Download or read book Health Hazard Evaluation Report HETA 90 390 2065 MHETA 86 012 2065 written by David P. Brown and published by . This book was released on 1990 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Government Reports Annual Index written by and published by . This book was released on 1991 with total page 1192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Environmental Pollution Control written by and published by . This book was released on 1991 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Government Reports Announcements Index written by and published by . This book was released on 1991-08 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Particles and Health 2021 an International Conference Addressing Issues in Science and Regulation written by Robert McCunney and published by Frontiers Media SA. This book was released on 2023-01-30 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Particles and Health is an international conference taking place in October 2021 addressing issues in science and regulation. Regulatory initiatives in the European Union (EU) have suggested uniform hazard classifications for all poorly soluble low toxicity particles (PSLTs). Examples of PSLTs include carbon black, titanium dioxide and iron oxide, among others. Approaches have also been proposed for setting workplace exposure limits for PSLTs such as those of the German MAK Commission. The conference will include specific sections over a two day period of about 25 presentations, associated with PSLTs regarding the following major topics: (1) human studies, (2) animal inhalation studies associated with lung cancer,(3) animal and human studies associated with non pulmonary impacts, including reproductive, genetic and cardiac effects, and (4) regulatory application of scientific studies. This conference will include presentations regarding: Definition of PSLT’s with attention to both similarities and differences among these substances. • Address scientific studies regarding human health effects of PSLTs. The value of human studies over animal studies-when human-exposed populations can be studied adequately- will be emphasized. • Address translational toxicology challenges, including the appropriateness of rats as models for human lung pathogenesis (particularly lung cancer) in light of lung overload phenomena and species differences. • Serve as a platform to present current scientific information about PSLTs important for regulatory action. • Publication of pertinent conference presentations in the peer reviewed scientific literature will allow the presentations to live beyond the conference and subsequently be reviewed part of regulatory deliberations. • Establish an interdisciplinary setting for industry, academia and regulatory professionals to interact on an important topic. Such interaction can facilitate enhanced understanding of the science and ideally, more appropriate regulations, appropriate classification and labeling as well as for setting exposure limits, among others. • Recommend areas for further clarifying research regarding the significance of the rat as a model for translation toxicology. The goal of this conference is to present current scientific evidence regarding the numerous dimensions of particles and health and to facilitate interaction and discussions among attendees with expertise in toxicology, epidemiology, occupational and pulmonary medicine and exposure assessment. Interactions between these disciplines will aid in the sound and evidence-based scientific underpinning of regulatory considerations regarding PSLTs. Although regulatory concern regarding PSLTs has focused on lung cancer risk as a result of rat inhalation overload studies, this conference will address all relevant health end points, including genetic and reproductive issues as well, consistent with ECHA guidelines. Sample of Topics related to substances that may be characterized as PSLTs, including carbon black, coal, titanium dioxide, cerium oxide, aluminum oxide barium sulfate and iron oxide, among others. • Defining PSLTs • Epidemiological studies of PSLTs • Inhalation studies evaluating human cellular response to particles • Basic research studies on inflammatory to malignancy pathways • Animal studies, PLSTs and human risk: “New Insights into old data.” • New studies on PSLTs; 2 year carcinogenicity assays • Animal studies and gender specific responses to PSLTs. How does the USA National Cancer Institute (NCI) and National Institute of Environmental Health Sciences (NIEHS) address this challenge of extrapolating rodent data to human risk assessment? • Role of the rodent model in human risk assessment of PSLTs and lung cancer risk • Adverse Outcome Pathways (AOPs) and Modes of Action (MOA): identification and recommendations for closing gaps in knowledge for rodents and humans. • Are there lessons to be learned from how the pharmaceutical industry’s approach to translational science (safety and efficacy) as evolved in recent years? • Setting exposure limits for PSLTs and Translational Toxicology. • Genotoxicity and Reproductive toxicity studies of PSLTs.
Download or read book Annual Report 1989 90 written by New Brunswick. Department of Transportation and published by . This book was released on 1991 with total page 1272 pages. Available in PDF, EPUB and Kindle. Book excerpt: General activity review of associated branches and agencies to the Department which includes corporate securities registrations, a list of tenders received, and general financial data. Branches and agencies reviewed are responsible for motor vehicle activity, highway construction, traffic engineering, telecommunications and public utilities.
Download or read book Basketball Sports Medicine and Science written by Lior Laver and published by Springer Nature. This book was released on 2020-10-05 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed as a comprehensive educational resource not only for basketball medical caregivers and scientists but for all basketball personnel. Written by a multidisciplinary team of leading experts in their fields, it provides information and guidance on injury prevention, injury management, and rehabilitation for physicians, physical therapists, athletic trainers, rehabilitation specialists, conditioning trainers, and coaches. All commonly encountered injuries and a variety of situations and scenarios specific to basketball are covered with the aid of more than 200 color photos and illustrations. Basketball Sports Medicine and Science is published in collaboration with ESSKA and will represent a superb, comprehensive educational resource. It is further hoped that the book will serve as a link between the different disciplines and modalities involved in basketball care, creating a common language and improving communication within the team staff and environment.
Download or read book Diabetes and Hypertension written by Samy I. McFarlane and published by Springer Science & Business Media. This book was released on 2012-10-19 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes and hypertension have evolved as two of the modern day epidemics affecting millions of people around the world. These two common co-morbidities lead to substantial increase in cardiovascular disease, the major cause of morbidity and mortality of adults around the world. In Diabetes and Hypertension: Evaluation and Management, a panel of renowned experts address a range of critical topics -- from basic concepts in evaluation and management of diabetes and hypertension, such as dietary interventions, to evaluation and management of secondary hypertension in clinical practice. Other chapters focus on high cardiovascular risk populations such as those with coronary heart disease, chronic kidney disease and minority patients. In addition, evolving concepts and new developments in the field are presented in other chapters, such as prevention of type 2 diabetes and the epidemic of sleep apnea and its implication for diabetes and hypertension evaluation and management. An important title covering two of the most troubling disorders of our time, Diabetes and Hypertension: Evaluation and Management will provide the busy practitioner with cutting edge knowledge in the field as well as practical information that can translate into better care provided to the high-risk population of diabetics and hypertensive patients.
