory conditions. Finally, we demonstrate the safety of FMT in primates infected with lentivirus and examine the relationships between alterations to the microbiome and immunological parameters. We observed increased Th17 and Th22 cells as well as decreased activation of CD4+ T cells post-FMT, and these changes correlated most strongly across all sampling time points with lower abundance genera in the colon. Taken together, the data presented in this thesis improves our understanding of the mechanisms contributing to mucosal dysfunction and potential therapies that can be further investigated to improve overall health in HIV-infected individuals.
