Download or read book Herpes Simplex Virus Type 1 HSV 1 UL31 UL33 and UL34 Proteins Play Essential Roles in Herpesvirion Morphogenesis written by Ashley Elizabeth Reynolds and published by . This book was released on 2002 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Herpes Simplex Virus Type 1 UL31 and UL34 Proteins and Their Roles in Viral Envelopment at the Inner Nuclear Membrane written by Li Liang and published by . This book was released on 2005 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Herpes Simplex Virus Type 1 U L 31 and U L 34 Proteins and Their Roles in Viral Envelopment at the Inner Nuclear Membrane written by Li Liang and published by . This book was released on 2005 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes simplex virus type 1 (HSV-1) UL31 and UL34 proteins interact and target each other to the nuclear membrane of infected cells, and are both required for efficient envelopment of nucleocapsids at the inner nuclear membrane.

Download or read book The Roles of Herpes Simplex Virus Type 1 Ul34 and Us3 Proteins in Primary Envelopment written by Susan Lynn Bjerke and published by . This book was released on 2005 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genetics and Functions of Herpes Simplex Virus Type 1 Membrane Proteins in Virus induced Cell Fusion Virion Morphogenesis and Egress written by Jeffrey M. Melancon and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Structural and Functional Analysis of Herpes Simplex Virus Type 1 Glycoprotein L an Essential Component of the Viral Fusogenic Complex written by Michael J. Novotny and published by . This book was released on 1996 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genetics of Herpes Simplex Virus Type 1 Tegument Proteins Involved in Virion Morphogenesis and Egress written by Preston Fulmer and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Herpes Simplex Virus Type 1 written by Kari Lynn Roberts and published by . This book was released on 2011 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes simplex virus type 1 (HSV-1) replicates in the nucleus and buds through the nuclear membrane to access the cytosol and complete the maturation process. The HSV-1 protein pUL31, along with its binding partner, pUL34, has been previously shown to be required for nucleocapsids to successfully bud through the nuclear membrane. pUL31 is also required for efficient viral DNA synthesis and packaging. After the HSV-1 exits the nucleus, the capsid acquires several accessory proteins (tegument) and finally a mature envelope by budding into vesicles of the trans-Golgi network (TGN). These virion-laden vesicles traffic toward the cell periphery and through cortical actin until ultimately the virion is secreted upon fusion of the TGN vesicle with the plasma membrane. The data presented here reveals new roles for pUL31, as cells infected with a UL31-null virus were delayed for viral gene expression as well as activation of NF[kappa]B and c-Jun N-terminal kinase (JNK) in multiple cell lines. At least one representative from each kinetic class of viral genes was examined at various times post infection. The protein expression defects were not caused by a failure to enter cells, was not rescued by ICP27 expressed in trans and correlated with NF[kappa]B activation. The data shows that these defects were not observed in the absence of the pUL31 binding partner, pUL34, and that while most pUL31 is expressed at late times post infection, low levels are detectable as early as 2 hours post infection. Data presented in this work also demonstrates a role for the actin motor myosin Va in the secretion of HSV-1 virions. Expression of two isoforms of dominant negative myosin Va (DN-myoVa) decreased virion secretion by 5075% as well as significantly decreased surface expression of viral glycoproteins B, M and D. DN-myoVa colocalized with TGN markers and the conformation of native myosin Va in infected cells was altered by 4 hours post infection. These data suggest that myosin Va is involved in the egress of virion-laden TGN vesicles as they transit through cortical actin toward the plasma membrane.

Download or read book The Herpesviruses written by Bernard Roizman and published by Springer. This book was released on 2012-01-19 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great truth is a truth whose opposite. is also a great truth. Thomas Mann (Essay on Freud, 1937) This volume centers on pseudorabies (PR V), herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), and human cytomegalovirus (CMV) and fulfills three objectives. The chapters on the epidemiology and latency of HSV, and on the glycoproteins specified by HSV and CMV, set the stage for the discussions of the immunobiology and pathogenesis of human herpesvirus infections in Volume 4. The epidemiology of HSV is the basis of our understanding of the spread and survival of this virus in the human populations. Central to the epidemiology of HSV and its pathogenesis in humans is the ability of the virus to remain in a latent state for the life of its host. The viral membrane glycoproteins are among the most interesting virion proteins, primarily because of their critical role in the initiation of infection. Since they are the surface membrane proteins of the virion and appear on the surface of productively infected cells, they are also the obvious if not the exclusive targets of the immune response. The chapters on the transforming potential of HSV and CMV, and on the role of HSV in human cancer, deal with challenging problems requiring rather different experimental tools.

