Download or read book Hans Krebs written by Frederic Lawrence Holmes and published by Oxford University Press. This book was released on 1993-05-20 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume completes Frederic Holmes' notable and detailed biography of Hans Krebs, from the investigator's early development through the major phase of his groundbreaking investigation, which lay the foundations upon which the modern structure of intermediary metabolism is built. With access to Krebs' research notebooks as well as to Krebs himself through more than five years of personal interviews, the author provides an insightful analysis of Hans Krebs and of the scientific process as a whole. The first volume, published in 1991, covered Krebs' formative years in Germany, his work with Otto Warburg, and his discovery of the urea cycle in 1932. This second volume reconstructs the investigative pathway and the professional and personal life of Hans Krebs, from the time of his arrival in England in 1933 until 1937, when he made the discovery for which he is best known--the formulation of the citric acid cycle. Holmes portrays Krebs' activity at the intimate level of daily interactions of thought and action, from which the characteristic patterns of scientific creativity can best be seen. Holmes' fascinating portrait of Krebs integrates the great scientist's investigative pathways with his personal life. The result is an illuminating analysis of both man and scientist that will be of interest to biochemists and historians of science.
Download or read book Hans Krebs Architect of intermediary metabolism 1933 1937 written by Frederic Lawrence Holmes and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hans Krebs written by and published by . This book was released on 1993 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hans Krebs written by Frederic L. Holmes and published by . This book was released on with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second and final volume of the biography of Hans Krebs covers his early years in England, 1933-1937, when he laid the foundations for the modern understanding of intermediary metabolism.
Download or read book Transformer The Deep Chemistry of Life and Death written by Nick Lane and published by W. W. Norton & Company. This book was released on 2022-07-12 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life. “Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions—the origin of life itself, aging, and disease—have shaped my thinking since I first came across his work. He is one of my favorite science writers.”—Bill Gates What brings the Earth to life, and our own lives to an end? For decades, biology has been dominated by the study of genetic information. Information is important, but it is only part of what makes us alive. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight —how the same simple chemistry gives rise to life and causes our demise. Lane is among the vanguard of researchers asking why the Krebs cycle, the “perfect circle” at the heart of metabolism, remains so elusive more than eighty years after its discovery. Transformer is Lane’s voyage, as a biochemist, to find the inner meaning of the Krebs cycle—and its reverse—why it is still spinning at the heart of life and death today. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Now it does both. How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Transformer unites the story of our planet with the story of our cells—what makes us the way we are, and how it connects us to the origin of life. Enlivened by Lane’s talent for distilling and humanizing complex research, Transformer offers an essential read for anyone fascinated by biology’s great mysteries. Life is at root a chemical phenomenon: this is its deep logic.
Download or read book Companion Encyclopedia of Science in the Twentieth Century written by John Krige and published by Routledge. This book was released on 2013-11-05 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.
Download or read book Science in the Twentieth Century written by John Krige and published by Routledge. This book was released on 2013-11-19 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over forty chapters, written by leading scholars, this comprehensive volume represents the best work in America, Europe, and Asia. Geographical diversity of the authors is reflected in the different perspectives devoted to the subject, and all major disciplinary developments are covered. There are also sections concerning the countries that have made the most significant contributions, the relationship between science and industry, the importance of instrumentation, and the cultural influence of scientific modes of thought. Students and professionals will come to appreciate how, and why, science has developed - as with any other human activity, it is subject to the dynamics of society and politics.
Download or read book Early Adventures in Biochemistry written by L.A. Stocken and published by Elsevier. This book was released on 1995-06-28 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: The account in this inaugural volume of the series covers the period 1900 to 1960, but also outlines the principal developments in earlier centuries from which biochemistry emerged. Findings are considered in the light of present knowledge, rather than in a rigid historical framework.
Download or read book Investigative Pathways written by Frederic Lawrence Holmes and published by Yale University Press. This book was released on 2004-02-09 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating book is an investigation of scientific creativity. Following the research pathways of outstanding scientists over the past three centuries, it finds common features in their careers and their landmark discoveries and sheds light on the nature of long-term experimental research. Frederic Lawrence Holmes begins by discussing various approaches to the historical study of scientific practice. He then explains three kinds of analysis of the individual scientific life: broad-scale, which examines the phases of a scientist’s career—apprenticeship, mastery, distinction, and maturity—over a lifetime; middle-scale, which explores the episodes within such a career; and fine-scale, which scrutinizes laboratory notebooks and other data to focus on the daily interplay between thought and operation. Using these analyses, Holmes presents rich examples from his studies of six preeminent scientists: Antoine-Laurent Lavoisier, Claude Bernard, Hans Krebs, Matthew Meselson, Franklin Stahl, and Seymour Benzer. The similar themes that he finds in their work and careers lead him to valuable insights into enduring issues and problems in understanding the scientific process.
Download or read book A Short History of Medicine written by Erwin H. Ackerknecht and published by JHU Press. This book was released on 2016-05-01 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: A bestselling history of medicine, enriched with a new foreword, concluding essay, and bibliographic essay. Erwin H. Ackerknecht’s A Short History of Medicine is a concise narrative, long appreciated by students in the history of medicine, medical students, historians, and medical professionals as well as all those seeking to understand the history of medicine. Covering the broad sweep of discoveries from parasitic worms to bacilli and x-rays, and highlighting physicians and scientists from Hippocrates and Galen to Pasteur, Koch, and Roentgen, Ackerknecht narrates Western and Eastern civilization’s work at identifying and curing disease. He follows these discoveries from the library to the bedside, hospital, and laboratory, illuminating how basic biological sciences interacted with clinical practice over time. But his story is more than one of laudable scientific and therapeutic achievement. Ackerknecht also points toward the social, ecological, economic, and political conditions that shape the incidence of disease. Improvements in health, Ackerknecht argues, depend on more than laboratory knowledge: they also require that we improve the lives of ordinary men and women by altering social conditions such as poverty and hunger. This revised and expanded edition includes a new foreword and concluding biographical essay by Charles E. Rosenberg, Ackerknecht’s former student and a distinguished historian of medicine. A new bibliographic essay by Lisa Haushofer explores recent scholarship in the history of medicine.
Download or read book Chemical Structure Spatial Arrangement written by Peter J. Ramberg and published by Routledge. This book was released on 2017-05-15 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a comprehensive narrative of the early history of stereochemistry, Dr Ramberg explores the reasons for and the consequences of the fundamental change in the meaning of chemical formulas with the emergence of stereochemistry during the last quarter of the nineteenth century. As yet relatively unexplored by historians, the development of stereochemistry - the study of the three-dimensional properties of molecules - provides a superb case study for exploring the meaning and purpose of chemical formulas, as it entailed a significant change in the meaning of chemical formulas from the purely chemical conception of 'structure' to the physico-chemical conception of molecules provided by the tetrahedral carbon atom. This study is the first to treat the emergence of the unique visual language of organic chemistry between 1830 and 1874 to place in context the near simultaneous proposal of the tetrahedral carbon atom by J.H. van 't Hoff and J.A. Le Bel in 1874. Dr Ramberg then examines the research programs in stereochemistry by Johannes Wislicenus, Arthur Hantzsch, Victor Meyer, Carl Bischoff, Emil Fischer and Alfred Werner, showing how the emergence of stereochemistry was a logical continuation of established research traditions in chemistry. In so doing, he also illustrates the novel and controversial characteristics of stereochemical ideas, especially the unprecedented use of mechanistic and dynamic principles in chemical explanation.
Download or read book The First Miracle Drugs written by John E. Lesch and published by . This book was released on 2007 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the decade from 1935-1945, while the Second World War raged in Europe, a new class of medicines capable of controlling bacterial infections launched a therapeutic revolution that continues today. The new medicines were not penicillin and antibiotics, but sulfonamides, or sulfa drugs. The sulfa drugs preceded penicillin by almost a decade, and during World War II they carried the main therapeutic burden in both military and civilian medicine. Their success stimulated a rapid expansion of research and production in the international pharmaceutical industry, raised expectations of medicine, and accelerated the appearance of new and powerful medicines based on research. The latter development created new regulatory dilemmas and unanticipated therapeutic problems. The sulfa drugs also proved extraordinarily fruitful as starting points for new drugs or classes of drugs, both for bacterial infections and for a number of important non-infectious diseases. This book examines this breakthrough in medicine, pharmacy, and science in three parts. Part I shows that an industrial research setting was crucial to the success of the revolution in therapeutics that emerged from medicinal chemistry. Part II shows how national differences shaped the reception of the sulfa drugs in Germany, France, Britain, and the United States. The author uses press coverage of the day to explore popular perceptions of the dramatic changes taking place in medicine. Part III documents the impact of the sulfa drugs on the American effort in World War II. It also shows how researchers came to an understanding of how the sulfa drugs worked, adding a new theoretical dimension to the science of pharmacology and at the same time providing a basis for the discovery of new medicinal drugs in the 1940s, 1950s, and 1960s. A concluding chapter summarizes the transforming impact of the sulfa drugs on twentieth-century medicine, tracing the therapeutic revolution from the initial breakthrough in the 1930s to the current search for effective treatments for AIDS and the new horizons opened up by the human genome project and stem cell research.
