Download or read book High resolution PET CT Imaging for the Quantitative Assessment of Early Response to Treatment in Breast Cancer written by Andrea Ferrero and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Limitations in spatial resolution and sensitivity of whole-body (WB) E18F-fluorode-oxyglucose (FDG) positron emission tomography (PET) have been shown to reduce the potential of this imaging modality in predicting at an early stage the effectiveness of systemic treatment for breast cancer patients. Several institutions have been proposing the use of dedicated, high resolution PET scanners (bPET) to overcome these limitations. At our institution we have integrated a bPET scanner with a high resolution breast x-ray computed tomography (bCT) system, resulting in the first generation Davis breast PET/CT scanner (DbPET/CT-I). In this work, we report on the development of phantoms and data correction techniques to produce quantitative PET/CT data from DbPET/CT-I. We also present the initial results of a clinical trial to assess the potential of bPET/CT to predict response to neoadjuvant chemotherapy at an early stage in the course of treatment. Eight patients completed the study as part of this ongoing clinical evaluation. Novel methods were developed that improve on the accuracy of spatial coregistration between in vivo bPET/CT data and histopathology specimens, which represent the gold standard for the diagnosis and evaluation of tumor response. Although being developed for bPET/CT, once fully validated the approach could be used for a wide array of breast imaging modalities. Finally, we report on the design, assembly and performance characterization of a second generation scanner (DbPET/CT-II) with improved spatial resolution and count rate performance over the first prototype. The development of novel acquisition protocols that optimize the scanning time are presented together with the efforts towards producing quantitative images.
Download or read book PET CT in Breast Cancer written by Rakesh Kumar and published by Springer Nature. This book was released on 2023-07-26 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide crisp information related to pathology, management and radiological/molecular imaging in breast carcinoma, along with detailed information on FDG PET-CT in breast cancer, normal variants, artefacts, pitfalls with atlas illustrations. The book is unique in providing quick reference to practice of PET/CT in breast cancer. The initial few chapters are related to the pathology and management of breast carcinoma to help understand the pathophysiology of breast cancer before going to the imaging. The chapter on imaging in breast cancer highlights the role of different imaging modalities for different indications to the reader. The last four chapters describe in detail the role, normal variants, artefacts and pitfalls of FDG PET/CT along with recent molecular imaging advances in breast cancer. Written by Pathology, Oncology, Radiology and Nuclear Medicine experts from different countries with enormous experience in breast cancer practice, the book addresses nuclear medicine physicians and radiologists, but it may be of interest to a wider medical community, including oncologists and radiotherapists.
Download or read book Atlas of Clinical PET CT in Treatment Response Evaluation in Oncology written by Stefano Fanti and published by Springer Nature. This book was released on 2021-07-07 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas is a superb guide to the use of PET-CT for the evaluation of treatment response in oncology patients based on its ability to assess tumor metabolic status. The first part of the book explains the role of PET-CT in response evaluation in different treatment settings. For comparison, overviews of the value and limitations of CT alone, PET alone, and anatomical and functional MRI are included. Guidance is also provided on the reporting of PET-CT scans in post-therapy scenarios. The second part of the book describes and illustrates the use of PET-CT with FDG and other tracers to assess the treatment response of malignancies at different anatomic sites. Featuring a wealth of images, informative case-based discussion, and evidence-based teaching points, these disease-specific chapters clearly demonstrate the key role that PET-CT can play in distinguishing early responders from patients who are non-responders or are resistant to treatment. Prompt and accurate evaluation of treatment response is vital as we enter the era of individualized medicine, and this atlas will persuade readers of the considerable advantages of PET-CT over conventional radiological and clinical methods.
