Download or read book Neural Grafting written by United States. Congress. Office of Technology Assessment and published by . This book was released on 1990 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neural grafting repairing the brain and spinal cord written by and published by DIANE Publishing. This book was released on with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Neuronal Grafting and Alzheimer s Disease written by F.H. Gage and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's disease is one of the major scientific, medical and social challenges of our time. This book (the third volume of proceedings of the Colloques Médecine et Recherche of the Fondation Ipsen pour la Recherche Thérapeutique) is dedicated to neuronal grafting and Alzheimer's disease. The wealth of basic information presented testifies to the progress that has been achieved in intracerebral grafting and to the utility of intracerebral grafting as a tool for the understanding of brain development, adult neuronal plasticity and age-related pathology. An answer to the question, whether neuronal grafting will be useful as a therapy for Alzheimer's disease, must wait for a better understanding of the disease and the identification of animal models that can be used to test potential therapies. Meanwhile, the tool of intracerebral grafting may, in the future, be used to address the pathophysiology of Alzheimer's disease.

Download or read book Jasper s Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by Oxford University Press. This book was released on 2012-06-01 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in 1969. Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment." Since then, basic and clinical researchers in epilepsy have gathered together every decade and a half with these goals in mind -- assessing where epilepsy research has been, what it has accomplished, and where it should go. In 1999, the third volume of BME was named in honor of H.H. Jasper. In line with the enormous expansion in the understanding of basic epilepsy mechanisms over the past four decades, this fourth edition of Jasper's BME is the most ambitious yet. In 90 chapters, the book considers the role of interactions between neurons, synapses, and glia in the initiation, spread and arrest of seizures. It examines mechanisms of excitability, synchronization, seizure susceptibility, and ultimately epileptogenesis. It provides a framework for expanding the epilepsy genome and understanding the complex heredity responsible for common epilepsies as it explores disease mechanisms of ion channelopathies and developmental epilepsy genes. It considers the mechanisms of conditions of epilepsy comorbidities. And, for the first time, this 4th edition describes the current efforts to translate the discoveries in epilepsy disease mechanisms into new therapeutic strategies. This book, considered the 'bible' of basic epilepsy research, is essential for the student, the clinician scientist and all research scientists who conduct laboratory-based experimental epilepsy research using cellular, brain slice and animal models, as well as for those interested in related disciplines of neuronal oscillations, network plasticity, and signaling in brain strucutres that include the cortex, hippocampus, and thalamus. In keeping with the 1969 goals, the book is now of practical importance to the clinical neurologist and epileptologist as the progress of research in molecular genetics and modern efforts to design antiepileptic drugs, cures and repairs in the epilepsies converge and impact clinical care.

Download or read book Grafting Helen written by Matthew Gumpert and published by University of Wisconsin Pres. This book was released on 2012-11 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: History is a love story: a tale of desire and jealousy, abandonment and fidelity, abduction and theft, rupture and reconciliation. This contention is central to Grafting Helen, Matthew Gumpert's original and dazzling meditation on Helen of Troy as a crucial anchor for much of Western thought and literature. Grafting Helen looks at "classicism"—the privileged rhetorical language for describing cultural origins in the West—as a protracted form of cultural embezzlement. No coin in the realm has been more valuable, more circulated, more coveted, or more counterfeited than the one that bears the face of Helen of Troy. Gumpert uncovers Helen as the emblem for the past as something to be stolen, appropriated, imitated, extorted, and coveted once again. Tracing the figure of Helen from its classical origins through the Middle Ages, the French Renaissance, and the modern era, Gumpert suggests that the relation of current Western culture to the past is not like the act of coveting; it is the act of coveting, he argues, for it relies on the same strategies, the same defenses, the same denials, and the same delusions.

