Download or read book Glycoimmunology 2 written by John S. Axford and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Jenner International Glycoimmunology Meetings have charted the rapid devel opment of glycobiology within the field of inflammation. In less than a decade, the science has grown from basically being involved in carbohydrate analysis to the understanding of how sugars are associated with inflammation and how they have potential as anti inflammatory therapeutics. The 4th Jenner International Glycoimmunology Meeting was re cently held in Loutraki, Greece, and set the scene for what promises to be an exciting future for the speciality. Discussion reflected the rapid advances glycobiology is making and ranged from the basic biochemistry of carbohydrate physiology to therapeutic trials utilizing synthetic sugars designed to block inflammatory responses. The meeting is summarized in considerable detail in this book which will provide the interested scientist and clinician with the essential up-to-date facts within the field of glyco immunology. Acknowledgments Many people have been involved in ensuring the success of the Jenner Glycoimmu nology Meetings but none more so than my secretary Susan Henderson who has borne the brunt of all four meetings and is currently preparing for the 5th.
Download or read book Glycoimmunology written by Azita Alavi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Third Jenner International Glycoimmunology meeting held in Il Ciocco, Tuscany, Italy, October 11-14, 1994
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Glycobiology and Medicine written by John S. Axford and published by Springer Science & Business Media. This book was released on 2006-01-27 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The potential for glycobiology to improve the practice of medicine has been well recognised, which is why biannual meetings concerning the association have been taking place for the last 14 years. The science of glycobiology has matured rapidly, and with it the far reaching clinical implications are becoming understood. The next decade is going to see this final frontier of science conquered. The impact this understanding of glycobiology will have upon our practice of medicine is going to be exciting. The 7th Jenner Glycobiology and Medicine Symposium was designed to reflect these advances. All the major clinical areas were involved, with contributions from pivotal players in science and medicine.
Download or read book Carbohydrates in Chemistry and Biology written by Beat Ernst and published by . This book was released on 2000 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lectin in Host Defense Against Microbial Infections written by Shie-Liang Hsieh and published by Springer Nature. This book was released on 2020-03-09 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systemically presents the latest research on lectins, covering all the major topics in the field, including the heterocomplex of lectins and Toll-like receptors, protective versus pathogenic functions in connection with microbial infections, and novel strategies for enhancing host immunity against infectious diseases caused by viruses, bacteria, and fungi. Lectins are a large group of glycan-binding proteins that recognize diverse glycan and non-glycan structures expressed on prokaryotic and eukaryotic cells, and are vital to cell-cell interactions, the attachment of microbes to host cells, and the recognition and activation of immune responses to exogenous and endogenous danger signals. The composition and structure of microbes are complex and include numerous ‘pathogen-associated molecular patterns’ or ‘damage-associated molecular patterns’. As such, microbes’ interactions with immune cells activate multiple innate immunity receptors and produce distinct inflammatory reactions, which can be protective to contain microbial invasion, or pathogenic to cause tissue damage and shock syndrome in the host. The book shares lessons learned from state-of-the art research in this field, highlights the latest discoveries, and provides insightful discussions on lectin-mediated inflammatory reactions, while also outlining future research directions.
Download or read book Glycoscience Biology and Medicine written by Tamao Endo and published by Springer. This book was released on 2021-01-14 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the book is to provide a succinct overview of the current status of glycoscience from both basic biological and medical points of view and to propose future directions, in order to facilitate further integrations of glycoscience with other fields in biological and medical studies. Glycans (carbohydrate oligomers) are the so-called “building blocks” of carbohydrates, nucleic acids, proteins and lipids and play major roles in many biological phenomena as well as in various pathophysiological processes. However, this area of glycoscience has been neglected from the research community because glycan structures are very complex and functionally diverse and as compared to proteins and nucleic acids simple tools for the amplification, sequencing and auto-synthesis of glycans are not available. Many scientists in other fields of research have now realized that glycosylation, i.e. the addition of glycans to a protein backbone, is the most abundant post translational modification reactions and is an important field of research and sometimes they require a glycobiology and/or glycochemistry approach to be used. It is still difficult, however, for non-expert researchers to use these techniques. This book will provide numerous but simple overviews of current topics and protocols for the experiments. The book is aimed at university students and above, including non-experts in the field of glycoscience.
Download or read book Addressing Roles for Glycans in Immunology using Chemical Biology written by Matthew S. Macauley and published by Frontiers Media SA. This book was released on 2020-07-17 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carbohydrate Based Vaccines and Immunotherapies written by Zhongwu Guo and published by John Wiley & Sons. This book was released on 2009-06-17 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances. Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi Using adjuvants to improve immunogenicity and/or immunological properties of vaccines Choosing and designing proper adjuvants for specific targets Abnormal carbohydrates expressed by tumors Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy Clinical trials results for synthetic cancer vaccines Glycoengineering of cell surface carborhydrates and its anticancer applications Using cell surface carbohydrates for disease diagnosis A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.
Download or read book The Molecular Immunology of Complex Carbohydrates 3 written by Albert M. Wu and published by Springer Science & Business Media. This book was released on 2011-05-27 with total page 823 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the third symposium on “Molecular Immunology of Complex Carbohydrates,” this text covers the latest in glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences. This volume highlights the informative events of the Symposium on Molecular Immunology of Complex Carbohydrates III, held at the Institute of Biological Chemistry, Academia Sinica, on July 15-20, 2007, in Taipei, Taiwan.
Download or read book Protein Engineering Techniques written by Krishna Mohan Poluri and published by Springer. This book was released on 2016-11-12 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief provides a broad overview of protein-engineering research, offering a glimpse of the most common experimental methods. It also presents various computational programs with applications that are widely used in directed evolution, computational and de novo protein design. Further, it sheds light on the advantages and pitfalls of existing methodologies and future perspectives of protein engineering techniques.
Download or read book Anticarbohydrate Antibodies written by Paul Kosma and published by Springer Science & Business Media. This book was released on 2011-11-27 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. “Anticarbohydrate Antibodies – from molecular basis to clinical application” compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.
Download or read book Journal of the Royal Society of Medicine written by Royal Society of Medicine (Great Britain) and published by . This book was released on 1997 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes selected papers from meetings of the Society and of its sections.
Download or read book Carbohydrate Based Vaccines and Immunotherapies written by Zhongwu Guo and published by John Wiley & Sons. This book was released on 2009-06-09 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances. Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi Using adjuvants to improve immunogenicity and/or immunological properties of vaccines Choosing and designing proper adjuvants for specific targets Abnormal carbohydrates expressed by tumors Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy Clinical trials results for synthetic cancer vaccines Glycoengineering of cell surface carborhydrates and its anticancer applications Using cell surface carbohydrates for disease diagnosis A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.
Download or read book Glycobiology of Innate Immunology written by Cheorl-Ho Kim and published by Springer Nature. This book was released on 2022-03-31 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions. This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.
Download or read book Carbohydrate Recognition written by Binghe Wang and published by John Wiley & Sons. This book was released on 2011-09-06 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
Download or read book Glycosylation and Cancer written by and published by Academic Press. This book was released on 2015-02-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. - Provides information on cancer research - Outstanding and original reviews - Suitable for researchers and students
