Download or read book Glaucoma A Neurodegenerative Disease of the Retina and Beyond Part A written by and published by Elsevier. This book was released on 2020-09-22 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma: A Pancitopatia of the Retina and Beyond, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this volume include the Genetics of glaucoma, Artificial intelligence and deep learning in glaucoma detection and monitoring, The role of commensal microflora-induced T cells responses in glaucoma neurodegeneration, Retinal cell death in experimental glaucoma, Experimental and clinical evidence on the neuroprotective properties of Citicoline in glaucoma, Glaucoma neurodegeneration and myopia, Neuronal regeneration with pluripotent stem cells in glaucoma, and more. - Covers all key aspects of current research on glaucoma - Provides extensively referenced chapters, giving readers a comprehensive list of resources on topics covered - Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists
Download or read book Glaucoma A Neurodegenerative Disease of the Retina and Beyond Part B written by Giacinto Bagetta and published by Academic Press. This book was released on 2020-09-26 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma: A Neurodegenerative Disease of the Retina and Beyond Part B, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Topics covered in this new release include Glaucoma neurodegeneration and myopia, Links between obstructive sleep apnea and glaucoma neurodegeneration, Artificial intelligence and deep learning in glaucoma: Current state and future prospects, Brain networks reorganization and functional disability in glaucoma, Advanced vascular examinations of the retina and optic nerve head in glaucoma, and much more. - Covers all key aspects of current research on glaucoma - Provides extensively referenced chapters, giving readers a comprehensive list of resources on topics covered - Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists
Download or read book Glaucoma A Neurodegenerative Disease of the Retina and Beyond Part A written by and published by Elsevier. This book was released on 2020-09-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma: A Pancitopatia of the Retina and Beyond, Volume 257, the latest release in the Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this volume include the Genetics of glaucoma, Artificial intelligence and deep learning in glaucoma detection and monitoring, The role of commensal microflora-induced T cells responses in glaucoma neurodegeneration, Retinal cell death in experimental glaucoma, Experimental and clinical evidence on the neuroprotective properties of Citicoline in glaucoma, Glaucoma neurodegeneration and myopia, Neuronal regeneration with pluripotent stem cells in glaucoma, and more. Covers all key aspects of current research on glaucoma Provides extensively referenced chapters, giving readers a comprehensive list of resources on topics covered Includes comprehensive and in-depth background information written in a clear form that is accessible to both specialists and non-specialists
Download or read book New Trends in Basic and Clinical Research of Glaucoma A Neurodegenerative Disease of the Visual System Part A written by and published by Elsevier. This book was released on 2015-11-16 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System is the latest volume from Progress in Brain Research focusing on new trends in basic and clinical research of glaucoma. This established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields. - This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields
Download or read book New Trends in Basic and Clinical Research of Glaucoma A Neurodegenerative Disease of the Visual System Part B written by and published by Elsevier. This book was released on 2015-11-16 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System - Part B is the latest volume from Progress in Brain Research focusing on new trends in basic and clinical research of glaucoma. This established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields. - This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields
Download or read book Glaucoma An Open Window to Neurodegeneration and Neuroprotection written by Carlo Nucci and published by Newnes. This book was released on 2008-11-05 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma is one of the main causes of blindness throughout the world. It is characterized by death of the retinal ganglion cells, which is associated with loss of the axons making up the optic nerve. Recent studies have demonstrated support for the classification of glaucoma as a degenerative disease of the central nervous system (CNS), leading researchers to look at identifying neuroprotection strategies for the treatment of this disease, like those used for other degenerative diseases of the CNS. This book will provide an in-depth examination of the most recent findings regarding glaucoma, including risk factors, diagnosis, clinical monitoring, treatment, and above all, the need for treatment based on the concept of neuroprotection. A large part of the book is devoted to research related to this new approach to the treatment of glaucoma. - Describes the most recent developments on neuroprotection of the optic nerve, including experimental models now used and clinical protocols - Discusses new strategies for the prevention of neuronal injury in glaucoma patients - Focuses on evidence-based risk factors, innovative diagnostic aspects and advanced medical/surgical treatment of glaucoma
