Download or read book Histaminergic neurotransmission as a gateway for the effects of the fat sensing molecule Oleoylethanolamide written by Alessia Costa and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The histaminergic system is a pleiotropic system that commands general states of metabolism and consciousness, including learning and memorizing both pleasurable and aversive events. Brain histamine mediates the central effects of a signal molecule produced in the intestine, namely oleoylethanolamide (OEA). OEA is released by the enterocytes in response to high fat intake and reduces eating, by indirectly activating a subpopulation of histaminergic neurons. In her thesis, she explored other potential interactions between these two systems in the pursuit of unexplored neuronal mechanisms that may shed light on the mode of action of psychoactive agents and possibly lead to the development of new drugs.
Download or read book Functional validation of genetic variants identified by next generation sequencing in malformations of cortical development written by Dalila De Vita and published by Firenze University Press. This book was released on 2022 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malformations of cortical development (MCDs) result from a disruption in the process of the human brain cortex formation: currently, there are no pharmacological treatments for diffuse MCDs. Next-generation sequencing has accelerated the identification of MCDs causing genes: in some cases, functional studies are needed to clarify the role of genetic variants. The aim of this PhD project has been to apply a multidisciplinary approach to identify causative mutations in patients with MCDs, validate the pathogenic role of the identified mutations, and assess the effectiveness of novel in vitro treatment for mTOR pathway related MCDs.
Download or read book Isotopic fractionation study towards massive star forming regions across the Galaxy written by Laura Colzi and published by Firenze University Press. This book was released on 2022 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most important tools to investigate the chemical history of our Galaxy and our own Solar System is to measure the isotopic fractionation of chemical elements. In the present study new astronomical observations devoted to the study of hydrogen and nitrogen fractionation (D/H and 14N/15N ratios) of molecules, towards massive star-forming regions in different evolutionary phases, have been presented. Moreover, a new detailed theoretical study of carbon fractionation, 12C/13C ratios, has been done. One of the main results was the confirmation that the 14N/15N ratio increases with the galactocentric distance, as predicted by stellar nucleosynthesis Galactic chemical evolution models. This work gives new important inputs on the understanding of local chemical processes that favor the production of molecules with different isotopes in star-forming regions.
Download or read book Advanced Ground Based Real and Synthetic Aperture Radar written by Lapo Miccinesi and published by Firenze University Press. This book was released on 2022 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ground-based/terrestrial radar interferometry (GBRI) is a scientific topic of increasing interest in recent years. The GBRI is used in several field as remote sensing technique for monitoring natural environment (landslides, glacier, and mines) or infrastructures (bridges, towers). These sensors provide the displacement of targets by measuring the phase difference between sending and receiving radar signal. If the acquisition rate is enough the GBRI can provide the natural frequency, e.g. by calculating the Fourier transform of displacement. The research activity, presented in this work, concerns design and development of some advanced GBRI systems. These systems are related to the following issue: detection of displacement vector, Multiple Input Multiple Output (MIMO) and radars with 3D capability.
Download or read book Tectono metamorphic evolution of the continental units along the edge between Alpine and Hercynian Corsica written by Maria Di Rosa and published by Firenze University Press. This book was released on 2022 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this work the central area of Corsica island was studied in order to reconstruct the tectono-metamorphic history of the continental and oceanic high pressure units that occupy the structurally deeper levels of the tectonic stacking of Alpine Corsica and their stratigraphic and structural relationship with the European margin (Hercynian Corsica). The study includes the geological mapping, the mesoscale and microscale structural analysis, the acquisition of chemical analyzes and micromaps with the microprobe, thermobarometric estimation through specific methodologies for metapelites, U-Th-Pb dating of zircons and allanites. The results obtained allows to reconstruct the geodynamic model of this sector of the Alpine belt from the Permian to the Burdigalian.
Download or read book Histamine in the brain written by Jian-Sheng Lin and published by Frontiers Media SA. This book was released on 2015-03-18 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders.
Download or read book The Hood Health Handbook written by Supreme Understanding and published by Proven Publishing. This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over a dozen writers contributed to this handbook, edited by C BS Alife and Supreme Understanding. The contributors include fitness gurus, dieticians, personal trainers, and holistic practitioners from around the country.
Download or read book Mechanically Gated Channels and their Regulation written by Andre Kamkin and published by Springer. This book was released on 2015-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. In our opinion the book presents not only the latest achievements in the field but also brings the problem closer to the experts in related medical and biological sciences as well as practicing doctors. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different living organs and tissues and allows to predict changes, which arise due to alterations of their environment, and possibly will allow to develop new methods of artificial intervention. We also hope that presenting the problem will attract more attention to it both from researchers and practitioners and will assist to efficiently introduce it into the practical medicine.
Download or read book Micro Turbo Expander Design for Small Scale ORC written by Lorenzo Talluri and published by . This book was released on 2020 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Histamine Receptor written by J. C. Schwartz and published by . This book was released on 1992-01-24 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesizes the latest information and research involving the pharmacochemistry, biochemical properties and neurobiological function of histamine receptors. Contains over 50 illustrations.
Download or read book Memory written by Larry R. Squire and published by Roberts Publishers. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combining insights from both cognitive neuroscience and molecular biology, two of the world's leading experts address memory from molecules and cells to brain systems and cognition. What is memory and where in the brain is it stored? How is memory storage accomplished? This book touches on these questions and many more, showing how the recent convergence of psychology and biology has resulted in an exciting new synthesis of knowledge about learning and remembering. Memory: From Mind to Molecules is an ideal primer for courses on learning and memory or for general readers who are interested in discovering what is currently known about one of the basic aspects of human existence.
Download or read book Folding and Aggregation Studies in the Acylphosphatase like Family written by Francesco Bemporad and published by Firenze University Press. This book was released on 2009 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Folding and misfolding of proteins are considered two sides of the same coin. The delicate equilibrium existing between these two processes is crucial for any living organism and its alterations can lead to the onset of several tremendous diseases, such as Alzheimer's and Parkinson's disease. The attainment of a profound knowledge of folding/misfolding processes is a key step to understand how life works and for discovering new therapies to these diseases. In this work the author shows that proteins can display enzymatic activity even in the absence of a compact three-dimensional structure, with important implications for the study of protein enzymes. Furthermore, the author investigates the formation of protein aggregates similar to those observed in patients of amyloid-related diseases.
Download or read book A Firm Level Analysis of Small and Medium Size Enterprise written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Insights Into Creatine Transporter Deficiency written by Angelo Molinaro and published by . This book was released on 2020 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Memory Consolidation written by James L. McGaugh and published by Amer Psychological Assn. This book was released on 2001-01-01 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Memory Consolidation celebrates the contributions James L. McGaugh has made to the field of memory formation research. This volume is essential reading for researchers and practitioners studying the psychobiology of memory and for any reader wishing to see how a single scientist can utterly transform a field of inquiry.
Download or read book Conditioned Reflexes and Neuron Organization written by Jerzy Konorski and published by CUP Archive. This book was released on 1948 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Conditioned Reflexes An Investigation of the Physiological Activity of the Cerebral Cortex Translated and Edited by G V Anrep written by Ivan Petrovich Pavlov and published by . This book was released on 1927 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
