Download or read book Hadron Therapy Physics and Simulations written by Marcos d’Ávila Nunes and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief provides an in-depth overview of the physics of hadron therapy, ranging from the history to the latest contributions to the subject. It covers the mechanisms of protons and carbon ions at the molecular level (DNA breaks and proteins 53BP1 and RPA), the physics and mathematics of accelerators (Cyclotron and Synchrotron), microdosimetry measurements (with new results so far achieved), and Monte Carlo simulations in hadron therapy using FLUKA (CERN) and MCHIT (FIAS) software. The text also includes information about proton therapy centers and carbon ion centers (PTCOG), as well as a comparison and discussion of both techniques in treatment planning and radiation monitoring. This brief is suitable for newcomers to medical physics as well as seasoned specialists in radiation oncology.
Download or read book Hadron Therapy Physics and Simulations written by Marcos d'Ávila Nunes and published by Springer. This book was released on 2013-10-02 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief provides an in-depth overview of the physics of hadron therapy, ranging from the history to the latest contributions to the subject. It covers the mechanisms of protons and carbon ions at the molecular level (DNA breaks and proteins 53BP1 and RPA), the physics and mathematics of accelerators (Cyclotron and Synchrotron), microdosimetry measurements (with new results so far achieved), and Monte Carlo simulations in hadron therapy using FLUKA (CERN) and MCHIT (FIAS) software. The text also includes information about proton therapy centers and carbon ion centers (PTCOG), as well as a comparison and discussion of both techniques in treatment planning and radiation monitoring. This brief is suitable for newcomers to medical physics as well as seasoned specialists in radiation oncology.
Download or read book Proton Therapy Physics written by Harald Paganetti and published by CRC Press. This book was released on 2016-04-19 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton Therapy Physics goes beyond current books on proton therapy to provide an in-depth overview of the physics aspects of this radiation therapy modality, eliminating the need to dig through information scattered in the medical physics literature. After tracing the history of proton therapy, the book summarizes the atomic and nuclear physics background necessary for understanding proton interactions with tissue. It describes the physics of proton accelerators, the parameters of clinical proton beams, and the mechanisms to generate a conformal dose distribution in a patient. The text then covers detector systems and measuring techniques for reference dosimetry, outlines basic quality assurance and commissioning guidelines, and gives examples of Monte Carlo simulations in proton therapy. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. It also examines computerized treatment plan optimization, methods for in vivo dose or beam range verification, the safety of patients and operating personnel, and the biological implications of using protons from a physics perspective. The final chapter illustrates the use of risk models for common tissue complications in treatment optimization. Along with exploring quality assurance issues and biological considerations, this practical guide collects the latest clinical studies on the use of protons in treatment planning and radiation monitoring. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, the book helps readers understand the uncertainties and limitations of precisely shaped dose distribution.
Download or read book Proton Therapy Physics Second Edition written by Harald Paganetti and published by CRC Press. This book was released on 2018-11-19 with total page 917 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective
Download or read book Monte Carlo Techniques in Radiation Therapy written by Joao Seco and published by Taylor & Francis. This book was released on 2016-04-19 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern cancer treatment relies on Monte Carlo simulations to help radiotherapists and clinical physicists better understand and compute radiation dose from imaging devices as well as exploit four-dimensional imaging data. With Monte Carlo-based treatment planning tools now available from commercial vendors, a complete transition to Monte Carlo-base
Download or read book Theory of Heavy Ion Collision Physics in Hadron Therapy written by and published by Academic Press. This book was released on 2012-12-31 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Quantum Chemistry presents surveys of current topics in this rapidly developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry, and biology. It features detailed reviews written by leading international researchers. This volume focuses on the theory of heavy ion physics in medicine. Presents surveys of current topics in this rapidly developing field Features detailed reviews written by leading international researchers Focuses on the theory of heavy ion physics in medicine
Download or read book Hendee s Radiation Therapy Physics written by Todd Pawlicki and published by John Wiley & Sons. This book was released on 2016-01-21 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of this fourth edition, more than ten years on from the publication of Radiation Therapy Physics third edition, provides a comprehensive and valuable update to the educational offerings in this field. Led by a new team of highly esteemed authors, building on Dr Hendee’s tradition, Hendee’s Radiation Therapy Physics offers a succinctly written, fully modernised update. Radiation physics has undergone many changes in the past ten years: intensity-modulated radiation therapy (IMRT) has become a routine method of radiation treatment delivery, digital imaging has replaced film-screen imaging for localization and verification, image-guided radiation therapy (IGRT) is frequently used, in many centers proton therapy has become a viable mode of radiation therapy, new approaches have been introduced to radiation therapy quality assurance and safety that focus more on process analysis rather than specific performance testing, and the explosion in patient-and machine-related data has necessitated an increased awareness of the role of informatics in radiation therapy. As such, this edition reflects the huge advances made over the last ten years. This book: Provides state of the art content throughout Contains four brand new chapters; image-guided therapy, proton radiation therapy, radiation therapy informatics, and quality and safety improvement Fully revised and expanded imaging chapter discusses the increased role of digital imaging and computed tomography (CT) simulation The chapter on quality and safety contains content in support of new residency training requirements Includes problem and answer sets for self-test This edition is essential reading for radiation oncologists in training, students of medical physics, medical dosimetry, and anyone interested in radiation therapy physics, quality, and safety.