Download or read book Fast Facts Glaucoma written by Paul R. Healey and published by Karger Medical and Scientific Publishers. This book was released on 2010-01-01 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma is the most common neurodegenerative disease and the second most common cause of blindness worldwide after cataract. While the diagnosis of end-stage glaucoma can be made by any physician trained in the use of the ophthalmoscope, it is preferable to diagnose glaucoma at an early stage, when intervention can alter the course of the disease and change the prognosis. Packed with superb illustrations, 'Fast Facts: Glaucoma' is bursting with practical information on the disease, including: • A concise overview of the glaucoma subtypes and their global prevalence • A clear explanation of the pathophysiology alongside what the patient actually experiences • The questions to ask when taking a history • The key elements of a comprehensive eye examination • How to minimize the impact of the disease on the patient and reduce risk factors • The latest medical and surgical treatments • Monitoring of the condition - including detail of follow-up examinations 'Fast Facts: Glaucoma' is a highly readable practical reference for all medical and eyecare practitioners, an aid for students and scientists involved in the study of eye disease and a sound overview for anyone interested in this challenging disease. What is Glaucoma? How can it be detected? How can it be treated? 'Fast Facts: Glaucoma' answers all of these questions. Contents: • Definitions and epidemiology • Pathophysiology, natural history and prognosis • Diagnosis and clinical features • Principles of management • Medical treatment • Laser and surgical treatment • Monitoring • Prevention • Useful resources
Download or read book Mechanisms of Glaucoma Relevant Retinal Ganglion Cell Death written by Olivia J. Marola and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma is a neurodegenerative disease characterized by death of retinal ganglion cells (RGCs)?the output neurons of the retina. The present studies investigated the extrinsic and intrinsic signaling pathways that elicit RGC death in the context of glaucoma. There is growing evidence the endothelin (EDN) system, canonically known to regulate vasoconstriction, is an important RGC-extrinsic driver of glaucomatous neurodegeneration. Intravitreal injection of EDN ligands caused RGC death, and EDN-induced RGC death was largely mediated by activation of the transcription factor JUN?consistent with RGC death after other glaucoma-relevant injuries. However, it remained unknown which retinal and/or optic nerve cell types EDN ligand directly affects to elicit RGC death. EDN ligands act upon EDN receptors (EDNRA and EDNRB), which are expressed by several cell types including neurons, macroglia, endothelial cells, and vascular mural cells. We found mural cell-specific deletion of Ednra completely prevented both EDN-induced vasoconstriction and RGC death, suggesting EDN insults RGCs via vasoconstriction. These data indicate a potentially important role of impaired blood flow and vascular dysfunction in the context of glaucoma. In addition to extrinsic signaling, much work has investigated the intrinsic mechanisms of RGC death in the context of glaucoma. Degeneration of each RGC compartment (e.g. dendrites, soma, axon) is governed by distinct molecular mechanisms. Here, we tested the importance of the transcription factors DDIT3 (the apoptotic endoplasmic reticulum stress effector) and JUN (the target of MAPK-JNK signaling) in RGC degeneration after glaucoma-relevant injuries. In DBA/2J mice, which naturally develop glaucoma with age, Ddit3/Jun deletion did not prevent RGC axonal degeneration but provided near-complete protection to RGC somas. Despite robust somal protection, Ddit3/Jun deletion did not preserve RGC electrical function (as assessed by pattern electroretinography, PERG) or prevent dendritic retraction. These data indicate that together, DDIT3 and JUN are critical hubs regulating RGC somal degeneration after glaucoma-relevant injury. However, lack of protection to PERG amplitude, axonal survival, and dendritic arbor integrity suggests these degenerative events are controlled by pathways upstream or independent of JUN and DDIT3 activation. MAPKKs 4 and 7 (MKK4/7) act upstream of both JUN and DDIT3 activation and have been shown to drive axonal degeneration cascades. Therefore, we investigated the role of MKK4/7 in RGC somal, axonal, and dendritic degeneration after optic nerve crush (ONC), an acute glaucoma-relevant axonal injury. After ONC, Mkk4/7 deletion robustly protected both RGC somas and axons. Intriguingly, Mkk4/7 deletion preserved electrical output measured by PERGs and prevented dendritic remodeling. These data demonstrate MKK4 and MKK7 control degeneration of several RGC compartments independently of DDIT3 and JUN after glaucoma-relevant injury, suggesting inhibiting MKK4/7 signaling or signaling events upstream of their activation could be a powerful neuroprotective therapy for glaucomatous neurodegeneration.
