Download or read book Hair Follicle Stem Cell Regeneration in Aging written by Mingxing Lei and published by Frontiers Media SA. This book was released on 2022-01-18 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stem Cells Using the Bodies Own Cells to Treat Injuries Reverse Aging and Now Regrow Hair written by John Satino and published by Xlibris Corporation. This book was released on 2017-08-23 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of time, we have been looking for the fountain of youth. This has opened the doors for charlatans and con men throughout the centuries to separate us from our gold and silver, with promises of eternal youth. The prime example in the eighteen hundreds was the medicine wagons traveling across the prairies, offering entertainment and curing for everything from gout to baldness.

Download or read book Aging Hair written by Ralph M. Trüeb and published by Springer Science & Business Media. This book was released on 2010-04-02 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Aged? But he does not appear aged, just look, his hair has remained young!” Marcel Proust, In Search of Lost Time (1913–27) The appearance of hair plays an important role in peoples’ overall physical appe- ance and self-perception. With today’s increasing life-expectation, the desire to look youthful plays a bigger role than ever. The hair care industry has become aware of this, and capable to deliver active products that are directed toward meeting this c- sumer demand. The discovery of pharmacological targets and the development of safe and effective drugs such as minoxidil and fnasteride also indicate strategies of the drug industry for maintenance of healthy and beautiful hair in the young and old. The study of hair aging focuses on two main streams of interest: On the one hand, the esthetic problem of aging hair and its management, in other words everything that happens outside the skin; on the other hand, the biological problem of aging hair, in terms of microscopic, biochemical, and molecular changes, in other words the “secret life” of the hair follicle in the depth of the skin. Hair aging comprises hair shaft aging, and aging of the hair follicle. The former involves weathering and photoaging of the hair shaft, while the latter manifests as decrease of melanocyte function (graying) and decrease in hair production (alopecia).

Download or read book Keratinocyte Stem Cells written by Tuba M. Ansary and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells located in the skin are responsible for continual regeneration, wound healing, and differentiation of different cell lineages of the skin. The three main locations of skin stem cells are the epidermis, dermis, and hair follicles. The keratinocyte stem cells are located in the epidermal basal layer (the interfollicular stem cells), hair follicle bulge region (the hair follicle stem cells), and sebaceous glands (the sebaceous gland stem cells) and are responsible for the epidermal proliferation, differentiation, and apoptosis. The interfollicular (IF) stem cells are responsible for epidermis regeneration by proliferating basal cells that attach to the underlying basement membrane and with time they exit from the cell cycle, start terminal differentiation, and move upward to form the spinous, the granular, and the stratum corneum layers. The hair follicle (HF) stem cells are responsible for hair regeneration and these stem cells undergo a cycle consists three stages; growth cycles (anagen), degeneration (catagen), and relative resting phase (telogen). The sebaceous gland (SG) stem cells located in between the hair follicle bulge and the gland and are responsible for producing the entire sebaceous gland which secretes oils to moisture our skin. The role of epidermal stem cells is extremely crucial because they produce enormous numbers of keratinocytes over a lifetime to maintain epidermal homeostasis. However, the age-associated changes in the skin; for example; alopecia, reduced hair density, gray or thin hair, reduced wound healing capacity are related to skin stem cells,Äô decline functionality with age.

Download or read book Hair Follicle Regeneration written by Francisco Jimenez and published by Springer Nature. This book was released on 2022-06-03 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to comprehensively review the current cell-based strategies under investigation to achieve the regeneration of human hair follicles. The unique capacity of the human hair follicle to self-renew explains why this complex “mini-organ” has always attracted so much interest as a model for researchers to study stem cell biology and regenerative medicine. The hair follicle is considered a main reservoir of cutaneous stem cells, containing several pools of epithelial, melanocyte, and mesenchymal stem cells involved in hair follicle self-regeneration and pigmentation. In addition, while some of the different follicular cell types contribute to hair shaft growth, others participate in very important interfollicular functions such as dermal remodeling, re-epithelialization after wounding, and cutaneous stem cell homeostasis. The idea of human hair follicle regeneration either “de novo” or by activating dormant miniaturized follicles is not new, yet still continues to arouse enormous interest in the pursuit of a definitive cure for baldness. In contrast to hair follicle regeneration in mice, the attempts made with human follicles have been disappointing in terms of efficiency. However, recent advances in stem cell biology—as well as the appearance of new technologies like 3D printing—have revived expectations in this field of research. This book is divided into four sections. The first part includes an overview of the strategies used in hair follicle regeneration and a historical summary of the most important achievements to date. Parts two and three comprise the main body of the book, with detailed descriptions of the cells and tissue structures involved in hair follicle regeneration, followed by an elaboration of the different therapeutic strategies, engineering techniques, and a clinician’s perspective of stem cell-based therapies in hair loss treatments. Finally, the fourth part reviews the important contribution of the hair follicle in healing cutaneous wounds through the regeneration and remodeling of the dermis and epidermis after injury, as well as wound induced hair follicle neogenesis that occurs when the skin is injured.

