Download or read book Genomic and Biochemical Characterisation of the B PR61 Regulatory Subunit Family of Protein Phosphatase 2A written by Ellen Martens and published by Leuven University Press. This book was released on 2004 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is a Ph.D. dissertation. Reversible protein phosphorylation has become widely recognized as the most important reaction for the regulation of protein functioning in eukaryotic cells, being involved in switching cellular activities from one state to another and, in this way, regulating different cellular functions. It is the major mechanism by which cells respond to extracellular signals, such as hormones and growth factors, and control all events at various stages of the cell cycle, as well as the response of the cell to environmental and nutritional stresses. As much as one-third of cellular proteins have been estimated to undergo reversible protein phosphorylation, underlining the importance, and widespread occurrence of this modification. Contents include: General Introduction, Protein Phosphates, Multimetric Structure of PP2A, PP2A as a Kinase Phosphate, Aims of the Work, Materials and Methods, Results, B'/PR61-Interacting Proteins, Discussion."

Download or read book Biochemical Characterization and Validation of the Yeast Saccharomyces Cerevisiae as Model System for the Function of Human Protein Tau written by Tom Vandebroek and published by Leuven University Press. This book was released on 2006-09 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biochemical and Immuno Histochemical Analysis of APP Processing and Amyloid Pathology in Single and Multiple Transgenic Mice as Models for Alzheimer s Disease written by Tom V. Dooren and published by Leuven University Press. This book was released on 2006-09 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protein Phosphatase 1 Binding Motifs written by Paulina Wakula and published by Leuven University Press. This book was released on 2006 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book NIPP1 an Interactor of Protein Phosphatase 1 Displays Endoribonuclease and Transcriptional Repression Activities written by Qiming Jin and published by Leuven University Press. This book was released on 2004 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is a Ph.D. dissertation. This thesis deals with the eukaryotic protein NIPP1 (Nuclear Inhibitor of Protein Phosphate-1), which was initially described by the host laboratory in 1992 and still is the major focus of its research efforts. The first part of the introduction describes our current insights into the structure and function of NIPP1, with the exception of aspects that directly deal with this doctoral project. For reasons of clarity, the data are presented in a logical manner, which implies that they are not necessarily presented according to their order of discovery. In the final sections of the introduction, a brief overview will be given of the state of the art of the `structure and function of ribonucleases' and `transcriptional repression mechanisms,' two topics that directly related to this research project. Contents include: Introduction, The Structure and Function of NIPP1, The Structure and Function of Ribonucleases, Transcriptional Repression in Eukaryotes, Aims and Strategies, Materials and Methods, Results and Discussions, Mapping of the RNA-binding and Endoribonuclease Domain of NIPP1, Screening for Proteins that Interact with the C-Terminal domain of NIPP1."

Download or read book Characterization of the Presenilin 1 Telencephalin Interaction and Implications for Alzheimer s Disease written by Cary Esselens and published by Leuven University Press. This book was released on 2005 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Characterization of the Glypican Receptor Receptor Function written by Bart De Cat and published by Leuven University Press. This book was released on 2004-09 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Regulation of the Antibody Response to Pneumococcal Capsular Polysaccharides written by Axel Jeurissen and published by Leuven University Press. This book was released on 2005 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Ph.D. dissertation. S. pneumoniae is a major causative agent of serious infections. Besides, the emerging resistance of S. pneumoniae to multiple antibiotic drugs is a major concern in the treatment of infections caused by this micro-organism. Therefore it is important to study the molecular mechanisms that meditate the antibody response to caps-PS. The aim of the study is to better understand the regulation and the molecular mechanisms of the immune response to pneumococcal caps-PS. The present study was undertaken to determine the role of the CD40-CD40L interaction in the murine antibody response to pneumococcal caps-PS antigens.

Download or read book Variation in Sodium Regulating Genes in Relation to Blood Pressure and Associated Phenotypes in Caucasians and Chinese written by Jiguang Wang and published by Leuven University Press. This book was released on 2004-09 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Quantification of Regional Myocardial Deformation Normal Characteristics and Clinical Use in Ischaemic Heart Disease written by Lieven Herbots and published by Leuven University Press. This book was released on 2006 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genetic Variation and Environmental Factors in Biological and Arterial Ageing written by Tim Nawrot and published by Leuven University Press. This book was released on 2005 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ageing, the decline in survival and bodily functions, caused by damage to macromolecules and tissues is intrinsically linked to life. Although universal and unavoidable, ageing does not occur in a uniform way. In the general population, it is actually a continuously distributed phenotype, in which genetic as well as environmental factors play an interactive role and explain the large interindividual differences between biological and chronological age. Cardiovascular disorders, which find there origins in deterioration of the structure and function of the large arteries, explain a large part of morbidity and mortality in industrialized societies. In this doctoral dissertation, the focus was on telomere length and arterial stiffness as biomarkers of biological and arterial ageing, respectively. It was investigated to what extent genetic and environmental determinants of oxidative stress and inflammation impact on the ageing process. Contents include: Introduction, Arterial ageing in cardiovascular risk prediction, Genetic and environmental factors in biological and arterial ageing, Telomere length and possible link to X chromosome, Role of smoking, oxidative stress and the -174 G/C interleukin-6 polymorphism in biological and vascular ageing, Environmental factors in arterial ageing, Blood pressure and blood selenium: a cross-sectional and a longitudinal population study, Endothelial function and outdoor temperature, General Discussion, Summary, Short Curriculum Vitae.

Download or read book Cardioselective Nitric Oxide Synthase Gene Transfer to Target Myocardial Ischemia written by Zsolt Szelid and published by Leuven University Press. This book was released on 2005 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Ph.D. dissertation. Introduction: Cardiovascular and myocardial gene transfer, Gene delivery strategies to the cardiovascular system, Gene vector design, Adenovirus-mediated immunity and cardiovascular gene transfer, Myocardial gene transfer to target myocardial ischemia - reperfusion injury; Specific aims; Materials and methods: Construction of recombinant virus, Myocardial transfer and anti-adenoviral immunity, Gene transfer and myocardial ischemia-reperfusion injury, Statistical analysis; Results: Anti-adenoviral immunity and myocardial adenoviral gene transfer, Gene transfer and myocardial ischemia-reperfusion injury; Discussion: Pre-existing anti-adenoviral immunity and adenovirus-mediated myocardial gene transfer, Intramyocardial NOS3 gene transfer and adenovirus-mediated immune responses, Cardioselective NOS3 gene transfer and myocardial protection from reperfusion injury; General conclusions.

Download or read book Role of Nitric Oxide Synthase in the Regulation of Pulmonary Vascular Tone written by Leifu Jiang and published by Leuven University Press. This book was released on 2006-09 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mechanism and Role of Cyclooxygenase 2 Up Regulation by Photodynamic Therapy written by Nico Hendrickx and published by Leuven University Press. This book was released on 2006 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Protein bound Solute P cresol written by Bert Bammens and published by Leuven University Press. This book was released on 2005 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Modulation of CFTR and ENaC Channel Function by Interacting Proteins and Trafficking written by Lishuang Cao and published by Leuven University Press. This book was released on 2005 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Genetic Analysis of Herpesvirus Entry Receptors and Host Susceptibility to Herpes Simplex Virus Infection written by Frank Struyf and published by Leuven University Press. This book was released on 2004-09 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: