Download or read book Heat Shock Proteins in Neural Cells written by Christiane Richter-Landsberg and published by Springer Science & Business Media. This book was released on 2009-05-22 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable new title addresses the role of heat shock proteins and cellular stress responses in the brain, with a major focus on nerve cells and glia, namely oligodendrocytes and astrocytes. Heat shock proteins are involved in many physiological processes, including development and differentiation, organisation of the cytoarchitecture by binding to cytoskeletal elements, and regulation of the balance between cell death and survival.
Download or read book Heat Shock Proteins in Neural Cells written by Christiane Richter-Landsberg and published by Springer. This book was released on 2008-06-25 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stress Proteins written by David S. Latchman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is concerned with a group of proteins which were originally consid ered to be an esoteric phenomenon but which have now been shown to play critical roles both in normal and stressed cells as well as being involved in a variety of human diseases. It is the purpose of this work to give a comprehen sive view of these proteins and their various aspects. After an introductory chapter providing an overview of these proteins, the work is divided into four main sections each of which deals with one important aspect of these proteins. Thus, the first section contains a series of chapters which describe individual stress proteins and their roles in particular biological phenomena. Evidently, the induction of these proteins by elevated tempera ture or other stresses is their defining feature and the second section of this book therefore considers the regulation of stress protein gene expression both by stressful stimuli such as elevated temperature or ischaemia and by non stressful stimuli such as cytokines.
Download or read book Heat Shock Proteins and the Brain Implications for Neurodegenerative Diseases and Neuroprotection written by Alexzander A.A. Asea and published by Springer Science & Business Media. This book was released on 2008-04-06 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the prevalence of neurodegenerative diseases on the rise as average life expectancy increases, the hunt for effective treatments and preventive measures for these disorders is a pressing challenge. Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV). Key basic and clinical research laboratories from major universities and hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Neuroscience, Neurodegenerative Diseases, Molecular Medicine, Aging, Physiology, Pharmacology and Pathology.
Download or read book Heat Shock Proteins in the Nervous System written by R. J. Mayer and published by Academic Press. This book was released on 1994-07-13 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Cells respond to temperature elevation and other traumas by inducing a set of genes (cell stream genes) encoding cell stress (heat shock) proteins which may play important roles in cellular repair and/or protective mechanisms. This book surveys the current state of knowledge concerning the expression of heat shock genes and proteins in the nervous system following such traumatic events as hyperthermia, ischemia, and tissue wounding. The possible neuroprotective effects of the heat shock response are discussed. In addition to reviewing progress in animal model systems, this book discusses heat shock proteins such as ubiquitin in relation to human neurodegenerative diseases. Each chapter presents an overview of a specific subject area and includes current results from each authors laboratory and a viewpoint on future research directions. The book is organized in two parts: the first part deals with cell stress genes and their protein products; the second part deals with ubiquitin and the nervous system. The chapters are grouped so that each of the two sections begins with a description of the basic molecular cell biology of heat shock proteins or ubiquitin. Whether you are a new recruit to neuroscience or an established expert, look to this series for one-stop sources for the historical, physiological, pharmacological, biochemical, molecular biology and therapeutic aspects of your chosen research areas.
Download or read book Molecular and Cellular Biology of Neuroprotection in the CNS written by Christian Alzheimer and published by Springer. This book was released on 2012-11-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.
Download or read book Heat Shock Proteins in Neuroscience written by Alexzander A. A. Asea and published by Springer Nature. This book was released on 2019-10-30 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Proteins in Neuroscience provides the most comprehensive review on contemporary knowledge on the role of HSP in signaling pathways relevant to a number of diseases. Using an integrative approach, the contributors provide a synopsis of novel mechanisms, signal transduction pathways. To enhance the ease of reading and comprehension, this book has been subdivided into various section including; Section I, reviews current progress on our understanding of Neurological Aspects of HSP; Section II, focuses on Aspects of HSP in Neurodegenerative Diseases and Disorders, Section III, emphasizes the importance of HSP in Multiple Sclerosis; Section IV, reviews critical Aspects of HSP in Alzheimer’s Disease and Section V, gives a comprehensive update of the Development of HSP-Based Therapies for Neurological Disorders. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for starters and professionals in the fields of Neurology and Neurosciences, Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.