Download or read book Textbook of Aging Skin written by Miranda A. Farage and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 1255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive ‘Major Reference Book’ compiles all current and latest information on aging skin in a two-volume set. Highly structured with a reader-friendly format, it covers a wide range of areas such as basic sciences, the different diseases and conditions which occur with aging (from malignant to non-malignant), the latest techniques and methods being used such as bioengineering methods and biometrics as well as toxicological and safety considerations for the elderly population. It also illustrates the global consumers’ sociological and psychological implications, ethnicity and gender differences and includes marketing considerations for this elderly group. This unique and comprehensive guide will become the main reference textbook on this topic.

Download or read book Cell Engineering and Regeneration written by Heinz Redl and published by Springer. This book was released on 2017-02-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.

Download or read book An Apple Stem Cell derived Extract Increases Epithelial Stem Cells Number in the Hair Follicle Bulge written by Majid Alam and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The regenerative nature of hair follicle (HF) stem cells (SCs) facilitates HF cycling and support skin regeneration. Indeed, a reduction in HF SC number has been implicated as a key factor in skin and HF aging and in the development of hair disorders, such as androgenetic alopecia and the autoimmune hair loss disorder, lichen planopilaris. Fruit SC-derived extracts reportedly have positive effects on the regenerative capacity of primary human epidermal SCs. Namely, treatment with apple or grape SC extract increased the colony forming efficacy of primary human epidermal SCs, even under UV stimulation, and restored the organogenic potential of u201coldu201d (passage 14) primary human epidermal SCs to generate 3D epidermis in vitro. The purpose of this study was to investigate the impact of an apple (Malus domestica) SC extract (ACE) on human HF biology, and in particular on K15+ HF bulge SCs, using ex vivo human HF organ culture. Full length HFs, derived from two healthy donors, were treated with various concentrations of ACE (0.1% and 0.3%). Our results showed that neither tested concentration was cytotoxic, as evidenced by similar rates of LDH release into the medium and number of melanin clumps compared to vehicle. ACE, at both concentrations, did not significantly affect HF elongation, hair matrix keratinocyte proliferation and apoptosis, or anagen to catagen switch. However, the treatment with the higher concentration of ACE (0.3%) tendentially increased the expression of the HF epithelial SC marker K15, and significantly up-regulated the number of K15+ cells in the bulge. Therefore, our pilot data suggest that ACE specifically targets and selectively influences HF bulge SCs biology. While other investigations are required to discern whether ACE also impacts on the function of HF K15+ SCs, the current study indicates that ACE may be useful in cosmetic formulations to reverse the reduction in the number of bulge SCs reported in skin and HF aging/senescence and hair loss disorders.

Download or read book Stem Cells From Basic Research to Therapy Volume Two written by Federico Calegari and published by CRC Press. This book was released on 2016-04-19 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume in the Stem Cells series concentrates on the mechanisms of stem cell regeneration in the adult organism with a view towards understanding how lost tissue can be replaced during adulthood and aging. The second focus of this volume is on stem cell identification and manipulation, including applications in basic research, medicine, a

Download or read book Inflammation Stem Cells and Wound Healing in Skin Aging written by Ji Li and published by Frontiers Media SA. This book was released on 2022-11-16 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Liver Myofibroblasts written by Jiri Kanta and published by Frontiers Media SA. This book was released on 2016-10-25 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myofibroblasts (MFB) are found in most tissues of the body. They have the matrix-producing functions of fibroblasts and contractile properties that are known from smooth muscle cells. Fundamental work of the last decades has shed remarkable light on their origin, biological functions and role in disease. During hepatic injury, they fulfill manifold functions in connective tissue remodeling and wound healing, but overshooting activity of MFB on the other side induces fibrosis and cirrhosis. The present e-book "Liver myofibroblasts" contains 9 articles providing comprehensive information on "hot topics" of MFB. In our opening editorial we provide a short overview of the origin of MFB and their relevance in extracellular matrix formation which is the hallmark of hepatic fibrosis. Thereafter, leading experts in the field share their current perspectives on special topics of (i) MFB in development and disease, ii) their role in hepatic fibrogenesis, and (iii) promising therapies and targets that are suitable to interfere with hepatic fibrosis.

