Download or read book Glutamate based Therapies for Psychiatric Disorders written by Phil Skolnick and published by Springer Science & Business Media. This book was released on 2010-09-07 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both metabotropic and ionotropic glutamate receptors present attractive “druggable” targets in treating disorders of the central nervous system. There has been a dramatic shift in the focus of glutamate-based therapies away from neurologic disorders such as stroke and traumatic brain injury to the treatment of psychiatric disorders. This “Milestones in Drug Therapy” volume offers a unique, contemporary overview of preclinical and clinical evidence that modulating glutamatergic tone is an effective means of treating psychiatric disorders ranging from depression and anxiety to schizophrenia and drug abuse. The ability to treat diseases such as depression and schizophrenia through multiple, glutamate-based mechanisms offers a unique therapeutic opportunity, as described in this book.
Download or read book Glutamate based Therapies for Psychiatric Disorders written by Phil Skolnick and published by Birkhäuser. This book was released on 2010-11-06 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Both metabotropic and ionotropic glutamate receptors present attractive “druggable” targets in treating disorders of the central nervous system. There has been a dramatic shift in the focus of glutamate-based therapies away from neurologic disorders such as stroke and traumatic brain injury to the treatment of psychiatric disorders. This “Milestones in Drug Therapy” volume offers a unique, contemporary overview of preclinical and clinical evidence that modulating glutamatergic tone is an effective means of treating psychiatric disorders ranging from depression and anxiety to schizophrenia and drug abuse. The ability to treat diseases such as depression and schizophrenia through multiple, glutamate-based mechanisms offers a unique therapeutic opportunity, as described in this book.
Download or read book Dopamine and Glutamate in Psychiatric Disorders written by Werner Schmidt and published by Springer Science & Business Media. This book was released on 2010-04-21 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: An illuminating summary of our current understanding of the interactive role of dopamine and glutamate in psychiatric diseases and the therapeutic strategies and possibilities for future treatment. Among the new ideas presented are hypotheses on the role of dopamine and glutamate in aggression, the glutamate system in anxiety disorders, glutamate and neurodegeneration, and on the origin and progression of Parkinson's disease. Additional chapters offer novel insights into a variety of psychiatric diseases, including ADHD, stress, aggression, addiction, schizophrenia, depression, social phobias, dementias, bulimia, and neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Each chapter summarizes the prevalence and symptoms of the disease and explains the involvement of dopamine and/or glutamate systems using the newer molecular approaches such as transgenic knockout or knockin mice and recent brain imaging techniques.
Download or read book Metabotropic Glutamate Receptors and Neurological Psychiatric Disorders written by Enza Palazzo and published by Frontiers Media SA. This book was released on 2019-06-19 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considering that neurological and psychiatric illnesses do not still have efficient therapies and are becoming increasingly widespread, the search for novel targets appears fundamental. Neuroinflammation, alterations in adult neurogenesis and excitotoxicity, all associated with glutamate transmission dysfunction, are key components of the pathogenetic mechanisms underlying neuropsychiatric illnesses. Counteracting the neurotoxic actions of glutamate through the modulatory actions of metabotropic glutamate receptors (mGluRs), represents a rational intervention that offers tolerability compatible with clinical therapy. Their suitability as targets for developing novel therapies is also based on the fact that mGluRs are found abundantly expressed in synapses of the central nervous system (CNS) that are considered critical in certain neurological and psychiatric disorders. Moreover, recently there has been an exponential development of selective ligands, especially positive and negative allosteric modulators, which by binding to less conserved transmembrane domain sequences ensure, besides a good permeability in the CNS, an adequate selectivity for each mGluR subtype. The eBook “Metabotropic Glutamate Receptors and Neurological/Psychiatric Disorders”, collects contributes (original and review articles) on the beneficial effects of positive and negative allosteric modulators of mGluRs in animal models of neurological and psychiatric diseases from renown experts in the field. The hope is that the effort of both Editors and Contributors of this eBook confirms the unlimited potential of mGluRs in CNS diseases and generate a collaborative discussion on the state of art, overall trends, novel strategies, and future direction of this attractive field of research.