Download or read book Breast Cancer Advances in Molecular Imaging An Issue of PET Clinics E Book written by Gary A. Ulaner and published by Elsevier Health Sciences. This book was released on 2023-09-06 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue, guest editors bring their considerable expertise to this important topic. Contains 10 relevant, practice-oriented topics including current dedicated breast imaging: recent advances and current limitations; breast cancer systemic staging (comparison of CT, bone scan, FDG PET); breast cancer treatment response (comparison of CT, bone scan, FDG PET); artificial intelligence and machine learning in breast cancer imaging; molecular classification of breast cancer; and more. Provides in-depth clinical reviews on breast cancer: advances in molecular imaging, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Download or read book PET and PET CT written by Eugene C. Lin and published by Thieme. This book was released on 2019-01-18 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Top-selling, concise guide to PET and PET/CT imaging from distinguished radiologists, now in a new edition! PET and PET/CT have been increasingly used as effective imaging modalities in the management of patients with cancer, neurologic disease, musculoskeletal disease, and cardiac disease. PET and PET/CT: A Clinical Guide, Third Edition by world renowned molecular imaging pioneer Abass Alavi and esteemed diagnostic and nuclear radiologist Eugene Lin features the latest advances in PET technology in an easy-to-read format. The book lays a solid foundation with opening chapters on scanner physics, radionuclide basics, study interpretation, patient preparation, quantitative whole-body PET/CT imaging, normal variants, benign findings, and clinical applications. Key Highlights Oncology-related chapters include the use of PET for rare and common cancers — from brain neoplasms and musculoskeletal tumors — to breast and colorectal cancers Updated with the latest scientific literature and guidelines Specialized topics include Gadolinium-68 imaging techniques, pediatric PET/CT, utilization for radiation therapy planning and infection and inflammation evaluations, and neurological and cardiac applications A state-of-the-chapter on PET/MRI More than 500 high-quality images, including many in full color Succinct yet comprehensive, this state-of-the-art book will enable clinicians to master a highly complex imaging discipline at an accelerated pace. Residents and veteran practitioners in the fields of nuclear medicine, radiology, oncology, radiation oncology, and nuclear medicine technology will benefit from reading this resource.
Download or read book PET and PET CT written by Eugene C. Lin and published by Thieme. This book was released on 2019-01-18 with total page 799 pages. Available in PDF, EPUB and Kindle. Book excerpt: Top-selling, concise guide to PET and PET/CT imaging from distinguished radiologists, now in a new edition! PET and PET/CT have been increasingly used as effective imaging modalities in the management of patients with cancer, neurologic disease, musculoskeletal disease, and cardiac disease. PET and PET/CT: A Clinical Guide, Third Edition by world renowned molecular imaging pioneer Abass Alavi and esteemed diagnostic and nuclear radiologist Eugene Lin features the latest advances in PET technology in an easy-to-read format. The book lays a solid foundation with opening chapters on scanner physics, radionuclide basics, study interpretation, patient preparation, quantitative whole-body PET/CT imaging, normal variants, benign findings, and clinical applications. Key Highlights Oncology-related chapters include the use of PET for rare and common cancers — from brain neoplasms and musculoskeletal tumors — to breast and colorectal cancers Updated with the latest scientific literature and guidelines Specialized topics include Gadolinium-68 imaging techniques, pediatric PET/CT, utilization for radiation therapy planning and infection and inflammation evaluations, and neurological and cardiac applications A state-of-the-chapter on PET/MRI More than 500 high-quality images, including many in full color Succinct yet comprehensive, this state-of-the-art book will enable clinicians to master a highly complex imaging discipline at an accelerated pace. Residents and veteran practitioners in the fields of nuclear medicine, radiology, oncology, radiation oncology, and nuclear medicine technology will benefit from reading this resource.
