Download or read book Glial Man written by Yves Agid and published by Oxford University Press, USA. This book was released on 2020-07-15 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding glial cells is key to explaining human movement, emotion, and thoughts. This book provides many examples of the decisive role glial cells play in the functioning of the human brain, as well as in neurological and psychiatric pathologies.

Download or read book The Root of Thought written by Andrew Koob and published by FT Press. This book was released on 2009-06-03 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until recently, neuroscientists thought glial cells did little more than hold your brain together. But in the past few years, they've discovered that glial cells are extraordinarily important. In fact, they may hold the key to understanding intelligence, treating psychiatric disorders and brain injuries and perhaps even curing fatal conditions like Alzheimer's, Parkinson's, and Lou Gehrig's Disease. In The Root of Thought, leading neuroscientist Dr. Andrew Koob reveals what we've learned about these remarkable cells, from their unexpected role in information storage to their function as adult stem cells that can keep your brain growing and adapting longer than scientists ever imagined possible. Ranging from fruit flies to Einstein, Koob reveals the surprising correlation between intelligence and the brain's percentage of glial cells - and why these cells' unique wavelike communications may be especially conducive to the fluid information processing human beings depend upon. You'll learn how crucial glial cells grow and develop... why almost all brain tumors are comprised of glial cells and the potential implications for treatment... even the apparent role of glial cells in your every thought and dream!

Download or read book The Other Brain written by R. Douglas Fields and published by Simon and Schuster. This book was released on 2009-12-29 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite everything that has been written about the brain, a potentially critical part of this vital organ has been overlooked—until now. The Other Brain examines the growing importance of glia, which make up approximately 85 percent of the cells in the brain, and the role they play in how the brain functions, malfunctions, and heals itself. Long neglected as little more than cerebral packing material, glia (meaning “glue”) are now known to regulate the flow of information between neurons and to repair the brain and spinal cord after injury and stroke. But scientists are also discovering that diseased and damaged glia play a significant role in psychiatric illnesses such as schizophrenia and depression, and in neurodegenerative diseases such as Parkinson’s and Alzheimer’s. Diseased glia cause brain cancer and multiple sclerosis and are linked to infectious diseases such as HIV and prion disease (mad cow disease, for example) and to chronic pain. The more we learn about these cells that make up the “other” brain, the more important they seem to be. Written by a neuroscientist who is a leader in glial research, The Other Brain gives readers a much more complete understanding of how the brain works and an intriguing look at potentially revolutionary developments in brain science and medicine.

Download or read book Enteric Glia written by Brian D. Gulbransen and published by Biota Publishing. This book was released on 2014-07-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography

Download or read book The Autobiography of a Transgender Scientist written by Ben Barres and published by MIT Press. This book was released on 2018-10-30 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: A leading scientist describes his life, his gender transition, his scientific work, and his advocacy for gender equality in science. Ben Barres was known for his groundbreaking scientific work and for his groundbreaking advocacy for gender equality in science. In this book, completed shortly before his death from pancreatic cancer in December 2017, Barres (born in 1954) describes a life full of remarkable accomplishments—from his childhood as a precocious math and science whiz to his experiences as a female student at MIT in the 1970s to his female-to-male transition in his forties, to his scientific work and role as teacher and mentor at Stanford. Barres recounts his early life—his interest in science, first manifested as a fascination with the mad scientist in Superman; his academic successes; and his gender confusion. Barres felt even as a very young child that he was assigned the wrong gender. After years of being acutely uncomfortable in his own skin, Barres transitioned from female to male. He reports he felt nothing but relief on becoming his true self. He was proud to be a role model for transgender scientists. As an undergraduate at MIT, Barres experienced discrimination, but it was after transitioning that he realized how differently male and female scientists are treated. He became an advocate for gender equality in science, and later in life responded pointedly to Larry Summers's speculation that women were innately unsuited to be scientists. Privileged white men, Barres writes, “miss the basic point that in the face of negative stereotyping, talented women will not be recognized.” At Stanford, Barres made important discoveries about glia, the most numerous cells in the brain, and he describes some of his work. “The most rewarding part of his job,” however, was mentoring young scientists. That, and his advocacy for women and transgender scientists, ensures his legacy.

Download or read book The Role of Glia in Neurotoxicity written by Michael Aschner and published by CRC Press. This book was released on 1996-03-27 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is well established that glial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. The Role of Glia in Neurotoxicity brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function. This book explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity. This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity. This timely review not only presents an excellent overview of the state of the science but also provides direction for future research into the consequences of an altered glial-neuronal unit.

Download or read book Environmental Health Perspectives written by and published by . This book was released on 1986 with total page 1130 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cerebellar Dentate Nucleus written by V. Chan-Palay and published by Springer. This book was released on 2013-12-20 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent physiologic investigations have shown that the deep cerebellar nuclei may play an important role in the initiation and monitoring of skilled move ments. Much of this physiologic work has been carried out in the absence of a secure foundation in neuroanatomical information. Although the main sources of the afferent fibers and the major terminations of the efferent fibers related to these nuclei have been known for many years, remarkably little information about the organization of the nuclei themselves has been collected. The kinds of nerve cells, their arrangement within the nuclei, the patterns of their dendritic arborizations, the distribution of incoming fibers among the neurons, the relationship between the outgoing nerve fibers and the nerve cells from which they originate - these and many other morphologic features were either unknown or only superficially explored. In fact, so little was known about the deep cerebellar nuclei when I began to work on this subject that the investigations reported here are virtually without antecedents, a refreshing change from the cerebellar cortex which has been repeatedly and exhaustively surveyed. My studies on the cerebellar nuclei began in the spring of 1972. They were initiated with the intent of applying the principles of analysis that had been developed for the cerebellar cortex to a different but related part of the brain.

Download or read book Duality and Unity of the Brain written by David Ottoson and published by Springer. This book was released on 2016-01-13 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Role of Glial Cells of the Central and Peripheral Nervous System in the Pathogenesis of Neurodegenerative Disorders written by Guanghui Wang and published by Frontiers Media SA. This book was released on 2022-05-26 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Glial Physiology and Pathophysiology written by Alexei Verkhratsky and published by John Wiley & Sons. This book was released on 2013-01-31 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells. Coverae includes: the morphology and interrelationships between glial cells and neurones in different parts of the nervous systems the cellular physiology of the different kinds of glial cells the mechanisms of intra- and inter-cellular signalling in glial networks the mechanisms of glial-neuronal communications the role of glial cells in synaptic plasticity, neuronal survival and development of nervous system the cellular and molecular mechanisms of metabolic neuronal-glial interactions the role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson's Neuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it. An up-to-date and fully referenced text on the most numerous cells in the human brain Detailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous system Describes the role og glial cells in neuropathology Focus boxes highlight key points and summarise important facts Companion website with downloadable figures and slides

Download or read book Neuroglia Function and Pathology written by Alexej Verkhratsky and published by Elsevier. This book was released on 2023-05-12 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diverse specialised neuroglial cells guarantee the development, preservation, and health of the central nervous system, the peripheral nervous system, the enteric nervous system, and the special senses. In the central nervous system, it is the astrocytes, oligodendrocytes, and microglia that safeguard nerve cell function and integrity that controls all behaviours and encompasses the cerebral cortex of the brain which is the root of humanity. In the peripheral nervous system, Schwann cells play the leading role, together with satellite glial cells of the sensory and autonomic ganglia, ensuring correct communication between the organs and tissues with the brain and the spinal cord. In the enteric nervous system, specialised enteric glial cells maintain all aspects of gastrointestinal function. Then there are distinctive glial cells of the special senses that ensure how the body perceives and reacts to its environment. In pathology, neuroglia strive to protect the diverse cellular components of the nervous system and are responsible for a proactive programme of posttraumatic restructuring that is aimed at recovery of life-sustaining function. Neuroglia: Function and Pathology provides a highly original and comprehensive account of the physiology and pathophysiology of glial cells in the central and peripheral nervous systems. The first part of the book provides a far-reaching description of glial cell form and function, from their evolution in invertebrates to their complexity in humans, encompassing the developmental origin of the varied glial cell types and their diversity of morphology, molecular biology and cellular physiology. The second part of the book is devoted to an all-embracing evaluation of glial cell pathophysiology, commencing with definitive explanations of the fundamental pathologies of the main glial cell types, and ending in a systematic examination of glial contributions to specific neurological diseases. This book emphasises the central roles played by the different classes of neuroglial cells in the progression and outcome of neurological disorders of the central and peripheral nervous systems and highlights potential of glial cells as therapeutic targets. The book contains more than 2500 key references from over 150 years of glial research and is superbly illustrated with over 350 original and explanatory full colour figures that describe the diverse characteristics and properties of glial cells in health and disease. Under the same cover, this book combines an authoritative reference book for research and clinical neuroscientists and at the same time serves as an instructive textbook for students of neuroscience, from undergraduates to postgraduates. - Single volume covering key aspects of glial cell physiology and pathology - In depth overview of the history of glial cell research - Comprehensive review of glial cell physiology and pathology - Authoritative special chapters on the major neurological diseases - Full colour throughout, with 360 illustrations

Download or read book CSA Neurosciences Abstracts written by and published by . This book was released on 1994 with total page 910 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Glial Cell Function Paperback written by Bernardo Castellano and published by Gulf Professional Publishing. This book was released on 2003-09-15 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although knowledge of the development and differentiation of glial cells has significantly increased in recent years, there are still many questions unanswered. The first section of the book is devoted to this very active topic and includes contributions on Schwann cells, oligodendrocytes, astroglia and microglia. The second section of the book covers cellular interactions, the role they play on myelination and remyelination, how these interactions take place and the molecules involved. The third section of this volume focuses on the interactions of neurons with glial cells and their role in brain function. Neuron-glia cross talk appears to be fundamental for synaptic transmission and several chapters in this section address this topic. The topic of how glial cells react to brain injury and how they participate in neuroprotection and brain repair is covered in section four of this book. As our knowledge about the molecules involved in the regenerative properties of glia increases, new avenues are open for the use of genetically modified glia with therapeutic purposes. The final section of the book is devoted to therapeutic approaches to tumours, viral and prion infections. Gene therapy is a promising approach for the treatment of gliomas, one of the most devastating forms of cancer. A chapter on prion diseases and microglia addresses a question of tremendous actuality, since prion diseases in cows is at this moment the major veterinary problem in Europe and has created a considerable social alarm.

Download or read book Otic Antiinfectives Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Otic Antiinfectives: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Otic Antiinfectives in a concise format. The editors have built Otic Antiinfectives: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Otic Antiinfectives in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Otic Antiinfectives: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Evolutionary Neuroscience written by Jon H Kaas and published by Academic Press. This book was released on 2020-05-30 with total page 964 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evolutionary Neuroscience, Second Edition, is a collection of chapters on brain evolution that combines selected topics from the recent comprehensive reference, Evolution of Nervous Systems (Elsevier, Academic Press, 2017, 9780128040423). The selected chapters cover a broad range of topics, from historical theory, to the most recent deductions from comparative studies of brains. The articles are organized in sections focused on history, concepts and theory, the evolution of brains from early vertebrates to present-day fishes, amphibians, reptiles and birds, the evolution of mammalian brains, and the evolution of primate brains, including human brains. Each chapter is written by a leader or leaders in the field. Specific topics include brain character reconstruction, principles of brain scaling, basic features of vertebrate brains, the evolution of the major sensory systems, other parts of brains, what we can learn from fossils, the origin of neocortex, and the evolution of specializations of human brains. The collection of articles will be interesting to anyone who is curious about how brains evolved from the simpler nervous systems of the first vertebrates into the many different complex forms now found in present-day vertebrates. - Provides the most comprehensive, authoritative and up-to-date single volume collection on brain evolution - Presents a full color treatment, with many illustrations - Written by leading scholars and experts - Features chapters on brain character reconstruction, principles of brain scaling, basic features of vertebrate brains, the evolution of the major sensory systems, and other parts of brains - Discusses what we can learn from fossils, the origin of neocortex, and the evolution of specializations of human brains

Download or read book Astrocytes in Patho Physiology of the Nervous System written by Vladimir Parpura and published by Springer Science & Business Media. This book was released on 2008-12-11 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into question the assumption by classical neuroscience that neurons and glia are derived from distinct pools of progenitor cells. Astrocytes have long been neglected as active participants in intercellular communication and information processing in the central nervous system, in part due to their lack of electrical excitability. The follow up chapters review the “nuts and bolts” of ast- cytic physiology; astrocytes possess a diverse assortment of ion channels, neu- transmitter receptors, and transport mechanisms that enable the astrocytes to respond to many of the same signals that act on neurons. Since astrocytes can detect chemical transmitters that are released from neurons and can release their own extracellular signals there is an increasing awareness that they play physiological roles in regulating neuronal activity and synaptic transmission. In addition to these physiological roles, it is becoming increasingly recognized that astrocytes play critical roles during pathophysiological states of the nervous system; these states include gliomas, Alexander disease, and epilepsy to mention a few.