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Download or read book Viral Molecular Machines written by Michael G. Rossmann and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will contain a series of solicited chapters that concern with the molecular machines required by viruses to perform various essential functions of virus life cycle. The first three chapters (Introduction, Molecular Machines and Virus Architecture) introduce the reader to the best known molecular machines and to the structure of viruses. The remainder of the book will examine in detail various stages of the viral life cycle. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, synthesis and assembly of viral structural components, genome packaging and maturation into an infectious virion. Each chapter will describe the components of the respective machine in molecular or atomic detail, genetic and biochemical analyses, and mechanism. Topics are carefully selected so that the reader is exposed to systems where there is a substantial infusion of new knowledge in recent years, which greatly elevated the fundamental mechanistic understanding of the respective molecular machine. The authors will be encouraged to simplify the detailed knowledge to basic concepts, include provocative new ideas, as well as design colorful graphics, thus making the cutting-edge information accessible to broad audience.

Download or read book Virology written by John B. Carter and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The second edition of Virology is an accessible introduction designed to enable students to understand the principles of virus structure, replication and genetics. The aim of this book is to help the reader appreciate the relevance of virology in the modern world, including the fields of vaccines, anti-viral drugs and cancer. There is also a chapter on prions. The second edition has been extensively revised and updated to reflect the many developments in virology and offers deeper insights into the subject. Newly-discovered viruses are discussed and there is an additional chapter on the influenza virus."--Publisher's website.

Download or read book Alpha Herpesviruses written by Rozanne Marie Sandri-Goldin and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cytomegaloviruses written by Matthias Johannes Reddehase and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book leading international experts provide comprehensive and authoritative reviews on every aspect of current research. By integrating viral genomics, proteomics, immunology and molecular biology with the emerging knowledge of the genomics of the host organism, penetrating new insights into the virus-host interaction are provided. The focus of the book is on the molecular and genomic aspects and the authors provide an insight into the current understanding of the subject and the future direction of research. Topics covered include disease mechanisms, genomics, proteomics, BAC mutagenes.

Download or read book Foamy Viruses written by Axel Rethwilm and published by Springer Science & Business Media. This book was released on 2003-05-12 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aberrant replication pathway of foamy viruses distinguishes them from all other retroviruses. Many details have been accumulated over the past ten or so years. Most of the findings on foamy viruses were obtained by research on a single virus isolate previously called "human foamy virus", which appeared to be the first to be investigated on a molecular level. However, to the editor's knowledge, genuine human foamy viruses do not exist, but several trans-species transmissions of different simian foamy viruses from monkeys and apes to human hosts.

Download or read book The Herpesviruses written by Bernard Roizman and published by . This book was released on 1982 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Analysis of Genes and Genomes written by Richard J. Reece and published by Halsted Press. This book was released on 2004 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analysis of GenesA and Genomes is a clear introduction to the theoretical and practical basis of genetic engineering, gene cloning and molecular biology. All aspects of genetic engineering in the post-genomic era are covered, beginning with the basics of DNA structure and DNA metabolism. Using an example-driven approach, the fundamentals of creating mutations in DNA, cloning in bacteria, yeast, plants and animals are all clearly presented. Newer technologies such as DNA macro and macroarrays, proteomics and bioinformatics are introduced in later chapters helping students to analyse and understand the vast amounts of data that are now available through genome sequence and function projects. Aimed at students with a basic knowledge of the molecular side of biology, this will be invaluable to those looking to better understand the complexities and capabilities of these important new technologies. A modern post-genome era introduction to key techniques used in genetic engineering. An example driven past-to-present approach to allow the experiments of today to be placed in an historical context Beautifully illustrated in full colour throughout. Associated website including updates, additional content and illustrations