Download or read book Guidance framework for testing genetically modified mosquitoes written by and published by World Health Organization. This book was released on 2021-05-18 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Guidance framework for testing the sterile insect technique SIT as a vector control tool against Aedes borne diseases written by and published by World Health Organization. This book was released on 2020-03-30 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Compendium of WHO and other UN guidance in health and environment 2024 update written by World Health Organization and published by World Health Organization. This book was released on 2024-07-02 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the 2024 update of the Compendium of WHO and other UN guidance on health and environment. The Compendium is a comprehensive collection of available WHO and other UN guidance for improving health by creating healthier environments. It provides an overview and easy access of more than 500 actions, and a framework for thinking about health and environment interventions. It covers a broad range of areas such as air pollution, water, sanitation and hygiene, climate change, chemicals, radiation, or food systems. Guidance is classified according to principal sectors involved, level of implementation (national, community, health care), the type of instrument (taxes, infrastructure etc.) and the category of evidence. The Compendium compiles existing guidance from hundreds of documents in a simple and systematized format. To ensure the most up-to-date information is provided to the end users, the Compendium is updated on a regular basis and incorporates the latest major WHO or other UN guidance on health and environment. The target audience includes any decision-makers with relevance to health and environment, and those assisting them (such as mayors, staff in ministries, UN country staff etc.). The Compendium has been prepared by WHO in cooperation with UN Environment, UNDP and UNICEF.

Download or read book Global guidance framework for the responsible use of the life sciences written by and published by World Health Organization. This book was released on 2022-09-13 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The framework aims to provide global perspectives on principles, tools and mechanisms to support Member States and relevant stakeholders to mitigate and prevent biorisks and govern dual-use research. The framework adopts the One health approach and focuses on the role that responsible life sciences research can play in preventing and mitigating risks caused by accidents, inadvertent or deliberate misuse with the intention to cause harm to humans, nonhuman animals, plants and agriculture, and the environment. The framework is primarily intended for those who have responsibilities in the governance of biorisks, such as policy makers and regulators in charge of developing national policies to harness the potential benefits of the life sciences while constraining their risks. The framework is also directed towards scientists and research institutions, educators, trainers, project management staff, funding bodies, publishers, editors, the private sector and all relevant stakeholders that are part of the research life cycle. The governance of biorisks is an issue that should engage all countries, although countries will have different contexts, needs and starting points. Mitigating these risks will require individual and collective actions among different stakeholders and disciplines. Mitigating biorisks and governing dual-use research is a shared responsibility.

Download or read book Genetically Modified and other Innovative Vector Control Technologies written by Brij Kishore Tyagi and published by Springer Nature. This book was released on 2022-01-01 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.

Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Download or read book Policy and Regulation in Bioengineering and Biotechnology written by Andrea Wilcks and published by Frontiers Media SA. This book was released on 2023-12-13 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mosquito Gene Drives and the Malaria Eradication Agenda written by Rebeca Carballar-Lejarazú and published by CRC Press. This book was released on 2023-02-24 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years. A significant number of people still die from this mosquito-borne disease, despite the use of various malaria prevention and control methods over hundreds of years and more than a century of coordinated global control efforts using modern tools, together with research into and development of new strategies for prevention, diagnosis, and disease treatment. Genetic approaches that focus on the vector mosquitoes to prevent malaria parasite transmission have been considered for many decades. Genetic control strategies received a significant boost with the successful development of gene drive systems, genetic methods for rapidly spreading beneficial genes and phenotypes through mosquito populations. This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.

Download or read book Transgenic Insects 2nd Edition written by Mark Q. Benedict and published by CABI. This book was released on 2022-10-31 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technology for modifying the genotypes and phenotypes of insects and other arthropods has steadily progressed with the development of more precise and powerful methods, most prominently transgenic modification. For many insect pests, there is now almost unlimited ability to modify phenotypes to benefit human health and agriculture. Precise DNA modifications and gene drive have the power to make wild-type populations less harmful in ways that could never have been performed with previous transgenic approaches. This transition from primarily laboratory science to greater application for field use has also necessitated greater development of modeling, ethical considerations and regulatory oversight. The 2nd Edition of Transgenic Insects contains chapters contributed by experts in the field that cover technologies and applications that are now possible. This edition includes increased attention to associated challenges of risk assessment, regulation, and public engagement. This book will be very valuable to students and researchers in entomology, molecular biology, genetics, public health and agriculture, and will also appeal to practitioners who are implementing the technology, and to regulators, stakeholders and ethicists.

Download or read book Mosquito Research written by Henry Puerta-Guardo and published by BoD – Books on Demand. This book was released on 2023-01-04 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: With around 3,500 species identified so far, mosquitoes can be found in virtually every environment and continent around the globe. Blood-feeding biters (e.g., Anopheles, Culex, Aedes, Ochlerotatus, and Mansonia) are among the most influential vectors for harboring and transmitting mosquito-borne diseases (MBDs) such as Zika, Japanese encephalitis, West Nile fever, dengue fever, yellow fever, and malaria, among other diseases. More than 700 million human infections and 725,000 deaths occur every year. Mosquitoes are increasing in number worldwide, yet there are still no effective vaccines or prevention strategies. Thus, traditional vector control strategies remain the most common ways to combat these diseases. Despite this, MBDs linger as one of the major challenges for public health and vector control programs at both global and local levels. This book provides a comprehensive overview of MBDs and vector control strategies.

