Download or read book Genotoxicity and DNA Repair written by L. María Sierra and published by Humana Press. This book was released on 2014-08-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genotoxicity and DNA Repair: A Practical Approach provides a key reference for determining how to analyze the genotoxic activity of molecules or materials and, at the same time, serves as a useful tool for researchers in the Environmental Mutagenesis and DNA Repair fields. Focused on genotoxicity assays recommended by the “OECD guidelines for the testing of chemicals”, this volume also covers other useful assays, such as some gene mutation assays, the comet assay in different species and applications, and the SMART assays of Drosophila. For all the assays, the book presents brief theoretical introductions to the topics and updated standard and modified step-by-step protocols to perform them. Special emphasis is placed on the analysis of nanoparticles, including an integrative approach analysis. The DNA Repair section includes several assays that provide information on repair activity in vitro and in vivo, as well as recent applications to study DNA repair in humans, cell cultures, and animal models. As a volume in the Methods in Pharmacology and Toxicology series, the chapters contain the kind of detail and key implementation advice that ensures reproducible results in the lab. Authoritative and invaluable, Genotoxicity and DNA Repair: A Practical Approach aims to aid scientists in their pursuit of forwarding this vital field of study.

Download or read book Karl Fischer Titration written by Eugen Scholz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Karl Fischer titration is used in many different ways following its publication in 1935 and further applications are continually being explored. At the present time we are experiencing another phase of expansion, as shown by the development of new titration equipment and new reagents. KF equipment increasingly incorporates microprocessors which enable the course of a titration to be programmed thus sim plifying the titration. Coulometric titrators allow water determinations in the micro gram-range: the KF titration has become a micro-method. The new pyridine-free re agents make its application significantly more pleasant and open up further possibili ties on account of their accuracy. To make the approach to Karl Fischer titrations easier, we have summarized the present knowledge in this monograph and we have complemented it with our own studies and practical experience. As this book should remain "readable", we have tried to keep the fundamentals to a minimum. Historical developments are only mentioned if they seem to be necessary for understanding the KF reaction. The ap plications are described more fully. Specific details which may interest a particular reader can be found in the original publications cited. The referenced literature is in chronological order as the year of publication may also prove informative. Thus, [6902] for example denotes 69 for 1969 being the year of publication and 02 is a non-recurring progressive number. The referenced litera ture includes summaries which we hope will be of help to find the "right" publica tion easily.

Download or read book Nanotheranostics For Personalized Medicine written by Patrick Couvreur and published by World Scientific. This book was released on 2016-02-22 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of nanotechnology in the biomedical field, known as nanomedicine, has gained much interest in the recent past as a versatile strategy for selective drug delivery and diagnostic purposes. The nanotheranostic approach, which aims to combine both therapeutic and imaging/diagnostic functionalities, is characterized by a strong pluridisciplinarity where the chemistry of materials, bioconjugate chemistry, pharmaceutical technology, drug delivery, imaging, and pharmacology, work together. Nanotheranostics combine simultaneous non-invasive diagnosis and treatment of diseases with the exciting possibility to monitor drug release and distribution in real time; thus offering the opportunity to optimize treatment outcomes in cancer and other severe diseases. Clinical applications of nanotheranostics would enable earlier detection and treatment of diseases, and earlier assessment of the response, thus allowing to identify patients which would potentially respond to therapy and have higher possibilities of a favorable outcome.Nanotheranostics for Personalized Medicine presents an integrated and transdisciplinary description of nanotheranostics. It provides principles of imaging techniques and concrete examples of advances and challenges in the development of nanotheranostics for personalized medicine.This book is written for students (Bachelors to Doctoral level) as well as experienced researchers, in academia or the industry, interested in this emerging concept in the nanomedicine field.

Download or read book Translational Toxicology written by Claude L. Hughes and published by Humana Press. This book was released on 2016-03-23 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together a distinguished interdisciplinary team of contributors, this volume provides a comprehensive exploration of translational toxicology—a systematic approach to developing therapeutic interventions that can protect against, mitigate, or reverse the effects of exposures. In particular, the book addresses modes of action and biomarkers, developmental risks of exposures, and potential translational toxicology therapeutics. The result is a compelling application of developmental toxicology in a new therapeutic discipline that is destined to become part of standard medical practice. Translational Toxicology: Defining a New Therapeutic Discipline is an essential text for regulatory authorities, scientists, and physicians who are concerned with environmental exposures, public health, nutrition, and pharmaceutical research and development. Basic science, epidemiological, and clinical investigators will also find this book a significant resource.

