Download or read book Handbook of Anticancer Drugs from Marine Origin written by Se-Kwon Kim and published by Springer. This book was released on 2014-11-27 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

Download or read book Studies in Natural Products Chemistry written by Ajai Prakash Gupta and published by Elsevier Inc. Chapters. This book was released on 2013-06-25 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a dreadful human disease, increasing with changing lifestyle, nutrition, and global warming. Its treatments do not have potent medicine as the currently available drugs results in severe side effects. Past activities in this area focused on the natural products derived from medicinal plants. According to the WHO, 80% of the world’s population primarily those from developing countries rely on plant-derived medicines for the health care. Over the past few decades, significant efforts have been made, jointly by pharmaceutical and academic institutions, to isolate and identify new marine-derived natural products. With the advancement of technology and methodology in this area, numerous new compounds have been isolated and several novel anticancer compounds are under clinical investigations. The ocean biomass, covering two-third of the earth, with huge unexplored natural product offers enormous scope and presents an effective alternative in natural product drug discovery. The uniqueness in oceanic mega-diversity is due to spatial as well as temporal competition along with unique habitat with extreme pressure, temperature, and saline conditions. As a result of this, marine organisms have adapted and evolved themselves successfully since centuries in these conditions by producing molecules which are unique in structures, biosynthesis, and function. This “chemical adaptations” is an excellent source of novel chemical entities which is absent in land-based organisms. The past decade has seen more than 10,000 compounds isolated from marine sources which have dramatically increased the number of preclinical anticancers drug under evaluation, and over 300 patents on bioactive natural products from marine sources were granted during this tenure. Efforts, in this direction, became more serious and focused with National Cancer Institute, USA taking a lead role. By collaborative interactions between pharmaceutical companies and research organization, numerous drug-like molecules with several of them having clinical and preclinical potential were discovered. Ecteinascidin-743/ET-743 from Caribbean tunicate and Didemnin and Aplidine from Aplidium albicans are some of the successful examples. Sterols and dietary fibers from seaweeds also hold immense potential. However, investigation of the marine floras chemical entities as drug-like molecule is still in its embryonic stage. The present chapter showcases the past research and reviews the baseline data for promoting further research in this field.

Download or read book Handbook of Anticancer Drug Discovery and Development written by Octavia Settle and published by American Medical Publishers. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anticancer drugs refer to drugs that are used for treating cancerous or malignant diseases. They are classified into several categories, including antimetabolites, hormones, alkylating agents and natural products. Preclinical research, clinical research and post-clinical research are the three primary steps in the development of a novel drug. Clinical trial evaluation, in vivo confirmation, and in vitro cytotoxicity on cancer cells are the major assessment methods used while creating an anticancer drug. The evaluation of cytotoxicity towards cancer cell lines is a popular method for discovering anticancer agents. New cancer drugs can be discovered in a variety of ways including testing of animals, plants and fungi, understanding the chemical structure of a drug target, unintentional discovery, developing drugs that are similar to existing drugs, and researching the biology of cancer cells. This book unravels the recent studies on anticancer drug discovery and development. Those in search of information to further their knowledge will be greatly assisted by it.

Download or read book Marine Antioxidants written by Se-Kwon Kim and published by Academic Press. This book was released on 2022-12-04 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine Antioxidants: Preparations, Syntheses, and Applications provides the most updated and comprehensive knowledge on utilizing marine-derived substances for cosmeceutical, pharmaceutical and nutraceutical developments. The book delivers the isolation procedures and biological activity of marine-derived antioxidant substances as discussed by international experts on antioxidant material from actinobacteria, crustaceans, diatoms, fish, microalgae, microbes, and mangrove-associated marine organisms and seagrasses. In addition, the book details marine-derived bioactive antioxidants substances in the form of proteins, peptides, polysaccharides and lipids. Finally, the book provides the latest information on the mechanistic pathways of antioxidant substances with various diseases and nutritional perspectives. This is an essential resource for marine biotechnologists and marine biologists who want to better understand isolation procedures and antioxidant applications. Researchers interested in pharmaceutical nutrients, polymer science, and cosmeceuticals industries scientists, as well as students and academics, will also benefit from this book. Explores under-utilized marine products for commercial applications Offers isolated information and biological applications of each identified marine antioxidant Discusses the latest approaches to treatments of diseases, such as diabetes, arthritis, and cancer using marine resources

