Download or read book High Performance In Memory Genome Data Analysis written by Hasso Plattner and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent achievements in hardware and software developments have enabled the introduction of a revolutionary technology: in-memory data management. This technology supports the flexible and extremely fast analysis of massive amounts of data, such as diagnoses, therapies, and human genome data. This book shares the latest research results of applying in-memory data management to personalized medicine, changing it from computational possibility to clinical reality. The authors provide details on innovative approaches to enabling the processing, combination, and analysis of relevant data in real-time. The book bridges the gap between medical experts, such as physicians, clinicians, and biological researchers, and technology experts, such as software developers, database specialists, and statisticians. Topics covered in this book include - amongst others - modeling of genome data processing and analysis pipelines, high-throughput data processing, exchange of sensitive data and protection of intellectual property. Beyond that, it shares insights on research prototypes for the analysis of patient cohorts, topology analysis of biological pathways, and combined search in structured and unstructured medical data, and outlines completely new processes that have now become possible due to interactive data analyses.

Download or read book A Course in In Memory Data Management written by Hasso Plattner and published by Springer. This book was released on 2014-05-28 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent achievements in hardware and software development, such as multi-core CPUs and DRAM capacities of multiple terabytes per server, enabled the introduction of a revolutionary technology: in-memory data management. This technology supports the flexible and extremely fast analysis of massive amounts of enterprise data. Professor Hasso Plattner and his research group at the Hasso Plattner Institute in Potsdam, Germany, have been investigating and teaching the corresponding concepts and their adoption in the software industry for years. This book is based on an online course that was first launched in autumn 2012 with more than 13,000 enrolled students and marked the successful starting point of the openHPI e-learning platform. The course is mainly designed for students of computer science, software engineering, and IT related subjects, but addresses business experts, software developers, technology experts, and IT analysts alike. Plattner and his group focus on exploring the inner mechanics of a column-oriented dictionary-encoded in-memory database. Covered topics include - amongst others - physical data storage and access, basic database operators, compression mechanisms, and parallel join algorithms. Beyond that, implications for future enterprise applications and their development are discussed. Step by step, readers will understand the radical differences and advantages of the new technology over traditional row-oriented, disk-based databases. In this completely revised 2nd edition, we incorporate the feedback of thousands of course participants on openHPI and take into account latest advancements in hard- and software. Improved figures, explanations, and examples further ease the understanding of the concepts presented. We introduce advanced data management techniques such as transparent aggregate caches and provide new showcases that demonstrate the potential of in-memory databases for two diverse industries: retail and life sciences.

Download or read book High Performance Computing written by Ponnuswamy Sadayappan and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 35th International Conference on High Performance Computing, ISC High Performance 2020, held in Frankfurt/Main, Germany, in June 2020.* The 27 revised full papers presented were carefully reviewed and selected from 87 submissions. The papers cover a broad range of topics such as architectures, networks & infrastructure; artificial intelligence and machine learning; data, storage & visualization; emerging technologies; HPC algorithms; HPC applications; performance modeling & measurement; programming models & systems software. *The conference was held virtually due to the COVID-19 pandemic. Chapters "Scalable Hierarchical Aggregation and Reduction Protocol (SHARP) Streaming-Aggregation Hardware Design and Evaluation", "Solving Acoustic Boundary Integral Equations Using High Performance Tile Low-Rank LU Factorization", "Scaling Genomics Data Processing with Memory-Driven Computing to Accelerate Computational Biology", "Footprint-Aware Power Capping for Hybrid Memory Based Systems", and "Pattern-Aware Staging for Hybrid Memory Systems" are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Download or read book Real Time Business Intelligence and Analytics written by Malu Castellanos and published by Springer Nature. This book was released on 2019-10-10 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the thoroughly refereed conference proceedings of the BIRTE workshops listed below, which were held in in conjunction with VLDB, the International Conference on Very Large Data Bases: 9th International Workshop on Business Intelligence for the Real-Time Enterprise, BIRTE 2015, held in Kohala Coast, Hawaii, in August 2015, 10th International Workshop on Enabling Real-Time Business Intelligence, BIRTE 2016, held in New Delhi, India, in September 2016, 11th International Workshop on Real-Time Business Intelligence and Analytics, BIRTE 2017, held in Munich, Germany, in August 2017. The BIRTE workshop series provides a forum for the discussion and advancement of the science and engineering enabling real-time business intelligence and the novel applications that build on these foundational techniques. The book includes five selected papers from BIRTE 2015; five selected papers from BIRTE 2016; and three selected papers from BIRTE 2017.

Download or read book Advanced Information Networking and Applications written by Leonard Barolli and published by Springer Nature. This book was released on 2021-04-30 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the theory, design and applications of computer networks, distributed computing and information systems. Networks of today are going through a rapid evolution, and there are many emerging areas of information networking and their applications. Heterogeneous networking supported by recent technological advances in low-power wireless communications along with silicon integration of various functionalities such as sensing, communications, intelligence and actuations is emerging as a critically important disruptive computer class based on a new platform, networking structure and interface that enable novel, low-cost and high-volume applications. Several of such applications have been difficult to realize because of many interconnections problems. To fulfill their large range of applications, different kinds of networks need to collaborate, and wired and next-generation wireless systems should be integrated in order to develop high-performance computing solutions to problems arising from the complexities of these networks. The aim of the book “Advanced Information Networking and Applications” is to provide latest research findings, innovative research results, methods and development techniques from both theoretical and practical perspectives related to the emerging areas of information networking and applications.

Download or read book Secure Multiparty Computation written by Ronald Cramer and published by Cambridge University Press. This book was released on 2015-07-15 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information on theoretically secure multiparty computation (MPC) and secret sharing, and the fascinating relationship between the two concepts.

Download or read book The Digital Patient written by C. D. Combs and published by John Wiley & Sons. This book was released on 2015-12-11 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: A modern guide to computational models and constructive simulation for personalized patient care using the Digital Patient The healthcare industry’s emphasis is shifting from merely reacting to disease to preventing disease and promoting wellness. Addressing one of the more hopeful Big Data undertakings, The Digital Patient: Advancing Healthcare, Research, and Education presents a timely resource on the construction and deployment of the Digital Patient and its effects on healthcare, research, and education. The Digital Patient will not be constructed based solely on new information from all the “omics” fields; it also includes systems analysis, Big Data, and the various efforts to model the human physiome and represent it virtually. The Digital Patient will be realized through the purposeful collaboration of patients as well as scientific, clinical, and policy researchers. The Digital Patient: Advancing Healthcare, Research, and Education addresses the international research efforts that are leading to the development of the Digital Patient, the wealth of ongoing research in systems biology and multiscale simulation, and the imminent applications within the domain of personalized healthcare. Chapter coverage includes: The visible human The physiological human The virtual human Research in systems biology Multi-scale modeling Personalized medicine Self-quantification Visualization Computational modeling Interdisciplinary collaboration The Digital Patient: Advancing Healthcare, Research, and Education is a useful reference for simulation professionals such as clinicians, medical directors, managers, simulation technologists, faculty members, and educators involved in research and development in the life sciences, physical sciences, and engineering. The book is also an ideal supplement for graduate-level courses related to human modeling, simulation, and visualization.

Download or read book Building a Columnar Database on RAMCloud written by Christian Tinnefeld and published by Springer. This book was released on 2015-07-07 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the field of parallel database management systems and illustrates the great variety of solutions based on a shared-storage or a shared-nothing architecture. Constantly dropping memory prices and the desire to operate with low-latency responses on large sets of data paved the way for main memory-based parallel database management systems. However, this area is currently dominated by the shared-nothing approach in order to preserve the in-memory performance advantage by processing data locally on each server. The main argument this book makes is that such an unilateral development will cease due to the combination of the following three trends: a) Today’s network technology features remote direct memory access (RDMA) and narrows the performance gap between accessing main memory on a server and of a remote server to and even below a single order of magnitude. b) Modern storage systems scale gracefully, are elastic and provide high-availability. c) A modern storage system such as Stanford’s RAM Cloud even keeps all data resident in the main memory. Exploiting these characteristics in the context of a main memory-based parallel database management system is desirable. The book demonstrates that the advent of RDMA-enabled network technology makes the creation of a parallel main memory DBMS based on a shared-storage approach feasible.

Download or read book Big Data Management and Processing written by Kuan-Ching Li and published by CRC Press. This book was released on 2017-05-19 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the Foreword: "Big Data Management and Processing is [a] state-of-the-art book that deals with a wide range of topical themes in the field of Big Data. The book, which probes many issues related to this exciting and rapidly growing field, covers processing, management, analytics, and applications... [It] is a very valuable addition to the literature. It will serve as a source of up-to-date research in this continuously developing area. The book also provides an opportunity for researchers to explore the use of advanced computing technologies and their impact on enhancing our capabilities to conduct more sophisticated studies." ---Sartaj Sahni, University of Florida, USA "Big Data Management and Processing covers the latest Big Data research results in processing, analytics, management and applications. Both fundamental insights and representative applications are provided. This book is a timely and valuable resource for students, researchers and seasoned practitioners in Big Data fields. --Hai Jin, Huazhong University of Science and Technology, China Big Data Management and Processing explores a range of big data related issues and their impact on the design of new computing systems. The twenty-one chapters were carefully selected and feature contributions from several outstanding researchers. The book endeavors to strike a balance between theoretical and practical coverage of innovative problem solving techniques for a range of platforms. It serves as a repository of paradigms, technologies, and applications that target different facets of big data computing systems. The first part of the book explores energy and resource management issues, as well as legal compliance and quality management for Big Data. It covers In-Memory computing and In-Memory data grids, as well as co-scheduling for high performance computing applications. The second part of the book includes comprehensive coverage of Hadoop and Spark, along with security, privacy, and trust challenges and solutions. The latter part of the book covers mining and clustering in Big Data, and includes applications in genomics, hospital big data processing, and vehicular cloud computing. The book also analyzes funding for Big Data projects.

