Download or read book Handbook of Carcinogen Testing written by Harry A. Milman and published by William Andrew Inc.. This book was released on 1994-01-01 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1961 the National Cancer Institute initiated a program to conduct bioassays of selected compounds to determine whether they might be carcinogens. Although some similarities continue with the program as it was in 1961, there are many more differences. Since 1985 when the first edition of this book appeared, these differences have been substantial enough to merit an updated version. This updated edition will provide the reader with an overview of how to proceed with the various tests and how the data are eventually used for regulatory decisions.
Download or read book HANDBOOK OF CARCINOGEN TESTING written by HA MILMAN (Ed) and published by . This book was released on 1985 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Carcinogenic Potency and Genotoxicity Databases written by Lois Swirsky Gold and published by CRC Press. This book was released on 1996-11-26 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.
Download or read book Breast Cancer Screening written by Harri Vainio and published by World Health Organization. This book was released on 2002 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the leading site of new cancer cases in women. Breast cancer detection is currently primarily based on physical examination by health care professionals, chance findings by women, breast self-examination and mammography used for diagnosis or for routine screening. Early enough detection through mass screening with mammography has been introduced in many countries in the hope that early intervention would lead to reduced mortality and less aggressive treatment. The aim of this publication is to provide an independent, authoritative review of the evidence of the efficacy and effectiveness of breast cancer screening. This will be of value to governments, public health officials and others concerned with policy recommendations for cancer control.
Download or read book Toxicological Testing Handbook written by Jacobson-Kram David and published by CRC Press. This book was released on 2000-11-21 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed to aid toxicology testing study design, this text provides data on issues such as species selection, dose level and dosing regimes, animal models, routes of exposure, statistical evaluation, data interpretation, fulfillment of regulatory requirements, and adherence to good laboratory practices.
Download or read book Handbook of Carcinogenic Potency and Genotoxicity Databases written by Lois Swirsky Gold and published by CRC Press. This book was released on 1996-11-26 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique new reference contains the Carcinogenic Potency Database (CPDB), which analyzes results of decades of animal cancer tests, including all Technical Reports of the National Toxicology Program (NTP) and the general published literature. A guide to the literature of animal cancer tests, the CPDB includes references to each published experiment and never-before published analyses. For each of 5,000 long-term experiments on 1,300 chemicals, the user-friendly format includes data on the species, strain, and sex of the test animal; features of experimental protocol such as the route of administration, duration of dosing, dose levels, and duration of the experiment; histopathology and tumor incidence; the shape of the dose-response curve; published author's opinion about the carcinogenicity at each site; and reference to the original publication of the test results. In addition, a measure of carcinogenic potency, the TD50, its statistical significance and confidence limits, are given for each tumor site. An overview is provided of earlier publication updates, such as positivity rates, reproducibility, interspecies extrapolation, and ranking possible carcinogenic hazards. The book also includes a summary of the NTP genetic toxicity test results on 1,500 chemicals, which are referenced to the original publications, including the Salmonella (Ames) test, L5178Y mouse lymphoma cell mutation test, chromosome aberration and sister chromatid exchange tests in cultured Chinese hamster ovary cells, and the sex-linked recessive lethal mutation test in Drosophila melanogaster. An index with chemicals listed by CAS number allows cross referencing between the carcinogenicity and genotoxicity databases, making data easy to find.
Download or read book Handbook of Cancer Risk Assessment and Prevention written by Graham A. Colditz and published by Jones & Bartlett Learning. This book was released on 2004 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for health care providers at all levels, this handbook covers in depth fourteen of the most common cancers in the U.S. -- providing for each a scientific summary of risk factors, a risk assessment tool for patients, and helpful hints to promote risk-reducing lifestyle changes. Additional chapters focus specifically on five key lifestyle behaviors that lower not only the risk of cancer but also the risk of other chronic diseases.Throughout its entirety, the handbook emphasizes the importance of communicating risk effectively to patients. A chapter is devoted solely to this topic, and risk information about each cancer is presented in a variety of formats. Finally, the risk assessment tools -- adaptations from the popular website Your Cancer Risk -- offer patients the option to estimate their cancer risk and receive practical, personal tips for lowering that risk.At a time when the public is surrounded by conflicting health messages, especially from the media and the Internet, the Handbook of Cancer Risk-Assessment and Prevention is an essential source for reliable, up-to-date information on cancer prevention. It delivers positive health messages and offers practical advice that health care providers can use to help patients implement strategies to prevent cancer and other chronic diseases.
Download or read book Handbook of Mutagenicity Test Procedures written by B.J. Kilbey and published by Elsevier. This book was released on 2012-12-02 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt: The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.
Download or read book Toxicological Testing Handbook written by David Jacobson-Kram and published by CRC Press. This book was released on 2006-07-11 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Furnishing essential data on all areas of toxicity testing, this Second Edition provides guidance on the design and evaluation of product safety studies to help ensure regulatory acceptance. Every chapter highlights regulatory requirements specific to the United States, Europe, and Japan, and in addition to expanded information on data interpretation, hazard assessment, carcinogenicity studies, and Good Laboratory Practices, new chapters regarding safety pharmacology, juvenile studies, the health safety assessment of pharmaceuticals, and health assessment strategies in the food and cosmetic industry have been added to reflect changes to regulatory requirements. Toxicological Testing Handbook, Second Edition is a must-have reference for individuals responsible for assuring the safety of new pharmaceutical, biotechnical, and chemical products and materials.