Download or read book Grafting Memories Essays on War and Commemoration written by Bill Lipke and published by Bard Owl Books. This book was released on 2015-09-16 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: THIS COLLECTION OF ESSAYS examines how the American Civil War and the Great War of 1914-1918 together launched new practices for honoring the dead as individuals. Some of these practices included the uniformity of burial of both officers and the field soldier; the actual naming of the dead; the erection of memorials to the missing and unknown; and individual recognition in photos, statuary and living memorials. Also discussed is how countless streams of private grief has joined the mainstream of public mourning, how monuments have been used for "nation building," and how the memorial landscape has changed from the nearly ubiquitous standing Civil War monuments to the World War One doughboys, to almost nothing.

Download or read book Memory written by Bennett L. Schwartz and published by SAGE Publications. This book was released on 2013-07-02 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: The science and practice of memory come to life with Bennett Schwartz' Memory, Second Edition. Integrated coverage of cognitive psychology and neuroscience throughout the text connect theory and research to the areas in the brain where memory processes occur, while unique applications of memory concepts to such areas as education, investigations, and courtrooms engage students in an exploration of how memory works in everyday life. Four themes create a framework for the text: the active nature of learning and remembering; memory's status as a biological process; the multiple components of memory systems; and how memory principles can improve our individual ability to learn and remember. Substantive changes in each chapter and 156 new references bring this new edition completely up to date and offer students an array of high-interest examples for augmenting their own memory abilities and appreciation of memory science.

Download or read book Textbook of Organ Transplantation Set written by Allan D. Kirk and published by John Wiley & Sons. This book was released on 2014-07-21 with total page 1880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brought to you by the world’s leading transplantclinicians, Textbook of Organ Transplantation provides acomplete and comprehensive overview of modern transplantation inall its complexity, from basic science to gold-standard surgicaltechniques to post-operative care, and from likely outcomes toconsiderations for transplant program administration, bioethics andhealth policy. Beautifully produced in full color throughout, and with over 600high-quality illustrations, it successfully: Provides a solid overview of what transplantclinicians/surgeons do, and with topics presented in an order thata clinician will encounter them. Presents a holistic look at transplantation, foregrounding theinterrelationships between transplant team members and non-surgicalclinicians in the subspecialties relevant to pre- andpost-operative patient care, such as gastroenterology, nephrology,and cardiology. Offers a focused look at pediatric transplantation, andidentifies the ways in which it significantly differs fromtransplantation in adults. Includes coverage of essential non-clinical topics such astransplant program management and administration; research designand data collection; transplant policy and bioethical issues. Textbook of Organ Transplantation is the market-leadingand definitive transplantation reference work, and essentialreading for all transplant surgeons, transplant clinicians, programadministrators, basic and clinical investigators and any othermembers of the transplantation team responsible for the clinicalmanagement or scientific study of transplant patients.

Download or read book Remembering the Times of Our Lives written by Patricia J. Bauer and published by Psychology Press. This book was released on 2014-01-14 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of Remembering the Times of Our Lives: Memory in Infancy and Beyond is to trace the development from infancy through adulthood in the capacity to form, retain, and later retrieve autobiographical or personal memories. It is appropriate for scholars and researchers in the fields of cognitive psychology, memory, infancy, and human development.

Download or read book Plasticity in the Central Nervous System written by James L. McGaugh and published by Routledge. This book was released on 2019-01-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalyzed by the development of new neurobiological and behavioral techniques as well as new conceptual and theoretical approaches to the study of the relationship between brain and behavior, research exploring brain functions enabling learning and memory has greatly accelerated in recent years. The chapters in this book reflect current theoretical approaches to the study of brain and memory and provide new insights concerning the cellular bases of memory and the differential involvement of brain systems in different forms of memory. By presenting up-to-date summaries of research investigating brain mechanisms underlying learning and memory, these chapters help to place current findings in appropriate theoretical context, and further stimulate research inquiry attempting to understand how the brain makes memory. Divided into three sections, coverage in this volume includes: * a discussion of pharmacological approaches to the study of brain and memory; * a review of experiments using a variety of techniques, including brain lesions, brain grafting, and electrophysiological recording to investigate the role of different brain regions in learning and memory; and * an examination of molecular analyses of events associated with memory formation.

