Download or read book Hepatitis C Virus The Next Epidemic An issue of Gastroenterology Clinics of North America written by K. Rajender Reddy and published by Elsevier Health Sciences. This book was released on 2016-01-07 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are over 180 million people with chronic HCV infection worldwide with between 2.7 and 3.9 million in the United States. Hepatitis C most significantly affects Asia and Africa, with rates up to 15% in countries such as Egypt and up to 30% in certain regions such as Punjab, Pakistan. Hepatitis C places a significant burden on the public health infrastructure, as it remains the leading cause of chronic liver disease, accounting for 50-75% of primary liver cancers and is responsible for 30% of all liver transplantations. It is estimated to have cost the United States $5.5 billion in 1997, comparable to the national cost of asthma, $5.8 billion in 1994.This number is only expected to grow as the current HCV population ages, increasing overall rates of compensated cirrhosis/end-stage liver disease. The evolution of directly acting anti-virals has ushered in a new era for chronic hepatitis C. Ongoing drug development strategy has involved targeting several replication steps of the virus and the hope is to see all oral therapies by late 2014 or early 2015. Thus we are at an exciting cross roads with regard to new information and challenges with HCV: rising disease burden with associated high costs, the challenges globally and in multiple patient populations, and the impending availability of effective and well tolerated treatments. Therefore there is a need to commission an exclusive issue of GCNA for HCV.

Download or read book Eliminating the Public Health Problem of Hepatitis B and C in the United States written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-06-01 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the first of two, examines the feasibility of hepatitis B and C elimination in the United States and identifies critical success factors. The phase two report will outline a strategy for meeting the elimination goals discussed in this report.

Download or read book Helicobacter Pylori Therapies An Issue of Gastroenterology Clinics of North America written by Akiko Shiotani and published by Elsevier Health Sciences. This book was released on 2015-09-03 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicobacter pylori (H. pylori) infection is a worldwide disease with a significant morbidity and mortality; it is the leading cause of non-ulcer dyspepsia, peptic ulcers and gastric tumors, including low-grade mucosa-associated lymphoid tissue-lymphoma and adenocarcinoma. In addition, it has also been recognized that the interaction between H. pylori and non-steroidal, anti-inflammatory drugs is damaging to the gastroduodenal mucosa. H. pylori treatment still remains a challenge for physicians, since no current first-line therapy is able to cure the infection in all treated patients. This issue will serve to update gastroenterologists on current therapies, evaluation and management of disease progression, and the future of management of H. pylori infection.

Download or read book Gastroparesis An issue of Gastroenterology Clinics of North America written by Henry P. Parkman and published by Elsevier Health Sciences. This book was released on 2015-04-07 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue will be an informative treatise on gastroparesis, a symptomatic chronic disorder of the stomach characterized by delayed gastric emptying in the absence of mechanical obstruction. Gastroparesis is an increasingly recognized and diagnosed disorder. Treatment can be challenging due to several mechanisms which play a role in causing the symptoms. Symptoms of gastroparesis are variable and include early satiety, nausea, vomiting, bloating, and upper abdominal discomfort. These symptoms can range from mild to severe leading to such complications as malnutrition, functional disability, and multiple hospitalizations. The three most common etiologies are diabetes, post-surgical, and idiopathic (unknown). Treatment consists of dietary manipulation, medical, and surgical therapy. The articles will provide a comprehensive review and in-depth information on gastroparesis. Each chapter will be written by an expert in the area. This issue will give the reader a better appreciation for the breadth of gastroparesis.

Download or read book Management of Pancreatic Diseases An Issue of Gastroenterology Clinics of North America written by Nuzhat A. Ahmad and published by Elsevier Health Sciences. This book was released on 2016-02-19 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue details the latest knowledge of early diagnosis, risk factors, limited surgical treatments, and novel therapies for pancreatic diseases. Clinicians will learn the most prognostic scoring systems for acute pancreatitis, review the basics for early management of the disease, and see how current practice guidelines have evolved. Advances in radiological imaging when applied to the pancreas have resulted in enhanced staging and improved selection for surgical intervention. Endoscopy of the pancreas via both ERCP and endoscopic ultrasound has led to unprecedented access and potential for non-operative intervention. Pancreatic surgery now takes advantage of both minimally invasive approaches and techniques learned from organ transplantation. These latest advances are addressed in this issue by key opinion leaders.

Download or read book Barrett s Esophagus An issue of Gastroenterology Clinics of North America written by Prasad G. Iyer and published by Elsevier Health Sciences. This book was released on 2015-06-25 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough update is presented by the Guest Editors on the diagnosis, treatment, and management of Barrett’s Esophagus. Not only do they address the most pertinent clinical issues like screening, biomarkers, surveillance, therapeutics, and predictors of disease progression but they present state of the art material on therapeutic/treatment modalities like EMR, ESD, and ablative therapy. Further, articles are presented on epidemiology, molecular pathogensis, and cost-analysis studies so that the reader will come away with a comprehensive update on Barrett’s Esophagus.

Download or read book Obesity and Gastroenterology An Issue of Gastroenterology Clinics of North America E Book written by Octavia Pickett-Blakely and published by Elsevier Health Sciences. This book was released on 2016-11-15 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last three decades, the prevalence of obesity has doubled with over 600 million obese adults worldwide. The gastrointestinal complications of obesity are well publicized; however, the role of the gastrointestinal tract in the development and treatment of obesity is often understated. From the pathophysiologic role of gut hormones and the microbiota, to the purposeful, anatomic derangement of the gastrointestinal tract that is utilized as a treatment for obesity, it is imperative that gastroenterologists understand the full scope of obesity in relation to the gastrointestinal system. Studies suggest that in the U.S. obesity is underrecognized and undertreated by health care providers. Given its complex sociology, pathophysiology, and treatment, obesity, like many other diseases, requires a multidisciplinary approach. Therefore, gastroenterologists must be equipped with the relevant knowledge of obesity that will empower them to properly manage their patients.

Download or read book Management of Helicobacter pylori Related Diseases An Issue of Gastroenterology Clinics of North America written by Akiko Shiotani and published by Elsevier Health Sciences. This book was released on 2015-09-03 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helicobacter pylori (H. pylori) infection is a worldwide disease with a significant morbidity and mortality; it is the leading cause of non-ulcer dyspepsia, peptic ulcers and gastric tumors, including low-grade mucosa-associated lymphoid tissue-lymphoma and adenocarcinoma. In addition, it has also been recognized that the interaction between H. pylori and non-steroidal, anti-inflammatory drugs is damaging to the gastroduodenal mucosa. H. pylori treatment still remains a challenge for physicians, since no current first-line therapy is able to cure the infection in all treated patients. This issue will serve to update gastroenterologists on current therapies, evaluation and management of disease progression, and the future of management of H. pylori infection.

Download or read book Women s Health in Gastroenterology An Issue of Gastroenterology Clinics of North America E Book written by Laurel R. Fisher and published by Elsevier Health Sciences. This book was released on 2016-07-06 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this issue of Gastroenterology Clinics is to present GI diseases which affect women uniquely, such as pelvic floor problems and pregnancy related disorders, or which require a more considered approach such as functional bowel disease or autoimmune processes. It will also address the position of women and female gastroenterologists in the health system as a whole. This issue is published at an exciting, transitional time in the future of gastroenterology, as we adjust approaches for the assessment of disease in a large portion of our patient population, and as we address the challenges in practicing medicine based on the uniqueness of specific populations.

Download or read book Gastrointestinal Neoplasia An Issue of Gastroenterology Clinics of North America written by Paul J. Limburg and published by Elsevier Health Sciences. This book was released on 2016-08-24 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrointestinal (GI) cancers account for nearly 150,000 deaths each year, in the United States alone. Encouragingly, environmental risk factors, premalignant conditions, and high-risk familial kindreds are well described for many GI cancers. In this comprehensive volume on GI Neoplasia, all luminal cancers will be discussed, along with pancreas cancer, gastrointestinal stromal tumors (GISTs), carcinoid tumors, and neuroendocrine tumors. Hepatobiliary cancers are not addressed, as these tumors could form the basis of a separate volume. Articles are organized to address several key topics for each cancer type, such as: public health burden, molecular pathways, risk and protective factors, early detection, clinical evaluation, management, and survivorship.

Download or read book Hepatitis Third Edition written by Alan Hecht and published by Infobase Holdings, Inc. This book was released on 2019-09-01 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis means an inflammation of the liver, but it also refers to a group of viral infections that affect the liver. There are several types of viral hepatitis, but the most common are A, B, and C. Viral hepatitis is spread through contact with infected blood, bodily fluids, or feces, though it may also result from alcohol and drug use or from other diseases. Acute hepatitis refers to the initial infection and can be mild or severe; chronic hepatitis refers to a serious condition in which the infection lasts six months or longer. Currently, vaccines are available for the prevention of hepatitis A and B viruses. This third edition of Hepatitis delves into the history, causes, and current treatments for this disease, giving valuable and up-to-date information to student researchers. Chapters include: Introduction to Hepatitis The Phases of Hepatitis Looking at the Liver Inflammation and Immune Response Hepatitis A Hepatitis B Hepatitis C.

Download or read book Hepatitis and Liver Cancer written by Institute of Medicine and published by National Academies Press. This book was released on 2010-04-23 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: The global epidemic of hepatitis B and C is a serious public health problem. Hepatitis B and C are the major causes of chronic liver disease and liver cancer in the world. In the next 10 years, 150,000 people in the United States will die from liver disease or liver cancer associated with chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infections. Today, between 800,000 and 1.4 million people in the United States have chronic hepatitis B and between 2.7 and 3.9 million have chronic hepatitis C. People most at risk for hepatitis B and C often are the least likely to have access to medical services. Reducing the rates of illness and death associated with these diseases will require greater awareness and knowledge among health care workers, improved identification of at-risk people, and improved access to medical care. Hepatitis B is a vaccine-preventable disease. Although federal public health officials recommend that all newborns, children, and at-risk adults receive the vaccine, about 46,000 new acute cases of the HBV infection emerge each year, including 1,000 in infants who acquire the infection during birth from their HBV-positive mothers. Unfortunately, there is no vaccine for hepatitis C, which is transmitted by direct exposure to infectious blood. Hepatitis and Liver Cancer identifies missed opportunities related to the prevention and control of HBV and HCV infections. The book presents ways to reduce the numbers of new HBV and HCV infections and the morbidity and mortality related to chronic viral hepatitis. It identifies priorities for research, policy, and action geared toward federal, state, and local public health officials, stakeholder, and advocacy groups and professional organizations.