Download or read book Quantitative Targeting and Radiation Therapy of Breast Cancer Using a Dedicated Breast Computed Tomography Platform written by Nicolas Demetrios Prionas and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Dedicated breast computed tomography (bCT) is a fully tomographic cone beam x-ray based imaging modality that generates three-dimensional images of the breast. During a bCT scan, the patient lies prone and each breast is imaged, one at a time, in a pendant geometry without compression. While most research has focused on the potential of bCT for diagnostic imaging of the breast, the bCT platform may play a role in other phases of breast cancer management including the delivery of image-guided therapies. Image-guidance is particularly useful in verifying treatment accuracy and monitoring response to therapy. Currently, quantification of tumor size and response to therapy are given by linear measurements; however, there is a push towards three-dimensional evaluation of tumor volume. The accuracy and precision of tumor volumetry using computed tomography were established. The potential of bCT as a quantitative imaging modality was demonstrated through an initial evaluation of contrast-enhanced bCT (CE-bCT), using injected iodine-based contrast medium. Lesion enhancement at CE-bCT was quantified and the differential enhancement observed between benign and malignant lesions was supported as a metric to aid in the detection and diagnosis of breast cancer. Upon identifying the location and extent of disease, image-guided radiation therapy (IGRT) can be delivered on the bCT platform. The feasibility of external beam radiation therapy using kilovoltage x-rays (kV-EBRT) and rotational therapy within the geometric constraints of the bCT platform was demonstrated through Monte Carlo simulation. Dose distributions were generated for whole breast irradiation (WBI), partial breast irradiation (PBI), and dose painting. A preliminary treatment planning algorithm was developed to determine the optimal beam intensities and collimation widths for WBI through kV-EBRT on a bCT platform. As a high-resolution tomographic imaging system, the bCT platform is ideally suited for quantitative tumor targeting and delivery of IGRT. The use of the same platform for both tumor targeting and therapy may provide more accurate treatment delivery and shorter treatment times. Overall, the breast CT platform may be best commissioned in women's health clinics as a multimodality system aiming to increase access to procedures needed for early detection, diagnosis, and treatment of breast cancer.
Download or read book Breast Cancer Uses and Opportunities for Molecular Imaging An Issue of PET Clinics E Book written by Elizabeth McDonald and published by Elsevier Health Sciences. This book was released on 2018-07-13 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of PET Clinics focuses on Breast Cancer: Uses and Opportunities for Molecular Imaging, and is edited by Drs. Elizabeth McDonald and Gary A. Ulaner. Articles will include: Overview of Breast Cancer Screening and Diagnosis; Nuclear Imaging for Osseous Staging; Therapeutic Role of FDG in Breast Cancer: Treatment Response; Clinical Potential of HER2 Receptor Imaging; Novel Targets for Imaging Breast Cancer: Amino Acid Imaging with Fluciclovine; Overview of Breast Cancer Therapy; Molecular Classification of Breast Cancer; Clinical Potential of Estrogen and Progesterone Receptor Imaging; Diagnostic Role of FDG in Breast Cancer: Discovery to Current; Imaging Breast Cancer Proliferation; Dedicated Breast Gamma Camera Imaging and Breast Positron Emission Tomography: Current Status and Future Directions; and more!
Download or read book Response Assessment with Quantitative FLT PET CT Imaging written by Matthew Scarpelli and published by . This book was released on 2018 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: The defining characteristic of malignant tumors is excessive, uncontrolled cell proliferation, suggesting that measurements of cell proliferation would be useful for characterizing tumors and tumor responses to therapy. Molecular imaging with the experimental modality 3'-Deoxy-3'-18F-fluorothymidine (FLT) positron emission tomography (PET) can be used to non-invasively measure longitudinal changes in cell proliferation. The overall goal of this dissertation is to investigate the clinical value of FLT PET as a biomarker of patient response to cancer therapy. It focuses on utilization of FLT PET to improve anti-angiogenic and immunotherapies as they are promising cancer therapies but widespread efficacy has been hindered by acquired or intrinsic resistance to therapy. In this dissertation a methodology for performing dynamic PET scanning and FLT compartmental modelling in clinical studies is developed. Applying this methodology shed new insights relating to the interplay of vascular and proliferative changes occurring in tumors during anti-angiogenic therapy. It was found that increases in tumor cell proliferation occurred during week-long breaks in anti-angiogenic therapy. This led in part to development of a novel treatment paradigm where chemotherapy is applied sequentially during breaks in anti-angiogenic therapy to boost therapeutic efficacy. We tested this novel treatment regimen and found greater decreases in tumor FLT uptake when chemotherapy was applied during anti-angiogenic treatment breaks, indicating sequential chemotherapy enhances the pharmacodynamic effect of anti-angiogenic therapy. In the context of immunotherapy, we found increased FLT PET uptake in draining lymph nodes that provides evidence of regional activation of immune cells. During immunotherapy, changes in FLT uptake in tumors were predictive of time to progression and increased FLT uptake in thyroid lobes was predictive of the occurrence of thyroid-related adverse events. These results strongly support continued study of FLT PET as imaging biomarker for devising improved therapeutic strategies and as an early predictor of patient response.