Download or read book The Processing of Memories PLE Memory written by Norman E. Spear and published by Psychology Press. This book was released on 2014-05-09 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 1978, this volume contains the evidence that is most crucial for our understanding the processes of forgetting and retention. Organized in terms of problem areas and issues that are particularly pertinent to understanding these processes, the book deals with both animal and human studies. The author begins by defining the topic and reviewing its historical development. A theoretical orientation follows, and then the author begins to address the major factors that determine what is, and what is not, remembered. Although we cannot yet specify the principles from which we can predict when an episode, once learned, will be remembered well or forgotten entirely, the author demonstrates that such principles are not that far away. He considers the issues that must be resolved before such principles are established, and in the course of doing so covers the major research on why we remember events and why they are forgotten.

Download or read book Man and Memory written by Daniel Stephen Halacy and published by . This book was released on 1970 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Memory Reconsolidation written by Cristina M. Alberini and published by Academic Press. This book was released on 2013-03-18 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: As little as 10 years ago, it was believed that memory went from short to long term via one consolidation practice that made that memory intractable. Since then, research has shown that long-term memories can be activated, modified, and reconsolidated in their new form. This research indicates that memories are more dynamic than once believed. And understanding how this process works and helping people to redefine established memories can be clinically useful if those memories lead to problems, as is the case in post-traumatic stress disorder. This book provides a comprehensive overview of research on memory reconsolidation; what this has to say about the formation, storage, and changeability of memory; and the potential applications of this research to treating clinical disorders. Presents both neuroscience and psychological research on memory reconsolidation Discusses what findings mean for understanding memory formation, storage, and retrieval Includes treatment applications of these findings

Download or read book Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation written by Narinder K. Mehra and published by Frontiers Media SA. This book was released on 2017-07-25 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first real major breakthrough that laid the basis of HLA antibody detection in the field of solid organ transplantation, came with the introduction of the complement dependent cytotoxicity (CDC) test in 1964 by Terasaki and McClelland. Since then, methods for antibody detection have evolved remarkably from conventional cell-based assays to the current advanced solid phase systems on the Luminex platform, with increasing degree of sensitivity and specificity. The latter have been indispensable for more accurate identification of donor specific HLA antibodies in broadly reactive allo antisera, and to guide donor selection and kidney paired exchange programs through virtual crossmatching, in addition to serving as excellent tools for initiating pre-transplant desensitization and post- transplant antibody monitoring. Consensus is evolving on the optimal routine employment of these methods in donor selection strategies along with an understanding of the clinical relevance of antibodies detected by each of them. The immunoassays based on the Luminex platform and flow cytometric beads are however unable to discriminate complement fixing from non-complement fixing HLA antibodies. This is important because the former are considered clinically more pertinent in the peri-transplant period. The C1q assay which is a modification of the solid phase assay based on Luminex single antigen beads, which can be used effectively to monitor high dose IVIG desensitization is essentially a surrogate complement fixing assay, retaining the exquisite sensitivity and specificity of the Luminex platform. Currently, information obtained from these assays is preliminary and much needs to be done to standardize technologies and set a consensus ‘MFI cut off’ for antibody positivity. Besides the overriding influence of anti-HLA antibodies on overall solid organ graft survival, immune response to non-HLA antigens has become a topic of substantial interest in recent years. An ever expanding list of non-HLA antigens has been implicated in graft rejection for various organs, of which the most noted are the Major Histocompatibility Complex class I chain-related molecule A (MICA), Vimentin, Myosin, Angiotensin II type 1 receptor (AT1R), Tubulin and Collagen. MICA is one of the most polymorphic and extensively studied non-HLA antigenic targets especially in renal transplantation. Although there are clear indications of MICA antibodies being associated with adverse graft outcome, to date a definitive consensus on this relationship has not been agreed. Because MICA molecules are not expressed constitutively on immunocompetent cells such as T and B lymphocytes, it is of utmost importance to address the impact of MICA donor specific antibodies (DSA) as compared to those that are non- donor specific (NDSA) on graft outcome. The soluble isoform of MICA molecule (sMICA) that is derived from the proteolytic shedding of membrane bound molecules has the potential to engage the NK-cell activating receptor NKG2D and down-regulate its expression. Consequent to the interaction of NKG2D by sMICA, the receptor ligand complex is endocytosed and degraded and thus suppresses NKG2D mediated lysis of the target by NK cells. Thus interaction between NKG2D and sMICA leads to expansion of immunosuppressive/anergic T cells thereby resulting in suppression of NKG2D mediated host innate immunity. These concept support the possible involvement of an immunosuppressive role for sMICA during allotransplantation as shown recently for heart transplantation. This research topic focusses on the clinical utility of investigating the complete antibody repertoire in solid organ transplantation.

