Download or read book Between the Lines of Genetic Code written by Leonid Padyukov and published by Elsevier Inc. Chapters. This book was released on 2013-09-28 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid arthritis (RA) is a chronic autoimmune disease with poorly understood etiology. Over the years, many genetic risk factors and some environmental risk factors were discovered to be important for RA. Genetic variants from the HLA-DRB1 locus, the shared epitope alleles, in different populations show a relatively strong and consistent effect on risk of RA. Non-HLA genetic risk factors have only a moderate effect. Gene–gene and gene–environment interactions were suspected to be important with regard to the risk of RA. Indeed, some combinations were demonstrated to be extremely influential. An important feature of RA is the development of autoantibodies, e.g., RF and ACPA, that serve as biomarkers and are used in diagnosing the disease. Interestingly, most of the genetic predisposition for RA observed so far concerns risk of developing the autoantibody positive subset of the disease, that is, the form where antibodies are present. In this chapter, we will review the current knowledge on genetics in RA and introduce multiple examples of interaction.
Download or read book Genetics of Rheumatoid Arthritis written by Hafsah Muhammad Chishti and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Genetics of rheumatoid arthritis'' describes details or minutia of a disease that is highly prevalent across the globe. This book has been prepared based on worldwide research carried out to explore the genetic basis of Rheumatoid Arthritis (RA), a multifactorial and multigenic disease. It uses original experimental work to identify contribution of a candidate gene that causes onset of RA. It is the account of methodologies and results relevant to this specific discipline. The author has tried to put her best academic knowledge and dedicated practical approaches to make the theme of this book understandable for the impending geneticists and Rheumatologists. The book is distinguished from the existing book in the way of narration, even very difficult terms and experiments are described in such a precise way that the researchers and the students would feel ease in reading and practicing. These procedures can easily be selected for developing Standard Operating Procedure (SOPs) for disease gene association studies. The entire text of the book is also justified by providing rational references.
Download or read book Rheumatoid Arthritis and Proteus written by Alan Ebringer and published by Springer Science & Business Media. This book was released on 2011-10-05 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid Arthritis and Proteus explores the idea that Rheumatoid arthritis is caused by a urinary tract infection as a result of Proteus bacteria. Rheumatoid arthritis is a severe, painful and crippling disease affecting millions of people throughout the world, especially women. Genetic studies over the last 30 years have shown that individuals who possess the white cell blood groups HLA-DR1/4 carry a susceptibility sequence and are more likely to develop the disease. This book uses the methods of Sir Karl Popper, the philosopher of science, to present 12 “Popper sequences” which have been identified to indicate that Proteus is the causative agent of Rheumatoid Arthritis. Rheumatoid Arthritis and Proteus proposes that Anti-Proteus therapies should be followed as early as possible to prevent the crippling and irreversible joint deformities that occur in Rheumatoid Arthritis.
Download or read book Genomics in Rheumatic Diseases An Issue of Rheumatic Disease Clinics of North America written by S. Louis Bridges Jr. and published by Elsevier Health Sciences. This book was released on 2017-08-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Rheumatic Disease Clinics focuses on Genetics. Article topics cover: Genetic Influences on Susceptibility and Severity of Rheumatoid Arthritis; HLA-disease associations in rheumatoid arthritis; Autoinflammatory Syndromes as a Model of Monogenic Diseases; Genomic Influences on Hyperuricaemia and Gout; Genetics of Systemic Lupus Erythematosus; Genetics of Ankylosing Spondylitis;Genetics of Scleroderma; Genetics of Osteoarthritis; Genetics of Juvenile Inflammatory Arthritis; Genetic Influences on Treatment Response in Rheumatic Diseases; Integrative approaches/computational biology; Future directions of genetic research in rheumatic diseases; and Population genetics and natural selection in rheumatic disease.
Download or read book The Hereditary Basis of Rheumatic Diseases written by Rikard Holmdahl and published by Springer Science & Business Media. This book was released on 2006-07-02 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared heredity of rheumatic diseases, e.g., RA, lupus and ankylosing spondylitis. The third part of the volume describes tools for analysing genetic complexity, ranging from animal models to new molecular tools. The volume is essential reading for researchers and clinicians from rheumatology, inflammation research, immunology, and cell and molecular biology.
Download or read book Early Rheumatoid Arthritis written by Paul Emery and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue covers the latest developments in the understanding of rheumatoid arthritis at the early stage. Treatments such as with newer biologic agents and conventional disease-modifying antirheumatic drugs are reviewed. Also included are articles on imaging modalities as a means of identifying those in the early stages and monitoring response to treatment.
