Download or read book Glutathione S transferases and Drug Resistance written by John D. Hayes and published by Taylor & Francis Group. This book was released on 1990 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proceedings of the 3rd International GST Conference held at the Royal College of Physicians, Edinburgh, on 20-30 August 1989. The conference was divided into five sessions - enzymology, toxication, control of expression, drug resistance and clinical applications of GST.
Download or read book Toxicology of Glutathione Transferases written by Yogesh C. Awasthi and published by CRC Press. This book was released on 2006-07-27 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in
Download or read book The Role of Glutathione S transferases in Drug Resistance written by Dylan James Thomas and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Role of Glutathione and Glutathione S transferases in Drug Resistance written by Dylan James Thomas and published by . This book was released on 1996 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glutathione S transferase and Cellular Resistance to Alkylating Agents written by Ralph B. Puchalski and published by . This book was released on 1991 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure and Function of Glutathione S Transferases written by Kenneth D. Tew and published by CRC Press. This book was released on 1993-08-26 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structure and Function of Glutathione S-Transferases provides some of the latest information available on a variety of structural and functional components of glutathione S-transferases, a family of isozymes involved in many endogenous and exogenous functions in cells. Molecular studies presented in the book focus on the regulation of these enzymes and identify important response elements. X-ray crystallographic structures show detailed information on the structural aspects of these proteins. Metabolism of a number of carcinogens and drugs is covered in detail, and the role that these enzymes play in governing drug resistance at the preclinical and clinical levels is discussed. The book will be excellent for biochemists, pharmacologists, oncologists, experimental therapeutic specialists, and others interested in glutathione S-transferases.
Download or read book Glutathione Transferase mediated Inactivation of Alkylating Agents and Its Role in Drug Resistance written by Kiflu Berhane and published by . This book was released on 1993 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heterogeneous Expression in Human Tumors of Anionic Glutathione S transferase a Phase II Enzyme Associated with Multidrug Resistance written by and published by . This book was released on 1988 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glutathione S Transferases written by Gerard J. Mulder and published by CRC Press. This book was released on 1996-05-23 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutathione s-transferases (GSTs) constitute the most important enzymes protecting human and many other organisms from potentially toxic chemicals, including drugs and carcinogens. This book reviews scientific developments in research of this enzyme.
Download or read book Microsomal Glutathione Transferase 1 in Anti cancer Drug Resistance and Protection Against Oxidative Stress written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is the second leading cause of death in privileged countries. Tremendous efforts have been done to improve the efficiency of cancer treatment. Anti-cancer drug resistance is still a major problem in failure of cancer therapy. Microsomal glutathione transferase 1 (MGST1) is a membrane protein located in the endoplasmic reticulum and the outer membrane of mitochondria. MGST1 is involved in the direct conjugation of glutathione to endogenous and exogenous toxic electrophilic hydrophobic compounds. The enzyme is often upregulated in tumours, and has been suggested to be an early marker of tumorigenesis. Furthermore, MGST1 has been connected to drug resistance in the clinic. Herein we show that MGST1 plays a potential role in inducing resistance against some commonly used anti-cancer drugs including chlorambucil, melphalan, carmustine, doxorubicin and cisplatin as examined in a human breast carcinoma cell line (MCF7) overexpressing MGST1. Further, we show that MGST1 dependent resistance against cisplatin can be reversed by ethacraplatin, a combination of the drug with a GST inhibitor (ethacrynic acid, EA). Upon cellular uptake, this compound is cleaved and the EA moiety is released. When cisplatin and ethacrynic acid were added together as such they were not as effective as ethacraplatin. Ethacraplatin can therefore be a useful alternative to overcome drug resistance by MGST1. Instead of inhibition of GSTs to reverse resistance, an alternate strategy is to use prodrugs that release cytotoxic molecules catalysed by GSTs. Here we show that prodox, a doxorubicin derivative, releases doxorubicin upon MGST1 and GSTP dependent catalysis. In MGST1 overexpressing cells the protection against prodox was lower compared to doxorubicin. With GSTP a dramatic effect was observed. Prodox was considerably more toxic to GSTP overexpressing than control cells. Thus prodrugs such as prodox, that are preferentially cleaved in GST overexpressing tumours, could be a useful therapeutic