Download or read book Human Memory written by Mary B. Howes and published by SAGE Publications. This book was released on 2006-11-22 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Howes′ new textbook, Human Memory, offers a thorough and expansive introduction to the science of remembering and forgetting. With highly accessible prose, Howes keeps the student clearly in mind as she deftly weaves together traditional and novel approaches to memory research. Unlike any other memory textbook on the market . . . it looks to be a definite winner in the classroom." —James S. Nairne, Purdue University Presented in a clear and accessible format, Human Memory: Structures and Images offers students a comprehensive overview of research in human memory. Providing a theoretical background for the research, author Mary B. Howes covers three major areas—mainstream experimental research; naturalistic research; and work in the domains of the amnesias, malfunctions of memory, and neuroscience. Key Features: Presents extensive coverage of naturalistic research: Areas of current naturalistic research, such as eyewitness testimony and courtroom procedures, are included, as are the functioning of memory under atypical or abnormal conditions and traumatic and repressed memories. Emphasizes the constructivist position: Offering greater coverage than other books on this model of memory, this text also examines the debate between constructivist and nonconstructivist theories. Offers two chapters online on computers and memory: Chapter 1 on computer functioning simulation of memory and Chapter 2 on computer models of long-term memory are easily accessed online. Supplies instructors with thoughtfully crafted support material: An Instructor′s Resources CD-ROM, including PowerPoint slides, study quizzes, test items, and worksheets, is available to all qualified adopters. Intended Audience: This text is designed for advanced undergraduate and graduate courses such as Memory, Human Memory, Memory and Cognition, and Memory and Forgetting.

Download or read book Transplantation Bioengineering and Regeneration of the Endocrine Pancreas written by Giuseppe Orlando and published by Academic Press. This book was released on 2019-11-09 with total page 890 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 1, sets a new standard in transplant and regenerative medicine. The book details the-state-of-the-art in modern whole pancreas and islet transplantation, including donor selection, immunosuppression, complications, allograft pathology, and more. As regenerative medicine is changing the premise of solid organ transplantation, this volume catalogs the technologies being developed and the methods being implemented to bioengineer or regenerate the endocrine pancreas in order to more effectively treat diabetes. Edited and authored by unparalleled leaders in the field, this new volume argues for a much needed synergy between organ transplantation and regenerative medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Includes sections that address donor selection, immunosuppression, complications, allograft pathology, and more Offers an update on the progress of regenerative medicine research aimed at beta cells replacement in the treatment of diabetes

Download or read book Corneal Transplantation written by John V. Forrester and published by World Scientific. This book was released on 2004 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: - Concise but comprehensive guidebook/handbook - Current and translational information - New concepts of rejection and tolerance - Multimedia display of microsurgical technique