Download or read book Rapid Acting Antidepressants written by and published by Academic Press. This book was released on 2020-06-29 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Advances in Pharmacology series presents a variety of chapters from the best authors in the field. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Download or read book Glutamate Related Biomarkers in Drug Development for Disorders of the Nervous System written by Institute of Medicine and published by National Academies Press. This book was released on 2011-08-05 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutamate is the most pervasive neurotransmitter in the central nervous system (CNS). Despite this fact, no validated biological markers, or biomarkers, currently exist for measuring glutamate pathology in CNS disorders or injuries. Glutamate dysfunction has been associated with an extensive range of nervous system diseases and disorders. Problems with how the neurotransmitter glutamate functions in the brain have been linked to a wide variety of disorders, including schizophrenia, Alzheimer's, substance abuse, and traumatic brain injury. These conditions are widespread, affecting a large portion of the United States population, and remain difficult to treat. Efforts to understand, treat, and prevent glutamate-related disorders can be aided by the identification of valid biomarkers. The Institute of Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop on June 21-22, 2010, to explore ways to accelerate the development, validation, and implementation of such biomarkers. Glutamate-Related Biomarkers in Drug Development for Disorders of the Nervous System: Workshop Summary investigates promising current and emerging technologies, and outlines strategies to procure resources and tools to advance drug development for associated nervous system disorders. Moreover, this report highlights presentations by expert panelists, and the open panel discussions that occurred during the workshop.
Download or read book Neurotransmitter Receptors in Actions of Antipsychotic Medications written by Michael S. Lidow and published by CRC Press. This book was released on 2000-06-22 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Years of extensive investigation into neurophysiology, neurochemistry, and behavioral pharmacology have produced an understanding of antipsychotic medication action that is much more refined than the original dopamine hypothesis. New perspectives offer an array of novel drugs - drugs that pose a lower risk of developing tardive dyskinesia, have few
Download or read book Obsessive Compulsive Disorder written by Christopher Pittenger and published by Oxford University Press. This book was released on 2017 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obsessive-compulsive disorder (OCD) affects one person in 40 and can cause great suffering. This volume provides the first comprehensive summary of our understanding of this enigmatic condition, summarizing current work ranging from genetics and neurobiology through cognitive psychology, treatment, personal experiences, and societal implications
Download or read book Pain in Psychiatric Disorders written by D.P. Finn and published by Karger Medical and Scientific Publishers. This book was released on 2015-09-28 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a series of authoritative reviews on pain in psychiatric disorders written by leading experts. They discuss the complex interplay between pain and psychiatric disorders such as anxiety, depression and borderline personality disorder, as well as neurosteroids, epigenetic mechanisms and TRPV1, with a strong focus on neurobiological mechanisms and current and future therapeutic targets. Special attention is given to the importance of inflammation and the immune system as a common substrate in both pain and psychiatric disorders. The state-of-the-art reviews present both preclinical and clinical research, providing the reader with sound knowledge that provides a basis for further research and clinical practice. Pain in Psychiatric Disorders is of special interest to psychiatrists, neurologists, neuroscientists, pharmacologists and other healthcare professionals treating pain in psychiatric patients, as well as research students with an interest in this field.
Download or read book Ketamine for Treatment Resistant Depression written by Sanjay J. Mathew and published by Springer. This book was released on 2016-11-25 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together an international group of clinicians and researchers from a broad swath of inter-related disciplines to offer the most up-to-date information about clinical and preclinical research into ketamine and second-generation “ketamine-like” fast-acting antidepressants. Currently available antidepressant medications act through monoaminergic systems, are ineffective for many individuals suffering from depression, and are associated with a delayed onset of peak efficacy of several months. The unexpected emergence of ketamine, an anesthetic N-methyl-D-aspartate (NMDA) receptor antagonist, as a rapid-acting antidepressant has reinvigorated CNS drug discovery research and catalyzed investigation in patient populations historically ignored in antidepressant drug development programs, particularly treatment-resistant patients and those with suicidality. Recent industry and academic research efforts have coalesced to explore NMDA receptor and glutamatergic molecular targets that lack ketamine’s psychotomimetic side effects and abuse liability but retain its rapid onset of efficacy. However, many fundamental questions remain regarding the neurobiological mechanisms underlying ketamine’s rapid antidepressant effects and the puzzling persistence of benefits observed in some patients following a single dose. This book examines how insights from these studies are forging new conceptual models of the neurobiology of stress-related affective, anxiety, and addictive disorders and the nature of treatment resistance. It also discusses how ketamine’s rapid antidepressant effects provide a scientific platform to facilitate innovation in clinical trial designs pertaining to patient selection, choice of control group, outcome measures, and dose-optimization. This book brings together data and insights from this rapidly expanding and extraordinarily promising field of study. Readers will be able to extract integrated themes and useful insights from the material contained in these diverse chapters and appreciate the paradigm-shifting contributions of ketamine to modern psychiatry and clinical neuroscience research.
