Download or read book High Spatiotemporal Resolution Mapping of Retinal Physiology written by Qiuxiang Zhang and published by . This book was released on 2014 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of my PhD dissertation research is to explore high resolution imaging of retinal function using transient intrinsic optical signals (IOSs) correlated with retinal physiological activation. The retina is responsible for capturing photons and preliminary visual information processing. Functional examination of retinal neural cells is important for eye disease detection and treatment evaluation. It is known that different diseases can target different retinal cell types, and thus high resolution imaging of retinal function is desirable. Fast IOSs with time courses comparable to retinal electroretinogram (ERG) kinetics can act as a unique biomarker to map physiological distortions correlated with eye diseases. In vitro IOS imaging of wild-type and mutant mouse retinas has revealed IOS distortions correlated with retinal diseases. In order to achieve in vivo IOS imaging, a rapid line-scan confocal ophthalmoscope was constructed. Confocal IOS imaging of laser-injured frog eyes unambiguously detected localized (30 mm) functional lesions in the retina before morphological abnormality is detectable. Comparative IOS and ERG measurement revealed a close correlation between the observed optical response and retinal electrophysiological dynamics, particularly the ERG a-wave, which has been widely used to evaluate photoreceptor function. To further uncover the anatomic source of fast IOSs in retinal photoreceptors, a functional spectral domain optical coherence tomography (SD-OCT) system was constructed to provide depth-resolved IOS mapping at subcellular resolution. High spatiotemporal resolution OCT disclosed that fast IOSs was predominantly confined to the outer retina, particularly in the photoreceptor outer segment. Comparative study of dark- and light-adapted retinas demonstrated the feasibility of functional OCT mapping of rod and cone photoreceptors, with great potential for early disease detection and improved treatment evaluation of age-related macular degeneration (AMD) and other eye diseases that can cause photoreceptor damage. In addition to functional retinal imaging, we also applied the SD-OCT system for in vivo dynamic observation of light-driven melanosome translocation in RPE. Comparative OCT examination of dark- and light- adapted frog eyes verified that RPE melanosomes are the primary source of reflectivity in the RPE band. To the best of our knowledge, this is the first time demonstration of the feasibility of dynamic OCT monitoring of sub-cellular RPE translocation. Thus, SD-OCT is a versatile tool to assess posterior segment dynamics that may have relevance in the clinical setting.

Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Berne and Levy Physiology E Book written by Bruce M. Koeppen and published by Elsevier Health Sciences. This book was released on 2017-01-18 with total page 944 pages. Available in PDF, EPUB and Kindle. Book excerpt: Berne & Levy Physiology has long been respected for its scientifically rigorous approach – one that leads to an in-depth understanding of the body’s dynamic processes. The long-awaited 7th Edition by Drs. Bruce M. Koeppen and Bruce A. Stanton, continues this tradition of excellence. With integrated coverage of biophysics and neurophysiology, key experimental observations and examples, and full-color design and artwork, this mid-size text is "just right" for a strong understanding of this complex field. A logical and intuitive organ-system-based approach clearly describes all of the mechanisms that control and regulate bodily function. Authored by experts with both science and medical backgrounds. More "In the Clinic" and "At the Molecular Level" boxes help readers better understand and apply what they’ve learned. New coverage includes expanded discussions of gut and lung microbiota,; the limbic system; the hypthalamus and control of food intake; cardiac and vascular function curves during exercise; new aspects of lipid absorption; GI and metabolic consequences of bariatric surgery, the role of innate lymphoid cells in defense of the respiratory system, molecular mechanisms in normal and pathological muscle contraction; arterial pulse changes with age and the ankle-brachial index; regulation of the blood-brain barrier and cerebral blood flow; the regulation of phosphate; and thyroid hormone mechanism of action. Each chapter begins with an all-new bulleted list of questions and ends with key concepts covered in that chapter.

