Download or read book Handbook of Enzyme Inhibitors written by Helmward Zollner and published by Wiley-Blackwell. This book was released on 1992-12-17 with total page 1065 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second revised and enlarged edition. In two parts. The rapid increase in data has made it necessary to bring an updated version of the highly successful first edition. The contents of the book have trebled; it now lists more than 8000 different inhibitors for about 2000 enzymes. Over 15000 enzyme-inhibitor interactions are tabulated. Equipped with this impressive amount of information, biochemists and other scientists working with enzymes will be able to plan and interpret experiments effectively. The organization of the first edition, which was welcomed enthusiastically by experts worldwide, has been retained. The user can search either for an inhibitor of a particular enzyme or for all enzymes which are inhibited by a particular compound.
Download or read book Handbook of Enzyme Inhibitors 1965 1977 written by Mahendra Kumar Jain and published by . This book was released on 1982 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evaluation of Enzyme Inhibitors in Drug Discovery written by Robert A. Copeland and published by John Wiley & Sons. This book was released on 2005-04-01 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vital information for discovering and optimizing new drugs "Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors." -Paul S. Anderson, PhD This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications. Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address: * What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism? * How are inhibitors evaluated for potency, selectivity, and mode of action? * What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo? * What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization? Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted. This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts.
Download or read book Handbook of Enzyme Inhibitors 1965 1977 written by Mahendra Kumar Jain and published by John Wiley & Sons. This book was released on 1982 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Enzyme Inhibition written by Kimberly Flynn and published by . This book was released on 2015-01-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzyme inhibition is basically described as a reduction in enzyme-related processes. This book deals with practical techniques of enzymes used in drug experimentation. It will serve the function of both; providing applied drug assessment methods in research projects as well as helping reasonably qualified enzyme experts who wish to expand their researches further. The content has been set in a manner where fundamental aspects of enzyme obstructions of cytochromes have been followed by latest features of functional medicine treatment; reliability evaluation; and new enzyme applications from mechanistic point of view.
Download or read book Handbook of Enzyme Inhibitors written by Helmward Zollner and published by Wiley-Blackwell. This book was released on 1992-12-17 with total page 1065 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second revised and enlarged edition. In two parts. The rapid increase in data has made it necessary to bring an updated version of the highly successful first edition. The contents of the book have trebled; it now lists more than 8000 different inhibitors for about 2000 enzymes. Over 15000 enzyme-inhibitor interactions are tabulated. Equipped with this impressive amount of information, biochemists and other scientists working with enzymes will be able to plan and interpret experiments effectively. The organization of the first edition, which was welcomed enthusiastically by experts worldwide, has been retained. The user can search either for an inhibitor of a particular enzyme or for all enzymes which are inhibited by a particular compound.
Download or read book Evaluation of Enzyme Inhibitors in Drug Discovery written by Robert A. Copeland and published by John Wiley & Sons. This book was released on 2013-01-31 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine.
Download or read book Enzyme Handbook written by Thomas E. Barman and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: I t is a pleasure to write a few lines to welcome this labour of Iove. I t is always dangeraus to draw sharp divisions between the interests of different scientists. However, in the present stage of progress in enzymology, there are those who are primarily interested in the molecular mechanisms of the reactions of a few selected enzymes, while others are involved in the grand scheme of the chemical metabolism of cells or whole organisms. Fortunately Dr. Barman has had experience in both the molecular and the metabolic aspects of enzymology. He therefore knows the require ments of research workers interested in enzymes from many different points of view. It would be foolish to hope that a handbook of this kind will provide all the information about enzymes which different specialists would wish to find. The author has attempted to help users in the following way. If one Iooks up a particular enzyme one will find all the basic data and a very good Iist of references for more specialized information. Apart from selection of the type of information provided, the author's judgement on the reliability of data is, of course, of critical importance in a handbook. If contradicting published information about some property of an enzyme has to be sorted out, it is often neither possible to teil the whole story nor to give an objective judgement.
