Download or read book Heterogeneity of Being written by Marco Luis Dorfsman and published by University Press of America. This book was released on 2015-01-26 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: One hundred years after his birth, Nobel laureate Octavio Paz is considered one of the most important thinkers of Mexican identity, one of the most influential Mexican poets, and one of the main representatives of a national cosmopolitanism. Most readings of his work, whether critical or laudatory, operate within these parameters. Through a careful analysis of Latin Americanist discourses on identity and difference, Heterogeneity of Being goes beyond the standard interpretations of Octavio Paz as a thinker of national identity and proposes a radical rethinking of the rift and the bond between literature and philosophy. It puts forth the key concept of “dif/herencia”—a difference, a wound, an inheritance, a burden and a dispossession—and reads it through the notion of similitude in order to show that Paz’s “tradition of rupture” properly displays a continuity between self and other, identity and difference, time and space. The work of Octavio Paz yields invaluable insights for the fields of literary theory, cultural studies, history of science, and art history.
Download or read book Heterogeneity in Statistical Genetics written by Derek Gordon and published by Springer. This book was released on 2020-12-17 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.
Download or read book Heterogeneity High Performance Computing Self Organization and the Cloud written by Theo Lynn and published by Springer. This book was released on 2018-05-18 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY NC ND license. It addresses the most recent developments in cloud computing such as HPC in the Cloud, heterogeneous cloud, self-organising and self-management, and discusses the business implications of cloud computing adoption. Establishing the need for a new architecture for cloud computing, it discusses a novel cloud management and delivery architecture based on the principles of self-organisation and self-management. This focus shifts the deployment and optimisation effort from the consumer to the software stack running on the cloud infrastructure. It also outlines validation challenges and introduces a novel generalised extensible simulation framework to illustrate the effectiveness, performance and scalability of self-organising and self-managing delivery models on hyperscale cloud infrastructures. It concludes with a number of potential use cases for self-organising, self-managing clouds and the impact on those businesses.
Download or read book Heterogeneity written by Tobias Werler and published by Waxmann Verlag. This book was released on 2012 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is true that modern teaching is faced with heterogeneous students. Ironically, this is not a recent development: students have always been different. Consequently, there is a broad discourse on "heterogeneity" in education. On the normative level of meta-narratives about modern democracy one will find the idea that more and more people have to be included in the modern welfare state. Nevertheless, before talking about inclusion one has to deal with the mechanisms of exclusion, if one is interested in the phenomenon of heterogeneity. At the heart of it, one will find the debate on the meaning of differences between students from an age group and their implications for school-based learning. Even more basically, Didaktik has to give a response on the dilemma arising of balancing "individual" and "collective" modes of teaching. However, Didaktik theory speaks in the singular and in the light of normality. It normally speaks of generalized homogenized students, axis-constructions and vertexes in the singular, denying their heterogeneity. How can the teacher's relation to this simultaneous heterogeneity be carried out in a justified way? The central idea of the book is to explore whether this professional Didaktik challenge can be studied through the concept of the others' "strangeness". This volume analyzes the constructions of heterogeneity in pedagogy based on the leitmotif of the stranger. In doing so, the stranger is seen as a didactic key. The book shows that there is a necessity to understand the filter of strangeness/otherness. Beyond that it elaborates criteria for establishing the filter and didactically relevant mechanisms of this filter.
Download or read book Philosophy as Experimentation Dissidence and Heterogeneity written by José Miranda Justo and published by Cambridge Scholars Publishing. This book was released on 2021-09-24 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contemporary philosophical research interconnects classical domains of philosophy, the arts, literature and social sciences. This collection of essays explores the operational role of experimentation, dissidence and heterogeneity in this process. It offers fundaments for the criticism of monolithical tendencies often put forward under the banner of the ‘Speculative Turn’ or New Realism, by means of exploring the contribution and influence of authors such as J. G. Hamann, Kierkegaard, Nietzsche and Guy Debord. These philosophers, historically placed within the margins of the philosophical mainstream, were decisive in the emergence of the philosophical thought and practices of Deleuze, Wittgenstein and Bataille, as shown here. The reader will also find re-evaluations of the contributions of Vico, Spinoza or Kant to posterity, next to new readings of authors like Foucault, Hadot, Benjamin and Adorno with regards to their significant experimental and dissident positions.
Download or read book Developing a Protocol for Observational Comparative Effectiveness Research A User s Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)
Download or read book Towards an Understanding of Tinnitus Heterogeneity written by Christopher Cederroth and published by Frontiers Media SA. This book was released on 2019-07-19 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tinnitus is the perception of a sound when no external sound is present. The severity of tinnitus varies but it can be debilitating for many patients. With more than 100 million people with chronic tinnitus worldwide, tinnitus is a disorder of high prevalence. The increased knowledge in the neuroscience of tinnitus has led to the emergence of promising treatment approaches, but no uniformly effective treatment for tinnitus has been identified. The large patient heterogeneity is considered to be the major obstacle for the development of effective treatment strategies against tinnitus. This eBook provides an inter- and multi-disciplinary collection of tinnitus research with the aim to better understand tinnitus heterogeneity and improve therapeutic outcomes.
Download or read book The Origin of the Plasma Cell Heterogeneity written by Catherine Pellat-Deceunynck and published by Frontiers Media SA. This book was released on 2015-12-22 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controversial whether the regulation of PCs numbers and the “active” in vivo Ig diversity depend or not on non-specific reactivation of B-cells during infections. Depending on the stimulus (T-independent/T-dependent antigen, cytokines, partner cells) and B-cell types (naïve or memory, circulating or germinal center, lymph nodes or spleen, B1 or B2...), both the phenotype and isotype of PCs differ suggesting that PC diversity is either linked to B-cell diversity or to the type of stimulus or to both. Knowledge of the mechanisms supporting PC diversity has important consequences for the management of i) plasma cell neoplasia such as Multiple Myeloma and Waldenström's Macroglobulinemia, ii) vaccine protection against pathogens and iii) auto-immune diseases.
