Download or read book OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices GIVIMP written by OECD and published by OECD Publishing. This book was released on 2018-12-10 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...

Download or read book Alternative Toxicological Methods written by Harry Salem and published by CRC Press. This book was released on 2003-03-26 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist

Download or read book Drug Discovery Toxicology written by Yvonne Will and published by John Wiley & Sons. This book was released on 2016-03-16 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices

Download or read book OECD Guidelines for the Testing of Chemicals Section 4 Test No 420 Acute Oral Toxicity Fixed Dose Procedure written by OECD and published by OECD Publishing. This book was released on 2002-02-08 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...

Download or read book Principles of Toxicology Testing written by Frank A Barile and published by CRC Press. This book was released on 2013-04-02 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nationally, toxicology programs have evolved from a traditional exploration of the chemistry and applied toxicity of chemicals and drugs to a more comprehensive study of toxicology and toxicology testing as independent entities. Consequently, the second edition of Principles of Toxicology Testing starts with basic toxicological principles, includin

Download or read book Handbook of Nanotoxicology Nanomedicine and Stem Cell Use in Toxicology written by Saura C. Sahu and published by John Wiley & Sons. This book was released on 2014-04-22 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.

Download or read book Fire Toxicity written by A A Stec and published by Elsevier. This book was released on 2010-03-12 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxic fire effluents are responsible for the majority of fire deaths, and an increasing large majority of fire injuries, driven by the widespread and increasing use of synthetic polymers. Fire safety has focused on preventing ignition and reducing flame spread through reducing the rate of heat release, while neglecting the important issue of fire toxicity. This is the first reference work on fire toxicity and the only scientific publication on the subject in the last 15 years.Assessment of toxic effects of fires is increasingly being recognised as a key factor in the assessment of fire hazards. This book raises important issues including the types of toxic effluents that different fires produce, their physiological effects, methods for generation and assessment of fire toxicity, current and proposed regulations and approaches to modelling the toxic impact of fires.The contributors to Fire toxicity represent an international team of the leading experts in each aspect of this challenging and important field. This book provides an important reference work for professionals in the fire community, including fire fighters, fire investigators, regulators, fire safety engineers, and formulators of fire-safe materials. It will also prove invaluable to researchers in academia and industry. - Investigates the controversial subject of toxic effluents as the cause of the majority of fire deaths and injuries - Describes the different types of toxic effluents and the specific fires that they produce, their physiological effects and methods for generation - Provides an overview of national and international fire safety regulations including current and proposed regulations such as a standardized framework for prediction of fire gas toxicity

Download or read book Nanocarriers for Drug Delivery written by Josimar O. Eloy and published by Springer Nature. This book was released on 2021 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers basic aspects of different nanoparticles, including type of materials, lipid, polymeric and inorganic structures, synthesis strategies, as well as the main physicochemical characterization techniques. Moreover, this book addresses applications for both treatment and diagnosis of diseases, highlighting in vitro and in vivo findings and clinical evaluation. The chapters highlight the main barriers for drug delivery which can benefit from nanoencapsulation: the topical and oral routes. The main innovations in the field, such as gene therapy and functionalization of nanoparticles with a variety of moieties, including monoclonal antibodies for selective delivery, are discussed and illustrated with examples. Finally, the application of nanoparticles for drug delivery to cancer is reviewed considering toxicology and regulatory aspects.

Download or read book Biological Concepts and Techniques in Toxicology written by Jim E. Riviere and published by CRC Press. This book was released on 2006-03-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicol

Download or read book The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals written by Robert C. Hubrecht and published by John Wiley & Sons. This book was released on 2010-01-19 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: The seminal reference on the care of laboratory and captiveanimals, The UFAW Handbook on the Care and Management ofLaboratory and Other Research Animals is a must-have for anyoneworking in this field. The UFAW Handbook has been thedefinitive text since 1947. Written for an international audience,it contains contributions from experts from around the world. The book focuses on best practice principles throughout, providingcomprehensive coverage, with all chapters being peer reviewed byanonymous referees. As well as addressing the husbandry oflaboratory animals, the content is also of great value to zoos andaquaria. Changes for the eighth edition: Revised and updated to reflect developments since publicationof the previous edition. New chapters on areas of growing concern, including: the 3Rs;phenotyping; statistics and experimental design; welfareassessment; legislation; training of people caring for lab animals;and euthanasia. All material combined into one volume for ease ofreference. This book is published on behalf of UFAW (The UniversitiesFederation for Animal Welfare), with whom we also publish theUFAW/Wiley-Blackwell Animal Welfare Book Series. This majorseries of books provides an authoritative source ofinformation on worldwide developments, current thinking and bestpractice in the field of animal welfare science and technology. Fordetails of all of the titles in the series see ahref="http://www.wiley.com/go/ufaw"www.wiley.com/go/ufaw/a.