Download or read book Tracing Value Change in the International Legal Order written by Heike Krieger and published by Oxford University Press. This book was released on 2023-04-28 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: International law is constantly navigating the tension between preserving the status quo and adapting to new exigencies. But when and how do such adaptation processes give way to a more profound transformation, if not a crisis of international law? To address the question of how attacks on the international legal order are changing the value orientation of international law, this book brings together scholars of international law and international relations. By combining theoretical and methodological analyses with individual case studies, this book offers readers conceptualizations and tools to systematically examine value change and explore the drivers and mechanisms of these processes. These case studies scrutinize value change in the foundational norms of the post-1945 order and in norms representing the rise of the international legal order post-1990. They cover diverse issues: the prohibition of torture, the protection of women's rights, the prohibition of the use of force, the nonproliferation of nuclear weapons, sustainability norms, and accountability for core international crimes. The challenges to each norm, the reactions by norm defenders, and the fate of each norm are also studied. Combined, the analyses show that while a few norms have remained surprisingly robust, several are changing, either in substance or in legal or social validity. The book concludes by integrating the conceptual and empirical insights from this interdisciplinary exchange to assess and explain the ambiguous nature of value change in international law beyond the extremes of mere progress or decline.

Download or read book Rethinking Clinical Trials and Redefining Responsibility for Research Participants written by Ike Iyioke and published by Ethics International Press. This book was released on 2023-03-17 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a new treatment of clinical research ethics in an African context, and an indispensable resource for researchers, students, policy makers and research institutions interested in African research ethics. In re-appraising the African philosophical notion of selfhood, it argues for the need to re-conceptualize responsibility in clinical trials, pushing researchers to go beyond autonomy-based considerations based on the individual only, and to develop clinical trials that appropriately embed research subjects within their community and their environment. The African standpoint stresses communalism and communitarianism. As such, responsibility for, and by, the individual can only make sense through the community in which the individual is rooted. The book emphasizes the African viewpoint by making explicit the importance of the self in the re-contextualized arena of the community. It forces research ethicists to go beyond autonomy-based considerations for the individual only, and to appropriately embed research subjects within their community and their environment.

Download or read book Genetic Control of Malaria and Dengue written by Zach N. Adelman and published by Academic Press. This book was released on 2015-10-15 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission Provides a summary of the concepts of both population suppression and population replacement Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies

Download or read book The Promise and Peril of CRISPR written by Neal Baer and published by JHU Press. This book was released on 2024-07-02 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely collection of essays on the pressing possibilities and risks of gene-editing technology. Scientists and genetic engineers are becoming increasingly adept at editing the human genome. How far can—and should—they go in editing future generations? In The Promise and Peril of CRISPR, editor Neal Baer brings together a timely collection of essays by influential bioethicists, philosophers, and geneticists to explore the moral, ethical, and policy challenges posed by CRISPR technology. We are at a technological and ethical crossroads in grappling with the impacts of genetic editing. Gene-editing technology holds the promise of curing more than 7,000 known genetic diseases. Yet with that promise comes the peril of using CRISPR to edit the human genome, which could not only lead to manipulating human evolution, but also to creating and releasing pathogens capable of wreaking havoc on human, animal, and plant life. Although CRISPR has already cured several genetic diseases, it could also be used to design biological weapons or to edit the embryos of people who can afford to purchase genetic "enhancements" for their children. What role can and should the public play in discussing the far-reaching implications of gene editing? What oversights should be put in place to prevent a rogue scientist from engineering another baby – as was recently done with twins in China? Essay contributors offer informed predictions and guidelines for how the uses of CRISPR today will affect life in the future. Decisions we make now may have unpredictable consequences for future generations. For anyone concerned about the uses and potential abuses of gene editing, these essays provide a critical and comprehensive discussion of the central issues surrounding CRISPR technology. Contributors: Florence Ashley, R. Alta Charo, Marcy Darnovsky, Kevin Doxzen, Rosemarie Garland-Thomson, Gigi Kwik Gronvall, Jodi Halpern, Katie Hasson, Andrew C. Heinrich, Jacqueline Humphries, J. Benjamin Hurlbut, Ellen D. Jorgensen, Peter F. R. Mills, Carol Padden, Marcus Schultz-Bergin, Robert Sparrow, Sandra Sufian, Krystal Tsosie, Ethan Weiss, Rachel M. West

Download or read book Transformative Novel Technologies and Global Environmental Governance written by Florian Rabitz and published by Cambridge University Press. This book was released on 2023-08-31 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transformative Novel Technologies are potential gamechangers for confronting climate change, biodiversity loss, and many other elements of the global environmental crisis, allowing us to achieve a more sustainable future. The contemporary and future international governance of these technologies has crucial implications for managing the global transition towards sustainability. This book is the first to present a comprehensive assessment of the impact of these technologies on international politics. The author examines the responses of international institutions to the emergence of these technologies, focusing on three broad domains: biotechnology, climate engineering, and mineral extraction in areas beyond national jurisdiction (the ocean floor or near-Earth asteroids). This book is aimed at a non-specialist, academic audience with interest in the international and environmental politics of sustainability and technology. This title is part of the Flip it Open Programme and may also be available Open Access. Check our website - Cambridge Core - for details.

Download or read book Evaluation of genetically modified mosquitoes for the control of vector borne diseases written by and published by World Health Organization. This book was released on 2020-09-30 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Global Network of WHO Collaborating Centres for Bioethics written by World Health Organization and published by World Health Organization. This book was released on 2022-03-31 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2009 WHO established its Global Network of Collaborating Centres for Bioethics. This publication provides an overview of the activities of the Network during the years 2019-2021.