Download or read book High Performance Liquid Chromatography Tandem Mass Spectrometry for Trace Analysis in Environmental Samples written by Heather L. Fleming and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: 1,3-Dimethylamylamine (1,3-DMAA) is a stimulant commercially sold in a variety of dietary supplements as a chemical species derived from geranium plants (Pelargonium graveolens). Whether 1,3-DMAA naturally occurs in geranium plants or other dietary ingredients, it has important regulatory and commercial ramifications. An extraction method combined with HPLC-MS/MS is used to determine 1,3-DMAA and 1,4-dimethylamylamine (1,4-DMAA) concentrations in geranium plants with both external calibration and standard addition methods. Samples from the Changzhou, Kunming, and Guiyang regions of China during both winter and summer were analyzed. Following the detection of DMAA in the Changzhou sample, an extraction and pre-column, chiral derivatization chemistry method was developed for the separation and analysis of the four stereoisomers of 1,3-DMAA and two enantiomers for 1,4-DMAA. Two chiral derivatizing agents (CDAs) were investigated: ( - )-1-(9-fluorenyl)ethyl chloroformate [( - )-FLEC] and (R)-( - )-alpha-methoxy-alpha-(trifluoromethyl) phenylacetyl [( - )-MTPA]. Optimization studies and detailed method detection limit (MDL), accuracy, and precision and linearity studies are presented for analysis of the DMAA-FLEC species in geranium plants. The DMAA-FLEC product was found to be unstable and a second, more stable CDA [( - )-MTPA] was employed. A preparatory scale HPLC separation was added prior to derivatization with ( - )-MTPA to aid in the separation of all DMAA stereoisomers. The propagation of error prohibited a confident analysis of individual DMAA stereoisomers, but the DMAA-FLEC and DMAA-MTPA methods both confirmed the presence of DMAA in the Changzhou plant samples. Haloacetic acids (HAAs) are formed during the chlorination of drinking water. Previous work detected HAAs in bulk sodium hypochlorite solutions with post column reaction ion chromatography (PCR-IC). A HPLC-MS/MS method was designed to provide confirmation of the presence of HAAs in the sodium hypochlorite solutions. Detailed MDL, accuracy, and precision studies are presented for the analysis of nine haloacetic acids in sodium hypochlorite solutions. Due to the complex nature of the sample matrix a solid phase extraction step was added to the HPLC-MS/MS procedure. The HAAs monochloroacetic acid, dichloroacetic acid, and trichloroacetic acid were detected in the bulk sodium hypochlorite solutions by both the HPLC-MS/MS and the PCR-IC although the two methods disagree on reported concentrations.
Download or read book Liquid Chromatography written by Mira Petrovic and published by Elsevier Inc. Chapters. This book was released on 2013-01-08 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapter gives a general overview of liquid chromatography–based methods for the determination of emerging contaminants in environmental samples. New trends and potentials for the trace analysis of selected classes of emerging contaminants, including brominated flame retardants, drugs of abuse, hormones and endocrine-disrupting compounds, nanomaterials, pefluorinated compounds, pharmaceuticals, and sunscreen agents are outlined. Various aspects of current LC–MS methodology, using tandem and hybrid MS instruments, including sample preparation, are discussed.
Download or read book Ultra Performance Liquid Chromatography Mass Spectrometry written by Mu Naushad and published by CRC Press. This book was released on 2014-03-18 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to its high sensitivity and selectivity, liquid chromatography–mass spectrometry (LC–MS) is a powerful technique. It is used for various applications, often involving the detection and identification of chemicals in a complex mixture. Ultra Performance Liquid Chromatography Mass Spectrometry: Evaluation and Applications in Food Analysis presents a unique collection of up-to-date UPLC-MS/MS methods for the separation and quantitative determination of components, contaminants, vitamins, and aroma and flavor compounds in a wide variety of foods and food products. The book begins with an overview of the history, principles, and advancement of chromatography. It discusses the use of UHPLC techniques in food metablomics, approaches for analysis of foodborne carcinogens, and details of UPLC-MS techniques used for the separation and determination of capsaicinoids. Chapters describe the analysis of contaminants in food, including pesticides, aflatoxin, perfluorochemicals, and acrylamide, as well as potentially carcinogenic heterocyclic amines in cooked foods. The book covers food analysis for beneficial compounds, such as the determination of folate, vitamin content analysis, applications for avocado metabolite studies, virgin olive oil component analysis, lactose determination in milk, and analysis of minor components of cocoa and phenolic compounds in fruits and vegetables. With contributions by experts in interdisciplinary fields, this reference offers practical information for readers in research and development, production, and routing analysis of foods and food products.