Download or read book Cutaneous Aging written by Albert M. Kligman and published by Columbia University Press. This book was released on 1988 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterisation of Hair Follicle Stem Cell Function in Epidermal Regeneration and Tumourigenesis written by Monika Petersson and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hair written by Kurt Stenn and published by Simon and Schuster. This book was released on 2016-02-15 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A microhistory in the vein of Salt and Cod exploring the biological, evolutionary, and cultural history of one of the world's most fascinating fibers. Most people don't give a second thought to the stuff on their head, but in Hair, Kurt Stenn — one of the world's foremost hair follicle experts — takes readers on a global journey through history, from fur merchant associations and sheep farms to medical clinics and patient support groups, to show the remarkable impact hair has had on human life. From a completely bald beauty queen with alopecia to the famed hair-hang circus act, Stenn weaves the history of hair through a variety of captivating examples, with sources varying from renaissance merchants’ diaries to interviews with wig makers, modern barbers, and more. In addition to expelling the biological basis and the evolutionary history of hair, the fiber is put into context: hair in history (as tied to textile mills and merchant associations), hair as a construct for cultural and self-identity, hair in the arts (as the material for artist's brushes and musical instruments), hair as commodity (used for everything from the inner lining of tennis balls to an absorbent to clean up oil spills), and hair as evidence in criminology. Perfect for fans of Mark Kurlansky, Hair is a compelling read based solidly in historical and scientific research that will delight any reader who wants to know more about the world around them.

Download or read book Neural Crest Stem Cells written by Maya Sieber-Blum and published by World Scientific. This book was released on 2012 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. Delving into stem cells from different locations of the body, this book explores the best possible source of such cells for the use in medical applications.

Download or read book Stem Cells in Clinical Practice and Tissue Engineering written by Rakesh Sharma and published by BoD – Books on Demand. This book was released on 2018-05-02 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Download or read book Androgenetic Alopecia From A to Z written by Konstantinos Anastassakis and published by Springer Nature. This book was released on 2022-01-11 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference volume conveys complete understanding and management of Androgenetic Alopecia and Female Pattern Hair Loss (AGA/FPHL). These are probably the most common adult (18-50 yrs.) health disorders besides dental caries, accounting for over 98% of hair loss cases in males and over 70% cases in females. The present volume, the first of three related volumes, is structured in 4 sections: 22 dedicated chapters, ranging from basic science (Biology, Anatomy, Physiology, Embryology), the etiology of adult, childhood & adolescent AGA/FPHL, diagnostic steps and evaluation, to related disorders and comorbidities. For the first time in the scientific literature, all pathogenic contributors of AGA/FPHL, including micro-inflammation, scalp vascularization, biochemical stress, aging, solar radiation, and the sebaceous gland, are examined in comprehensive, dedicated chapters. The effects of every hormone on AGA/FPHL, as well as the psychological impact of the condition, are explored in depth. An extensive chapter on childhood and adolescent AGA/FPHL, a more common than previously thought condition, is another unique feature. Finally, two extremely detailed sections are included on the pathogenic links of AGA/FPHL to life-threatening comorbidities: cardiovascular disease, metabolic syndrome, hypertension, insulin resistance, and prostatic disorders, with suggested guidelines on how to save lives of balding patients by adopting early screening strategies. In providing a fully updated, thorough guide to this popular topic, this richly illustrated volume (over 200 figures, tables, and algorithms) offers the latest, evidence-based information on every aspect of AGA/FPHL causing hair loss to countless patients. Each subject is addressed according to learning and clinical needs, and the presented information is supported by a wealth of peer-reviewed papers. Every aspect of this condition is considered, including biology, diagnosis, etiology, from drug treatment, the influence of nutrition, lifestyle and food supplements, to related disorders, surgical hair restoration, hair care, and future treatment options. This handbook will be an invaluable conveying best management standards to readers, whether experienced practitioners, clinicians, dermatologists, surgeons or researchers interested in hair restoration.