Download or read book Particle Accelerators From Big Bang Physics to Hadron Therapy written by Ugo Amaldi and published by Springer. This book was released on 2015-01-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rather than focusing on the contributions of theoretical physicists to the understanding of the subatomic world and of the beginning of the universe - as most popular science books on particle physics do - this book is different in that, firstly, the main focus is on machine inventors and builders and, secondly, particle accelerators are not only described as discovery tools but also for their contributions to tumour diagnosis and therapy. The characters of well-known (e.g. Ernest Lawrence) and mostly unknown actors (e.g. Nicholas Christofilos) are outlined, including many colourful quotations. The overall picture supports the author’s motto: “Physics is beautiful and useful”. Advance appraisal: “Accelerators go all the way from the unique and gargantuan Large Hadron Collider to thousands of smaller versions in hospitals and industry. Ugo Amaldi has experience across the range. He has worked at CERN and has for many years been driving the application of accelerators in medicine. This is a must-read introduction to this frontier of modern technology, written beautifully by a world expert.” Frank Close, Professor of Physics at Oxford University author of "The Infinity Puzzle" “This book should be read by school teachers and all those interested in the exploration of the microcosm and its relation to cosmology, and in the use of accelerators for medical applications. With a light hand and without formulae the autho r easily explains complicated matters, spicing up the text with amusing historical anecdotes. His reputation as an outstanding scientist in all the fields treated guarantees high standards.” Herwig Schopper, former CERN Director General author of "LEP - The Lord of the Collider Rings at CERN" “This book tells the story of modern physics with an unusual emphasis on the machine-builders who made it all possible, and their machines. Learning to accelerate particles has enabled physicists to probe the subatomic world and gain a deeper understanding of the cosmos. It has also brought numerous benefits to medicine, from the primitive X-ray machines of over a century ago to today's developments in hadron therapy for cancer. Amaldi tells this story in a most fascinating way.” Edward Witten, Professor of Mathematical Physics at the Institute for Advanced Study in Princeton; Fields Medal (1990)
Download or read book Monte Carlo in Heavy Charged Particle Therapy written by Pablo Cirrone and published by CRC Press. This book was released on 2023-11-08 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the current difficulties and unsolved problems in the field of particle therapy and, after analysing them, discusses how (and if) innovative Monte Carlo approaches can be used to solve them. Each book chapter is dedicated to a different sub-discipline, including multi-ion treatments, flash-radiotherapy, laser-accelerated beams, nanoparticles effects, binary reactions to enhance radiobiology, and space-related issues. This is the first book able to provide a comprehensive insight into this exciting field and the growing use of Monte Carlo in medical physics. It will be of interest to graduate students in medicine and medical physics, in addition to researchers and clinical staff. Key Features: Explores the exciting and interdisciplinary topic of Monte Carlo in particle therapy and medicine. Addresses common challenges in the field. Edited by an authority on the subject, with chapter contributions from specialists. Pablo Cirrone is a medical physicist and researcher at the Laboratori Nazionali del Sud of INFN, Italy, where he supports and coordinates various experimental groups. Dr. Cirrone is an expert in the use of proton and ion in radiation treatment and of absolute and relative dosimetry in electron, photon and ion beam. He is an expert in the development and test of detectors for medical applications, of the production and use of laser-driven beams for medical and multidisciplinary applications and recipient of the Michael Gotein Award. He is active on many scientific committees and organizes national and international conferences. Giada Petringa is a researcher at the Laboratori Nazionali del Sud of INFN, Italy. Dr. Petringa has a professional experience in the field of Monte Carlo simulations for medical applications, dosimetry, microdosimetry, and diagnostics with conventional and laser-driven proton beams. In 2019 she had a MSCA-IF-2019 (Marie Sklodowska-Curie Actions-Individual Fellowship) grant funded by the European Community in the framework of the H2020 program. She is a member of the Editorial Board of the international journal Physica Medica - European Journal of Medical. She organized more than fifteen international Geant4 Schools. She is an official member of the Geant4 code Collaboration at CERN since 2019. She is a code developer, and she collaborates to maintain two of the official examples of the code.
