Download or read book Transport and Trafficking in the Malaria Infected Erythrocyte written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an urgent need to uncover new therapies that will protect against malaria, as the parasite becomes increasingly resistant to available drugs and this book offers insights into three interrelated aspects of the malaria-infected erythrocyte: * The transport of solutes into and out of the infected cell and the use of specific trafficking pathways in drug targeting * The traffic of proteins produced by the intracellular parasite as an essential process for the biogenesis of transport systems. * The relationship between the transport of drugs into the infected cell and the mode of drug action and drug resistance.
Download or read book Glucose Transport in Malaria Infected Erythrocytes written by Ian D. Goodyer and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Malaria and the Red Cell written by David Evered and published by John Wiley & Sons. This book was released on 2009-09-18 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.
Download or read book Glucose Transport in Malaria Infected Erthrocytes written by Ian D. Goodyer and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book An Exported Malaria Protein Regulates Glucose Uptake During Intraerythrocytic Infection written by Tamira K. Butler and published by . This book was released on 2014 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is the world's second biggest infectious killer after tuberculosis. It accounts for 219 million cases each year, with an estimated 660,000 deaths. The majority of these deaths occur in sub-Saharan Africa, in children under 5 years old. In addition to Africa, malaria is endemic to Asia, Central and South America, the Caribbean and the Middle East. Plasmodium falciparum (P. falciparum) is the protozoan parasite that is responsible for the deadliest form of human malaria. Plasmodia are carried by the female Anopheles mosquito and infected into humans during a blood meal. The parasites invade liver cells and form merozoites which erupt from liver cells to invade red blood cells. The intraerythrocytic cycle of infection is responsible for the clinical manifestations of malaria, namely fever and chills. The intraerythrocytic cycle is also the stage of disease that is most studied and targeted for treatment. Although treatment for malaria is available, drug-resistant forms of the parasite are increasingly rampant. For this reason, new, more effective treatments for malaria are necessary. To develop these treatments, we must have a better understanding of the biological processes that the parasite employs to survive in the host to cause disease. In 1996, an international effort was launched to sequence the genome of P. falciparum with the expectation that the genome sequence could be exploited in the search for new drugs and vaccines to fight malaria. In 2002, the genome sequence was published with gaps in some chromosomes. Approximately 5,300 protein-encoding genes were identified; of these about 60% were labeled as hypothetical proteins. Our studies focus on determining the function of one hypothetical protein, PFB0923c, that we now call Glucose Uptake Restoration Protein (GURP). We show that GURP localizes to novel double membrane vesicles in the RBC cytosol and is essential during P. falciparum intraerythrocytic infection. GURP interacts with and sequesters the host protein stomatin, which is known to depress glucose uptake in mammalian cells. Knockdown of GURP decreases glucose uptake and impairs parasite growth in RBCs. This phenotype can be rescued with antioxidants, suggesting that hexose monophosphate/pentose phosphate pathway impairment is lethal in the knockdown parasites. GURP C183 is essential to parasite viability and trafficking of GURP vesicles to the RBC cytosol. Together, these data demonstrate that GURP is essential to P. falciparum viability and glucose uptake during infection of red blood cells.
Download or read book The Ins and Outs of Macromolecular Transport in Malaria infected Erythrocytes written by Darin P. Trelka and published by . This book was released on 1998 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Export of Proteins in Malaria Parasite infected Erythrocytes written by Akinola Olutoye Adisa and published by . This book was released on 2002 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Nutrient Transport in the Plasmodium Falciparum infected Erythrocyte written by Rowena Elizabeth Martin and published by . This book was released on 2005 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Induction of Eryptosis in Plasmodium Falciparum Infected Erythrocytes Through ABC Protein mediated Oxidative Stress written by Ohud Fallatah and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Malaria is a widespread disease found in tropical and subtropical areas. The majority of cases occur in children under five years of age. Many efforts are placed to control the spread of this lethal disease. However, drug resistance is playing a major role in the treatment failure. Malaria is known to be caused by the transmission of the pathogen from the saliva of an infected female Anopheles mosquito to the host during the blood meal. In malaria elimination, the focus is primarily placed on targeting the vector and the pathogen in the blood stage, where the malaria symptoms start to appear. However, targeting the pathogen has consistently resulted in the development of resistance to the selected drugs. It has been shown that the infection of erythrocytes by the parasite causes an elevation of the oxidative stress in the infected erythrocytes compare to the un-infected one. This effect is due to the digestion of the hemoglobin by the parasite and the dramatic increase in the metabolic rate. Heterozygote of several erythrocyte genetic disorders exhibits some protection against the deadliest species of plasmodium (Plasmodium falciparum). These advantages in mutant erythrocytes have shown to be caused by the enhancement of the oxidative stress. The infection of mutant erythrocyte by malaria parasite induces eryptosis and accelerates the clearance of the infected erythrocyte at an early parasite stage (ring stage) by the host immune system (macrophages). In this project, we propose a novel approach for the development of antimalarials, which has