Download or read book Next Generation Sequencing Data Analysis written by Xinkun Wang and published by CRC Press. This book was released on 2016-04-06 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Practical Guide to the Highly Dynamic Area of Massively Parallel SequencingThe development of genome and transcriptome sequencing technologies has led to a paradigm shift in life science research and disease diagnosis and prevention. Scientists are now able to see how human diseases and phenotypic changes are connected to DNA mutation, polymorphi

Download or read book Genome Data Analysis written by Ju Han Kim and published by Springer. This book was released on 2019-04-30 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader’s bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. The textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics.

Download or read book Data Analysis for the Life Sciences with R written by Rafael A. Irizarry and published by CRC Press. This book was released on 2016-10-04 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers several of the statistical concepts and data analytic skills needed to succeed in data-driven life science research. The authors proceed from relatively basic concepts related to computed p-values to advanced topics related to analyzing highthroughput data. They include the R code that performs this analysis and connect the lines of code to the statistical and mathematical concepts explained.

Download or read book Heterogeneous Data Management Polystores and Analytics for Healthcare written by Vijay Gadepally and published by Springer. This book was released on 2019-03-21 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed post-conference proceedings of International Workshops: Polystores and other Systems for Heterogeneous Data, Poly 2018, and Data Management and Analytics for Medicine and Healthcare, DMAH 2018, in Rio de Janeiro, Brazil, in August 2018, held in conjunction with the 44th International Conference on Very Large Data Bases, VLDB 2018. The 11 regular papers presented together with 2 invited papers and 1 abstract of a keynote talk were carefully reviewed and selected from 16 initial submissions. The Poly 2018 Workshop focus on growing a larger and more diverse research agenda around data system solutions for heterogeneous data. The DMAH 2018 Workshop aims to foster exchange of information and discussions on innovative data management and analytics technologies.

Download or read book High Performance Computing written by Julian M. Kunkel and published by Springer. This book was released on 2016-06-14 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 31st International Conference, ISC High Performance 2016 [formerly known as the International Supercomputing Conference] held in Frankfurt, Germany, in June 2016. The 25 revised full papers presented in this book were carefully reviewed and selected from 60 submissions. The papers cover the following topics: Autotuning and Thread Mapping; Data Locality and Decomposition; Scalable Applications; Machine Learning; Datacenters andCloud; Communication Runtime; Intel Xeon Phi; Manycore Architectures; Extreme-scale Computations; and Resilience.

Download or read book Introduction to Bioinformatics written by Arthur M. Lesk and published by . This book was released on 2019 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lesk provides an accessible and thorough introduction to a subject which is becoming a fundamental part of biological science today. The text generates an understanding of the biological background of bioinformatics.

Download or read book Computational Genomics with R written by Altuna Akalin and published by CRC Press. This book was released on 2020-12-16 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015.

Download or read book High Performance Computing for Big Data written by Chao Wang and published by CRC Press. This book was released on 2017-10-16 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: High-Performance Computing for Big Data: Methodologies and Applications explores emerging high-performance architectures for data-intensive applications, novel efficient analytical strategies to boost data processing, and cutting-edge applications in diverse fields, such as machine learning, life science, neural networks, and neuromorphic engineering. The book is organized into two main sections. The first section covers Big Data architectures, including cloud computing systems, and heterogeneous accelerators. It also covers emerging 3D IC design principles for memory architectures and devices. The second section of the book illustrates emerging and practical applications of Big Data across several domains, including bioinformatics, deep learning, and neuromorphic engineering. Features Covers a wide range of Big Data architectures, including distributed systems like Hadoop/Spark Includes accelerator-based approaches for big data applications such as GPU-based acceleration techniques, and hardware acceleration such as FPGA/CGRA/ASICs Presents emerging memory architectures and devices such as NVM, STT- RAM, 3D IC design principles Describes advanced algorithms for different big data application domains Illustrates novel analytics techniques for Big Data applications, scheduling, mapping, and partitioning methodologies Featuring contributions from leading experts, this book presents state-of-the-art research on the methodologies and applications of high-performance computing for big data applications. About the Editor Dr. Chao Wang is an Associate Professor in the School of Computer Science at the University of Science and Technology of China. He is the Associate Editor of ACM Transactions on Design Automations for Electronics Systems (TODAES), Applied Soft Computing, Microprocessors and Microsystems, IET Computers & Digital Techniques, and International Journal of Electronics. Dr. Chao Wang was the recipient of Youth Innovation Promotion Association, CAS, ACM China Rising Star Honorable Mention (2016), and best IP nomination of DATE 2015. He is now on the CCF Technical Committee on Computer Architecture, CCF Task Force on Formal Methods. He is a Senior Member of IEEE, Senior Member of CCF, and a Senior Member of ACM.