Download or read book Heat Shock and Development written by Lawrence E. Hightower and published by Springer Science & Business Media. This book was released on 2013-06-05 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: The possible roles of heat shock proteins in normal develop- ment in animals, plants and model systems and the effects microorganisms and the effects of elevated temperature on developmental programs are comprehensively treated. All re- levant aspects of heat shock genes in normal and abnormal development are covered all of the major biological systems currently used to study the developmental biology of heat s- hock genes included. Heat is a medically significant terato- gen in humans and (other) animals. The heat shock response itself is developmentally regulated and is likely to be pro- tective in the developingembryo. In addition to roles in stress responses, heat shock genes are differentially ex- pressed during normal development in germ tissues and fur- ther in the specialized cell types of somatic tissues such as the mammalian brain. Heat shock genes are regulated du- ring the cell cycle and heat shock promoters are being used in ectopic expression systems to study the functions of particular genes during development.
Download or read book The Big Book on Small Heat Shock Proteins written by Robert M. Tanguay and published by Springer. This book was released on 2015-06-15 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based upon a workshop entitled “The Small HSP World” held in Québec 2-5 October 2014. Twenty-five scientists provided chapters for the book. The chapters are from the best scientists currently working in this field. These colleagues include Arrigo, Benesch, Benjamin, Buchner-Haslbeck-Weinkauf, Benndorf, Boelens, Carra, Chang, Currie, Ecroyd, Emanuelsson, Fu, Garrido, Golenhofen, Gusev, Hightower, Kampinga, Lavoie, MacRae, Quinlan, Tanguay, Vierling, Vigh, Weeks and Wu. Briefly, the book starts with the structure of small heat shock proteins, moving to their functions and finishing with their involvement in diseases. Although this is quite broad, the structural aspect will be the unifying theme of the book.
Download or read book Heat Shock Proteins and Whole Body Physiology written by Alexzander A. A. Asea and published by Springer Science & Business Media. This book was released on 2009-12-10 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat Shock Proteins and Whole Body Physiology is an exciting new book in the Heat Shock Proteins series which provides the most up-to-date review on novel mechanisms insights into the important role played by heat shock proteins in human physiology. Written by leaders in the field of heat shock protein exercise physiology, neuroscience and aging, the chapters systematically and in a step wise fashion takes the reader through the fascinating mechanisms by which heat shock proteins modulate human disease and pathophysiology and provides answers as to its biological significance to the host. Section I, introduces the readers to the role played by heat shock proteins in various diseases and disorders (Heat Shock Proteins and Disease). Section II, addresses the role heat shock proteins play in psychological disorders including post traumatic stress disorders and learning (Heat Shock Proteins and Psychological Stress). Section III, present a detailed review of the role played by heat shock proteins in exercise physiology (Heat Shock Proteins and Exercise Physiology). This book is a must read for heat shock protein researchers, graduate and postgraduate fellows in the field of Medicine in general and specialities in Excersie Physiology, Neuroscience, Immunology, Aging and Pathology.