Download or read book Fundamentals of Oncologic PET CT E Book written by Gary A. Ulaner and published by Elsevier Health Sciences. This book was released on 2018-06-21 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the fast-changing age of precision medicine, PET/CT is increasingly important for accurate cancer staging and evaluation of treatment response. Fundamentals of Oncologic PET/CT, by Dr. Gary A. Ulaner, offers an organized, systematic introduction to reading and interpreting PET/CT studies, ideal for radiology and nuclear medicine residents, practicing radiologists, medical oncologists, and radiation oncologists. Synthesizing eight years’ worth of cases and lectures from one of the largest cancer centers in the world, this title provides a real-world, practical approach, taking you through the body organ by organ as it explains how to integrate both the FDG PET and CT findings to best interpret each lesion.
Download or read book PET CT in Cancer An Interdisciplinary Approach to Individualized Imaging written by Mohsen Beheshti and published by Elsevier Health Sciences. This book was released on 2017-05-25 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited, authored, and reviewed by an expert team of oncologists and nuclear physicians/radiologists, this one-of-a-kind title helps you make the most of the critical role PET/CT plays in cancer staging and therapeutic responses to individualized treatments. Drs. Mohsen Beheshti, Werner Langsteger, and Alireza Rezaee place an emphasis on cutting-edge research and evidence-based practice, ensuring that you’re up to date with every aspect of this fast-changing field. For each tumor entity, you’ll find authoritative discussions of background, pathology, common pattern of spread, TNM classification, clinical guidelines, discussion, evidence-based recommendations, key points, and pitfalls. Contains 130 teaching cases with high-quality PET/CT images. Presents clear, practical guidance from multiple experts across subspecialties: nuclear medicine, oncology, oncologic surgery, radiation oncology, and clinical research. Includes separate, comprehensive chapters on head and neck, lung, breast, esophageal/gastric, pancreas/neuroendocrine, colorectal, hepatobiliary, lymphoma, gynecologic, prostate, melanoma, and brain cancers. Features short reviews of clinical aspects of different cancers, primary diagnostic procedures, and recommendations regarding PET/CT from ESMO and NCCN. Helps to reveal positive outcomes or potential deficits or weaknesses in an individual plan of care, allowing for better outcomes in patient care, future cancer research, and application of radiotracers beyond 18F-FDG.
Download or read book Clinical PET and PET CT written by H. Jadvar and published by Springer Science & Business Media. This book was released on 2006-01-20 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical manual covering the full spectrum of PET and PET/CT imaging, now in common clinical practice, this book includes images of normal variants, artifacts, and pathologic conditions. Indications for and the relative clinical value of PET in the armamentarium of diagnostic medical imaging are reviewed. The information in the book is organized to be brief, concise, easy-to-understand and readily accessed. This book is intended for all health practitioners who need a concise reference and review of PET imaging indications, protocols and clinical applications. It will be useful to radiologists, nuclear medicine physicians, and clinicians who refer their patients to PET Centers for diagnostic imaging, including neurologists, neurosurgeons, psychiatrists, cardiologists, internists, and oncologists. Radiologic and nuclear medicine technologists, and physicians in training will also benefit from this work.