Download or read book Principles and Practice of Particle Therapy written by Timothy D. Malouff and published by John Wiley & Sons. This book was released on 2022-06-13 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Practice of Particle Therapy Although radiation has been used therapeutically for over 100 years, the field of radiation oncology is currently in the midst of a renaissance, particularly with regards to the therapeutic use of particles. Over the past several years, access to particle therapy, whether it be proton therapy or other heavy ion therapy, has increased dramatically. Principles and Practice of Particle Therapy is a clinically oriented resource that can be referenced by both experienced clinicians and those who are just beginning their venture into particle therapy. Written by a team with significant experience in the field, topics covered include: Background information related to particle therapy, including the clinically relevant physics, radiobiological, and practical aspects of developing a particle therapy program “Niche” treatments, such as FLASH, BNCT, and GRID therapy The simulation process, target volume delineation, and unique treatment planning considerations for each disease site Less commonly used ions, such as fast neutrons or helium Principles and Practice of Particle Therapy is a go-to reference work for any health professional involved in the rapidly evolving field of particle therapy.
Download or read book Monte Carlo Simulation of Active Scanning Proton Therapy System with Gate Geant4 written by Loïc Grevillot and published by . This book was released on 2020 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hadron Therapy is an advanced radiotherapy technique for cancer treatment. It offers a better irradiation ballistic than conventional techniques and therefore requires appropriate quality assurance procedures. In this work, we upgraded the GEANT4-based GATE Monte Carlo platform in order to recalculate the TPS dose distributions in view of further benchmarking. In a first step, we selected an appropriate simulation environment (physics models and parameters) in order to produce accurate and efficient simulations. GATE simulations were validated using measurements and other Monte Carlo codes for depth-dose and transverse profiles. While a good agreement was found for depth-dose profiles, larger discrepancies were pointed out for transverse profiles. In a second step, we developed a modeling method to simulate active scanning beam delivery systems, which does not require to simulate the components of the treatment nozzle. The method has been successfully applied to an IBA proton therapy system and validated against measurements for complex treatment plans. Interfaces have also been developed in order to link DICOM RT ION PLAN and DICOM RT DOSE with GATE. Finally, we compared in a third step the TPS and Monte Carlo dose distributions in homogeneous and heterogeneous configurations. The beam models of both dose engines were in satisfactory agreement, allowing further evaluation of clinical treatment plans. A two-field prostate plan has been evaluated, showing a satisfactory agreement between the TPS and Monte Carlo, and demonstrating the novel capabilities of the platform for the evaluation of the TPS. To summarize, we selected an appropriate simulation environment for proton therapy, proposed a modeling method for active scanning systems and presented a method to compare the TPS and Monte Carlo dose distributions. All tools developed in GATE were or will be publicly released. A detailed validation stage of the system including absolute dosimetry is still necessary, in order to quantitatively evaluate its accuracy in various homogeneous and heterogeneous configurations. In this thesis, we have demonstrated that the GATE Monte Carlo platform is a good candidate for the simulation of active scanning delivery systems, allowing further TPS benchmarking. Moreover, the GATE platform also handles imaging applications, such as PET or prompt-gamma imaging towards online treatment monitoring and paves the way of interdisciplinary research advances.
Download or read book Towards Offline PET Monitoring at a Cyclotron Based Proton Therapy Facility written by Matthias Würl and published by Springer. This book was released on 2016-05-30 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: Matthias Würl presents two essential steps to implement offline PET monitoring of proton dose delivery at a clinical facility, namely the setting up of an accurate Monte Carlo model of the clinical beamline and the experimental validation of positron emitter production cross-sections. In the first part, the field size dependence of the dose output is described for scanned proton beams. Both the Monte Carlo and an analytical computational beam model were able to accurately predict target dose, while the latter tends to overestimate dose in normal tissue. In the second part, the author presents PET measurements of different phantom materials, which were activated by the proton beam. The results indicate that for an irradiation with a high number of protons for the sake of good statistics, dead time losses of the PET scanner may become important and lead to an underestimation of positron-emitter production yields.
