Download or read book Hepatocellular Carcinoma in the 3rd Millennium written by Massimiliano Berretta and published by . This book was released on 2016 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: HCC is the most common primary cancer of the liver and according to the WHO report, the fourth commonest cause of death. The estimated incidence of new cases worldwide is about 500,000-1,000,000 per year causing 600,000 deaths globally per year. Although there are large areas of the world where the incidence of HCC is still unknown, several countries in East Asia and some Sub-Saharan African regions are affected by a very high prevalence of HCC (over 20 cases/100,000 population). Areas with a moderately high risk (11-20 cases/100,000 population) include Italy, Spain and Latin America, while France, Germany and the United Kingdom have instead an intermediate risk (5-10 cases/100,000 population). A relatively low prevalence (less than 5 cases/100,000 population) is found in the United States, Canada and Scandinavia. The incidence of HCC has been rising in developed western countries in the last two decades, along with the emergence of the hepatitis C virus infection and due to the rise of immigration rates from HBV-endemic countries. In addition, even though the incidence of HCC reaches its highest peak among persons over 65 years, an increased incidence among younger individuals has been noted in the last two decades both in USA and Europe. A multidisciplinary approach should be taken when assessing patients with HCC; stage of HCC and liver disease should always be taken into account and the best treatment should be offered. Liver resection and ablative treatments should never be denied to patients, and curative procedures should be performed in hepato-biliary-pancreatic centers. Each HCC patient has to be evaluated singularly, stratifying each time the risk for the procedure so as to determine which treatment is the best treatment. It is also important to analyze all the possibilities that can be offered. This similar approach showed a good efficacy and safety in all "frail" patient categories, such as elderly patients or patients with HCC and HIV infection. Early diagnosis of HCC and retreatment for HCC recurrence have a key role in the survival of patients. Therefore, regular screening programs for HCC should be extended to all patients according to proposed guidelines, together with a greater proclivity for treatment and retreatment options in cases of an HCC diagnosis or recurrence. This may be an important and needed breakthrough for this rising problem.

Download or read book Receptor Chemistry Towards the Third Millennium written by M. Gianella and published by Elsevier. This book was released on 2000-05-31 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptor Chemistry Towards the Third Millennium is the result of papers presented at the 12th Camerino-Noordwijkerhout Symposium, held in Camerino, Italy in September 1999. Although much is known about the way ligands interact with receptors, which have now been isolated, characterized and cloned, many aspects still remain to be explored. In particular, differentiation into distinct subpopulations and the multiplicity of transduction processes offer more specific targets in the search for new drugs. This book will be of interest to medicinal chemists, pharmacologists, biochemists and neurologists and will also be a valuable source of reference for medical students and postgraduate students in related fields.

Download or read book Mitochondria The Anti cancer Target for the Third Millennium written by Jiri Neuzil and published by Springer. This book was released on 2014-05-26 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will be focused on mitochondria as very promising targets for anti-cancer drugs, yet to be fully exploited. It will contain chapters focused on aspects of basic research as well as on clinical relevance, which will be written by specialists in the field. That the role of mitochondria in human pathologies goes beyond the neoplastic diseases will be documented by a chapter of the role of mitochondria in Friedreich's ataxia.

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Molecular Aspects of Hepatocellular Carcinoma written by Liang Qiao and published by Bentham Science Publishers. This book was released on 2012 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic options for late-stage liver cancer are very limited and the prognosis is often poor. A better understanding of the molecular mechanisms involved in the initiation, progression, and metastasis of hepatocellular carcinoma is critical for developing more rational diagnostic and therapeutic approaches. This e-book covers current developments on clinically relevant research on the molecular biology of hepatocellular carcinoma. This e-book should be a valuable reference for professional gastroenterologists, hepatologists and oncologists as well as medical students and researchers.

Download or read book Textbook of Hepatology written by Juan Rodés and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 2360 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE encyclopedic guide to hepatology – for consultation by clinicians and basic scientists Previously the Oxford Textbook of Clinical Hepatology, this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people). Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter – giving you the best science and clinical practice discussed by the best authors. It includes unique sections on: Symptoms and signs in liver disease Industrial diseases affecting the liver The effects of diseases of other systems on the liver The effects of liver diseases on other systems It's bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more. Plus, it comes with a fully searchable CD ROM of the entire content. Click here to view a sample chapter on the liver and coagulation

Download or read book Genomic and Personalized Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2012-11-29 with total page 1343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Personalized Medicine, Second Edition - winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Download or read book International Seminar On Nuclear War And Planetary Emergencies 46th Session The Role Of Science In The Third Millennium written by Richard C Ragaini and published by World Scientific. This book was released on 2014-07-07 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 46th Session of the International Seminars on Nuclear War and Planetary Emergencies held in Erice, Sicily. This Seminar has again gathered, in 2013, over 100 scientists from 43 countries in an interdisciplinary effort that has been going on for the last 32 years, to examine and analyze planetary problems which had been followed up, all year long, by the World Federation of Scientists' Permanent Monitoring Panels.

Download or read book Blumgart s Surgery of the Liver Pancreas and Biliary Tract E Book written by William R. Jarnagin and published by Elsevier Health Sciences. This book was released on 2012-03-09 with total page 2302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and complete, Blumgart’s Surgery of the Liver, Pancreas and Biliary Tract – edited by Dr. William R. Jarnagin and a team of experts- delivers the comprehensive, cutting-edge guidance you need to achieve optimal outcomes in surgery of the liver, biliary tract, and pancreas. Edited by a panel of experts and featuring contributions by many leading authorities, this 2-volume reference brings you the latest information on pathology, diagnostics, surgery, and non-operative intervention all in one source. At www.expertconsult.com you can not only access the complete contents online, but also an abundance of detailed illustrations and step-by-step procedural video clips from the Memorial Sloan Kettering video library that show you how to perform key procedures step by step. Glean all essential, up-to-date, need-to-know information in one comprehensive reference that provides extensive coverage of pathology, diagnostics, surgery, and non-operative intervention as well as hepatobiliary and pancreatic surgery. Deepen your understanding of surgical anatomy to help with diagnosis, surgical operation, interventional radiology, and endoscopy. See how to perform key procedures by watching operative videos from the Memorial Sloan Kettering video library. Apply the most advanced diagnostic and management options for each disease, including interventional techniques. Stay current with the latest knowledge and advancements including minimally invasive techniques in hepatic resection; surgical considerations for congenital disorders of the pancreas; non-surgical therapies for pancreatic cancer; microwave ablation and other emerging technologies; the most recent developments in the rapidly changing area of transplantation; and the newest best practices in pre- and post-operative care and blood transfusion. Get in-depth coverage of the pancreas from the only fully comprehensive text on both hepatobiliary and pancreatic surgery. Learn from the very best. Rely on the trusted guidance of experts, with a fresh perspective from senior editor, Dr. William Jarnigan, who has earned a national and international reputation in the surgical management of diseases of the biliary tract. Access the full text online at www.expertconsult.com, along with image and video libraries, tables, figures, and more! Over 200 additional contributing experts. A single, comprehensive reference that covers pathology, diagnostics, surgery, and non-operative intervention all in one text!

Download or read book Handbook of Oxidative Stress in Cancer Therapeutic Aspects written by Sajal Chakraborti and published by Springer Nature. This book was released on 2022-09-28 with total page 4078 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy. ​

Download or read book Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers written by Ganji Purnachandra Nagaraju and published by Springer Nature. This book was released on 2020-10-07 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrointestinal (GI) malignancies account for a large portion of cancers worldwide. Although incidence of esophageal, gastric, and colorectal cancers has decreased in recent years, pancreatic and liver cancer have increased. The mainstay of GI cancer therapy is chemoradiation and surgery. Despite significant medical advancements, diagnosis and therapy for GI cancers remain challenging due to tumor cell resistance to chemoradiotherapy. The tumor’s increased cell signalling due to excessive transcription factor activation and increased stellate cell activity leads to collagen deposition formation of a dense stroma around the tumor, which prevents drugs from reaching the malignant cells. This leads to tumor chemoresistance. To circumvent these difficulties, drug therapy targeting the tumor’s specific microenvironment and the additive anticancer effect of phytochemicals can allow for more effective treatment. This volume will be the first on the market on the topic of phytochemicals and their effect on the tumor microenvironment (TME). TME is an emerging area of research and the book will be a welcome introductory addition to the field.

Download or read book Liver Failure written by Nikolaos Pyrsopoulos and published by Springer Nature. This book was released on 2020-10-30 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive overview of liver failure including Epidemiology, mechanism of the disease, and its clinical manifestations. The diagnosis of numerous types of liver disease leading to liver failure; with specific emphasis on the current and future treatment modalities including up-to-date and extensive information on liver transplantation. It provides the most up-to-date information on liver failure for clinicians, practitioners including GPs, scientists/researchers, postgraduates and allied health professionals. It features an overview of the relevant classification and epidemiologic aspects of acute liver failure along with a thorough review of the mechanisms associated with acute liver failure and multisystemic involvement. Detailed guidance is also provided on the latest treatment techniques including those available for liver transplantation and potential future approaches, enabling the reader to develop a detailed understanding of the topic. Liver Failure: Acute and Acute on Chronic provides a practically applicable guide to the epidemiology and management of liver failure. It features contributions from an outstanding panel of experts in hepatology, gastroenterology and surgery making it a vital up-to-date reference for trainee and practicing medical professionals in a variety of disciplines who encounter these patients.