Download or read book PET and PET CT in Oncology written by Peter Oehr and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion, the book offers instructive information and overviews of the basic principles of PET and PET-CT as well as the routine clinical PET scanning procedures for all important oncological indications. It is designed to serve as a reference work for specialists in nuclear medicine and radiology (including therapy planning) and for oncologists. It also provides student and physicians in other medical specialities with a general introduction to the effective integration of this modern technique into routine clinical diagnostics. Above all, this volume illustrates the importance of PET and PET-CT in comparison with other imaging techniques.
Download or read book Atlas of PET CT written by Stefano Fanti and published by Springer Science & Business Media. This book was released on 2008-10-28 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This user-friendly atlas, featuring about 500 images, should be a quick guide to interpreting PET/CT images with FDG in oncology. It also illustrates how to recognize normal, para-physiological, and benign pathological uptakes in a case-based practical manner. The text, which includes most relevant technical and pathophysiological premises, covers the main clinical applications and clearly articulates learning points and pitfalls. This atlas aims to become a standard text for nuclear medicine physicians and radiologists, residents and technicians whose work involves PET/CT imaging. This book is also suitable for both undergraduate and postgraduate courses.
Download or read book Breast Cancer Imaging E Book written by Marie Tartar and published by Elsevier Health Sciences. This book was released on 2008-07-11 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Through a case-based approach, this book illustrates the best practices for all facets of breast cancer imaging – from screening of asymptomatic patients to cancer staging, identifying metastases, and assessing efficacy of treatment – in a succinct, practical source. Contributing authors from a wide range of subspecialties provide well-rounded guidance to meet the needs of today’s multidisciplinary work environment. Presents multidisciplinary discussions on the advantages and/or limitations of all available modalities. Includes advice from leading experts on cross-sectional imaging, breast imaging, and PET/CT, with input from radiation oncology, medical oncology, and breast surgery, to span the complete spectrum of care from screening to diagnosis to treatment, reflecting today’s team approach to patient care. Covers all imaging modalities to help you correlate disease presentations on mammography, CT, MR, US, and PET images. Offers a very practical, clinical, concise approach to the subject in a case-based format. Provides over 1,000 high-resolution images of disease appearance for comparison with the findings you encounter in your practice.
Download or read book PET and PET CT in Oncology written by Peter Oehr and published by Springer Science & Business Media. This book was released on 2003-11-13 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and PET-CT in Oncology describes the principles of positron emission tomography and is a useful resource for incorporating the technique in clinical practice. In a clear and straightforward fashion, the book offers instructive information and overviews of the basic principles of PET and PET-CT as well as the routine clinical PET scanning procedures for all important oncological indications. It is designed to serve as a reference work for specialists in nuclear medicine and radiology (including therapy planning) and for oncologists. It also provides student and physicians in other medical specialities with a general introduction to the effective integration of this modern technique into routine clinical diagnostics. Above all, this volume illustrates the importance of PET and PET-CT in comparison with other imaging techniques.
Download or read book PET CT Beyond FDG written by Stefano Fanti and published by Springer Science & Business Media. This book was released on 2010-05-10 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although [18F]fluorodeoxyglucose (FDG) generally shows an excellent performance as a cancer-imaging agent when using PET-CT, there are some settings in which other radiopharmaceuticals offer advantages. Such non-FDG tracers are now gaining widespread acceptance not only in research but also in clinical practice. This atlas, including about 500 high-quality images, is a user-friendly guide to PET-CT imaging beyond FDG. A wide range of tracers is covered, such as 18F- and 11C-choline, 11C-methionine, 18F-ethyl-L-tyrosine, 68Ga-DOTA-NOC, 11C-acetate, 11C-thymidine, and 18F-DOPA. Throughout, the emphasis is on image interpretation, with guidance on the recognition of normal, benign, and malignant uptake and clear instruction on learning points and pitfalls. This atlas is designed to serve as a reference text for both nuclear physicians and radiologists, and will also be of great benefit to radiographers, technologists, and nuclear medicine and radiology residents.