Download or read book Particle Physics Reference Library written by Christian W. Fabjan and published by Springer Nature. This book was released on 2020 with total page 1083 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second open access volume of the handbook series deals with detectors, large experimental facilities and data handling, both for accelerator and non-accelerator based experiments. It also covers applications in medicine and life sciences. A joint CERN-Springer initiative, the "Particle Physics Reference Library" provides revised and updated contributions based on previously published material in the well-known Landolt-Boernstein series on particle physics, accelerators and detectors (volumes 21A, B1,B2,C), which took stock of the field approximately one decade ago. Central to this new initiative is publication under full open access
Download or read book Proton Therapy Physics Second Edition written by Harald Paganetti and published by CRC Press. This book was released on 2018-11-19 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature. After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed. This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics. Features: Updated with the latest technologies and methods in the field, covering all delivery methods of proton therapy, including beam scanning and passive scattering Discusses clinical aspects, such as treatment planning and quality assurance Offers insight on the past, present, and future of proton therapy from a physics perspective
Download or read book Proton and Carbon Ion Therapy written by C-M Charlie Ma and published by CRC Press. This book was released on 2012-10-09 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proton and Carbon Ion Therapy is an up-to-date guide to using proton and carbon ion therapy in modern cancer treatment. The book covers the physics and radiobiology basics of proton and ion beams, dosimetry methods and radiation measurements, and treatment delivery systems. It gives practical guidance on patient setup, target localization, and treatment planning for clinical proton and carbon ion therapy. The text also offers detailed reports on the treatment of pediatric cancers, lymphomas, and various other cancers. After an overview, the book focuses on the fundamental aspects of proton and carbon ion therapy equipment, including accelerators, gantries, and delivery systems. It then discusses dosimetry, biology, imaging, and treatment planning basics and provides clinical guidelines on the use of proton and carbon ion therapy for the treatment of specific cancers. Suitable for anyone involved with medical physics and radiation therapy, this book offers a balanced and critical assessment of state-of-the-art technologies, major challenges, and the future outlook of proton and carbon ion therapy. It presents a thorough introduction for those new to the field while providing a helpful, up-to-date reference for readers already using the therapy in clinical settings.
Download or read book State of the art Reviews on Energetic Ion atom and Ion molecule Collisions written by Dževad Belkić and published by World Scientific Publishing Company. This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book is based upon a part of the invited and contributing talks at the 25th International Symposium on Ion-Atom Collisions, ISIAC (biennial), held on July 23-25, 2017 in Palm Cove, Queensland, Australia. To aid the general reader, all the authors tried to present their chapters in the context of the development of the addressed particular themes and the underlying major ideas and intricacies. Some chapters contain new results that have not been previously published elsewhere. Whenever possible, the authors made their attempts to connect the basic research in atomic and molecular collision physics with some important applications in other branches of physics as well as across the physics borders. It is hoped that the material presented in this book will be interesting and useful to the beginners and specialists alike. The contents and expositions are deemed to be helpful to the beginners in assessing the potential overlap of some of the presented material with their own research themes and this might provide motivations for possible further upgrades. Likewise, specialists could take advantage of these reviews to see where the addressed themes were and where they are going, in order to acknowledge the fruits of the efforts made thus far and actively contribute to tailoring the directions of future research. Overall, this book is truly interdisciplinary. It judiciously combines experiments and theories within particle collision physics on atomic and molecular levels. It presents state-of-the-art fundamental research in this field. It addresses the possibilities for significant and versatile applications outside standard atomic and molecular collision physics ranging from astrophysics, surface as well as cluster physics/chemistry, hadron therapy in medicine and to the chemical industry. It is then, as Volume 2, fully in the spirit of the "Aims and Scope" of this book series by reference to its "Mission Statement"."-- Back cover.
Download or read book Monte Carlo Techniques in Radiation Therapy written by Frank Verhaegen and published by CRC Press. This book was released on 2021-10-13 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: About ten years after the first edition comes this second edition of Monte Carlo Techniques in Radiation Therapy: Introduction, Source Modelling, and Patient Dose Calculations, thoroughly updated and extended with the latest topics, edited by Frank Verhaegen and Joao Seco. This book aims to provide a brief introduction to the history and basics of Monte Carlo simulation, but again has a strong focus on applications in radiotherapy. Since the first edition, Monte Carlo simulation has found many new applications, which are included in detail. The applications sections in this book cover the following: Modelling transport of photons, electrons, protons, and ions Modelling radiation sources for external beam radiotherapy Modelling radiation sources for brachytherapy Design of radiation sources Modelling dynamic beam delivery Patient dose calculations in external beam radiotherapy Patient dose calculations in brachytherapy Use of artificial intelligence in Monte Carlo simulations This book is intended for both students and professionals, both novice and experienced, in medical radiotherapy physics. It combines overviews of development, methods, and references to facilitate Monte Carlo studies.
