Download or read book Gpcrs As Therapeutic Targets Volume 2 written by Gilchrist and published by Wiley-Blackwell. This book was released on 2022-11-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book GPCRs as Therapeutic Targets written by Annette Gilchrist and published by John Wiley & Sons. This book was released on 2022-09-19 with total page 1610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eine umfassende Betrachtung der Struktur, Pharmakologie, Funktion und Rolle von G-Protein-gekoppelten Rezeptoren Mit GPCRs as Therapeutic Targets legt die renommierte Forscherin Dr. Annette Gilchrist einen maßgeblichen, umfassenden Leitfaden für einen dynamischen, aktiven Bereich der akademischen und industriellen Arzneimittelforschung vor. Das Werk, in dem die molekulare Pharmakologie dieser wichtigen Zielklasse behandelt wird, ist ein wichtiges Referenzwerk für neue und erfahrene Forscher, die sich mit G-Protein-gekoppelten Rezeptoren beschäftigen. Es enthält außerdem aktuelle Daten zu GPCR-Strukturen und dem strukturbasierten Wirkstoffdesign. In diesem Werk wird die Rolle von GPCR bei der Behandlung von Krankheiten und für neue Ansätze in deren Erforschung analysiert. Dabei werden nicht nur Informationen über die Struktur, Pharmakologie und Funktion von GPCR dargestellt, sondern es wird auch deren Rolle bei Krankheitszuständen erörtert. Neue Methoden zur Messung der GPCR-Aktivität werden auf verständliche und ansprechende Weise präsentiert. Das Werk bietet: * Eine gründliche Einführung in die molekulare Pharmakologie G-Protein-gekoppelter Rezeptoren mit aktuellen Angaben zu GPCR-Strukturen und dem strukturbasierten Wirkstoffdesign * Ausführliche Erörterungen der entstehenden Pharmakologie von GPCR, des intrazellulären Transports und der subzellulären GPCR-Signalübertragung * Umfassende Betrachtung der allosterischen Modulation, Rezeptordimerisierung, Deorphanisierung und Ubiquitinierung * Ausführliche Besprechung der Rolle von GPCR bei der Behandlung von Krebs, Substanzmissbrauch, zerebrovaskulären Erkrankungen und Stoffwechselkrankheiten Als ideales Referenzwerk für Forscher in den Bereichen Biochemie, Zellbiologie und Pharmakologie sollte GPCRs as Therapeutic Targets auch in den Bibliotheken von Fachleuten der Medizinischen Chemie, Strukturbiologie und klinischen Pharmakologie einen Platz finden.
Download or read book Gpcrs As Therapeutic Targets Volume 1 written by Gilchrist and published by Wiley-Blackwell. This book was released on 2022-11-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nuclear G Protein Coupled Receptors written by Bruce G. Allen and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear G-Protein Coupled Receptors: Methods and Protocols is a compilation of a number of conceptual and methodological aspects important for the validation and characterization of intacrine signaling systems. To date, the best-characterized intracrine signaling system is that of angiotensin II (Ang II), covered in depth in various chapters. Methodology to study the subcellular localization and function of GPCRs and other signaling systems is provided, as well as numerous chapters focusing on methods designed to understand signaling mediated by nuclear and other internal GPCRs. Methods are also described to study the formation of second messengers such as cAMP and to study the trafficking of receptors from the cell surface. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Nuclear G-Protein Coupled Receptors: Methods and Protocols seeks to serve both professionals and novices with state-of-the-art approaches to characterize what is becoming a common theme in cellular signaling.