Download or read book Monocyte Heterogeneity and Function written by Pierre Guermonprez and published by Frontiers Media SA. This book was released on 2021-02-11 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heterogeneity in Asthma written by Allan R. Brasier and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention.
Download or read book Ecological Heterogeneity written by Jurek Kolasa and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: An attractive, promising, and frustrating feature of ecology is its complex ity, both conceptual and observational. Increasing acknowledgment of the importance of scale testifies to the shifting focus in large areas of ecology. In the rush to explore problems of scale, another general aspect of ecolog ical systems has been given less attention. This aspect, equally important, is heterogeneity. Its importance lies in the ubiquity of heterogeneity as a feature of ecological systems and in the number of questions it raises questions to which answers are not readily available. What is heterogeneity? Does it differ from complexity? What dimensions need be considered to evaluate heterogeneity ade quately? Can heterogeneity be measured at various scales? Is heterogeneity apart of organization of ecological systems? How does it change in time and space? What are the causes of heterogeneity and causes of its change? This volume attempts to answer these questions. It is devoted to iden tification of the meaning, range of applications, problems, and methodol ogy associated with the study of heterogeneity. The coverage is thus broad and rich, and the contributing authors have been encouraged to range widely in discussions and reflections. vi Preface The chapters are grouped into themes. The first group focuses on the conceptual foundations (Chapters 1-5). These papers exarnine the meaning of the term, historical developments, and relations to scale. The second theme is modeling population and interspecific interactions in hetero geneous environments (Chapters 6 and 7).
Download or read book Science Abstracts written by and published by . This book was released on 1919 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Critical Exposition of Bergson s Philosophy written by John M'Kellar Stewart and published by . This book was released on 1911 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rift lines within european regulatory framework for biosimilars when taking heterogeneity and variation during lifecycle of the reference biologic and the biosimilar into account written by Malik Osmane and published by Anchor Academic Publishing (aap_verlag). This book was released on 2014-02-01 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopharmaceutical medicinal products (biologics) represent a huge financial market. Thus upon patent protection expiry of the innovator (reference) biologic there is interest from industry to gain a portion of this market by launching a 'similar' biologic at a reduced development cost, thus boosting potential gains. The EMA responded to this desire and lead the guidance process with industry on the topic of biosimilars. Based on the experience gained with biosimilars in the past, the EMA started to introduce a second generation series of guidance documents, which take into account the past, current and possibly future challenges of biosimilars. Those proposals were evaluated by EMA and partially incorporated into new guidance documents. This work highlights the challenges and risks associated with biosimilar submissions for large and complex bio-molecules such antibodies. Results: There are unaddressed questions for the regulator with regard to the unsolved dynamic of heterogeneity and variations of the quality profile, which have potential implications on safety and efficacy. This is neglected and not taken into account seriously enough by the stakeholders. Solution: Further, the only (in my view) progressive way to deal with such foreseeable situations from the biosimilar developer’s point of view is to incorporate a design space.
Download or read book The Humanitarian Review written by and published by . This book was released on 1909 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Key Issues in Women s Work Female Heterogeneity and the Polarisation of Women s Employment written by Catherine Hakim and published by A&C Black. This book was released on 1996-01-01 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr Hakim tests the power of patriarchy theory against economic and psychophysiology theories. Sex discrimination, part-time work, flexible hours, homeworking, marriage and career patterns, labour mobility, labour turnover and the impact of the European Union are all considered. Analysis of the grand sweep of history over the last century, based on large national surveys, is complemented by case studies of people working in occupations undergoing change and their resistance to it. Throughout the book comparisons are drawn between Britain, the USA, and other European countries and also China, Japan and other Far Eastern societies. The analysis draws on sociology, economics, psychology, labour law, history and anthropology to conclude that female heterogeneity is increasing, explaining the growing polarisation of women's employment and many contradictory research results
Download or read book The Heterogeneity Link of the Welfare State and Redistribution written by Udaya R. Waglé and published by Springer Science & Business Media. This book was released on 2013-11-26 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book situates ethnic heterogeneity in the larger discussion of the welfare state and its redistributive outcomes, poverty and inequality. By using comprehensive, longitudinal data covering 1980 to 2010 from 17 high income countries, this analysis helps achieve a major milestone in comparative welfare state research both conceptually and methodologically. Conceptually, it elevates the relevance of growing ethnic heterogeneity in thinking about how politics and economics of the welfare state operate, collectively impacting the magnitudes of poverty and inequality. Methodologically, the analysis conducted in this book provides broader empirical tests for the many propositions and discourses found in the literature based largely on anecdotal evidence, case studies, and unjustifiably limited quantitative data. The innovative oeprationalization of the multidimensional character of both welfare state policies and ethnic heterogeneity help broaden the analytical frameworks of comparative welfare state research. The outcome is a major advance in the way we understand the causes and redistributive consequences of the welfare state, in which ethno-racial, religious, and especially immigration heterogeneity can play a crucial role. A thorough and insightful analysis presented in this book helps students, researchers, and policymakers better understand the ethnic heterogeneity connections of the welfare state and redistribution, together with a comparative perspective of the changing faces of ethnic heterogeneity, welfare state policies, and poverty and inequality in high income countries.