Download or read book Marine Glycobiology written by Se-Kwon Kim and published by CRC Press. This book was released on 2016-10-14 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine glycobiology is an emerging and exciting area in the field of science and medicine. Glycobiology, the study of the structure and function of carbohydrates and carbohydrate-containing molecules, is fundamental to all biological systems and represents a developing field of science that has made huge advances in the last half-century. This book revolutionizes the concept of marine glycobiology, focusing on the latest principles and applications of marine glycobiology and their relationships.

Download or read book Marine Waterborne and Water Resistant Polymers written by Johannes Karl Fink and published by John Wiley & Sons. This book was released on 2015-10-01 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the chemistry of marine polymers, waterborne polymers, and water-resistant polymers, as well as the special applications of these materials. After the chemistry of marine polymers and their types are discussed, the uses of these polymers are detailed, as well as various analytical and characterization testing methods. The book also emphasizes the polymers that are most environmentally-friendly along with their origin and industrial applications. The polymers from these 3 types serve a variety of industries including medical equipment and devices, outdoor coatings and corrosion protection, food packaging, saltwater and freshwater marine purposes, paper, and marine well application, to name just a few.

Download or read book Marine Glycosides written by Thomas E Adrian and published by MDPI. This book was released on 2019-05-03 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones.

Download or read book A Guide to Intellectual Property Issues in Access and Benefit sharing Agreements written by Maria Julia Oliva and published by WIPO. This book was released on 2018-06-22 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential complement to the WIPO Database of Access and Benefit-sharing Agreements, this guide offers users and providers of genetic resources an accessible overview of intellectual property issues in access and benefit-sharing agreements.

Download or read book Marine Glycoconjugates written by Vladimir I. Kalinin and published by MDPI. This book was released on 2020-05-27 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The books described marine glycoconjugates. Two articles concern microalgal metabolites such as steroid and sphingoid glycoconjugates, and a glycoprotein from a sea cucumber with interesting biological activities, respectively. One article discusses the fatty acid composition and thermotropic behavior of glycolipids and other membrane lipids of green macrophyte Ulva lactuca. Three articles cover lectin subjects. One review article analyzes perspectives of marine and freshwater lectins’ application in experimental oncology and the therapy of oncological diseases; another article describes the use of a sponge lectin in the construction of a recombinant virus. The third article concerns the function of the immunity of a lectin in producing this compound crinoid. Two articles concern steroid glycosides from starfish, and two others concern triterpene glycosides from sea cucumbers. One article describes the effect of a glycosaminoglycan from the sea cucumber Apostichopus japonicus on hyperglycemia in the liver of insulin-resistant mice. One article concerns the isolation of 10 new triterpene glycosides from a fungus associated with a sea cucumber. The article by Dworaczek et al. characterizes the O-specific polysaccharide (O-antigen) of a bacterial pathogen of common carp by chemical and immunochemical methods. In total, the Special Issue comprises14 articles, including the editorial and two reviews.

Download or read book Marine Based Bioactive Compounds written by Stephen T. Grabacki and published by CRC Press. This book was released on 2022-12-26 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ocean offers boundless benefits to human health. Known for millennia as a source of food, it is continuously gaining recognition as a provider for a variety of materials, and as the largest habitat on our planet, the ocean’s biodiversity stands far above anywhere else. Functional ingredients derived from marine algae, invertebrates, and vertebrates can help fill the need for novel bioactives to treat chronic conditions such as cancer, microbial infections, and inflammatory processes. The latest addition to the Nutraceuticals: Basic Research/Clinical Applications series, Marine-Based Bioactive Compounds: Applications in Nutraceuticals provides an account of marine-derived nutraceuticals and their potential health benefits. Key Features: Provides the latest information on trends in this fast-growing market Focuses on the six marine taxa that offer the most exciting potential Gives practical guidance to anyone wishing to enter this sector With contributions from an international group of experts, this book presents a great many opportunities in marine nutraceuticals from the six oceanic taxa that offer the most potential to benefit human health. It is a great resource for established nutraceutical companies.