Download or read book Constitutively Expressed Heat Shock Proteins in the Rat Nervous System written by Sheng Chen and published by . This book was released on 2007 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The induction of heat shock proteins (Hsps) has been established as a characteristic feature of the heat shock response. Some Hsps are constitutively expressed in non-stressed cells. Constitutive Hsps may be of particular importance in the mammalian nervous system because of their higher expression levels in the neural tissues than other tissues. In this thesis, we examined the expression levels of constitutive Hsps in different classes of neurons, and investigated the involvement of Hsc70 in the neuronal heat shock response. Quantitative immunohistochemistry analysis revealed differing expression levels of constitutive Hsc70 and Hsp27 in different populations of neurons. Motor neurons in the spinal cord showed high levels of Hsc70 compared to dopaminergic neurons of the substantia nigra while neurons in the entorhinal cortex and hippocampus demonstrate even lower levels of Hsc70. Hsp27 was constitutively expressed at high levels in motor neurons of the spinal cord but was not detectable in neurons of the entorhinal cortex, hippocampus and substantia nigra. Other constitutively expressed Hsps, such as Hsp110, Hsp90, Hsp60 and Hsp40, did not demonstrate significant differences in levels in the various classes of neurons. The widely differing levels of constitutive Hsc70 and Hsp27 in different classes of neurons may have implications in neurodegenerative diseases. Neural cell types showing high levels of Hsc70 and Hsp27 may have a high buffering capacity against protein misfolding disorders. Following thermal stress, Hsc70 demonstrated a translocation to synapse-enriched areas of the cerebral cortex where it associated with Hsp40 to form a complex that can refold denatured proteins. The induction of Hsp70 was mainly observed in glial cells. Our results suggest that the heat shock response in the nervous system involves not only the synthesis of stress-inducible Hsps but also the redeployment of constitutively expressed Hsc70 to the synapse-enriched areas. Lipid rafts are an important compartment of synapses and platforms for signal transduction complexes involved in neurotransmission events. A set of constitutive Hsps was associated with lipid rafts and did not show major changes following thermal stress, suggesting that they may play roles in maintaining the stability of lipid raft-associated signal transduction complexes following neural stress.
Download or read book Heat Shock Proteins and Stress written by Alexzander A. A. Asea and published by Springer. This book was released on 2018-10-24 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Proteins and Stress provides the most comprehensive review on contemporary knowledge on the role of HSP in Stress. Using an integrative approach to understanding the regulation of HSP responses, the contributors provide a synopsis of novel mechanisms by which HSP responses are regulated under normal physiological and pathophysiological conditions. Key basic and clinical research laboratories from major universities and academic medical hospitals around the world contribute chapters that review present research activity and importantly project the field into the future. The book is a must read for researchers, postdoctoral fellows and graduate students in the fields of Translational Medicine, Clinical Psychologists, Human Physiology, Zoologists, Botanists, Biotechnology, Molecular Medicine, Infectious Diseases Experts and Pathologists.
Download or read book Heat Shock Proteins in Inflammatory Diseases written by Alexzander A. A. Asea and published by Springer Nature. This book was released on 2021-10-13 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Proteins in Inflammatory Diseases provides the most comprehensive highlight and insight of the expression, function and therapeutic activity of Heat Shock Proteins in inflammatory diseases including sepsis, psoriasis, neurodegenerative diseases, cancers, viral infection and autoimmune rheumatic diseases. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in inflammatory diseases. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.
Download or read book Encyclopedia of Signaling Molecules written by and published by . This book was released on 19?? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunity Tumors and Aging The Role of HSP70 written by Igor Malyshev and published by Springer Science & Business Media. This book was released on 2013-01-08 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer's disease and cardiac surgery. In this book, the author looks at HSP70 as a factor which prevents the transformation of homeostasis mechanisms of intracellular proteins into a link in the pathogenesis of a disease.
Download or read book Experimental Neurochemistry written by Abel Lajtha and published by Springer. This book was released on 1982-12-01 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume of the Handbook does not parallel any volume of the first edition; it is one more sign, or reflection, of the expansion of the field. By emphasizing the experimental approach, it illustrates the tools that have re cently become available for investigating the nervous system. Also, perhaps even more than other volumes, it illustrates the multidisciplinary nature of the field, requiring multidisciplinary methodology. It is now recognized that the availability of methodology is often the rate-limiting determinant of studies and that improvements or innovations in instrumentation can open up new avenues. A new improved method, although opening up new possibilities and being crucial to making advances, is only a tool whose use will determine its use fulness. If we do not recognize its possibilities, its use will be limited; if we do not recognize its limitations, it will mislead us. It is the possibilities and limitations and the results obtained that are illustrated here.