Download or read book Fast Facts Glaucoma written by Paul R. Healey and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma is the most common neurodegenerative disease and the second most common cause of blindness worldwide after cataract. While the diagnosis of end-stage glaucoma can be made by any physician trained in the use of the ophthalmoscope, it is preferable to diagnose glaucoma at an early stage, when intervention can alter the course of the disease and change the prognosis. Packed with superb illustrations, 'Fast Facts: Glaucoma' is bursting with practical information on the disease, including: • A concise overview of the glaucoma subtypes and their global prevalence • A clear explanation of the pathophysiology alongside what the patient actually experiences • The questions to ask when taking a history • The key elements of a comprehensive eye examination • How to minimize the impact of the disease on the patient and reduce risk factors • The latest medical and surgical treatments • Monitoring of the condition - including detail of follow-up examinations 'Fast Facts: Glaucoma' is a highly readable practical reference for all medical and eyecare practitioners, an aid for students and scientists involved in the study of eye disease and a sound overview for anyone interested in this challenging disease. What is Glaucoma? How can it be detected? How can it be treated? 'Fast Facts: Glaucoma' answers all of these questions. Contents: • Definitions and epidemiology • Pathophysiology, natural history and prognosis • Diagnosis and clinical features • Principles of management • Medical treatment • Laser and surgical treatment • Monitoring • Prevention • Useful resources
Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Describing the Roles of Myeloid Cells in the Compartmental Degeneration of Retinal Ganglion Cells in the Neurodegenerative Disease Glaucoma written by Kevin Thomas Breen and published by . This book was released on 2015 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Seeing Beyond the Eye The Brain Connection written by Christine Nguyen and published by Frontiers Media SA. This book was released on 2021-09-02 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Perspective on Gene Therapy for Glaucoma written by Hilda Petrs-Silva and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma is a chronic and multifactorial neurodegenerative disease marked by structural damage to the optic nerve with axonal loss, progressive retinal ganglion cell degeneration, and optic disc excavation. Both high intraocular pressure and aging are important risk factors, but not essential to the progression of glaucomatous neurodegeneration. Current treatments are based on controlling intraocular pressure, which is not always effective in avoiding the progression of visual loss. In this sense, novel therapeutic strategies to glaucoma should aim to promote the neuroprotection of both the cell soma of retinal ganglion cells and the axons of the optic nerve. Gene therapy is a new therapeutical approach to glaucoma with a great capacity to overcome neurodegeneration. It consists of the transfer of exogenous genetic material to target cells with a therapeutic purpose. Gene therapy strategies for glaucoma include both the neuroprotection aiming to prevent cell soma and axonal loss and the regeneration of optic nerve axons. In this chapter, we review the most promising current gene therapies for glaucoma that address the various aspects of glaucoma pathology. We also discuss the potential of combining neuroprotective and regenerative strategies to reach a synergic effect for the treatment of glaucoma.
Download or read book Exploring Molecular Targets to Treat Neurodegenerative Disorders written by Prashant Tiwari and published by Cambridge Scholars Publishing. This book was released on 2024-05-01 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delves into the delicate realm of neurodegenerative illnesses, navigating the vast landscape of molecular targets with care and purpose. Researchers are studying the complex pathways involved in diseases such as Alzheimer’s, Parkinson’s, and Huntington’s in order to identify specific molecules that could be targeted for therapy. The present work explores potential methods of intervention by carefully analysing neural circuits, protein misfolding, and genetic predispositions, unravelling the complexities of the human mind by focusing on individual molecular targets. As new findings emerge, reducing the severe consequences of neurodegenerative illnesses becomes increasingly possible, providing optimism for millions of people throughout the world.
Download or read book Glaucoma and Alzheimer s Disease Treatment Association written by Tho Doan and published by . This book was released on 2016 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma is a neurodegenerative disease depicts by axon degeneration in the optic nerve. It consider as one of the leading cause of irreversible blindness worldwide. Glaucoma pathophysiology is very similar degenerative brain disease like Alzheimer's. Alzheimer's disease (AD) is a common, incurable, and progressive dementia. The loss of learning and memory in AD results from neuropathologic accumulation of amyloid plaques and aggregrates of hyperphosphorylated tau protein (neurofibrillary tangles) in the brain. Significant risk factors for both of these diseases include age, family history, and specific areas of the brain are damaged over time. The only difference is that glaucoma affects specific area of the brain, which is optic nerve. The objective of this review it to look into the current understanding to pathophysiology of glaucoma and AD, the importance of neuroprotection, and various possible pharmacological approaches that could benefit both glaucoma and AD or not. Studies have shown that there is a possible higher risk of Alzheimer's patient developing glaucoma, however, glaucoma patient does not necessary develop AD. As a result, Alzheimer's treatment can apply to glaucoma patients. But glaucoma's management may not be useful in showing down the progression or treat AD.
Download or read book Ocular Therapeutics written by Thomas Yorio and published by Academic Press. This book was released on 2011-04-28 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ocular Therapeutics: Eye on New Discovery focuses on emerging areas in ocular research, from new approaches to dry eye to gene therapy in the management of retinal diseases. This comprehensive book features more than 25 chapters of information that will be vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. It is the intent of this book to provide not only information on current approaches to treatment, but also in giving the reader a greater understanding as to what may become available for treating a number of important eye diseases. Each chapter features some new aspect of treatment that holds great promise for the future. The approach has been to concentrate on those areas of ocular diseases that are more prevalent. It also features new insight for drug delivery and for managing devasting diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States. This book will serve as an important resource as it contains a number of relevant references highlighted for their importance to the field. New investigators will be able to obtain an historical perspective for each of the topics and to develop an understanding of the new research directions that are underway. Ocular Therapeutics: Eye on New Discovery is more than a reference book, as it also provides an important glimpse into the near future.* Contains information that is vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics.* Provides not only information on current approaches to treatment, but also gives the reader a greater understanding as to what may become available for treating a number of important eye diseases.* Historical perspective for each of the topics as well as an important glimpse into the near future to develop an understanding of the new research directions underway.* New insight for drug delivery and for managing devastating diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States
Download or read book Neurodegenerative Diseases written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2012-03-12 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.