Download or read book Commentaries on the History and Cure of Diseases written by William Heberden and published by . This book was released on 1816 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oxford Textbook of Rheumatoid Arthritis written by David L. Scott and published by Oxford University Press. This book was released on 2020-09-18 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brand new textbook of rheumatoid arthritis (RA) is an important addition to the Oxford Textbooks in Rheumatology series, and provides a comprehensive overview of both the scientific and clinical aspects of the disease. Divided into eight sections - from the history, diagnosis, and epidemiology of the disease, through the pathogenesis, clinical presentation, and assessment to treatments and management strategies, both drug- and non-drug based - each chapter is written by leading clinicians and scientists in the field to deliver a contemporary view of RA. During the past two decades there have been revolutionary changes in the understanding and management of rheumatoid arthritis, in particular the development of biological treatments. This has had wide-ranging effects on almost all aspects of treatment, from effectiveness and intensity to the nature and the cost. Providing a comprehensive account of the modern ideas about the disease, the Oxford Textbook of Rheumatoid Arthritis is a key new addition to the literature, with each chapter providing a detailed background, key recent advances, and areas of doubt and future developments. Featuring over 170 photographs, radiological images, and clinical charts to aid both diagnosis and illustrate the rationale behind key scientific studies, this new title will prove an indispensable resource for specialist rheumatologists, trainees in rheumatology, and other members of the multi-disciplinary team.
Download or read book Genetics of Rheumatoid Arthritis written by Susanna Laivoranta-Nyman and published by . This book was released on 2003 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rheumatoid Arthritis written by Josef S. Smolen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many advances have occurred in the last 5 years especially in understanding genetic susceptibility factors, the role of immune response in chronic arthritis and the relationship between cellular processes that underlie inflammation and tissue damage. All these are dealt with in depth in the individual contributions. Genetics studies included illustrate how studies of HLA genes and genes controlling the autoantibody repertoire may be involved. Environmental factors are believed to be important and studies both in humans and in experimental models on the role of viral and bacterial agents are covered. The fascinating relationship between microbes, dysregulated immune responses and oncogenes are also examined. Since autoimmunity is the key aspect of the immunological response in rheumatoid arthritis, the role of antigens is re-examined as is the part played by immune T and B cells. New areas of clinical application of basic science is well presented in this book, forexample, in examining how markers of cartilage destruction may become important in monitoring disease activity. A chapter reviewing possible future novel therapies is included.
Download or read book Genetics of Rheumatoid Arthritis Utilizing a Modified Sibling Pair Method to Test for Linkage of HLA to a Disease Susceptibility Locus written by R. Mark Sharp and published by . This book was released on 1984 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Epidemiology of the Rheumatic Diseases written by Alan J. Silman and published by . This book was released on 1993 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This major reference work is the first comprehensive text to review in detail the data currently available on the epidemiology of the main rheumatic and muscoskeletal diseases. The problems of disease definition and criteria are considered with data on the occurrence of these diseases, both prevalence and incidence, and their variation with age, sex, geographical area, ethnic group, and trends over time. The results of epidemiological investigations,looking at both genetic and environmental risk factors, are considered and the impact of specific diseases of survival is also considered. Covering 15 disease areas from inflammatory joint disease and connective tissue disease to degenerative joint disease and non articular conditions, such as low back pain and carpel tunnel syndrome, this is the only text available which offers full coverage of the subject with a truly international perspective.
Download or read book The Hereditary Basis of Rheumatic Diseases written by Rikard Holmdahl and published by Birkhäuser. This book was released on 2009-09-03 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared heredity of rheumatic diseases, e.g., RA, lupus and ankylosing spondylitis. The third part of the volume describes tools for analysing genetic complexity, ranging from animal models to new molecular tools. The volume is essential reading for researchers and clinicians from rheumatology, inflammation research, immunology, and cell and molecular biology.
Download or read book The Molecular and Genetic Basis of Rheumatoid Factor in Rheumatoid Arthritis written by Richard William Ermel and published by . This book was released on 1992 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Musculoskeletal Diseases 2021 2024 written by Juerg Hodler and published by Springer Nature. This book was released on 2021 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on imaging of the musculoskeletal diseases. Over the last few years, there have been considerable advances in this area, driven by clinical as well as technological developments. The authors are all internationally renowned experts in their field. They are also excellent teachers, and provide didactically outstanding chapters. The book is disease-oriented and covers all relevant imaging modalities, with particular emphasis on magnetic resonance imaging. Important aspects of pediatric imaging are also included. IDKD books are completely re-written every four years. As a result, they offer a comprehensive review of the state of the art in imaging. The book is clearly structured with learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers easily navigate through the text. As an IDKD book, it is particularly valuable for general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic knowledge, and for clinicians interested in imaging as it relates to their specialty.
Download or read book Oxford Textbook of Rheumatology written by Philip Conaghan and published by Oxford University Press. This book was released on 2013-10 with total page 1553 pages. Available in PDF, EPUB and Kindle. Book excerpt: A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.
Download or read book IL 1 Inhibition written by Francesca Oliviero and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