Download or read book Handbook of Enzyme Inhibitors written by Helmward Zollner and published by . This book was released on 1999 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enzyme Handbook written by Dietmar Schomburg and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 1037 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymes are applied in organic synthesis and in analytical chemistry, in industrial production processes of pharmaceuticals and in food processing. Finding a suitable enzyme for a desired transformation or with a de- fined specificity is not always an easy task. More than 3000 enzymes are well described to date. The Enzyme Handbook provides all the information for selecting the proper enzyme to perform defined transformations in a given environment. The Enzyme Handbook devotes a variable number of pages for each enzyme, depending on the amount of information available with the EC number as ordering criterion within a volume. Revised data sheets can be released for individual enzymes and newly characterized enzymes and they can easily be sorted into the binders at the appropriate place. Each data sheet is divided into 7 sections: - Nomenclature (EC number, Systematic name, Recom- mended name, Synonyms, CAS Reg. No.) - Reaction and specificity (Catalysed reaction, Reaction type, Natural substrates, Substrate spectrum, Product spectrum, Inhibitors, Cofactors/prosthetic groups, Metal compounds/salts, Turnover number, Specific activity, KM-value, pH-optimum, pH-range, Tem- perature optimum, Temperature range) - Enzyme structure (Molecular weight, Subunits, Glyco-/Lipoprotein) - Isolation/Preparation (Source organism, Source tissue, Localisation in source, Purification, Crystallization, Cloned, Renatured) - Stability (pH, Temperature, Oxidation, Organic sol- vent, General stability information, Storage) - Cross-References (to Structure Data Banks) - Literature references
Download or read book Enzyme Handbook written by Dietmar Schomburg and published by Springer. This book was released on 2014-11-14 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of the Enzyme Handbook is to provide in a concise form data on enzymes sufficiently well characterized. Data of about 3000 enzymes are presently known and their data sheets will be published at a frequency of 200 per quarter. The data sheets are arranged in their EC Number sequence, Vol. 6 containing Oxidoreductases (Class 1.2: Acting on aldehyde or keto-group of donors, Class 1.3: Acting on CH-CH group of donors, Class 1.4: Acting on CH-NH2 group of donors). For each enzyme, systematic and common names are given, information on reaction type, substrate and product spectrum, inhibitors, cofactors, kinetic data, pH and temperature range, origin, purification, molecular data and storage conditions are listed. A reference list completes the data sheet. This collection is an indispensable source of information for researchers applying enzymes in analysis, synthesis and biotechnology.
Download or read book Enzyme Inhibitors and Activators written by Murat Şentürk and published by BoD – Books on Demand. This book was released on 2017-03-29 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the recent years, medicinal chemistry has become responsible for explaining interactions of chemical molecule processes such that many scientists in the life sciences from agronomy to medicine are engaged in medicinal research. This book contains an overview focusing on the research area of enzyme inhibitor and activator, enzyme-catalyzed biotransformation, usage of microbial enzymes, enzymes associated with programmed cell death, natural products as potential enzyme inhibitors, protease inhibitors from plants in insect pest management, peptidases, and renin-angiotensin system. The book provides an overview on basic issues and some of the recent developments in medicinal science and technology. Especially, emphasis is devoted to both experimental and theoretical aspect of modern medicine. The primary target audience for the book includes students, researchers, chemists, molecular biologists, medical doctors, pharmacologists, and professionals who are interested in associated areas. The textbook is written by international scientists with expertise in biochemistry, enzymology, molecular biology, and genetics, many of which are active in biochemical and pharmacological research. I would like to acknowledge the authors for their contribution to the book. We hope that the textbook will enhance the knowledge of scientists in the complexities of some medical approaches; it will stimulate both professionals and students to dedicate part of their future research in understanding relevant mechanisms and applications of pharmacology.
Download or read book Enzymes and Their Inhibitors written by H. John Smith and published by CRC Press. This book was released on 2004-11-29 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the development of enzyme inhibitors as therapeutic drugs, Enzymes and Their Inhibitors: Drug Development provides a concise overview of the chemistry of major types of enzymes and their inhibitors. The opening chapters introduce readers to the structure, functions, mechanisms, and kinetics of enzymes, including their use as disease mar
Download or read book The Inhibitor Index written by Daniel Purich and published by CRC Press. This book was released on 2017-07-20 with total page 1362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and antagonists.The Inhibitor Index is a comprehensive, curated compendium of over 7,800 enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers.
Download or read book Enzyme Handbook written by Thomas E. Barman and published by . This book was released on 1969 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Active Site directed Enzyme Inhibitors written by Weiping Zheng and published by Royal Society of Chemistry. This book was released on 2023-09-13 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our biological system is enriched with enzyme-catalyzed (or enzymatic) reactions that mediate a great multitude of life processes such as gene transcription and metabolism, and the inappropriately up-regulated activity of these enzymatic reactions is a major cause of human diseases such as cancer and metabolic diseases. Therefore, the inhibitors of enzymatic reactions (generally called enzyme inhibitors) constitute a major class of therapeutic agents on the global drug market. One question would then be how to efficiently design enzyme inhibitors. This handbook is the first of its kind in the field, introducing to its readers in a single book the concepts whose exploitation has been demonstrated to be successful in efficiently furnishing effective active site-directed inhibitors for various enzymatic reactions. The book is organized by different concepts and for each concept there is a delineation of its mode of working and its applications with different types of enzymatic reactions. Active Site-directed Enzyme Inhibitors will help its readers to quickly and efficiently obtain effective active site-directed inhibitors for any of the enzymatic reactions under study without a need to resort to library screening- and biostructure-based techniques. This handbook is ideal as an immediate resource for researchers to consult or for students to supplement their study in medicinal chemistry and related courses.
Download or read book Class 2 Transferases XII written by Dietmar Schomburg and published by Springer Science & Business Media. This book was released on 2007-12-19 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Enzymes provides concise data on some 5,000 enzymes sufficiently well characterized – and here is the second, updated edition. Their application in analytical, synthetic and biotechnology processes as well as in food industry, and for medicinal treatments is added. Data sheets are arranged in their EC-Number sequence. The new edition reflects considerable progress in enzymology: the total material has more than doubled, and the complete 2nd edition consists of 39 volumes plus Synonym Index. Starting in 2009, all newly classified enzymes are treated in Supplement Volumes.