Download or read book Structure and Health Effects of Natural Products on Diabetes Mellitus written by Haixia Chen and published by Springer Nature. This book was released on 2021-01-04 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to introduce the classified chemical components of hypoglycemic compounds in natural products, summarize the recent research progress of natural products with hypoglycemic activity in the past 20 years, and provide the original analysis and development opinions of relevant scholars. Hypoglycemic compounds are to target diabetes mellitus, an important public health problem, one of four priority noncommunicable diseases (NCDs) targeted for action by world leaders. Diabetes mellitus is a common endocrine and metabolic disease, which not only causes physiological damage to patients' kidneys, cardiovascular and cerebrovascular vessels, peripheral blood vessels, nerves and eyes, but also causes mental and psychological pressure to patients. Due to the evidence that traditional medicine and natural herbal formula have advantages in treating diabetes, natural products with hypoglycemic activity have been studied extensively in recent years and have been accepted by many scholars all over the world. This book focuses on the progress on the study of the structure, hypoglycemic activities, structure-activity relationships and mechanism of a wide range of polysaccharides, flavonoids, saponins, alkaloids, terpenoids, polyphenols and other constituents. It will help students and researchers to understand current approaches and progress in the treatment of diabetes with natural products, which may also be beneficial to develop new hypoglycemic drugs.

Download or read book International Seminars On Nuclear War And Planetary Emergencies 48th Session The Role Of Science In The Third Millennium written by Richard C Ragaini and published by World Scientific. This book was released on 2016-07-28 with total page 900 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the 48th Session of the International Seminars on Nuclear War and Planetary Emergencies held in Erice, Sicily. This Seminar has again gathered, in 2015, over one hundred scientists from 43 countries in an interdisciplinary effort that has been going on for the last 32 years, to examine and analyze planetary problems which had been followed up, all year long, by the World Federation of Scientists' Permanent Monitoring Panels.

Download or read book Plant and Human Health Volume 3 written by Munir Ozturk and published by Springer. This book was released on 2019-02-11 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early anthropological evidence for plant use as medicine is 60,000 years old as reported from the Neanderthal grave in Iraq. The importance of plants as medicine is further supported by archeological evidence from Asia and the Middle East. Today, around 1.4 billion people in South Asia alone have no access to modern health care, and rely instead on traditional medicine to alleviate various symptoms. On a global basis, approximately 50 to 80 thousand plant species are used either natively or as pharmaceutical derivatives for life-threatening conditions that include diabetes, hypertension and cancers. As the demand for plant-based medicine rises, there is an unmet need to investigate the quality, safety and efficacy of these herbals by the “scientific methods”. Current research on drug discovery from medicinal plants involves a multifaceted approach combining botanical, phytochemical, analytical, and molecular techniques. For instance, high throughput robotic screens have been developed by industry; it is now possible to carry out 50,000 tests per day in the search for compounds which act on a key enzyme or a subset of receptors. This and other bioassays thus offer hope that one may eventually identify compounds for treating a variety of diseases or conditions. However, drug development from natural products is not without its problems. Frequent challenges encountered include the procurement of raw materials, the selection and implementation of appropriate high-throughput bioassays, and the scaling-up of preparative procedures. Research scientists should therefore arm themselves with the right tools and knowledge in order to harness the vast potentials of plant-based therapeutics. The main objective of Plant and Human Health is to serve as a comprehensive guide for this endeavor. Volume 1 highlights how humans from specific areas or cultures use indigenous plants. Despite technological developments, herbal drugs still occupy a preferential place in a majority of the population in the third world and have slowly taken roots as alternative medicine in the West. The integration of modern science with traditional uses of herbal drugs is important for our understanding of this ethnobotanical relationship. Volume 2 deals with the phytochemical and molecular characterization of herbal medicine. Specifically, it will focus on the secondary metabolic compounds which afford protection against diseases. Lastly, Volume 3 focuses on the physiological mechanisms by which the active ingredients of medicinal plants serve to improve human health. Together this three-volume collection intends to bridge the gap for herbalists, traditional and modern medical practitioners, and students and researchers in botany and horticulture.

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1796 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Living Donor Liver Transplantation 2nd Edition written by Sheung Tat Fan and published by World Scientific. This book was released on 2011-03-08 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book describes in detail the technical aspects of Living Donor Liver Transplantation (LDLT), the routine practice of the world renowned Liver Transplant Team at Hong Kong's Queen Mary Hospital, and our views on various issues of the operation. The thorough review on the history and technical procedures of LDLT and discussion on various aspects of the operation and its future perspectives will serve as a unique reference for surgeons, researchers, nurses, medical students, patients and laypersons seeking information on LDLT.This latest edition offers updated operative results from our center and the latest modifications of the technique. With contributions from a leading microvascular surgeon, a critical care clinician, a psychiatrist, and two anesthetists from the same liver transplant team, the LDLT experience at Queen Mary Hospital is depicted in an even greater extent.