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Book Glycoproteins in Human Malignant Disease

Download or read book Glycoproteins in Human Malignant Disease written by Sally Delong Bolmer and published by . This book was released on 1979 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Glycoproteins and Human Disease

Download or read book Glycoproteins and Human Disease written by Inka Brockhausen and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diverse alterations of glycosylation occur in diseases such as cancer, metastasis, leukemia, inflammatory and other diseases. The glycosylation abnormalities found in disease are the result of complex rearrangements of the oligosaccharide assembly by glycosyltransferases. This volume reviews several mechanisms that may underly the extremely complex alterations in disease. Disease specific glycosylation may contribute to the disease process by altering cellular functions, or may be exploited therapeutically. Specific therapy may be aimed at correcting glycosylation abnormalities based on knowledge of the mechanisms leading to the disease phenotype and the three-dimensional interactions between carbohydrates and carbohydrate-binding molecules.

Book Essentials of Glycobiology

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Book The Effect of Malignant Disease on Human and on Rat Plasma Glycoproteins

Download or read book The Effect of Malignant Disease on Human and on Rat Plasma Glycoproteins written by Julius George Bekesi and published by . This book was released on 1964 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present investigation was undertaken to study the effect of malignant disease on human and on rat plasma glycoproteins. The levels of galactose and mannose in plasma glycoproteins, in the absence of the seromucoid fraction, were determined in 654 human subjects. This group consisted of healthy individuals as well as patients suffering from malignant and non-malignant disease. In 118 representative patients the analysis was extended to include individual determinations of hexoses (galactose-mannose), hexosamines (glucosamine-galactosamine), N-acetylneuraminic acid and fucose in the plasma glycoproteins. Levels of carbohydrate in the plasma glycoproteins of patients with malignant disease showed significant elevation as compared with levels observed in normal individuals and patients with non-malignant disease. The behaviour of the various protein-bound carbohydrates in patients with localized carcinoma of the breast differed from that observed in patients with other types of malignancy or suffering from carcinoma of the breast with metastases. In ten patients with malignant disease, serial quantitative determinations of plasma glycoproteins indicated that these protein- carbohydrate complexes are intimately related to the neoplastic process. In order to determine the relationship between the plasma glycoproteins and tumour growth, adult Sprague-Dawley rats were implanted with Walker-256 carcinoma and serial determinations of the plasma protein-bound carbohydrates carried out. A total of 95 rats formed the test group and the animals were sacrificed at intervals following intramuscular implantation of the tumour. A control group of 32 rats was sacrificed at corresponding intervals following intramuscular injection of an homologous muscle homogenate. Changes in the levels of galactose-mannose, glucosamine- galactosamine, N-acetylneuraminic acid and fucose of the total plasma glycoproteins, as well as the hemoglobin, hematocrit and total plasma protein were determined. It was observed that the growth of Walker-256 carcinoma in the rat following implantation is associated with significant increases in the carbohydrate constituents of the plasma glycoproteins. However, the interval between implantation and the occurrence of a significant increase is different for each carbohydrate, and the magnitude of the increase is likewise not uniform. These observations would suggest that the site or the rate of synthesis of the various carbohydrate moieties of the plasma glycoproteins may not be similar, as is commonly believed.

Book Glycoproteins and Disease

Download or read book Glycoproteins and Disease written by J. Montreuil and published by . This book was released on 1996-09-27 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: The elucidation during the latter half of the 20th century of the mechanisms by which information flows from nucleic acids to proteins has completely changed the face of biological research. Many diseases are caused by abnormalities in control mechanisms which are not immediately essential for life itself but which maintain the normal social behavior of differentiated cells in multicellular organisms. The complex sugar chains of glycoproteins and glycolipids are believed to play important roles in the control of cellular functions and in recognition between the cell and its cellular and fluid environment. Investigations into the abnormalities of complex sugar chain assembly are expected to yield an important new underatanding of the etiology and pathogenesis of human diseases. This volume discusses several representative diseases which emphasize the current status of glycopathology, and will stimulate further research in this exciting field.

Book Altered Glycosylation in Tumor Cells

Download or read book Altered Glycosylation in Tumor Cells written by Sen-itiroh Hakomori and published by . This book was released on 1988 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Lectins and Glycoconjugates in Oncology

Download or read book Lectins and Glycoconjugates in Oncology written by Hans-Joachim Gabius and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular glycoconjugates and their specific receptors, e.g. lectins, form a recognitive and informative transfer system that justifies special scientific and clinical attention. In various contributions reviewing the initiation and recent progress in this rapidly developing field advances in clinical oncology are discussed with regard to basic sciences as well as their application in clinical sciences. The approaches comprise reports from diverse fields such as biochemistry, cell biology, pathology and clinical oncology, addressing questions of how tumors grow and spread, and leading to the improvement of clinical management and tumor diagnosis.

