Download or read book Glycobiology of Innate Immunology written by Cheorl-Ho Kim and published by Springer Nature. This book was released on 2022-03-31 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions. This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Glycoimmunology written by Azita Alavi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Third Jenner International Glycoimmunology meeting held in Il Ciocco, Tuscany, Italy, October 11-14, 1994
Download or read book Antibody Glycosylation written by Marija Pezer and published by Springer Nature. This book was released on 2021-10-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Transforming Glycoscience written by National Research Council and published by National Academies Press. This book was released on 2012-10-23 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
Download or read book Translational Glycobiology in Human Health and Disease written by Michelle Kilcoyne and published by Academic Press. This book was released on 2023-11-29 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. - Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology's growing role in human health and disease study - Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health - Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciences
Download or read book Damage Associated Molecular Patterns in Human Diseases written by Walter Gottlieb Land and published by Springer. This book was released on 2018-10-09 with total page 893 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
Download or read book Carbohydrate based Vaccines written by René Roy and published by ACS Symposium. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.
Download or read book Carbohydrate Based Vaccines and Immunotherapies written by Zhongwu Guo and published by John Wiley & Sons. This book was released on 2009-06-17 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental science and the latest developments in carbohydrate-based vaccines The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively reviews the state of this exciting field, offering a single source for both the fundamental science and the latest developments. With contributions by leading experts, this resource covers the design, synthesis, evaluation, and applications of various carbohydrate-based vaccines, including polysaccharides, neoglycoproteins, and neoglycolipids. The text approaches vaccine design from a chemical and molecular focus, staying in line with current advances. Key topics covered by Carbohydrate-Based Vaccines and Immunotherapies include: Recent developments towards clinically useful vaccines against bacteria, viruses, parasites, and fungi Using adjuvants to improve immunogenicity and/or immunological properties of vaccines Choosing and designing proper adjuvants for specific targets Abnormal carbohydrates expressed by tumors Carbohydrate-based therapeutic cancer vaccines or cancer immunotherapy Clinical trials results for synthetic cancer vaccines Glycoengineering of cell surface carborhydrates and its anticancer applications Using cell surface carbohydrates for disease diagnosis A single, convenient source of state-of-the-art information from leading authorities in the field, Carbohydrate-Based Vaccines and Immunotherapies is an essential reference for organic chemists and biochemists, academic researchers, and other students and professionals involved in vaccine design.
Download or read book The Sugar Code written by Hans-Joachim Gabius and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
Download or read book Glycoscience Basic Science to Applications written by Naoyuki Taniguchi and published by Springer. This book was released on 2019-09-25 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the state of the art in glycoscience and proposes a road map for the coming decade, focusing on the potential of glycoscience research to shed light on important basic science issues and give rise to exciting new applications, especially in the field of diagnosis and therapeutics. Individual sections offer in-depth coverage of various topics relating to glycans and biopharmaceuticals, glycans in medical science and medicine, glycan technologies, glycans in food and nutrients, and glycan-related materials and their uses. In addition, the book presents an exemplary training course on glycomics and highlights educational and analytical web resources, and also includes glossaries and boxes summarizing key facts to ensure ease of understanding for non-expert readers and students. Written by more than 150 active participants in the Japan Consortium for Glycobiology and Glycotechnology (JCGG), whose goal is to promote the development of interdisciplinary glycoscience and establish a global network in the field, it is a valuable resource for students, postdocs, and researchers in the life sciences as well as for stakeholders and professionals in government, funding agencies and industry.
Download or read book Handbook of Glycosyltransferases and Related Genes written by Naoyuki Taniguchi and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The so-called postgenomic research era has now been launched, and the field of gly cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl transferases. The regulation of the biosynthesis of sugar chains is under the control of the expression of glycosyltransferases, their substrate specificity, and their local ization in specific tissue sites. There is a growing body of evidence to suggest that these enzymes play pivotal roles in a variety of important cellular differentiation and developmental events, as well as in disease processes. Over 300 glycosyltransferases appear to exist in mammalian tissues. If the genes that have been purified and cloned from various species such as humans, cattle, pigs, rats and mice are counted as one, approximately 110 glycogenes that encode glycosyltransferases and related genes have been cloned at present, and this number continues to grow each day. However, most of the functions of the glycosyltransferase genes and related genes are unknown. This fact has stimulated numerous new and interesting approaches in molecular biologi cal investigations.
Download or read book C Type Lectin Receptors in Immunity written by Sho Yamasaki and published by Springer. This book was released on 2016-03-22 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents the latest findings on C-type lectin receptors, focusing on individual receptors and their signaling. In recent years there have been great advances in the understanding of the function of these receptors as a newly emerging family of pattern-recognition receptors (PRRs) for pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Comprising four parts: ITAM-coupled Activating Receptors; HemITAM-bearing Receptors; ITIM-bearing Receptors; and Other Receptors and Related Topics, this comprehensive review covers a broad range of C-type lectin receptors. The updated information on C-type lectin receptors and their ligands provided will appeal to a wide readership, from basic immunologists to physicians and surgeons. In addition, sections on novel drug development make this a valuable resource for pharmaceutical scientists.
Download or read book The Human Microbiome Diet and Health written by Food Forum and published by National Academies Press. This book was released on 2013-02-27 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.
Download or read book Advances in Comparative Immunology written by Edwin L. Cooper and published by Springer. This book was released on 2018-08-07 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunologists, perhaps understandably, most often concentrate on the human immune system, an anthropocentric focus that has resulted in a dearth of information about the immune function of all other species within the animal kingdom. However, knowledge of animal immune function could help not only to better understand human immunology, but perhaps more importantly, it could help to treat and avoid the blights that affect animals, which consequently affect humans. Take for example the mass death of honeybees in recent years – their demise, resulting in much less pollination, poses a serious threat to numerous crops, and thus the food supply. There is a similar disappearance of frogs internationally, signaling ecological problems, among them fungal infections. This book aims to fill this void by describing and discussing what is known about non-human immunology. It covers various major animal phyla, its chapters organized in a progression from the simplest unicellular organisms to the most complex vertebrates, mammals. Chapters are written by experts, covering the latest findings and new research being conducted about each phylum. Edwin L. Cooper is a Distinguished Professor in the Laboratory of Comparative Immunology, Department of Neurobiology at UCLA’s David Geffen School of Medicine.
Download or read book Machine Learning Techniques and Analytics for Cloud Security written by Rajdeep Chakraborty and published by John Wiley & Sons. This book was released on 2021-11-30 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: MACHINE LEARNING TECHNIQUES AND ANALYTICS FOR CLOUD SECURITY This book covers new methods, surveys, case studies, and policy with almost all machine learning techniques and analytics for cloud security solutions The aim of Machine Learning Techniques and Analytics for Cloud Security is to integrate machine learning approaches to meet various analytical issues in cloud security. Cloud security with ML has long-standing challenges that require methodological and theoretical handling. The conventional cryptography approach is less applied in resource-constrained devices. To solve these issues, the machine learning approach may be effectively used in providing security to the vast growing cloud environment. Machine learning algorithms can also be used to meet various cloud security issues, such as effective intrusion detection systems, zero-knowledge authentication systems, measures for passive attacks, protocols design, privacy system designs, applications, and many more. The book also contains case studies/projects outlining how to implement various security features using machine learning algorithms and analytics on existing cloud-based products in public, private and hybrid cloud respectively. Audience Research scholars and industry engineers in computer sciences, electrical and electronics engineering, machine learning, computer security, information technology, and cryptography.
Download or read book Glycosylation and Cancer written by and published by Academic Press. This book was released on 2015-02-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. - Provides information on cancer research - Outstanding and original reviews - Suitable for researchers and students