Download or read book G Protein coupled Receptors in Drug Discovery written by Marta Filizola and published by . This book was released on 2015 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical, and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists, and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets.--
Download or read book G Protein Coupled Receptors as Drug Targets written by Roland Seifert and published by Wiley-VCH. This book was released on 2005-12-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological process that has not yet been covered in such depth in any other existing books on GPCRs. The international team of highly distinguished authors addresses in detail current models and concepts, to introduce medicinal chemists, physiologists, pharmacologists, and medical researchers into the advances in the understanding of GPCR activation and constitutive activity. In addition, the book provides an overview on methods of investigating constitutive GPCR activity. The text is well illustrated by selected experimental data and schemes._The chaptes are all cross-referenced with each other and cover general mechnisms, methodological approaches and cover selected important GPCR sysstems, the consequences for drug action, including, side effects, and rational drug design for GPCR targets. A highly recommended reference for researchers in academia and industry. authors addresses in detail current models and concepts, so as to introduce pharmaceutical chemists, physiologists and medical researchers to the advances in the understanding of GPCR activation and constitutive activity, and provides an overview of the methods of investigating GPCR activity. The text is backed by abundant case studies and methodological advice for analyzing GPCRs, covering selected pharmacologically relevant GPCR systems, the consequences for drug action, including unwanted side effects, and rational drug design for GPCR targets. A highly practical reference for researchers in academia and industry.
Download or read book GPCR Molecular Pharmacology and Drug Targeting written by Annette Gilchrist and published by John Wiley & Sons. This book was released on 2010-12-10 with total page 675 pages. Available in PDF, EPUB and Kindle. Book excerpt: G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs are examined today, how they react, how their mutations lead to disease, and the many ways in which they can be screened for compounds that modulate them. Chemists, pharmacologists, and biologists will find essential information in this comprehensive reference.
Download or read book Neuromorphic Olfaction written by Krishna C. Persaud and published by CRC Press. This book was released on 2016-04-19 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p
Download or read book Neuropeptide GPCRs in Neuroendocrinology Volume II written by Maria Lucia Narducci and published by Frontiers Media SA. This book was released on 2023-07-07 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book GPCR Signalling Complexes Synthesis Assembly Trafficking and Specificity written by Denis J. Dupré and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality-controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling complex is selected to join a complex, and what makes this assembly possible. GPCRs are known to be able to function as oligomers, what drives the assembly into oligomers and what will be the effects of such organization on specificity and efficacy of signal transduction. Once the receptor complexes are assembled, they need to reach different locations in the cell; what drives and controls the trafficking of GPCR signalling complexes. Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCRs signalling complexes; how can we manipulate the system to make it function normally again? Pharmacological chaperones may just be part of the answer to this question.
Download or read book Free Fatty Acid Receptors written by Graeme Milligan and published by Springer. This book was released on 2017-02-08 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.
Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Download or read book Adhesion G Protein coupled Receptors written by Tobias Langenhan and published by Springer. This book was released on 2016-11-09 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how Adhesion GPCRs signal and how these receptors shape organ structure and function.
Download or read book Innovation and Small Business Volume 2 written by and published by Bookboon. This book was released on with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles of Endocrinology and Hormone Action written by Antonino Belfiore and published by Springer. This book was released on 2018-02-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides comprehensive coverage of the current knowledge of the physiology of the endocrine system and hormone synthesis and release, transport, and action at the molecular and cellular levels. It presents essential as well as in-depth information of value to both medical students and specialists in Endocrinology, Gynecology, Pediatrics, and Internal Medicine. Although it is well established that the endocrine system regulates essential functions involved in growth, reproduction, and homeostasis, it is increasingly being recognized that this complex regulatory system comprises not only hormones secreted by the classic endocrine glands but also hormones and regulatory factors produced by many organs, and involves extensive crosstalk with the neural and immune system. At the same time, our knowledge of the molecular basis of hormone action has greatly improved. Understanding this complexity of endocrine physiology is crucial to prevent endocrine disorders, to improve the sensitivity of our diagnostic tools, and to provide the rationale for pharmacological, immunological, or genetic interventions. It is such understanding that this book is designed to foster.
Download or read book Receptor Receptor Interactions written by Kjell Fuxe and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacology of Neurotransmitter Release written by Thomas C. Südhof and published by Springer Science & Business Media. This book was released on 2007-12-07 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.