Download or read book The Historiography of Contemporary Science Technology and Medicine written by Ronald E. Doel and published by Routledge. This book was released on 2006-10-02 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together authorities on the history, historiography and methodology of recent and contemporary science, this book reviews the problems facing historians of technology, contemporary science and medicine and explores new ways forward.
Download or read book A New Field in Mind written by Frank W. Stahnisch and published by McGill-Queen's Press - MQUP. This book was released on 2020-03-12 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent decades, developments in research technologies and therapeutic advances have generated immense public recognition for neuroscience. However, its origins as a field, often linked to partnerships and projects at various brain-focused research centres in the United States during the 1960s, can be traced much further back in time. In A New Field in Mind Frank Stahnisch documents and analyzes the antecedents of the modern neurosciences as an interdisciplinary field. Although postwar American research centres, such as Francis O. Schmitt's Neuroscience Research Program at MIT, brought the modern field to prominence, Stahnisch reveals the pioneering collaborations in the early brain sciences at centres in Germany, Austria, and Switzerland in the first half of the twentieth century. One of these, Heinrich Obersteiner's institute in Vienna, began its work in the 1880s. Through case studies and collective biographies, Stahnisch investigates the evolving relationships between disciplines – anatomy, neurology, psychiatry, physiology, serology, and neurosurgery – which created new epistemological and social contexts for brain research. He also shows how changing political conditions in Central Europe affected the development of the neurosciences, ultimately leading to the expulsion of many physicians and researchers under the Nazi regime and their migration to North America. An in-depth and innovative study, A New Field in Mind tracks the emergence and evolution of neuroscientific research from the late nineteenth century to the postwar period.
Download or read book Bibliography of the History of Medicine written by and published by . This book was released on 1993 with total page 1308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Making Modern Science written by Peter J. Bowler and published by University of Chicago Press. This book was released on 2010-02-24 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of science, according to respected scholars Peter J. Bowler and Iwan Rhys Morus, expands our knowledge and control of the world in ways that affect-but are also affected by-society and culture. In Making Modern Science, a text designed for introductory college courses in the history of science and as a single-volume introduction for the general reader, Bowler and Morus explore both the history of science itself and its influence on modern thought. Opening with an introduction that explains developments in the history of science over the last three decades and the controversies these initiatives have engendered, the book then proceeds in two parts. The first section considers key episodes in the development of modern science, including the Scientific Revolution and individual accomplishments in geology, physics, and biology. The second section is an analysis of the most important themes stemming from the social relations of science-the discoveries that force society to rethink its religious, moral, or philosophical values. Making Modern Science thus chronicles all major developments in scientific thinking, from the revolutionary ideas of the seventeenth century to the contemporary issues of evolutionism, genetics, nuclear physics, and modern cosmology. Written by seasoned historians, this book will encourage students to see the history of science not as a series of names and dates but as an interconnected and complex web of relationships between science and modern society. The first survey of its kind, Making Modern Science is a much-needed and accessible introduction to the history of science, engagingly written for undergraduates and curious readers alike.
Download or read book Making Modern Science Second Edition written by Peter J. Bowler and published by University of Chicago Press. This book was released on 2020-08-17 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this new edition of the top-selling coursebook, seasoned historians Peter J. Bowler and Iwan Rhys Morus expand on their authoritative survey of how the development of science has shaped our world. Exploring both the history of science and its influence on modern thought, the authors chronicle the major developments in scientific thinking, from the revolutionary ideas of the seventeenth century to contemporary issues in genetics, physics, and more. Thoroughly revised and expanded, the second edition draws on the latest research and scholarship. It also contains two entirely new chapters: one that explores the impact of computing on the development of science, and another that shows how the West used science and technology as tools for geopolitical expansion. Designed for entry-level college courses and as a single-volume introduction for the general reader, Making Modern Science presents the history of science not as a series of names and dates, but as an interconnected and complex web of relationships joining science and society.