Book Glycoproteins

    Book Details:
  • Author : Jean Montreuil
  • Publisher : Elsevier
  • Release : 1995
  • ISBN : 0444820752
  • Pages : 673 pages

Download or read book Glycoproteins written by Jean Montreuil and published by Elsevier. This book was released on 1995 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part I covers modern advances in the determination ofglycoprotein structure and in the biosynthesis of mammalian, bacterial, yeast, plant and insect glycoproteins. There are alsotwo chapters on functional aspects (glycoprotein hormones andcollagens). The content of the volume is very comprehensive in that, mostcontributors have focussed on discussing, in depth, the wealthof most recent advances in their field, and referring to previousreviews of older work for background information. This method caneffectively produce a very wide subject coverage in a smallernumber of chapters/volumes. The volume is an importantinformation source for all glycobiologist researchers (seniorinvestigators, post-doctoral fellows and graduate students), andas a good, comprehensive, reference text for scientists working inthe life sciences.

Book Identification of Altered Cell Surface Glycoproteins and Micropattern Assay Development in the Context of Human Malignancies

Download or read book Identification of Altered Cell Surface Glycoproteins and Micropattern Assay Development in the Context of Human Malignancies written by Jennifer Williams Bergstrom and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastatic melanoma and relapsed acute T cell lymphoblastic leukemia remain incurable despite major advancements in our understanding of these cancers. In some ways, the foundation for a cure has already been laid; many molecular targets for drug development are now clearly defined, and recently novel therapeutics have shown promise in the clinical setting. However, this immense progress has not translated into a marked increase in patient survival. This graduate project focused on two aims, which with further research and development may lead to a cure for these cancers. First, the development of a cellular-based high-throughput synergistic assay was looked at, that would allow for rapid screening of multiple drug combinations. Second, cancer-specific alterations in the cell surface high mannose glycoprotein profile were identified in the context of metastatic melanoma and T-ALL cells. The feasibility of these two aims is demonstrated by existing innovations and research. First, protein microarrays have been developed to isolate and characterize a variety of cell types. Second, growth factors and other molecules have been successfully printed onto these arrays. Third, cancer cells and cancer stem cells have been previously shown to have alterations in their cell surface glycome. As part of the first project, micropatterned silane and polyethylene glycol (PEG) coated glass slides were successfully developed, with these modifications acting as a non-fouling surface for cell attachment. On these slides cell-specific antibodies, antiCD3 and anti-GD3, were printed and demonstrated successful capture ofT-ALL and melanoma cell lines, respectively. However, the effectiveness of this cell capture needs further improvement, with regards to uniform cell seeding. Future studies will utilize recently developed epoxide coated slides, which allow for covalent attachment of capture antibodies. Additionally, anti-CD4 antibody will be printed for T-ALL cell capture. With respect to the characterization of the cell surface glycome of malignant melanoma and TALL cell lines versus their non- or less-malignant counterparts, we were able to successfully demonstrate that MHC class I and sodium/potassium A TPase proteins were differentially glycosylated on both of these diverging cancers. MHC class I had significantly higher expression on high metastatic potential B 16F 10 cells compared to B16FO cells (p-value = 0.014), and in Jurkat cells as compared to normal pan T cells (pvalue = 0.011). Additionally, sodium/potassium ATPase had significantly higher expression on B16F10 (p-value = 0.028) and Jurkat cells (p-value = 0.013) verses B16F0 and normal T cells, respectively. These proteins, along with other identified high mannose surface proteins are directly linked to cancer cell proliferation promotion. Additionally, the altered glycosylation patterns identified in this graduate project may have a direct impact on MHC class I and sodium/potassium A TPase' s roles in cancer cell promotion. Based on obtained data, future studies will focus on conforming the presence of identified proteins on the cell surface through antigen immunofluorescence labeling, and foot printing of high mannose glycans. Footprinting will be done to both determine the extent of glycosylation modifications occurring on cancer cells, as well to characterize any changes in protein conformation due to changes in glycosylation, as determined through in silica modeling.

Book Glycosignals in Cancer  Mechanisms of Malignant Phenotypes

Download or read book Glycosignals in Cancer Mechanisms of Malignant Phenotypes written by Koichi Furukawa and published by Springer. This book was released on 2016-01-26 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of cutting-edge studies on the functions and mechanisms of glycosylation in cancers. Along with progress in genomics and proteomics, new findings in the significance of these complex carbohydrates, through the regulation of cell signals, have been elucidated in a wide variety of biological events. This volume provides a comprehensive summary of glycosignals and their involvement in cancer, covering numerous topics such as glycosylation machineries, regulation of phenotypes, cell signaling, immune regulation, complex carbohydrate organization, and clinical applications. The contents have been organized to promote ready understanding, covering basic to clinical research and studies on micromolecules, to animal/human cells and tissues. This book is an essential read for students and young researchers interested in cancers and carbohydrates. Specialists in glycobiology will also benefit from the new results and approaches detailed here, which provide insights into future directions of functional studies of sugar chains in both basic and applied research.

Book The Purification and Biochemical Characterization of a Human Malignancy related Glycoprotein

Download or read book The Purification and Biochemical Characterization of a Human Malignancy related Glycoprotein written by Matthew James McCarthy and published by . This book was released on 1983 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Glycosylation and Cancer

Download or read book Glycosylation and Cancer written by and published by Academic Press. This book was released on 2015-02-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. - Provides information on cancer research - Outstanding and original reviews - Suitable for researchers and students

Book Functional and Structural Proteomics of Glycoproteins

Download or read book Functional and Structural Proteomics of Glycoproteins written by Raymond J. Owens and published by Springer Science & Business Media. This book was released on 2010-12-02 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been predicted that nearly half of all human proteins are glycosylated indicating the significance of glycoproteins in human health and disease. For example, the glycans attached to proteins have emerged as important biomarkers in the diagnosis of diseases such as cancers and play a significant role in how pathogenic viruses gain entry into human cells. The study of glycoproteins has now become a truly proteomic science. In the last few years, technology developments including in silico methods, high throughput separation and detection techniques have accelerated the characterization of glycoproteins in cells and tissues. Glyco-engineering coupled to rapid recombinant protein production has facilitated the determination of glycoprotein structures key to exploring and exploiting their functional roles. Each chapter in this volume is written by experts in the field and together provide a review of the state of the art in the emerging field of glycoproteomics.

Book Glycobiology and Medicine

    Book Details:
  • Author : John S. Axford
  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • ISBN : 1461500656
  • Pages : 290 pages

Download or read book Glycobiology and Medicine written by John S. Axford and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the Proceedings of the Sixth Jenner Glycobiology and Medicine Symposium, held 14-17 September, 2002, in Seillac, France. This book highlights the latest developments in glycoimmunology, including glycosylation-dependent bacterial and viral infections, lectin and proteoglycan-dependent interactions in leukocyte homing processes to lymphoid tissues and inflamed tissues, congenital defects in glycosylation of glycoproteins and glycolipids, and the role of carbohydrates in tumour development and neuropathology, including Creutzfeldt-Jakob disease.

Book Lectins and Cancer

    Book Details:
  • Author : Hans-Joachim Gabius
  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • ISBN : 3642767397
  • Pages : 332 pages

Download or read book Lectins and Cancer written by Hans-Joachim Gabius and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular recognition undoubtedly governs any aspect of cellular interaction. To understand tumor cell growth regulation and spread, analysisof protein carbohydrate interactions can contribute to lead to the establishment of rational methods for diagnosis and therapy. Chemically and biochemically optimized preparation of adequate tools, their application for localization of receptor (tissue lectin) and ligand (cellular glycoconjugate) pairs in tumor cells and tumor sections and the usefulness of a lectin from a plant extract as potent immunomodulator indicate the prospect for a place of such techniques in pathology and oncology.

Book Cell Surface Carbohydrates and Cell Development

Download or read book Cell Surface Carbohydrates and Cell Development written by Minoru Fukuda and published by CRC Press. This book was released on 1991-12-13 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Surface Carbohydrates and Cell Development summarizes knowledge on the structure and function of cell surface carbohydrates in development and differentiation. The chapters include reviews on the expression of cell type-specific carbohydrates and their roles in cell-cell interaction. In particular, the role of cell surface carbohydrates in immune cell response, malignant transformation, fertilization, and neural cell development are addressed. This includes the exciting discovery about the role of adhesive molecules in leukocyte-endothellium interaction. Cell Surface Carbohydrates and Cell Development also summarizes the latest knowledge on structure and biosynthesis of carbohydrates, the role of specific carbohydrate modification, and animal lectins. The book will be useful to researchers and students interested in the biology of glycoproteins and biotechnology.

Book Cancer as a Metabolic Disease

Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried and published by John Wiley & Sons. This book was released on 2012-05-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.