Download or read book Management of Industrial Cleaning Technology and Processes written by John Durkee and published by Elsevier. This book was released on 2006-07-21 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: More stringent quality standards and environmental/safety regulations as well as new process and chemical technology have changed industrial cleaning from a "wet and wipe application to a valued and demanding process operation. This book will help cleaning operatives, designers of equipment, metal finishers, industrial chemists and decontaminators understand the value and demands required within the industrial cleaning process and an environment of continuing change.* Covers all aspects of modern cleaning technologies, helping readers to understand basics of cleaning, equipment used, techniques and possible changes to come within the industry.* Includes environmental regulations and the basis for modern cleaning technologies, ensuring the reader is up to date on cleaning chemicals and their affects.* Covers testing for cleanliness, ensuring cleaning operatives, technicians and end users understand how to achieve the demands required within the industrial cleaning process and an environment of continuing change.

Download or read book Reducing Refining and Replacing the Use of Animals in Toxicity Testing written by Dave Allen and published by Royal Society of Chemistry. This book was released on 2013-10-31 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.

Download or read book OECD Guidelines for Testing of Chemicals written by Organisation for Economic Co-operation and Development and published by Organisation for Economic Co-operation and Development ; [Montréal : Renouf]. This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Stem Cell Biology in Normal Life and Diseases written by Kamran Alimoghaddam and published by BoD – Books on Demand. This book was released on 2013-05-08 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells have a prominent role in normal life and also in pathogenesis of disorders. Today, these cells are clinically applicable in hematopoietic stem cell transplantation but expansion of their application in many more disorders needs more work. For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical application we need to understand better, their separation methods and safe manipulation. This book is written to clarify some aspects of stem cell biology, their characteristics, assessment of damage to cells during ex vivo manipulation and also their role in a model of cancers (chronic myeloid leukemia).

Download or read book The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals written by Huw Golledge and published by John Wiley & Sons. This book was released on 2024-04-15 with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt: The UFAW Handbook on The Care and Management of Laboratory and Other Research Animals The latest edition of the seminal reference on the care and management of laboratory and research animals The newly revised ninth edition of The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals delivers an up-to-date and authoritative exploration on worldwide developments, current thinking, and best practices in the field of laboratory animal welfare science and technology. The gold standard in laboratory and captive animal care and management references, this latest edition continues the series’ tradition of excellence by including brand-new chapters on ethical review, the care of aged animals, and fresh guidance on the care of mole rats, corvids, zebrafish, and decapods. The book offers introductory chapters covering a variety of areas of laboratory animal use, as well as chapters on the management and care of over 30 different taxa of animals commonly utilised in scientific procedures and research around the world. It also provides: A thorough introduction to the design of animal experiments, laboratory animal genetics, and the phenotyping of genetically modified mice Comprehensive explorations of animal welfare assessment and the ethical review process Practical discussions of legislation and oversight of the conduct of research using animals from a global perspective In-depth examinations of the planning, design, and construction of efficient animal facilities, special housing arrangements, and nutrition, feeding, and animal welfare The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals Ninth Edition is essential for laboratory animal scientists, veterinarians, animal care staff, animal care regulatory authorities, legislators, and professionals working in animal welfare non-governmental organizations.

Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-10-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Download or read book Cosmetic Formulation written by Heather A.E. Benson and published by CRC Press. This book was released on 2019-04-05 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cosmetics are the most widely applied products to the skin and include creams, lotions, gels and sprays. Their formulation, design and manufacturing ranges from large cosmetic houses to small private companies. This book covers the current science in the formulations of cosmetics applied to the skin. It includes basic formulation, skin science, advanced formulation, and cosmetic product development, including both descriptive and mechanistic content with an emphasis on practical aspects. Key Features: Covers cosmetic products/formulation from theory to practice Includes case studies to illustrate real-life formulation development and problem solving Offers a practical, user-friendly approach, relying on the work of recognized experts in the field Provides insights into the future directions in cosmetic product development Presents basic formulation, skin science, advanced formulation and cosmetic product development