Download or read book Protocol Handbook for Cancer Biology written by Gauri Misra and published by Academic Press. This book was released on 2021-02-12 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protocol Handbook for Cancer Biology brings together a comprehensive collection of the methods used for cancer assessment, diagnostics, and therapeutics. Various protocols are discussed along with alternative strategies, including the advantages and limitations of techniques that have been used in labs globally. These protocols are presented by cancer biology experts based on their real-world experience. The protocols in this book will be a valuable resource for cancer researchers and graduate students, who can utilize the techniques described to conduct research more efficiently and successfully. Presents comprehensive protocols used for cancer assessment, diagnostics, and therapeutics all in one place Encompasses alternative strategies considering the requirements of the end user and taking into consideration diverse research settings Discusses limitations and advantages of each method in experimental design and execution, thus saving time during the research process
Download or read book Handbook of in Vivo Toxicity Testing written by Douglas L. Arnold and published by . This book was released on 1990 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evaluating the Effectiveness of Smoke free Policies written by IARC Working Group on Evaluating the Effectiveness of Smoke-free Policies and published by World Health Organization. This book was released on 2009 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the evidence on the effectiveness of measures enforced at the societal level to eliminate tobacco smoking and tobacco smoke from the environments where exposure takes place. This volume offers a critical review of the evidence on the economic effects and health benefits of smoke-free legislation and the adoption of voluntary smoke-free policies in households.
Download or read book Handbook of Carcinogen Testing written by Harry A. Milman and published by Taylor & Francis US. This book was released on 1985 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Colorectal cancer screening written by International Agency for Research on Cancer and published by International Agency for Research on Cancer. This book was released on 2019-10-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Working Group of 23 independent experts from 15 countries, convened by the International Agency for Research on Cancer (IARC) in November 2017, reviewed the scientific evidence and assessed the cancer-preventive and adverse effects of various methods of screening for colorectal cancer. Colorectal cancer is the third most common cancer in men and the second most common in women worldwide, and represents more than 10% of the global cancer burden. This publication provides evidence-based evaluations of the effectiveness of colorectal cancer screening in reducing colorectal cancer incidence and mortality. The Working Group also reviewed the body of evidence on the comparison of endoscopic and stool-based techniques, on the determinants of participation in screening programs, and on the most mature emerging techniques that may be alternatives to current practices for colorectal cancer screening, as well as presenting the different categories of high-risk populations and the surveillance strategies for such individuals.
Download or read book Cancer Registration written by Ole Møller Jensen and published by IARC. This book was released on 1991 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data obtained by population based cancer registries have a pivotal role in cancer control. Now also available in Spanish and French, this volume, which contains 15 authored chapters and four useful appendices, remains a standard reference for those planning to establish new cancer registries and those keen to adopt recognized methodologies. Information is given on the techniques required to collect, store, analyse and interpret data.
Download or read book Haschek and Rousseaux s Handbook of Toxicologic Pathology Volume 2 Safety Assessment and Toxicologic Pathology written by Wanda M. Haschek and published by Academic Press. This book was released on 2023-02-18 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2: Toxicologic Pathology in Safety Assessment is an essential part of the most authoritative reference on toxicologic pathology principles and techniques for assessing product safety and human risk. Volume 2 describes the integration of product-induced structural and functional changes in tissues and the interpretation of their biological implications. Completely revised with many new chapters, Volume 2 of the Fourth Edition covers product safety assessment from many angles including current and emerging issues in toxicologic pathology for many product classes. Volume 2 of the Handbook of Toxicologic Pathology is a key resource for pathologists, toxicologists, research scientists, and regulators who use toxicologic pathology methods to study and make decisions on product safety. - Previous chapters on such topics as drug discovery and development, toxicity and carcinogenicity testing, report preparation, and risk assessment and communication have undergone extensive revision that includes in-depth discussion of new developments in the field - New chapters consider fundamental attributes for additional product classes including protein therapeutics, nucleic acid pharmaceutical agents, gene therapy and gene editing, stem cell and other cell therapies, vaccines, agricultural and bulk chemicals, and assigning adversity - Chapters dealing with product-specific practices address pathology and regulatory issues - Chapters offer high-quality and up-to-date content in a trusted work written by the collaborative efforts of many leading international subject matter experts - Hundreds of full-color images and diagrams are featured in both the print and electronic versions of this book to illustrate classic examples and highlight difficult concepts
Download or read book Reversal of Risk After Quitting Smoking written by IARC Working Group on Reversal of Risk after Quitting Smoking. Meeting and published by World Health Organization. This book was released on 2007 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the 11th IARC Handbook of Cancer Prevention, and the first in a series focusing on tobacco control. It reviews the scientific literature and evaluates the evidence on changes in the risk of cancer, coronary heart disease, cerebrovascular disease, abdominal aortic aneurysm, peripheral artery disease and chronic obstructive pulmonary disease observed following smoking cessation. It considers whether the risk of dying from or of developing these diseases decreases after smoking cessation, the time course of the change in risk and whether the risk returns to that of never-smokers? The review and evaluation presented in the Handbook goes on to identify relevant public health and research recommendations.