Download or read book Advanced Biophotonics written by Ruikang K. Wang and published by Taylor & Francis. This book was released on 2016-04-19 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a number of books on biophotonics imaging for medical diagnostics and therapy, the field still lacks a comprehensive imaging book that describes state-of-the-art biophotonics imaging approaches intensively developed in recent years. Addressing this shortfall, Advanced Biophotonics: Tissue Optical Sectioning presents contemporary methods and

Download or read book Berne Levy Physiology Updated Edition E Book written by Bruce M. Koeppen and published by Elsevier Health Sciences. This book was released on 2009-12-11 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Berne and Levy Physiology has long been respected for its scientifically rigorous approach and now includes major updates to bring you all of the latest knowledge in the field. Bruce M. Koeppen and Bruce A. Stanton present a honed and shortened edition that emphasizes the core information needed by students of physiology today and features a full-color design and artwork to enhance readability and enrich your comprehension of every concept. With access to the full contents online at Student Consult, this time-honored book delivers an in-depth understanding of physiology more powerfully and effectively than ever before. Describes all of the mechanisms that control and regulate bodily function using a clear and intuitive organ system-based approach. Provides a rich understanding of the body's dynamic processes through key experimental observations and examples. Includes Student Consult access to the complete and searchable contents of the book online, as well as relevant bonus content from other Student Consult titles, an image gallery, 10 physiology animations, and much more. Features updated coverage throughout to expand your understanding of the most current trends in physiology and medicine, including the latest cellular and molecular knowledge. Includes shaded boxes that highlight and explain important clinical and molecular information. Presents new section editors who ensure that you are getting the freshest, most clinically relevant information available today. Summarizes need-to-know information in each chapter with Key Points sections.

Download or read book Canadian Journal of Physiology and Pharmacology written by and published by . This book was released on 1988 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Berne and Levy Physiology E Book written by Bruce M. Koeppen and published by Elsevier Health Sciences. This book was released on 2023-02-12 with total page 866 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pairing necessary detail with concise readability, Berne & Levy Physiology, 8th Edition, provides a perfect balance of content to deliver an in-depth understanding of the body’s dynamic processes. Long respected for its scientifically rigorous approach, this highly regarded, mid-size text offers essential physiology with integrated coverage of biophysics andkey experimental observations and examples—all designed to provide a solid scientific foundation in physiology for future scientists and clinicians. Uses a logical, organ system-based approach that clearly describes all of the mechanisms that control and regulate bodily function. Includes new clinical case examples, as well as In the Clinic and At the Molecular Level boxes that highlight practical aspects of this fundamental science. Provides key experimental observations and examples that offer a rich understanding of the body's dynamic processes. Discusses recent discoveries such as the role of lymphatics in the nervous system. Begins each chapter with a bulleted list of questions and ends with key concepts covered in that chapter.

Download or read book Adler s Physiology of the Eye written by Leonard A Levin and published by Elsevier Health Sciences. This book was released on 2024-02-14 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written and designed to enhance your understanding of ocular function, structure, and anatomy, Adler's Physiology of the Eye is a classic, best-selling text that makes critical information easier to learn and retain. The fully revised 12th Edition continues the successful Adler’s approach that connects basic science and clinical aspects in a user-friendly, highly visual format—ideal for study, review, and exam preparation. It captures the latest molecular, genetic, and biochemical discoveries and offers you unparalleled knowledge and insight into the physiology of the eye and its structures. Covers the full structure and function of the eye and its related anatomy and makes the connection between physiology and clinical practice. Includes major updates throughout, including new information on OCT/OCTA imaging, new drug delivery methods, ocular biomechanics, and evolving gene therapies. Organizes content by function, rather than anatomy, to help you make a stronger connection between physiological principles and clinical practice. Explains the physiological principles that underlie visual acuity, intraocular pressure, ocular circulation, the extraocular muscles, and much more. Features approximately 1,000 illustrations throughout, including medical artwork; schematics, charts, and graphs; clinical photographs; and more. Any additional digital ancillary content may publish up to 6 weeks following the publication date.

Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.