Download or read book Chromatographic Analysis of the Environment written by Leo M.L. Nollet and published by CRC Press. This book was released on 2017-03-03 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed handbook covers different chromatographic analysis techniques and chromatographic data for compounds found in air, water, and soil, and sludge. The new edition outlines developments relevant to environmental analysis, especially when using chromatographic mass spectrometric techniques. It addresses new issues, new lines of discussion, and new findings, and develops in greater detail the aspects related to chromatographic analysis in the environment. It also includes different analytical methodologies, addresses instrumental aspects, and outlines conclusions and perspectives for the future.
Download or read book Liquid Chromatography Mass Spectrometry MS MS and Time of Flight MS written by Imma Ferrer and published by American Chemical Society. This book was released on 2003-08-14 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores state-of-the-art mass spectrometric techniques. It focuses on liquid chromatography/mass spectrometry/mass spectrometry and time-of-flight/mass spectrometry to determine emerging contaminants, such as pharmaceuticals, hormones, pesticides, surfactants and unknown natural products.
Download or read book Fast Liquid Chromatography mass Spectrometry Methods In Food And Environmental Analysis written by Oscar Nunez and published by World Scientific. This book was released on 2015-02-03 with total page 625 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing need for high-throughput separations in food and environmental research that are able to cope with the analysis of a large number of compounds in very complex matrices. Whereas the most common approach for solving many analytical problems has often been high-performance liquid chromatography (HPLC), the recent use of fast or ultra-fast chromatographic methods for environmental and food analysis has increased the overall sample throughput and laboratory efficiency without loss (and even with an improvement) in the resolution obtained by conventional HPLC systems.This book brings together researchers at the top of their field from across the world to discuss and analyze recent advances in fast liquid chromatography-mass spectrometry (LC-MS) methods in food and environmental analysis. First, the most novel approaches to achieve fast and ultra-fast methods as well as the use of alternative and complementary stationary phases are described. Then, recent advances in fast LC-MS methods are addressed, focusing on novel treatment procedures coupled with LC-MS, new ionization sources, high-resolution mass spectrometry, and the problematic confirmation and quantification aspects in mass spectrometry. Finally, relevant LC-MS applications in food and environmental analysis such as the analysis of pesticides, mycotoxins, food packaging contaminants, perfluorinated compounds and polyphenolic compounds are described.The scope of the book is intentionally broad and is aimed at worldwide analytical laboratories working in food and environmental applications as well as researchers in universities worldwide.
Download or read book Perchlorate in the Environment written by Edward Todd Urbansky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a symposium sponsored by the Environmental Division of the American Chemical Society, Perchlorate in the Environment is the first comprehensive book to address perchlorate as a potable water contaminant. The two main topics are: analytical chemistry (focusing on ion chromatography and electrospray ionization mass spectrometry), and treatment or remediation. Also included are topics such as ion exchange, phytoremediation, bacterial reduction of perchlorate, bioreactors, and in situ bioremediation. To provide complete coverage, background chapters on fundamental chemistry, toxicology, and reulatory issues are also included. The authors are environmental consultants, government researchers, industry experts, and university professors from a wide array of disciplines.
