Download or read book Glutathione Conjugation written by Helmut Sies and published by . This book was released on 1988 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glutathione Conjugation and Bioactivation of 1 2 dibromo Compounds written by Clementia E. Zoetemelk and published by . This book was released on 1987 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Reactive Intermediates III written by James J. Kocsis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1028 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
Download or read book Glutathione Conjugation as a Determinant in 1 2 dihaloethane and Alpha naphthylisothiocyanate Toxicity written by Paul A. Jean and published by . This book was released on 1991 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Aflatoxins written by Mehdi Razzaghi-Abyaneh and published by BoD – Books on Demand. This book was released on 2013-01-23 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is broadly divided into five sections and 17 chapters, highlighting recent advances in aflatoxin research from epidemiology to molecular genomics and control measures, biocontrol approaches, modern analytical techniques, economic concerns and underlying mechanisms of contamination processes. This book will update readers on several cutting-edge aspects of aflatoxins research with useful up-to-date information for mycologists, toxicologists, microbiologists, agriculture scientists, plant pathologists and pharmacologists, who may be interest to understanding of the impact, significance and recent advances within the field of of aflatoxins with a focus on control strategy.
Download or read book Glutathione Conjugation by Glutathione S transferase s and Related Mechanisms written by Omar Abussalam Aghil and published by . This book was released on 1991 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book In Vivo Characterization of Glutathione Conjugation in Humans written by Titia Martine Truce Mulders and published by . This book was released on 1995 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glutathione Conjugation in Non human Primates written by Alfred Rayney Waller and published by . This book was released on 1985 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Conjugation Reactions In Drug Metabolism written by Gerard J. Mulder and published by CRC Press. This book was released on 1990-02-21 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text investigates the molecular biology of conjugation, and the subsequent activity of the transfered genes "in vivo". Conjugation may be very important when considering biotransformations, as expression of transfered genes may allow organisms to metabolize certain substrates.
Download or read book The Dual Role of Glutathione Conjugation in the Biotransformation of Xenobiotics written by Peter Jan van Bladeren and published by . This book was released on 1981 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Thiol Redox Transitions in Cell Signaling Part B written by and published by Academic Press. This book was released on 2010-08-19 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, along with its companion (volume 474), presents methods and protocols dealing with thiol oxidation-reduction reactions and their implications as they relate to cell signaling. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Over 450 volumes have been published to date, and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Along with companion volume, provides a full overview of techniques necessary to the study of thiol redox in relation to cell signaling Gathers tried and tested techniques from global labs, offering both new and tried-and-true methods Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines
Download or read book The Organic Chemistry of Drug Design and Drug Action written by Richard B. Silverman and published by Academic Press. This book was released on 2004-01-12 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discovery, design and development. Receptors. Enzymes. Enzyme inhibition and inactivation. DNA-interactive agents. Drug metabolism. Prodrugs and drug delivery systems.
Download or read book Conjugation Deconjugation Reactions in Drug Metabolism and Toxicity written by Frederick C. Kauffman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology. An up-to-date source of information of broad interest to pharmacologists and toxicologists.
Download or read book Glutathione Conjugation of 2 bromocarboxylic Acids and Their Urea Derivatives written by Martina Polhuijs and published by . This book was released on 1992 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Distributed in space Glutathione Conjugation Kinetics of Ethacrynic Acid in Liver written by Rommel Giongco Tirona and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The factors affecting the hepatocellular glutathione (GSH) conjugation of ethacrynic acid (EA), a model substrate, in the formation of the glutathione adduct EA-SG were assessed for their influence on local GSH conjugation rates from the inlet to the outlet of the liver. These included plasma protein binding, sinusoidal uptake, spontaneous and enzyme-catalyzed conjugation, co-substrate (GSH) availability and EA-SG efflux at canalicular and sinusoidal membranes and their zonation within the acinus. The spontaneous coupling of EA with GSH was rapid, whereas the 'in vitro' conjugation catalyzed by the glutathione 'S'-transferases (GSTs) in rat liver was even faster. The conjugation rates greatly exceeded the EA uptake rate by saturable and non-saturable processes in isolated rat hepatocytes. When these ' in vitro' data were viewed with respect to events in whole liver (single-pass perfused rat liver), transport and not GSH conjugation was found to be rate-limiting in the rapid conversion of EA to EA-SG. In studies with isolated, enriched periportal and perivenous hepatocytes, EA uptake and EA-SG efflux were functionally similar among hepatocytes throughout the acinus. However, a shallow and increasing (portal to venous) GST activity gradient was observed in rat liver. When these zonal, uptake and metabolic 'in vitro' data were utilized to predict EA disposition in liver perfusions in the presence and absence of bovine serum albumin (BSA), a series compartment model was found to be most consistent with data obtained in the absence of albumin. The model predicted both a temporal and zonal depletion of GSH among hepatocytes and a change in the rate-limiting step with increasing perfusion time from uptake to co-substrate availability. The model was less capable of predicting the influence of high albumin protein binding on uptake and metabolism, unless a role of BSA in facilitating drug uptake was assumed. This investigation showed for the first time that, in addition to metabolic enzymes, flow and substrate binding, other important factors such as zonal transport, co-substrate, and GSH conjugate efflux further influence the distributed-in-space processing of acceptor substrates in GSH conjugation.
Download or read book Structure and Function of Glutathione S Transferases written by Kenneth D. Tew and published by CRC Press. This book was released on 1993-08-26 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Structure and Function of Glutathione S-Transferases provides some of the latest information available on a variety of structural and functional components of glutathione S-transferases, a family of isozymes involved in many endogenous and exogenous functions in cells. Molecular studies presented in the book focus on the regulation of these enzymes and identify important response elements. X-ray crystallographic structures show detailed information on the structural aspects of these proteins. Metabolism of a number of carcinogens and drugs is covered in detail, and the role that these enzymes play in governing drug resistance at the preclinical and clinical levels is discussed. The book will be excellent for biochemists, pharmacologists, oncologists, experimental therapeutic specialists, and others interested in glutathione S-transferases.
Download or read book Glutathione Conjugation of Bromosulfophthalein in the Rat written by Cornelis Alfonsus Wilco Snel and published by . This book was released on 1995 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:
