Download or read book Glucose and Oxygen Sensors Implanted in the Subcutaneous Tissue written by Sima Ertefai and published by . This book was released on 1989 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Long term Oxygen Sensor Implantation in the Porcine Subcutaneous Environment written by Lucas Stefan Kumosa and published by . This book was released on 2011 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effect of long-term implantation on metabolically active devices is of utmost importance for not only the success of implanted glucose sensors used in diabetic therapy, but also for the development of artificial tissues and encapsulated cell devices. Such devices are dependent on the constant, predictable supply of metabolites from the local vasculature. Long-term implantation leads to the formation of a foreign body capsule whose purpose is the protection of the host and isolation of the foreign material from local tissue resources. While this encapsulation is successful in protecting tissues from invading agents, metabolite flow continues, albeit at greatly reduced levels. The understanding of this encapsulation process is critical for the design and successful implementation of active implants dependent on metabolite supply. The project goal is to utilize implantable wireless telemeters designed and manufactured by Glysens, Inc. to understand changes in oxygen levels of the surrounding subcutaneous tissues over the course of implantation in pigs. This is performed in three distinct, yet interrelated parts, namely: the analysis of oxygen signals collected from the long-term implantation of telemeters, the histological analysis of serial tissue samples collected from regions adjacent to the telemeter-like shams over the course of implantation, and the investigation of an accurate model for the dynamics of metabolite supply to implanted devices over the long-term. Oxygen signals collected from sensors implanted into the subcutaneous tissues of pigs were found to contain several salient features. First, a long-term trend exhibiting exponential decay properties was discovered and is attributed to the impedance of mass transfer by the formation of a thick, avascular, fibrous foreign body capsule. The existence of such a capsule is demonstrated via histological examinations, and its impact on mass transfer of oxygen from the underlying vasculature to implant surface is investigated utilizing analytical and numerical methods. Second, a dominant frequency with a period of oscillation of 7-14 days was found for most of the signals examined. A model is proposed detailing the critical components of such an oscillations and how they might correlate with specific stages of the wound healing response. The successful completion of this project provide a better understanding of the tissue changes that occur during the foreign body reaction, and the findings will be of direct benefit to the implant and device community allowing for better design parameters and device performance.
Download or read book Oxygen Availability to Sensors Implanted in Tissue written by Michael Emanuel Miller and published by . This book was released on 1998 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Implantation of Glucose Sensors written by Jon Christopher Armour and published by . This book was released on 1988 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biocompatibility of Subcutaneous Implanted Glucose Sensors written by Raeann Gifford and published by . This book was released on 2004 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book SUBCUTANEOUS TISSUE RESPONSE TO IMPLANTABLE SENSORS MULTINUCLEATED GIANT CELLS PREDOMINATION written by Mercedes Rigla and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We have previously described the tissue response to enzymatic glucose sensors in humans, being macrophages the key component of the inflammatory reaction. Their accumulation is associated with sensor function impairment. The aim of the study was to describe a method to explore the tissue response to implanted glucose sensors. Thus, we enrolled 12 type 1 diabetes patients who wore an Eversense sensor for 90 days. Sensors were removed following the manufacturer instructions. Then, an imprint smear of the probe was done for cytology study, and the probe conserved in salinum for recovering the tissue adhered to it. Additionally, the pocket where the sensor had been allocated was washed with 1 ml of saline solution, which was then recovered and processed (cell block). A significant number of multinucleated giant cells were observed in the tissue surrounding the sensor. Unexpectedly, pigment accumulation (Figure 1) was observed free and inside the cells. This material did not show birefringence under polarized light and corresponds to some element among those used for coating the sensor surface (HEMA (hydroxethyl methacrylate), poly methyl methacrylate (PMMA) or platinum).Multinucleated giant cells reaction to wear-particles released from the sensor surface is the commonest cell response to implantable Eversense sensors.
Download or read book Implantable Glucose Sensors written by Ernst Friedrich Pfeiffer and published by . This book was released on 1988 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glucose Monitoring Devices written by Chiara Fabris and published by Academic Press. This book was released on 2020-06-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glucose Monitoring Devices: Measuring Blood Glucose to Manage and Control Diabetes presents the state-of-the-art regarding glucose monitoring devices and the clinical use of monitoring data for the improvement of diabetes management and control. Chapters cover the two most common approaches to glucose monitoring–self-monitoring blood glucose and continuous glucose monitoring–discussing their components, accuracy, the impact of use on quality of glycemic control as documented by landmark clinical trials, and mathematical approaches. Other sections cover how data obtained from these monitoring devices is deployed within diabetes management systems and new approaches to glucose monitoring. This book provides a comprehensive treatment on glucose monitoring devices not otherwise found in a single manuscript. Its comprehensive variety of topics makes it an excellent reference book for doctoral and postdoctoral students working in the field of diabetes technology, both in academia and industry. Presents a comprehensive approach that spans self-monitoring blood glucose devices, the use of continuous monitoring in the artificial pancreas, and intraperitoneal glucose sensing Provides a high-level descriptions of devices, as well as detailed mathematical descriptions of methods and techniques Written by experts in the field with vast experience in the field of diabetes and diabetes technology
Download or read book Finite Element Modeling of Dermally implanted Enzymatic Microparticle Glucose Sensors written by Saniya Ali and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: With the rising prevalence of diabetes, effective means of successful management of blood glucose levels are increasingly important. To improve on the ease of measurements, new technology is being developed to enable less invasive measurements. Some recent efforts have focused on the development of optical microscale glucose sensing systems based on the encapsulation of glucose oxidase within microspheres coated with polyelectrolyte multilayer nanofilms. In such sensors, a phosphorescent oxygen indicator is also co-encapsulated with the enzyme inside so that when glucose is present, glucose oxidase within the sensor reduces the local oxygen levels, causing a corresponding change in the luminescence intensity of the sensors. To test the aforementioned factors, a two-substrate, 2D FEM model of microscale optical glucose sensors in the dermis was developed. The model was used to predict the response time and sensitivity of glucose sensors with varying number and spacing of particles distributed in the dermis and varying physiological characteristics of the surrounding tissue; specifically, capillary density, blood vessel location relative to sensor, and glucose and oxygen consumption in tissue. Simulations were conducted to determine the magnitude of the change in the response time of sensors. Because the steady-state oxygen concentration within the sensors for a given blood glucose level determines the signal output, steady-state concentration of oxygen within sensors and the surrounding tissue for the entire physiological glucose range was evaluated. The utility of the model to predict the performance and efficacy of the sensors in the event of a host response to the foreign body implant was also evaluated. Simulations were performed to evaluate changes in sensor response and sensitivity in the occurrence of inflammation and progression of fibrous encapsulation of various thickness and density. The results from these simulations have provided knowledge on the impact of physiological factors that can potentially degrade sensor function in vivo. Our results indicate that upon the occurrence of a host response, sensitivity is reduced while range is extended. Furthermore, using the model we have been able to determine which conditions in vivo improve response time, sensitivity, and the linear response range for these sensors.
Download or read book Biosensors 92 Proceedings written by W.R. Heineman and published by Elsevier. This book was released on 2016-07-29 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keeping up to date with new biosensors developments has been getting harder ... – one of the fastest moving fields of academic and industrial research in the world – a constant stream of new commercial applications – centres of research excellence all over Europe, North America and the Pacific Rim – enormous implications for monitoring personal health and fitness, the food we eat, the environment, health services and industry The answer came on 20–22 May 1992, with BIOSENSORS 92. With a core of invited speakers and over 220 original contributed papers from 24 countries, BIOSENSORS 92 was the largest and most comprehensive event of its kind – a response to the growing importance of biosensors as a powerful new technology. Elsevier Advanced Technology, the organizers of BIOSENSORS 92, have now published the proceedings of this important event. Biosensors 92 Proceedings contains over 150 papers presenting current research and developments straight from those who are leading the way in: – Enzyme–based Sensors – Affinity Sensors – Environmental Monitoring using Biosensors – Biosensors and Bioelectronics Biosensors 92 Proceedings – Your key to current awareness in sensor technology for just £90 [dollar rate subject to current £/$ exchange rate].
Download or read book In Vivo Glucose Sensing written by David D. Cunningham and published by John Wiley & Sons. This book was released on 2009-11-19 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Vivo Glucose Sensing is a key reference for scientists and engineers working on the development of glucose sensing technologies for the management of diabetes and other medical conditions. It discusses the analytical chemistry behind the strategies currently used for measuring glucose in vivo. It focuses on analyzing samples in the real world and discusses the biological complexities that make glucose sensing difficult. Covering current implantable devices, next-generation implantable sensing methods, and non-invasive methods for measuring glucose, this book concludes with an overview of possible applications other than diabetes.
Download or read book Biosensors in the Body written by David M. Fraser and published by . This book was released on 1997-04-30 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a practical, concise guide to existing and future biosensor methodologies and technologies (i.e. portable sensing devices for continuous monitoring of parameters of blood glucose, carbon dioxide, PH, neurochemical analysis.) It considers why continuous in vivo sensing might be preferable to discontinuous in vitro sensing, which diagnostic parameters are of immediate health-care and commercial interest and which existing commercial devices lie on the path to fully autonomas, implantable devices.
Download or read book Development of Amperometric Glucose Biosensors Suitable for Implantation Into the Subcutaneous Tissue of Diabetic Patients written by Gillian Wendy Shaw and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of an Implantable Glucose Sensor written by Joseph Yancey Lucisano and published by . This book was released on 1987 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Medical Coatings and Deposition Technologies written by David Glocker and published by John Wiley & Sons. This book was released on 2016-07-11 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Coatings and Deposition Technologies is an important new addition to the libraries of medical device designers and manufacturers. Coatings enable the properties of the surface of a device to be controlled independently from the underlying bulk properties; they are often critical to the performance of the device and their use is rapidly growing. This book provides an introduction to many of the most important types of coatings used on modern medical devices as well as descriptions of the techniques by which they are applied and methods for testing their efficacy. Developers of new medical devices and those responsible for producing them will find it an important reference when deciding if a particular functionality can be provided by a coating and what limitations may apply in a given application. Written as a practical guide and containing many specific coating examples and a large number of references for further reading, the book will also be useful to students in materials science & engineering with an interest in medical devices. Chapters on antimicrobial coatings as well as coatings for biocompatibility, drug delivery, radiopacity and hardness are supported by chapters describing key liquid coating processes, plasma-based processes and chemical vapor deposition. Many types of coatings can be applied by more than one technique and the reader will learn the tradeoffs given the relevant design, manufacturing and economic constraints. The chapter on regulatory considerations provides important perspectives regarding the marketing of these coatings and medical devices.
Download or read book Subcutaneously Implanted Sensors for Continuous Glucose Monitoring written by Peter Helding Kvist and published by . This book was released on 2006 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Measuring Oxidants and Oxidative Stress in Biological Systems written by Lawrence J. Berliner and published by Springer Nature. This book was released on 2020-08-08 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