Download or read book Fast Liquid Chromatography Mass Spectrometry Methods in Food and Environmental Analysis written by Oscar Núñez and published by World Scientific Publishing Company Incorporated. This book was released on 2015 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing need for high-throughput separations in food and environmental research that are able to cope with the analysis of a large number of compounds in very complex matrices. Laboratories worldwide are now demanding fast and efficient analytical procedures with enough sensitivity, robustness, effectiveness and high resolution to be able to perform both qualitative and quantitative analysis while at the same time achieving cost-effective methodologies with reduced analysis times. Whereas the most common approach for solving many analytical problems has often been high-performance liquid chromatography (HPLC), the recent use of fast or ultra-fast chromatographic methods for environmental and food analysis has increased the overall sample throughput and laboratory efficiency without loss (and even with an improvement) in the resolution obtained by conventional HPLC systems.This book brings together researchers at the top of their field from across the world to discuss and analyze recent advances in fast liquid chromatography–mass spectrometry (LC–MS) methods for food and environmental analysis. It focuses on the development of the analytical method: sample preparation, chromatographic separation, mass spectrometry and, finally, confirmation and quantification aspects. These topics are addressed in three main parts. First, the most novel approaches to achieve fast and ultra-fast methods as well as the use of alternative and complementary stationary phases are described. In the second part, advances in fast LC–MS methods are addressed, focusing on novel treatment procedures coupled with LC–MS, new ionization sources, high-resolution mass spectrometry, and the problematic confirmation and quantification aspects in mass spectrometry. Finally, the third part is devoted to relevant LC–MS applications in food and environmental analysis and addresses the analysis of pesticides, mycotoxins, food packaging contaminants, perfluorinated compounds and polyphenolic compounds.This book brings together researchers working at the top of the field at universities and in industry from across the world to present the state-of-the-art in current research on food and environmental analysis. The scope of the book is intentionally broad and is aimed at worldwide analytical laboratories working in food and environmental applications as well as researchers in universities worldwide.
Download or read book Application of High Performance Liquid Chromatography mass Spectrometry to Environmental Analysis written by Leon D. Betowski and published by . This book was released on 1989 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt: High performance liquid chromatography (HPLC) coupled with mass spectrometry (MS) is described for the analysis of samples for environmental pollutants. During the course of this work different techniques were used to increase both the sensitivity and specificity of HPLC/MS. These included the utilization of two different interfaces for the mass spectrometer - the thermospray and the particle beam systems. Refinements to the thermospray system were made with the use of a wire-repeller to enhance sensitivity and also to increase the structural information obtained from mass spectra. The operation of the instrument in the discharge negative ionization mode further increased the specificity of these techniques as did the use of a triple quadrupole mass spectrometer in the HPLC/MS system. Two different sets of compounds were used in this study. Organic dyes were used to test the improvements in the system. Since work was performed with dyes previously and since dye compounds encompass a variety of structural functionalities, the dyes made good test compounds. Chlorinated herbicides were studied in an effort to analyze for these compounds directly without having to prepare derivatives before separation.
Download or read book Chromatographic Analysis of the Environment written by Leo M.L. Nollet and published by CRC Press. This book was released on 2017-03-03 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed handbook covers different chromatographic analysis techniques and chromatographic data for compounds found in air, water, and soil, and sludge. The new edition outlines developments relevant to environmental analysis, especially when using chromatographic mass spectrometric techniques. It addresses new issues, new lines of discussion, and new findings, and develops in greater detail the aspects related to chromatographic analysis in the environment. It also includes different analytical methodologies, addresses instrumental aspects, and outlines conclusions and perspectives for the future.
Download or read book Sample Handling and Trace Analysis of Pollutants written by Damia Barcelo and published by Elsevier. This book was released on 2000-03-08 with total page 1151 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an updated, completely revised version of a previous volume in this series entitled: ENVIRONMENTAL ANALYSIS -- Techniques, applications and quality assurance. The book treats different aspects of environmental analysis such as sample handling and analytical techniques, the applications to trace analysis of pollutants (mainly organic compounds), and quality assurance aspects, including the use of certified reference materials for the quality control of the whole analytical process. New analytical techniques are presented that have been developed significantly over the last 6 years, like solid phase microextraction, microwave-assisted extraction, liquid chromatography-mass spectrometric methods, immunoassays, and biosensors. The book is divided into four sections. The first describes field sampling techniques and sample preparation in environmental matrices: water, soil, sediment and biota. The second section covers the application areas which are either based on techniques, like the use of gas chromatography-atomic emission detection, immunoassays, or coupled-column liquid chromatography, or on specific application areas, like chlorinated compounds, pesticides, phenols, mycotoxins, phytotoxins, radionuclides, industrial effluents and wastes, including mine waste. Validation and quality assurance are described in the third section, together with the interpretation of environmental data using advanced chemometric techniques. The final section reports the use of somewhat advanced analytical methods, usually more expensive, less routinely used or less developed, for the determination of pollutants.
Download or read book Comprehensive Environmental Mass Spectrometry written by Albert Lebedev and published by ILM Publications. This book was released on 2012 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: "In full colour throughout, this book describes the power of mass spectrometry in resolving environmental issues, demonstrating how real-world complex problems can be solved in a simple and elegant way."--Worldcat.