Download or read book Characterization of the Glutathione Transferase Alpha Genes written by Nasser Fotouhi Ardakani and published by . This book was released on 2000 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The glutathione-S-transferases (GSTs) are a multigene family of enzymes that catalyze the conjugation of glutathione (GSH) with toxic endogenous and xenobiotic compounds including anticancer drugs, as part of detoxification pathways. Our laboratory previously isolated a melphalan resistant rat mammary carcinoma cell-line (MLNr MatB). The in vitro and in vivo studies demonstrated increased GST activity, especially elevated GST alpha class in MLNr cells. At the outset of my work, I examined the nature of the increased GST form in MLNr cells. I cloned the GSTA3 cDNA which is overexpressed in MLNr cells and found that it is identical to the previously described GSTA3 mRNA, suggesting that there is no additional GST alpha gene induced by melphalan. To study the role of the rat GSTA3 gene in chemotherapy resistance, and understand the mechanism of its overexpression in drug resistant tumors, I isolated the entire rGSTA3 subunit gene, including its regulatory regions, from a genomic library and characterized it. The rGSTA3 gene is approximately 15 kb in length and consists of seven exons interrupted by introns of different lengths. The functional activity of its promoter was shown by its ability to drive the expression of a CAT reporter gene in MatB cells, and its activity was greater in melphalan resistant cells. I also presented evidence that rGSTA3 subunit evolved as a duplication of the rGSTA5 subunit gene, increasing the diversification and functional benefits. In addition to drug resistance, I have been examining the implications of GST to carcinogenesis. Epidemiological studies have shown an association between Hepatitis B Virus (HBV) infection and exposure to chemical carcinogens in the incidence of hepatocellular carcinoma (HCC). The exact mechanism of these interactions is not known, but reduced GST activity could increase cellular sensitivity to chemical carcinogens. Semiquantitative RT-PCR revealed that HBV infected cells contain a significant decrease in th" --
Download or read book Mechanisms of Tumor Cell Drug Resistance written by Robyn Lee Schecter and published by . This book was released on 1993 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Drug Resistance in Neoplastic Cells written by Paul V. Woolley and published by Elsevier. This book was released on 2013-10-22 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bristol-Myers Cancer Symposia, Volume 9: Mechanisms of Drug Resistance in Neoplastic Cells provides information on both basic scientific and clinical studies on the causes and implications of tumor cell resistance to common antineoplastic agents. The book describes the colon cancer as a model for resistance to antineoplastic drugs; mathematical modeling of drug resistance; and the mechanism of induced gene amplification in mammalian cells. The text also discusses the cellular concomitants of multidrug resistance; resistance to alkylating agents; and the phosphoprotein and protein kinase C changes in human multidrug-resistant cancer cells. Novel drugs that affect glutathione metabolism; the regulation of genes encoding drug-metabolizing enzymes in normal and preneoplastic tissues; and the relevance of glutathione S-transferases to anticancer drug resistance are also considered. The book further tackles the cellular resistance to cyclophosphamide; the preclinical and clinical experiences with drug combinations designed to inhibit DNA repair in resistant human tumor cells; and the modification of the cytotoxicity of DNA-directed chemotherapeutic agents by polyamine depletion. The text also demonstrates multidrug resistance and the circumvention of resistance. Oncologists, molecular biologists, biochemists, geneticists, and pharmacologists will find the book invaluable.
Download or read book Drug Resistance written by William N. Hait and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Resistance to treatment represents the final common outcome for far too many patients with cancer. Even our most promising new drugs fall victim to drug resistance. Hormones and newer biological therapies, though safe and active, also lose their activity over time. In this volume of Drug Resistance, leading investigators in the field have reviewed the most basic mechanisms of drug resistance, and have proposed ways to modulate resistance. This comprehensive volume should be of value for basic and clinical scientists who wish to delve more deeply into this intriguing problem in the laboratory and devastating problem in the clinic.
Download or read book Glutathione Transferases in Human Cancer Cells and Their Contribution to Drug Resistance written by Xiao-Yong Hao and published by . This book was released on 1993 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Tumor Cell Drug Resistance written by Robyn Lee Schecter and published by . This book was released on 1993 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Activity Based Protein Profiling written by Benjamin F. Cravatt and published by Springer. This book was released on 2019-01-25 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.