several advantages compared to conventional elimination methods. This mechanism mimics the evolutionary strategy exemplified by the mutant erythrocytes such as the sickle cell trait, the ß-thalassemia trait, and glucose-6-phosphate dehydrogenase deficiency. Targeting an important mechanism in the host cells will not generate any resistance because it is not in the pathogen genetic sequence. Moreover, drugs developed based on our approach should be equally effective against drug-sensitive and resistant parasites. Mature erythrocytes are terminally differentiated and unlikely to lead to resistance to drugs triggering eryptosis. Glutathione (GSH) is one of the most important anti-oxidant in the erythrocytes, and it is known to play a significant role in keeping the reducing environment inside the erythrocyte. Using a combination of drugs that target GSH, we will be able to indirectly target the parasite and increase the reactive oxygen species, which are known to have a deleterious effect on the cells. For example, L-Buthionine (S, R) Sulfoximine (BSO) suppresses the synthesis process of GSH, Apigenin (API) accelerates the efflux of GSH through the ABCC1 (MRP1) transporter, and 2,5-dehydroxychalcone activates ABCG2 (BCRP) to transport GSH." --
Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Download or read book Molecular Transfer Across Parasite Membranes written by C. Arme and published by . This book was released on 1988 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Parasites and Parasitic Diseases written by Gilberto Antonio Bastidas Pacheco and published by BoD – Books on Demand. This book was released on 2019-04-24 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parasitic diseases are considered nowadays as an important public health problem due to the high morbidity and mortality rates registered in the world. These diseases result in more severe consequences for the social order of tropical and subtropical countries because many of them have low economic income that makes it even more difficult to design and implement health control programs. This situation opens the door to the emergence and reemergence of these diseases; therefore, it is convenient, necessary, and essential to study and update the epidemiological behavior of tropical diseases with the objective of offering official health professionals and institutions current information for decision-making in this area to ensure social welfare.
Download or read book Encyclopedia of Malaria written by and published by Springer. This book was released on 2018-07-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Malaria represents a vast databank of information about the study of malaria. It provides an overview of the historical, rapid and significant developments that have occurred in malaria research, including the 2002 genome sequencing of Plasmodium falciparum and its mosquito vector, Anopheles gambiae. This work provides a concise source of up-to-date research findings in the form of definitions and essays and present comprehensive coverage of topics from history to findings to diagnosis and treatment, written by recognized malaria researchers with practical experience. It appeals to a diverse audience, including malaria researchers, teachers, investigators and public health professionals.
Download or read book Hemolysis and Related Phenomena written by Eric Ponder and published by Saunders. This book was released on 1948 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Blood brain Barrier written by William M. Pardridge and published by Lippincott Williams & Wilkins. This book was released on 1993 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The characterization of the blood-brain barrier (BBB) is undergoing a paradigm shift as the century-old concept of a passive, impermeable barrier that segregates blood and brain interstitial fluid is giving way to the idea that the BBB is a dynamic conduit for the transport between blood and brain of those nutrients, peptides, proteins, or immune cells that have access to certain transport systems localized within the BBB membranes. This volume contains 20 contributed chapters organized in four parts: cell-cell interactions, subcellular organelle function, signal transduction mechanisms, and gene expression. There is also a foreword by the late W.H. Oldendorf (1925-1992) on the teleology of the blood-brain barrier and the survival advantage conferred upon the organism by its presence in the vertebrate brain. Annotation copyright by Book News, Inc., Portland, OR
Download or read book The Molecular Biology of Insect Disease Vectors written by J.M. Crampton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Only one generation ago, entomology was a proudly isolated discipline. In Comstock Hall, the building of the Department of Entomology at Cornell University where I was first introduced to experimental science in the laboratory of Tom Eisner, those of us interested in the chemistry of life felt like interlopers. In the 35 years that have elapsed since then, all of biology has changed, and entomology with it. Arrogant molecular biologists and resentful classical biologists might think that what has happened is a hostile take-over of biology by molecular biology. But they are wrong. More and more we now understand that the events were happier and much more exciting, amounting to a new synthesis. Molecular Biology, which was initially focused on the simplest of organisms, bacteria and viruses, broke out of its confines after the initial fundamental questions were answered - the structure of DNA, the genetic code, the nature of regulatory genes - and, importantly, as its methods became more and more generally applicable. The recombinant DNA revo lution of the 1970s, the development of techniques for sequencing macromolecules, the polymerase chain reaction, new molecular methods of genetic analysis, all brought molecular biology face to face with the infinite complexity and the exuber ant diversity of life. Molecular biology itself stopped being an isolated diScipline, pre occupied with the universal laws of life, and became an approach to addressing fas cinating specific problems from every field of biology.
Download or read book Red Cell Membranes written by Stephen Byron Shohet and published by . This book was released on 1988 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