Download or read book Obsessive Compulsive and Related Disorders written by Dan J. Stein and published by Oxford Psychiatry Library. This book was released on 2015 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This resource includes individual chapters on the phenomenology, pathogenesis, pharmacotherapy and psychotherapy of OCD and other related disorders, and features fully updated content and research, as well as a resources chapter, and an appendix with summaries of the major rating scales used to assess patients with OCD.
Download or read book Cognitive Impairment in Schizophrenia written by Philip D. Harvey and published by Cambridge University Press. This book was released on 2013-01-24 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides state-of-the-art information about cognition in schizophrenia with a wide ranging focus on measuring and treating cognitive deficits.
Download or read book Parkinson s Disease Current and Future Therapeutics and Clinical Trials written by Néstor Gálvez-Jiménez and published by Cambridge University Press. This book was released on 2016-03-24 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book emphasizes treatment options for Parkinson's disease, providing the necessary clinical and scientific basis for the foundations of solid therapeutics.
Download or read book Biomarkers in Bipolar Disorders written by Rodrigo Machado-Vieira and published by Academic Press. This book was released on 2022-01-16 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers in Bipolar Disorders summarizes cutting-edge findings in biomarkers' research, emphasizing the most promising findings, tools and technologies relevant to drug development and personalized medicine. Key findings cover different levels of evidence such as genes, molecules, cells, systems, brain and behavior related to diagnosis (state and trait/endophenotypes), prediction of treatment response and follow-up outcomes, along with the most promising perspectives in each area. Each section includes a comprehensive and focused overview on the state-of-the-art and perspectives. The book concludes with a section on practical applications, encompassing diagnostics development (genetic testing, biomarkers), and new drug development. Edited by Dr. Rodrigo Machado-Vieira and Dr. Jair C. Soares, and contributed by leading experts in the field of biomarker research, this book will be become the leading tool for all researchers and clinicians in Bipolar Disorder. Describes strategies for the biomarker discovery of relevant proteins differentially expressed in Bipolar Disorder Presents techniques and main findings in transcriptome research related to CNS synaptic function Provides an overview on current behavioral strategies and their validity in drug development in Bipolar Disorder Discusses current genetic findings, integrating tests for treatments leading to personalized treatments
Download or read book PCP phencyclidine Historical and Current Perspectives written by Edward F. Domino and published by . This book was released on 1981 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electroconvulsive and Neuromodulation Therapies written by Conrad M. Swartz and published by Cambridge University Press. This book was released on 2009-03-02 with total page 619 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electroconvulsive therapy (ECT) is a psychiatric treatment involving the induction of a seizure through the transmission of electricity in the brain. Because of exploitation movies and greatly heightened drug company promotional activities ECT was used less frequently in the 1980s and 1990s. Eventually these movies were understood as unrealistic. Now these drugs are increasingly recognized as dangers to body health. Because of recent refinements and a far better scientific understanding of the clinical procedures and mechanisms underpinning ECT, this treatment modality has seen a resurgence in use and widespread appreciation of its safety. This book is the new definitive reference on electroconvulsive and neuromodulation therapies. It comprehensively covers the scientific basis and clinical practice of ECT as well as comparisons between ECT and medication therapies including the new generation of antipsychotic drugs. It also provides readers with administrative perspectives and specific details for the management of this modality in clinical practice. The new forms of nonconvulsive electrical and magnetic brain stimulation therapy are also covered in detail, in a separate section. The chapter authors are leading scholars and clinicians.
Download or read book Schizophrenia and Psychotic Spectrum Disorders written by S. Charles Schulz and published by Oxford University Press. This book was released on 2016-04-01 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia and Psychotic Spectrum Disorders aims to engage young caregivers in psychiatry, psychology, nursing and social work so that they will be able to become well informed about this significant--and at times confusing--illness. Because schizophrenia is considered to be one of the most complicated and severe psychiatric disorders, this book has the goal of summarizing key issues of the illness, such as its presentation, frequency and age of onset, and diagnostic characteristics. It also contains informative chapters about the pathophysiology of schizophrenia, ranging from brain development issues, genetics, and likely abnormalities in neurotransmitters. This book will give young professionals and those joining the field an excellent and accessible background to treatment. In this area, Schizophrenia and Psychotic Spectrum Disorders provides a comprehensive approach to diagnosis, treatment initiation, strategies for non-response, approaches of therapy, and importantly, ways to provide family therapy and support.