Download or read book Climate Change and Impacts in the Pacific written by Lalit Kumar and published by Springer Nature. This book was released on 2020-01-31 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume addresses the impacts of climate change on Pacific islands, and presents databases and indexes for assessing and adapting to island vulnerabilities. By analyzing susceptibility variables, developing comprehensive vulnerability indexes, and applying GIS techniques, the book's authors demonstrate the particular issues presented by climate change in the islands of the Pacific region, and how these issues may be managed to preserve and improve biodiversity and human livelihoods. The book first introduces the issues specific to island communities, such as high emissions impacts, and discusses the importance of the lithological traits of Pacific islands and how these physical factors relate to climate change impacts. From here, the book aims to analyze the various vulnerabilities of different island sectors, and to formulate a susceptibility index from these variables to be used by government and planning agencies for relief prioritization. Such variables include tropical cyclones, built infrastructures, proximity to coastal areas, agriculture, fisheries and marine resources, groundwater availability, biodiversity, and economic impacts on industries such as tourism. Through the categorization and indexing of these variables, human and physical adaptation measures are proposed, and support solutions are offered to aid the inhabitants of affected island countries. This book is intended for policy makers, academics, and climate change researchers, particularly those dealing with climate change impacts on small islands.
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Download or read book Man made Vitreous Fibres written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2002 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This publication represents the views and expert opinions of an IARC working group on the evaluation of carcinogenic risks to humans, which met in Lyon, 9-16 October 2001."
Download or read book The Therapeutic Use of N Acetylcysteine NAC in Medicine written by Richard Eugene Frye and published by Springer. This book was released on 2018-09-20 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.
Download or read book Targeted Drug Delivery Concepts and Design written by Padma V. Devarajan and published by Springer. This book was released on 2014-12-08 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores the fundamental concepts and numerous applications of targeted delivery of drugs to the body. This compilation has been divided into eight sections comprised of the basic principles of drug targeting, disease and organ/organelle-based targeting, passive and active targeting strategies, and various advanced drug delivery tools such as functionalized lipidic, polymeric and inorganic nanocarriers. Together, the twenty-three chapters cover a wide range of topics in the field, including tumor and hepatic targeting, polymer-drug conjugates, nanoemulsion, physical and biophysical characteristics of nanoparticles, and in vivo imaging techniques, among others. The book also examines advanced characterization techniques, regulatory hurdles and toxicity-related issues that are key features for successful commercialization of targeted drug delivery system products. Targeted Drug Delivery is a comprehensive reference guide for drug delivery researchers, both beginners and those already working in the field.
Download or read book AI and Learning Systems written by Konstantinos Kyprianidis and published by BoD – Books on Demand. This book was released on 2021-02-17 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last few years, interest in the industrial applications of AI and learning systems has surged. This book covers the recent developments and provides a broad perspective of the key challenges that characterize the field of Industry 4.0 with a focus on applications of AI. The target audience for this book includes engineers involved in automation system design, operational planning, and decision support. Computer science practitioners and industrial automation platform developers will also benefit from the timely and accurate information provided in this work. The book is organized into two main sections comprising 12 chapters overall: •Digital Platforms and Learning Systems •Industrial Applications of AI
Download or read book Contaminants in Agriculture written by M. Naeem and published by Springer Nature. This book was released on 2020-04-25 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume covers recent studies into agricultural problems caused by soil and water contamination. Considering the importance of agricultural crops to human health, the editors have focused on chapters detailing the negative impact of heavy metals, excessive chemical fertilizer use, nutrients, pesticides, herbicides, insecticides, agricultural wastes and toxic pollutants, among others, on agricultural soil and crops. In addition, the chapters offer solutions to these negative impacts through various scientific approaches, including using biotechnology, nanotechnology, nutrient management strategies, biofertilizers, as well as potent PGRs and elicitors. This book serves as a key source of information on scientific and engineered approaches and challenges for the bioremediation of agricultural contamination worldwide. This book should be helpful for research students, teachers, agriculturalists, agronomists, botanists, and plant growers, as well as in the fields of agriculture, agronomy, plant science, plant biology, and biotechnology, among others. It serves as an excellent reference on the current research and future directions of contaminants in agriculture from laboratory research to field application.
Download or read book Particles and Nanoparticles in Pharmaceutical Products written by Henk G. Merkus and published by Springer. This book was released on 2018-09-06 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume brings together the expertise of numerous specialists on the topic of particles – their physical, chemical, pharmacological and toxicological characteristics – when they are a component of pharmaceutical products and formulations. The book discusses in detail properties such as the composition, size, shape, surface properties and porosity of particles with respect to how they impact the formulations and products in which they are used and the effective delivery of pharmaceutical active ingredients. It considers all dosage forms of pharmaceuticals involving particles, from powders to tablets, creams to ointments, and solutions to dry-powder inhalers, also including the latest nanomedicine products. Further, it discusses examples of particle toxicity, as well as the important subject of pharmaceutical industry regulations, guidelines and legislation. The book is of interest to researchers and practitioners who work on testing and developing pharmaceutical dosage and delivery systems.
Download or read book Manual of Antimicrobial Susceptibility Testing written by Stephen J. Cavalieri and published by ASM Press. This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