Download or read book Liver Pathology An Issue of Gastroenterology Clinics of North America E Book written by Jay H. Lefkowitch and published by Elsevier Health Sciences. This book was released on 2017-06-28 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Lefkowitch has created a primer on liver pathology for the gastroenterologist that provides depth of clinical coverage in an area not typically covered in depth for gastroenterologists. This issue will provide state-of-the-art reviews in the areas of NAFLD, liver biopsy, liver pathology, hepatitis, and genomics. Articles are specifically devoted to IgG4-related disease and the liver; current concepts in pediatric NAFLD; evaluation of the pediatric liver biopsy; hepatocellular adenomas: morphology and genomics; drug-induced liver injury: the hepatic pathologist’s approach; liver pathology in alpha-1-antitrypsin deficiency; immunohistochemistry in the diagnosis of hepatocellular carcinoma; HIV infection, antiretroviral therapy and liver pathology; autoimmune hepatitis overlap syndromes and liver pathology; current perspectives on the pathology of hepatocellular carcinoma and its variants; hepatitis E virus and the liver: clinical settings and liver pathology; hepatic progenitor cells; and cholangiocarcinoma: current genomics and pathology, to name a few.

Download or read book Guidelines on Hepatitis B and C Testing written by World Health Organization and published by World Health Organization. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Testing and diagnosis of hepatitis B (HBV) and C (HCV) infection is the gateway for access to both prevention and treatment services, and is a crucial component of an effective response to the hepatitis epidemic. Early identification of persons with chronic HBV or HCV infection enables them to receive the necessary care and treatment to prevent or delay progression of liver disease. Testing also provides an opportunity to link people to interventions to reduce transmission, through counselling on risk behaviors and provision of prevention commodities (such as sterile needles and syringes) and hepatitis B vaccination. These are the first WHO guidelines on testing for chronic HBV and HCV infection and complement published guidance by WHO on the prevention, care and treatment of chronic hepatitis C and hepatitis B infection. These guidelines outline the public health approach to strengthening and expanding current testing practices for HBV and HCV, and are intended for use across age groups and populations.

Download or read book FDA s Drug Review Process and the Package Label written by Tom Brody and published by Academic Press. This book was released on 2017-12-01 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: FDA's Drug Review Process and the Package Label provides guidance to pharmaceutical companies for writing FDA-submissions, such as the NDA, BLA, Clinical Study Reports, and Investigator's Brochures. The book provides guidance to medical writers for drafting FDA-submissions in a way more likely to persuade FDA reviewers to grant approval of the drug. In detail, the book reproduces data on efficacy and safety from one hundred different FDA-submissions (NDAs, BLAs). The book reproduces comments and complaints from FDA reviewers regarding data that are fragmentary, ambiguous, or that detract from the drug's approvability, and the book reveals how sponsors overcame FDA's concerns and how sponsors succeeded in persuading FDA to grant approval of the drug. The book uses the most reliable and comprehensive source of information available for writing FDA-submissions, namely text and data from NDAs and BLAs, as published on FDA's website. The source material for writing this book included about 80,000 pages from FDA's Medical Reviews, FDA's Clinical Pharmacology Reviews, and FDA's Pharmacology Reviews, from one hundred different NDAs or BLAs for one hundred different drugs. Each chapter focuses on a different section of the package label, e.g., the Dosage and Administration section or the Drug Interactions section, and demonstrates how the sponsor's data supported that section of the package label. - Reveals strategies for winning FDA approval and for drafting the package label - Examples are from one hundred FDA-submissions (NDAs, BLAs) for one hundred different drugs, e.g., for oncology, metabolic diseases, autoimmune diseases, and neurological diseases - This book uses the most reliable and comprehensive source of information available for writing FDA-submissions, namely, the data from NDAs and BLAs as published on FDA's website at the time FDA grants approval to the drug

Download or read book Molecular Virology of Human Pathogenic Viruses written by Wang-Shick Ryu and published by Academic Press. This book was released on 2016-03-30 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author's more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature. - Presents viruses within their family structure - Contains recommended journal articles with perspectives to put primary literature in context - Includes integrated recommended reading references within each chapter - Provides access to online ancillary package inclusive of annotated PowerPoint images, instructor's manual, study guide, and test bank

Download or read book Encyclopedia of Cardiovascular Research and Medicine written by and published by Elsevier. This book was released on 2017-11-27 with total page 2854 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Cardiovascular Research and Medicine, Four Volume Set offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.