Download or read book Identifying and Controlling Pulmonary Toxicants written by United States. Congress. Office of Technology Assessment and published by Office of Technology Assessment. This book was released on 1992 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hearing Impairment and Disability written by Ariel Tenenbaum and published by . This book was released on 2020 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Much research has been conducted to provide researchers and hearing healthcare professionals with updated information in regard to hearing assessments, results interpretation and case management. This ongoing research is particularly imperative to guide clinicians with optimized methods in assessing and managing pediatric patients with hearing impairment and disability. As such, tremendous research efforts have been made in determining the most optimum methods in assessing hearing using both subjective and objective tests. Since hearing loss can occur due to disrupted peripheral and/or central auditory pathway, there is also a growing interest to study children with auditory processing disorder (APD). Even though notable achievements have been observed in understanding APD, more research is required, particularly in establishing a gold standard APD test and its specific interventions. Aditionally, having an objective test such as speech-evoked auditory brainstem response is beneficial to understand how speech sounds are encoded within the brainstem region in hearing-impaired children, as well as in those with compromised neural function. In this book, we have gathered research from Malaysia and India in this field and hope it will be of interest to our readers"--

Download or read book Proceedings of the Joint International Symposium on Molten Salts written by Gleb Mamantov and published by . This book was released on 1987 with total page 1212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Statistical Evaluation of Mutagenicity Test Data written by David J. Kirkland and published by Cambridge University Press. This book was released on 2008-01-03 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds.

Download or read book Handbook of Mutagenicity Test Procedures written by B.J. Kilbey and published by Elsevier. This book was released on 2012-12-02 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt: The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.

Download or read book Immunotoxicity Testing written by Jamie C. DeWitt and published by Humana. This book was released on 2019-06-22 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches. Dedicated to identifying and describing exogenous agents that can modify immune function, uncovering modes and mechanisms of action for such agents, and translating data from the laboratory and from the clinic to better predict health risks as well as benefits to those who are exposed to immunomodulatory agents, immunotoxicity testing continues to be a vital field of study, and this collection highlights both the “tried and true” methods as well as alternative protocols that have been more recently developed. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunotoxicity Testing: Methods and Protocols, Second Edition serves as a valuable contribution to the continued evolution and the application of immunotoxicity testing.

Download or read book Chemical Assessments written by United States Government Accountability Office and published by Createspace Independent Publishing Platform. This book was released on 2018-01-24 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Assessments: Low Productivity and New Interagency Review Process Limit the Usefulness and Credibility of EPA's Integrated Risk Information System

Download or read book Test No 489 In Vivo Mammalian Alkaline Comet Assay written by OECD and published by OECD Publishing. This book was released on 2014-09-26 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.

Download or read book Evidence Based Practice Toward Optimizing Clinical Outcomes written by Xenia Maria Caldeira Brant and published by Springer Science & Business Media. This book was released on 2010-06-17 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Health care is witnessing an explosion of fundamental, clinical and translational research evidence. The emerging paradigm of evidence-based health care rests on the judicious integration of the patient needs/wants, the provider's expertise, and the best available research evidence in the treatment plan. The purpose of this book is to discuss the promise and the limitations of incorporating the best available evidence in clinical practice. It seeks to characterize and define how best available research evidence can be used in clinical practice and to what respect it applies to current public health issues.

Download or read book Endocrine Toxicology written by J. Charles Eldridge and published by CRC Press. This book was released on 2016-04-19 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology's increased importance in environmental safety issues

Download or read book Together written by Lydia M. Millard and published by . This book was released on 1865 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Endocrine Toxicology written by C. K. Atterwill and published by Cambridge University Press. This book was released on 1992-04-09 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to deal comprehensively with endocrine toxicology. It covers the whole spectrum of known toxicant effects on the endocrine system ranging from small disturbances in hormonal secretion to full endocrine neoplasia. In each chapter, internationally recognised authorities have addressed basic endocrine physiology, current techniques for studying endocrine toxicity in vivo and in vitro, known xenobiotic-induced toxicity phenomena and the latest scientific advances in understanding the underlying molecular and cellular events. Consideration is given to important issues such as dietary factors which influence endocrine toxicity, species differences in sensitivity to toxicants, and the toxicity of hormones and drugs. The volume provides a sound basis for understanding the scientific aspects of this complex and important area of toxicology and will be a useful source of information for all those working in this field.

Download or read book Drug Discovery Toxicology written by Yvonne Will and published by John Wiley & Sons. This book was released on 2016-03-22 with total page 899 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices