Download or read book Glycobiology of Innate Immunology written by Cheorl-Ho Kim and published by Springer Nature. This book was released on 2022-03-31 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest knowledge and the most recent research results on glycobiology of innate immunology. Innate immunity is the crucial part of the immunological defense system that exerts their distinct functions through binding to certain functional glycoproteins. They play a role in various human diseases and also function against microbial invaders and self-associated molecular patterns. Co-regulated expression of glycan-binding is associated with many biological components such as cellular oncotransformation, phenotype change, neuronal or embryonic development, regulation of cell division, cell–cell interaction, cell attachment, adhesion, and motility, and intracellular signaling via protein–carbohydrate or carbohydrate–carbohydrate interactions. This book opens by providing the key background on glycans in innate immunity and its mechanisms behind the Dendritic cell interactions during infection and inflammation are examined in depth, and the concluding chapter is devoted to signaling tumor immunotherapy. Up-to-date information is then presented on all aspects of glycan structure-recognizing signaling. The book should assist in the further development of new strategies against emerging infectious agents and intractable diseases.
Download or read book Glycobiology of the Immune Response Volume 1253 written by Gabriel Rabinovich and published by Wiley-Blackwell. This book was released on 2012-05-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrates are ubiquitous, essential molecules, as important as nucleic acids and proteins yet less well understood. Mounting data demonstrate that microbial and mammalian glycans and their protein-binding partners (lectins) play central roles in all innate and adaptive immune responses. Indeed, programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. Glycobiology of the Immune Response explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.1111/(ISSN)1749-6632. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Glycoimmunology 2 written by John S. Axford and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Jenner International Glycoimmunology Meetings have charted the rapid devel opment of glycobiology within the field of inflammation. In less than a decade, the science has grown from basically being involved in carbohydrate analysis to the understanding of how sugars are associated with inflammation and how they have potential as anti inflammatory therapeutics. The 4th Jenner International Glycoimmunology Meeting was re cently held in Loutraki, Greece, and set the scene for what promises to be an exciting future for the speciality. Discussion reflected the rapid advances glycobiology is making and ranged from the basic biochemistry of carbohydrate physiology to therapeutic trials utilizing synthetic sugars designed to block inflammatory responses. The meeting is summarized in considerable detail in this book which will provide the interested scientist and clinician with the essential up-to-date facts within the field of glyco immunology. Acknowledgments Many people have been involved in ensuring the success of the Jenner Glycoimmu nology Meetings but none more so than my secretary Susan Henderson who has borne the brunt of all four meetings and is currently preparing for the 5th.
Download or read book Glycobiology of the Immune System and Disease written by Shyamasree Ghosh and published by Academic Press. This book was released on 2022-11-15 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Considering the central role that glycans play in immune interactions, glycoproteins and carbohydrates are becoming the targets of next-generation therapeutics, vaccines and diagnostics. Programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. This important reference investigates microbial and mammalian glycans and their protein-binding partners (lectins) and shows the role they play in all innate and adaptive immune responses. With its comprehensive overview of the field, it is an important resource for academicians, graduate and post graduate students as well as professors and faculty in the field of research in glycobiology and immunology. Is the first book that discusses on the glycobiology of the immune system Gives insight to the glycobiology of the epidemic and pandemic causing virus H1N1/H5N1 and coronavirus and COVID-19 Highlights the importance of glycobiology and its probable role in generating therapy for viral infections Provides up-to-date and accessible information for beginners in glycoimmunology and readers with an interest in infectious diseases and host response
Download or read book Glycoimmunology written by Azita Alavi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Third Jenner International Glycoimmunology meeting held in Il Ciocco, Tuscany, Italy, October 11-14, 1994
Download or read book The Role of Glycans in Immune Cell Functions written by Jasmeen S. Merzaban and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Antibody Glycosylation written by Marija Pezer and published by Springer Nature. This book was released on 2021-10-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Microbial Glycobiology written by Anthony P Moran and published by Elsevier. This book was released on 2009-10-01 with total page 1037 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. - Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews - Provides researchers with an overview and synthesis of the latest research - Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed - Allows researchers to see at a glance what each chapter will cover - Each chapter includes a Research Focus Box - Identifies important problems that still need to be solved and areas that require further investigation
Download or read book Glycoimmunology 2 written by John S Axford and published by . This book was released on 1998-01-31 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Introduction to Glycobiology written by Maureen E. Taylor and published by Oxford University Press, USA. This book was released on 2003 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structures of sugars attached to cells and proteins have been investigated by biochemists for more than a hundred years. The discipline of glycobiology has emerged more recently, as key principles about the biological functions of these complex sugars have been established and their importance for the study of cell biology and immunology has become apparent. Introduction to Glycobiology is the first textbook to present an introduction to the essential elements of glycobiology thatis readily accessible to undergraduates and other non-specialists. It focuses on coherent stories about what sugars do for cells and organisms. The importance of glycosylation in protein secretion and stability, cell-cell adhesion and signalling, and innate and adaptive immunity are emphasised. The ways in which glycobiology explains human disease are discussed throughout the book in order to place the subject in a biomedical context. The book is illustrated throughout with all new custom-drawn figures. The simple organisation, highlighted terms and annotated key reference lists make the text readable and accessible. Companion Web Site All the figures from the book will be available to download free from the companion web site at http://www.oup.com/uk/best.textbooks/biochemistry/glycobiolo gy/. A sample chapter will be available on line from 1 August 2002.
Download or read book Transforming Glycoscience written by National Research Council and published by National Academies Press. This book was released on 2012-10-23 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
Download or read book Translational Glycobiology in Human Health and Disease written by Michelle Kilcoyne and published by Academic Press. This book was released on 2023-11-29 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. - Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology's growing role in human health and disease study - Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health - Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciences
Download or read book Damage Associated Molecular Patterns in Human Diseases written by Walter Gottlieb Land and published by Springer. This book was released on 2018-10-09 with total page 893 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
Download or read book Influence of Host Genetics on Innate Immunity and Susceptibility to Urinary Tract Infection written by and published by . This book was released on 2009 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carbohydrate based Vaccines written by René Roy and published by ACS Symposium. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.
Download or read book The Sugar Code written by Hans-Joachim Gabius and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reader friendly overview of the structure and functional relevance of natural glycosylation and its cognate proteins (lectins), this book is also one of the few books to cover their role in health and disease. Edited by one of the pioneering experts in the field and written by a team of renowned researchers this resource is a perfect introduction for all students in life and medical sciences, biochemistry, chemistry and pharmacy. Website: WWW.WILEY-VCH.DE/HOME/THESUGARCODE
