Download or read book Genomics easy as Pi written by Uki D. Lucas and published by Uki Dominique Lucas. This book was released on 2016-04-09 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been inspired by recent convergence of two sciences, both of which are my life-long passions, both of which for the first time this year are becoming affordable to a an average person: genomics and cluster computers. The field of genomics has exploded in last few years beyond belief, the original human genome sequencing project, finished in year 2000, took 13 years and $3 billion to complete. Today, the cost of sequencing of the whole genome is approaching $800 (in bulk) and can be done in couple of hours. The genome research has been concentrated around the prestigious institutions with generous grants that could afford access to newest sequencing technology. The positive outcome of the research sponsored by the public funds is that the results are also public and anyone can have access to genetic sequence information from the Web base databases and FTP sites. With a quick search you can get sequences of many organisms ranging from common bacteria, yeast, corn, wheat, fruit flies, mouse, rats, extinct mammals, monkeys, apes, Neanderthal and many humans. Sequencing the next genome take hours now and there are thousands of them sequenced now, as you read it. For couple of hundreds of dollars you can determine presence of some interesting sequences using companies like 23andMe, best of all you can download the raw data of your test and start comparing it against other genomes or databases of genes immediately. At the same time the medical field is learning about hundreds of thousands on proteins and trying to figure out which genetic sequences code for them. Doctors are discovering the genetic association of many diseases and individual drug interactions. Each human genome is composed of 3.3 billion letters (base-pairs), comparing it against multiple other genomes requires some serious processing power. There are other organisms such as loblolly pine (Pinus taeda) that have 23 billion base pairs in their DNA, that is 7 time more than human! Due to the sheer amount of the data being generated every day there is a vast opportunity for new software tools and new applications of that knowledge. The field of genomics is growing faster than any other technological advance in human history and few would argue that with potentially the biggest impact on our future lives since we learned how to use fire.
Download or read book Exploring Personal Genomics written by Joel T. Dudley and published by Oxford University Press. This book was released on 2013-01-03 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advances in high-throughput genome sequencing technologies foreshadow a near-future in which millions of individuals will gain affordable access to their complete genome sequence. This promises to give unprecedented insights into the fundamental biological nature of ourselves and our species: where we came from, how we are born, how we interact with our environment, how we get sick, how we get well, and how we age. Personal genomics is therefore an important component of the inevitable transition towards personalized medicine, as the medical establishment begins to explore and evaluate the role of personal genomics in health and medicine. However there is currently very little training available for medical practitioners. Exploring Personal Genomics provides a novel, inquiry-based approach to understanding and interpreting the practical, medical, and societal aspects of personal genomic information. It is presented in two parts: the first provides readers of all backgrounds with a fundamental understanding of the biology of human genomes, information on how to obtain and understand digital representations of personal genomic data, tools and techniques for exploring the personal genomics of ancestry and genealogy, discovery and interpretation of genetic trait associations, and the role of personal genomics in drug response. The second part offers more advanced readers an understanding of the science, tools, and techniques for investigating interactions between a personal genome and the environment, connecting DNA to physiology, assessing rare variants and structural variation, and exploring resources for performing personal biological investigation. This advanced textbook is primarily aimed at undergraduate and graduate students taking classes in genomic medicine, genetics, and bioinformatics. It will also be of relevance and use to medical practitioners, evolutionary biologists, geneticists and individuals interested in exploring their personal genetic data.
Download or read book Bioinformatics for Beginners written by Supratim Choudhuri and published by Elsevier. This book was released on 2014-05-09 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses the relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis and demonstrates, with examples, targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis, also pointing to further study options. Avoids non-essential coverage, yet fully describes the field for beginners Explains the molecular basis of evolution to place bioinformatic analysis in biological context Provides useful links to the vast resource of publicly available bioinformatic databases and analysis tools Contains over 100 figures that aid in concept discovery and illustration
Download or read book Introduction to Computational Genomics written by Nello Cristianini and published by Cambridge University Press. This book was released on 2006-12-14 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
Download or read book Genomics Enabled Crop Genetics written by Yin Li and published by Frontiers Media SA. This book was released on 2021-06-24 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Next Generation Genome Sequencing written by Michal Janitz and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading experts from industry and academia, this first single comprehensive resource addresses recent developments in next generation DNA sequencing technology and their impact on genome research, drug discovery and health care. As such, it presents a detailed comparative analysis of commercially available platforms as well as insights into alternative, emerging sequencing techniques. In addition, the book not only covers the principles of DNA sequencing techniques but also social, ethical and commercial aspects, the concept of personalized medicine and a five-year perspective of DNA sequencing.