Download or read book Brain Mapping The Methods written by Arthur W. Toga and published by Academic Press. This book was released on 2002-09-25 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of scientists and laboratories involved with brain mapping is increasing exponentially; and the second edition of this comprehensive reference has also grown much larger than the first (published in 1996), including, for example, five chapters on structural and functional MRI where the fi

Download or read book Brain Mapping written by and published by Academic Press. This book was released on 2015-02-14 with total page 2668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Mapping: A Comprehensive Reference, Three Volume Set offers foundational information for students and researchers across neuroscience. With over 300 articles and a media rich environment, this resource provides exhaustive coverage of the methods and systems involved in brain mapping, fully links the data to disease (presenting side by side maps of healthy and diseased brains for direct comparisons), and offers data sets and fully annotated color images. Each entry is built on a layered approach of the content – basic information for those new to the area and more detailed material for experienced readers. Edited and authored by the leading experts in the field, this work offers the most reputable, easily searchable content with cross referencing across articles, a one-stop reference for students, researchers and teaching faculty. Broad overview of neuroimaging concepts with applications across the neurosciences and biomedical research Fully annotated color images and videos for best comprehension of concepts Layered content for readers of different levels of expertise Easily searchable entries for quick access of reputable information Live reference links to ScienceDirect, Scopus and PubMed

Download or read book Military Quantitative Physiology written by Karl Friedl and published by Department of the Army. This book was released on 2012 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: NOTE: NO FURTHER DISCOUNT FOR THIS PRINT PRODUCT- OVERSTOCK SALE -- Significantly reduced list price Few human activities demand or deserve as much attention of the citizens of a nation as the array of man-made and natural "environmental" threats faced by the soldiers and other warriors defending the nation - those that pose the risk of disease, injury, combat wounds, and even death. This book is the Army's first detailing research in computational physiology models and highlighting pivotal research. It outlines the extent to which basic and applied biomedical scientists, clinicians, modelers, and others stribe to understand the extent of these threats, and provide intellectual and materiel options to mitigate these risks. This book summarizes major Army research efforts to quantify and model military relevant physiology. These chapters highlight the translation of this research into useful predictive tools. The tools are of importance to medical planners, materiel developers, commanders, and in many cases, every soldier. These chapters detail the experimental basis for many of the predictive tools that are currently in use. This book is written for military clinicians, and medical researchers who may be reasonably expected to explain some of the background, as well as those who will extend the research. Many people will find this book interesting because it details research on topics that affect everyone in everyday life, including how we sleep, eat, and exercise, as well as more specific topics such as the effects of caffeine on performance, risks associated with laser pointers, and even Army blast models that have influenced safety thresholds for car airbag deployments.

Download or read book Foundations of Vision written by Brian A. Wandell and published by Sinauer Associates, Incorporated. This book was released on 1995 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for students, scientists and engineers interested in learning about the core ideas of vision science, this volume brings together the broad range of data and theory accumulated in this field.

Download or read book Neurocomputing written by James A. Anderson and published by MIT Press. This book was released on 1993-08-26 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: In bringing together seminal articles on the foundations of research, the first volume of Neurocomputing has become an established guide to the background of concepts employed in this burgeoning field. Neurocomputing 2 collects forty-one articles covering network architecture, neurobiological computation, statistics and pattern classification, and problems and applications that suggest important directions for the evolution of neurocomputing.James A. Anderson is Professor in the Department of Cognitive and Linguistic Sciences at Brown University. Andras Pellionisz is a Research Associate Professor in the Department of Physiology and Biophysics at New York Medical Center and a Senior National Research Council Associate to NASA. Edward Rosenfeld is editor and publisher of the newsletters Intelligence and Medical Intelligence.

Download or read book Investigative Ophthalmology Visual Science written by and published by . This book was released on 2002 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Human Physiology written by Rainer Greger and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 2478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Human Physiology is a significantly important publication on physiology, presenting state-of-the-art knowledge about both the molecular mechanisms and the integrative regulation of body functions. This is the first time that such a broad range of perspectives on physiology have been combined to provide a unified overview of the field. This groundbreaking two-volume set reveals human physiology to be a highly dynamic science rooted in the ever-continuing process of learning more about life. Each chapter contains a wealth of original data, clear illustrations, and extensive references, making this a valuable and easy-to-use reference. This is the quintessential reference work in the fields of physiology and pathophysiology, essential reading for researchers, lecturers and advanced students.