Download or read book Liquid Chromatography Mass Spectrometry written by Robert E. Ardrey and published by Wiley. This book was released on 2003-07-25 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: First explaining the basic principles of liquid chromatography and mass spectrometry and then discussing the current applications and practical benefits of LC-MS, along with descriptions of the basic instrumentation, this title will prove to be the indispensable reference source for everyone wishing to use this increasingly important tandem technique. * First book to concentrate on principles of LC-MS * Explains principles of mass spectrometry and chromatography before moving on to LC-MS * Describes instrumental aspects of LC-MS * Discusses current applications of LC-MS and shows benefits of using this technique in practice
Download or read book Analysis of Pesticides in Food and Environmental Samples Second Edition written by Jose L. Tadeo and published by CRC Press. This book was released on 2019-03-04 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a critical overview of analytical methods used for the determination of pesticide residues and other contaminants in food and environmental samples by modern instrumental analysis. It contains up-to-date material including recent trends in sample preparation, general methods used for pesticide analysis and quality assurance aspects, and chromatographic and immunoassay methods. The rest of the book describes particular analytical methods used for the determination of pesticides in food and soil, water and air. In addition, the levels of these chemicals found in food, their regulatory aspects and the monitoring of pesticides in the environment are described.
Download or read book High performance Liquid Chromatography And Mass Spectrometry Of Porphyrins Chlorophylls And Bilins written by Chang-kee Lim and published by World Scientific. This book was released on 2009-07-17 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The porphyrins, chlorophylls, bilins and related tetrapyrroles are vital for all living organisms. Natural and synthetic tetrapyrroles are used extensively in foods, cosmetics, biotechnology, pharmaceuticals, diagnostics and medicine. Methods for their separation and characterization therefore, have a very wide area of applications. Yet, there is a dearth of books dedicated to HPLC and HPLC/MS of tetrapyrroles. Lim addresses this problem admirably by providing practical HPLC and HPLC/MS protocols coupled with in-depth chromatographic and mass spectrometric reference data. These are invaluable in the analysis, identification and characterization of porphyrins, chlorophylls, bilins and other related compounds found in biological and clinical materials. HPLC method development and optimization for coupling to mass spectrometry are also described in rich detail. Sample preparation, and suggestions for avoiding procedural artifacts during extraction of clinical and biological samples are discussed. Clinical biochemists involved in biochemical diagnosis of human porphyrias will find this monograph assuredly helpful, as would analysts, biochemists and chemists involved in the separation, isolation and characterization of natural and synthetic tetrapyrroles. Undoubtedly, Lim has contributed a master-piece containing sufficient background material for beginners and up-to-date references for all researchers in the field.
Download or read book Fast Liquid Chromatography mass Spectrometry Methods in Food and Environmental Analysis written by Oscar Núñez Burcio and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book High Performance Liquid Chromatography and Mass Spectrometry written by William Kerr and published by . This book was released on 2019-08-23 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: High-performance liquid chromatography (HPLC), also known as high-pressure liquid chromatography, is an advanced type of LC. HPLC is amenable to a wide range of applications, such as pharmaceuticals and food analysis. It is especially useful for low or non-volatile organic compounds, which cannot be handled with gas chromatography. Liquid chromatography-mass spectrometry (LC-MS) is an analytical chemistry technique that combines the physical separation capabilities of liquid chromatography (or HPLC) with the mass analysis capabilities of mass spectrometry (MS). Coupled chromatography - MS systems are popular in chemical analysis because the individual capabilities of each technique are enhanced synergistically. While liquid chromatography separates mixtures with multiple components, mass spectrometry provides structural identity of the individual components with high molecular specificity and detection sensitivity. This tandem technique can be used to analyze biochemical, organic, and inorganic compounds commonly found in complex samples of environmental and biological origin. Therefore, LC-MS may be applied in a wide range of sectors including biotechnology, environment monitoring, food processing, and pharmaceutical, agrochemical, and cosmetic industries. Mass spectrometry (MS) is an analytical technique that measures the mass-to-charge ratio (m/z) of charged particles (ions). Although there are many different kinds of mass spectrometers, all of them make use of electric or magnetic fields to manipulate the motion of ions produced from an analyze of interest and determine their m/z. The book has primarily been designed for analysts who are unfamiliar with this technique or have limited training and experience in this or have constraints in finding a suitable HPLC method. The book presents a comprehensive compilation of reviews, opinions and applications of the use of Mass Spectrometry to analyze biomolecules.