Download or read book Genomic Perl written by Rex A. Dwyer and published by Cambridge University Press. This book was released on 2003 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introduction to computational molecular biology will help programmers and biologists learn the skills needed to start work in this important, expanding field. The author explains many of the basic computational problems and gives concise, working programs to solve them in the Perl programming language. With minimal prerequisites, the author explains the biological background for each problem, develops a model for the solution, then introduces the Perl concepts needed to implement the solution. The book covers pairwise and multiple sequence alignment, fast database searches for homologous sequences, protein motif identification, genome rearrangement, physical mapping, phylogeny reconstruction, satellite identification, sequence assembly, gene finding, and RNA secondary structure. The concrete examples and step-by-step approach make it easy to grasp the computational and statistical methods, including dynamic programming, branch-and-bound optimization, greedy methods, maximum likelihood methods, substitution matrices, BLAST searching, and Karlin-Altschul statistics. Perl code is provided on the accompanying CD.
Download or read book General Genetics written by M. J. Sirks and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Primer of Genome Science written by Greg Gibson and published by Sinauer Associates Incorporated. This book was released on 2004-01-01 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Primer of Genome Science bridges the gap between standard genetics textbooks and highly specialized, technical, and advanced treatments of the subdisciplines. It provides an affordable and up-to-date introduction to the field that is suited to advanced undergraduate or early graduate courses.
Download or read book Cereal Genomics written by Pushpendra K. Gupta and published by Springer Science & Business Media. This book was released on 2006-01-19 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cereals make an important component of daily diet of a major section of human population, so that their survival mainly depends on the cereal grain production, which should match the burgeoning human population. Due to painstaking efforts of plant breeders and geneticists, at the global level, cereal production in the past witnessed a steady growth. However, the cereal production in the past has been achieved through the use of high yielding varieties, which have a heavy demand of inputs in the form of chemical fertilizers, herbicides and insecticides/pesticides, leading to environmental degradation. In view of this, while increasing cereal production, one also needs to keep in mind that agronomic practices used for realizing high productivity do not adversely affect the environment. Improvement in cereal production in the past was also achieved through the use of alien genetic variation available in the wild relatives of these cereals, so that conservation and sustainable use of genetic resources is another important area, which is currently receiving the attention of plant breeders. The work leading to increased cereal production in the past received strong support from basic research on understanding the cereal genomes, which need to be manipulated to yield more from low inputs without any adverse effects as above. Through these basic studies, it also became fairly apparent that the genomes of all cereals are related and were derived from the same lineage, million of years ago.
Download or read book Plant Genome Analysis written by Peter M. Gresshoff and published by CRC Press. This book was released on 2020-09-10 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Genome Analysis presents outstanding analyses of technologies, as well as explanations of molecular technology as it pertains to agriculture. Advances in genome analysis, including DNA amplification (DAF and RAPD) markers, RFLPs, and microsatellites are reviewed by accomplished scientists, many of whom are the developers of the technique. Articles by patent lawyers experienced in plant biotechnology present the legal viewpoint. Chapters focus on special elements of genome analysis, such as the: use of antisense technology investigation of telomeres production of plant YACs importance of cell cycle genes in plants. Other chapters focus on specialized topics of genome analysis. These include a description of antisense technology in the study of photosynthesis and a comprehensive review of the characterization and isolation of plant telomere, including their use in varietal discrimination. A detailed anaysis of cytoplasmic male sterility in the french bean that focuses on the mitochondrial genome is described. The book provides a chapter on the production of yeast artificial chromosomes (YACs) carrying soybean DNA. Genes of the cell cycle in plants and their importance in developmental processes are presented, as well as detailed chapters on the molecular mapping of trees (apples and pines), and nodulation-related genes in legumes. A comprehensive index and a complete glossary are included.
Download or read book Microarrays for an Integrative Genomics written by Isaac S. Kohane and published by Bradford Books. This book was released on 2003 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to the use of DNA microarrays in functional genomics.
Download or read book Inside the Human Genome written by John C. Avise and published by Oxford University Press. This book was released on 2010-02-12 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humanity's physical design flaws have long been apparent--we get hemorrhoids and impacted wisdom teeth, for instance--but do the imperfections extend down to the level of our genes? Inside the Human Genome is the first book to examine the philosophical question of why, from the perspectives of biochemistry and molecular genetics, flaws exist in the biological world. Distinguished evolutionary geneticist John Avise offers a panoramic yet penetrating exploration of the many gross deficiencies in human DNA--ranging from mutational defects to built-in design faults--while at the same time offering a comprehensive treatment of recent findings about the human genome. The author shows that the overwhelming scientific evidence for genomic imperfection provides a compelling counterargument to intelligent design. He also develops a case that theologians should welcome rather than disavow these discoveries. The evolutionary sciences can help mainstream religions escape the shackles of Intelligent Design, and thereby return religion to its rightful realm--not as the secular interpreter of the biological minutiae of our physical existence, but rather as a respectable philosophical counselor on grander matters of ultimate concern.
Download or read book Microbial Genome Methods written by Kenneth W. Adolph and published by CRC Press. This book was released on 1996-08-28 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to apply powerful molecular biology and genetics techniques to your microbial research with this easy-to-understand, practical guide. Microbial Genome Methods distills complex experimental procedures into fundamental techniques that can be readily adapted to your own research. In addition, this book provides background information specifically relevant to microbial research, as well as descriptions of expected results. The book is divided into two sections. Section one covers eukaryotic microbes, with emphasis on the yeast Saccharomyces cerevisiae. Section two covers prokaryotic microbes, focusing on Escherichia coli, and other important bacteria. These microbes were selected because they are widely studied and understood, but all information can be easily applied to the microbe you are investigating. Chapters are written by nationally and internationally recognized research scientists currently active in this field. Don't miss out on the tremendous boost these research techniques can give your work.
Download or read book Combinatorics of Genome Rearrangements written by Guillaume Fertin and published by MIT Press. This book was released on 2009 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of a rapidly expanding field of combinatorial optimization, mathematically oriented but offering biological explanations when required. From one cell to another, from one individual to another, and from one species to another, the content of DNA molecules is often similar. The organization of these molecules, however, differs dramatically, and the mutations that affect this organization are known as genome rearrangements. Combinatorial methods are used to reconstruct putative rearrangement scenarios in order to explain the evolutionary history of a set of species, often formalizing the evolutionary events that can explain the multiple combinations of observed genomes as combinatorial optimization problems. This book offers the first comprehensive survey of this rapidly expanding application of combinatorial optimization. It can be used as a reference for experienced researchers or as an introductory text for a broader audience. Genome rearrangement problems have proved so interesting from a combinatorial point of view that the field now belongs as much to mathematics as to biology. This book takes a mathematically oriented approach, but provides biological background when necessary. It presents a series of models, beginning with the simplest (which is progressively extended by dropping restrictions), each constructing a genome rearrangement problem. The book also discusses an important generalization of the basic problem known as the median problem, surveys attempts to reconstruct the relationships between genomes with phylogenetic trees, and offers a collection of summaries and appendixes with useful additional information.
Download or read book Comparative Genomics written by Mathieu Blanchette and published by Springer. This book was released on 2018-10-04 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the proceedings of the 16th International Conference on Comparative Genomics, RECOMB-CG 2018, held in Magog-Orford, QC, Canada, in October 2018. The 18 full papers presented were carefully reviewed and selected from 29 submissions. The papers cover topics such as: genome rearrangements; genome sequencing; applied comparative genomics; reconciliation and coalescence; and phylogenetics.
Download or read book Advances in Bioinformatics and Computational Biology written by Marcilio C.P. de Souto and published by Springer. This book was released on 2012-08-10 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 7th Brazilian Symposium on Bioinformatics, BSB 2012, held in Campo Grande, Brazil, in August 2012. The 16 regular papers presented were carefully reviewed and selected for inclusion in this book. It also contains a joint paper from two of the guest speakers. The Brazilian Symposium on Bioinformatics covers all aspects of bioinformatics and computational biology, including sequence analysis; motifs, and pattern matching; biological databases, data management, data integration, and data mining; biomedical text mining; structural, comparative, and functional genomics; personal genomics; protein structure, modeling, and simulation; gene identification, regulation and expression analysis; gene and protein interaction and networks; molecular docking; molecular evolution and phylogenetics; computational systems biology; computational proteomics; statistical analysis of molecular sequences; algorithms for problems in computational biology; applications in molecular biology, biochemistry, genetics, medicine, microbiology and associated subjects.