Download or read book Encyclopedia of Marine Biotechnology written by Se-Kwon Kim and published by John Wiley & Sons. This book was released on 2020-08-04 with total page 3632 pages. Available in PDF, EPUB and Kindle. Book excerpt: A keystone reference that presents both up-to-date research and the far-reaching applications of marine biotechnology Featuring contributions from 100 international experts in the field, this five-volume encyclopedia provides comprehensive coverage of topics in marine biotechnology. It starts with the history of the field and delivers a complete overview of marine biotechnology. It then offers information on marine organisms, bioprocess techniques, marine natural products, biomaterials, bioenergy, and algal biotechnology. The encyclopedia also covers marine food and biotechnology applications in areas such as pharmaceuticals, cosmeceuticals, and nutraceuticals. Each topic in Encyclopedia of Marine Biotechnology is followed by 10-30 subtopics. The reference looks at algae cosmetics, drugs, and fertilizers; biodiversity; chitins and chitosans; aeroplysinin-1, toluquinol, astaxanthin, and fucoxanthin; and algal and fish genomics. It examines neuro-protective compounds from marine microorganisms; potential uses and medical management of neurotoxic phycotoxins; and the role of metagenomics in exploring marine microbiomes. Other sections fully explore marine microbiology, pharmaceutical development, seafood science, and the new biotechnology tools that are being used in the field today. One of the first encyclopedic books to cater to experts in marine biotechnology Brings together a diverse range of research on marine biotechnology to bridge the gap between scientific research and the industrial arena Offers clear explanations accompanied by color illustrations of the techniques and applications discussed Contains studies of the applications of marine biotechnology in the field of biomedical sciences Edited by an experienced author with contributions from internationally recognized experts from around the globe Encyclopedia of Marine Biotechnology is a must-have resource for researchers, scientists, and marine biologists in the industry, as well as for students at the postgraduate and graduate level. It will also benefit companies focusing on marine biotechnology, pharmaceutical and biotechnology, and bioenergy.

Download or read book Blue Biotechnology written by Stephane La Barre and published by John Wiley & Sons. This book was released on 2018-09-06 with total page 984 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its integral treatment of ecosystem and resource management, this is the only overview of the field to address current thinking and future trends. All contributions have been written with the novice in mind, explaining the basics and highlighting recent developments and achievements. Unmatched in scope, this two-volume reference covers both traditional and well-established areas of marine biotechnology, such as biomass production, alongside such novel ones as biofuels, biological protection of structures and bioinspired materials. In so doing, it ties together information usually only found in widely dispersed sources to assemble a grand unified view of the current state of and prospects for this multi-faceted discipline. The combination of the breadth of topics and the focus on modern ideas make this introductory book especially suitable for teaching purposes and for guiding newcomers to the many possibilities offered by this booming field.

Download or read book Marine Niche Applications in Pharmaceutical Sciences written by Neelam M Nathani and published by Springer Nature. This book was released on 2020-11-09 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive study of biological molecules acquired from marine organisms, which have been exploited for drug discovery with the aim to treat human diseases. Biomolecules have potential impacts on a diverse range of fields, including medical and pharmaceutical science, industrial science, biotechnology, basic research, molecular science, environmental science and climate change, etc. To understand and effectively apply medicinally important biomolecules, multidisciplinary approaches are called for. The ocean remains a rich biological resource, and the vast untapped potential of novel molecules from marine bio-resources has caught the interest of more and more researchers. These novel biological compounds have never been found in terrestrial or other ecosystems, but only in this rich niche. Advances in sampling techniques and technologies, along with increased funding for research and nature conservation, have now encouraged scientists to look deeper in the waters. Aquaculture supports both tremendous seafood production and the bulk production of marine-derived drugs. Furthermore, molecular methods are now being extensively employed to explore the untapped marine microbial diversity. With the help of molecular and biotech tools, the ability of marine organisms to produce new biosynthetic drugs can be greatly enhanced. This book provides an extensive compilation of the latest information on marine resources and their undisputedly vital role in the treatment of diverse ailments.

Download or read book Marine Biochemistry written by Se-Kwon Kim and published by CRC Press. This book was released on 2022-10-12 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the latest comprehensive methods for isolation and other novel techniques for marine product development. Furthermore, this book offers knowledge on the biological, medical, and industrial applications of marine-derived medicinal food substances. There has been a tremendous increase in the products derived from marine organisms for commercial application in industries every year. Functional foods of medicinal value are particularly in demand as new technology allows the stabilization of natural ingredients and their availability in pure forms to solve various human diseases. Marine flora and fauna have essential elements and trace minerals that nurture various hormones produced in the endocrine system to regulate the respective metabolisms, thereby providing a safe and healthy life to humans. The overall presentation and clear demarcation of the contents by worldwide contributions is a novel entry point into the market of medicinal foods from the sea. The exploration of marine habitats for novel materials are discussed throughout the book. The exploration and exploitation of the biochemistry of sea flora and fauna are limited, and this book extends the research possibilities into numerous marine habitats. Various approaches for extracting and applying the flora and fauna are discussed. This book will be of value to researchers, marine biotechnologists, and medical practitioners, due to the vast information, as well as industrial and medical applications of marine substances all in one place.

Download or read book Marine Carotenoids written by Tatsuya Sugawara and published by MDPI. This book was released on 2021-01-22 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carotenoids represent a large group of isoprenoid structures with many different structural characteristics and biological activities. They are the most important of the naturally occurring pigments and are responsible for the various colors of different fruits, vegetables, and plant parts. Marine carotenoids and their unique structures are responsible for the color of many fish, shellfish, and algae. However, while there have been many papers and reviews on carotenoids of terrestrial origin, there has been relatively little research conducted on the impact of marine carotenoids on human health. Recent research efforts have revealed that marine carotenoids have strong biological activity affecting human health and are candidates for nutraceuticals. This Topical Collection of Marine Drugs is dedicated to marine carotenoids, and will focus on the benefits of carotenoids for human beings. For a better understanding of the physiological effects of marine carotenoids, this collection should include the most recent developments in the presence, analysis, chemistry, and biochemistry of marine carotenoids.

Download or read book Handbook of Algal Technologies and Phytochemicals written by Gokare A. Ravishankar and published by CRC Press. This book was released on 2019-07-12 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key features: The most comprehensive resource available on the biodiversity of algal species, their industrial production processes and their use for human consumption in food, health and varied applications. Emphasis on basic and applied research, addressing aspects of scale-up for commercial exploitation for the development of novel phytochemicals (phytochemicals from algae). Addresses the underexplored and underutilized potential of chemicals from marine sources for health benefits. Each chapter, written by expert contributors from around the world, includes Summary Points, Figures and Tables, as well as up-to-date references. The first book in this two-volume set explores the diversity of algal constituents for health and disease applications. The commercial value of chemicals of value to food and health is about $6 billion annually, of which 30 percent relates to micro and macro algal metabolites and products for health food applications. This comprenhensive volume looks in detail at algal genomics and metabolomics as well as mass production of microalgae. As a whole, the two-volume set covers all micro and macro algal forms and their traditional uses; their constituents which are of value for food, feed, specialty chemicals, bioactive compounds for novel applications, and bioenergy molecules. Bio-business and the market share of algae-based products are also dealt with, providing global perspectives.

Download or read book Economic valuation of ecosystem services provided by deep sea sponges written by Ottaviani, D. and published by Food & Agriculture Org.. This book was released on 2020-12-16 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report represents the first economic valuation of the ecosystem services provided by deep-sea sponges in the North Atlantic. It is based on information available in the scientific literature at the time of writing, but also indicates the research areas where discoveries and research advances are shortly expected. The report is aimed at a generic public with no specialized knowledge on sponges or on economic valuation. It is outlined in a way to provide essential background information, but makes reference to a comprehensive list of scientific publications for further insights.