Download or read book Genetics of Asthma and Chronic Obstructive Pulmonary Disease written by Dirkje S. Postma and published by CRC Press. This book was released on 2007 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Responding to the substantial growth that has taken place in the field over the past decade, this reference provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment. With contributions by an esteemed team of international authorities on the topic, this source spans the latest developments in the utilization of microarray techniques, linkage and association studies, mapping strategies, comparative genetics, microarray techniques, proteomics, and pharmacogenomics.

Download or read book Candidate Gene Association Studies of Chronic Obstructive Pulmonary Disease and Asthma written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: COPD and asthma are complex diseases characterized by pulmonary inflammation. The roles of single nucleotide polymorphisms (SNPs) in the inflammatory cytokine IL10, IL10RA, CSF2, CSF3 and IL6 in COPD and SNPs in a Th2-polarizing cytokine thymic stromal lymphopoietin (TSLP) in asthma are not clear. Association studies were performed to explore the genetic contribution of these cytokines to COPD or asthma. Housekeeping genes on airway epithelium were also optimized. In the study of COPD in the Lung Health Study (LHS), no association was found for IL10, IL10RA and CSF2; an increase in the number of CSF3 -1719T alleles was associated with protection against low forced expiratory volume in one second (FEV1), odds ratio (OR) = .73, 95% confidence interval (CI) = .56 - .95, P = .018; three IL6 SNPs were associated with the rate of decline of FEV1 (.023 d"P d".041 in additive models). In the National Emphysema Treatment Trial - Normative Aging Study, IL6_-174G/C and four other highly linked SNPs were associated with COPD (.01 d"P d".04 in additive genetic models). Association between IL6 and rate of FEV1 decline was the most statistically significant observations in all of our studies in LHS, which has examined more than 40 candidate genes. In the study of TSLP association with asthma, the A allele of rs1837253 was associated with protection from asthma, atopic asthma, and airway hyperresponsiveness (AHR), with ORs (95% CI) and corrected P values for each being .79 (.69 - .90) and .0058; .75 (.63 - .88) and .0074; and .76 (.64 - .89) and .0094, respectively. These associations were the most statistically significant observations in our study, which has examined 98 candidate genes. Cyclophilin A was identified as the most suitable normalizer in gene expression studies involving human airway epithelium. In summary, we demonstrate for the first time that IL6 SNPs are associated with rapid decline of FEV1 and COPD; TSLP SNPs are associated with asthma and AHR. These results wil.

Download or read book Respiratory Genetics written by Edwin Silverman and published by CRC Press. This book was released on 2005-09-30 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a recent explosion of knowledge in the field of respiratory genetics. This authoritative text brings together current knowledge in respiratory genetics in a single volume. The book includes a comprehensive introductory section to provide guidance and aid understanding of key basic concepts in respiratory genetics, including statistical methods, sample collection, bioinformatics, and functional genomics. This is followed by a series of disease-specific chapters that review epidemiology, natural history, monogenic determinants, complex disease components, disease management, and likely future developments. Respiratory Genetics is an essential reference for pulmonologists, translational researchers, and clinical geneticists, and the text will also be a useful library reference.

Download or read book Asthma and COPD written by Peter J. Barnes and published by Elsevier. This book was released on 2009-03-19 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations

Download or read book Genetic Determinants of Pulmonary Disease written by Stephen. D. Litwin and published by CRC Press. This book was released on 2020-08-13 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a current and integrated approach to the subject of genetic determinants of pulmonary disease with emphasis on physiologic derangements and genetic mechanisms. It describes the epidemiologic-genetic approach to chronic pulmonary disease.

Download or read book Asthma COPD and Overlap written by Jonathan A. Bernstein and published by CRC Press. This book was released on 2018-03-22 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using illustrative case examples, this book thoroughly reviews similarities and differences between asthma, chronic obstructive pulmonary disease (COPD) and the overlap syndrome. It is important to highlight the distinctions because these commonly encountered conditions in respiratory and primary care share many similarities but have important differences often mistaken for each other. This can have serious implications for treatment, particularly as new treatments are targeted at specific phenotypes of the diseases. This practical guide shows how to distinguish between the diseases on a pathological and clinical basis so that appropriate management and treatment may be pursued.

Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Download or read book The Global Impact of Respiratory Disease written by Darcy D. Marciniuk and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Medical Genetics of Asthma written by Garden Grove Garden Grove Press and published by . This book was released on 2017-04-05 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This article collection reviews the medical genetics of asthma and includes 22 papers by various authors. Topics include: Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population; Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population; Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes; A functional polymorphism in the SPINK5 gene is associated with asthma in a Chinese Han Population; Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population; Analyses of associations between three positionally cloned asthma candidate genes and asthma or asthma-related phenotypes in a Chinese population; A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS); Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene; Association study between vitamin D receptor gene polymorphisms and asthma in the chinese han population: a case-control study; Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease; Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers; Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors; Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1; Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes; Leukotriene B4 receptor locus gene characterisation and association studies in asthma; Vitamin D binding protein variants associate with asthma susceptibility in the Chinese han population; Investigating highly replicated asthma genes as candidate genes for allergic rhinitis; Association of CD14 -260 (-159) C>T and asthma: a systematic review and meta-analysis; The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study; Genome-wide association study identifies PERLD1 as asthma candidate gene; Large scale genotyping study for asthma in the Japanese population; ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. Proceeds from the sale of this book go to the support of an elderly disabled person.

Download or read book Bronchial Vascular Remodeling in Asthma and COPD written by Aili Lazaar and published by CRC Press. This book was released on 2006-08-04 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Responding to the growth of research in the field over the past decade, this book brings together leading investigators with expertise in pulmonology, pathology, and developmental biology to clarify the mechanisms that regulate the development of bronchial vascular remodeling in asthma and COPD, as well as explore the pathophysiological processes t

Download or read book Ferri s Clinical Advisor 2020 E Book written by Fred F. Ferri and published by Elsevier Health Sciences. This book was released on 2019-06-01 with total page 2136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significantly updated with the latest developments in diagnosis and treatment recommendations, Ferri’s Clinical Advisor 2020 features the popular "5 books in 1" format to organize vast amounts of information in a clinically relevant, user-friendly manner. This efficient, intuitive format provides quick access to answers on 1,000 common medical conditions, including diseases and disorders, differential diagnoses, and laboratory tests – all reviewed by experts in key clinical fields. Updated algorithms, along with hundreds of new figures, tables, and boxes, ensure that you stay current with today’s medical practice. Contains significant updates throughout, covering all aspects of current diagnosis and treatment. Features 27 all-new topics including chronic traumatic encephalopathy, medical marijuana, acute respiratory failure, gallbladder carcinoma, shift work disorder, radial tunnel syndrome, fertility preservation in women, fallopian tube cancer, primary chest wall cancer, large-bowel obstruction, inguinal hernia, and bundle branch block, among others. Includes a new appendix covering Physician Quality Reporting System (PQRS) Measures. Provides current ICD-10 insurance billing codes to help expedite insurance reimbursements. Patient Teaching Guides for many of the diseases and disorders are included, most available in both English and Spanish versions, which can be downloaded and printed for patients.

Download or read book Bronchial Asthma written by Denis Leigh and published by Elsevier. This book was released on 2016-10-27 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bronchial Asthma: A Genetic, Population and Psychiatric Study presents the main theories of the cause of asthma which states that attacks occurred as a result of pathological changes in the lungs, heart, or large vessels. It discusses that spasms and paralysis of the bronchi were produced by nervous or humoral changes, or from bronchial exudation. Organized into 15 chapters, this book starts with an overview of the relationships between bronchial asthma and several conditions commonly regarded as allergic in nature, including hay fever, eczema, vasomotor rhinitis, urticarial, gastro-intestinal allergy, and psoriasis. This text then discusses the Weinberg genealogical proband method. Other chapters explore the inherited susceptibility of the bronchial tree to dysfunction, be it inflammation, as with bronchitis, or spasm, as with asthma. The final chapter deals with the inquiry using the Weinberg genealogical proband technique into the genetics of bronchial asthma. This book is a valuable resource for physicians, dermatologists, and allergists.

Download or read book Pharmacology and Therapeutics of Asthma and COPD written by Clive P. Page and published by Springer Science & Business Media. This book was released on 2004-01-07 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the book is to provide an in-depth review of our current understanding of the pathogenesis of both asthma and COPD. This volume also discusses the promising new options for pharmacological intervention of these diseases. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of lung biology.

Download or read book Asthma and COPD Overlap An Update An Issue of Immunology and Allergy Clinics of North America E Book written by Nicola A. Hanania and published by Elsevier Health Sciences. This book was released on 2022-08-17 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Download or read book Exploring the Role of Gene environment Interactions in Asthma written by Minal Caliskan and published by . This book was released on 2013 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human rhinovirus (HRV) is the most frequent causative pathogen of the common cold and is also involved in the inception and morbidity of several upper and lower respiratory illnesses including bronchiolitis in infancy, childhood pneumonia, and acute exacerbations of chronic respiratory diseases such as asthma, chronic obstructive lung disease, and cystic fibrosis. In this dissertation, I aimed to uncover the genetic and gene expression contributions to inter-individual variation in response to human rhinovirus infection (HRV) in relation to asthma and lung function phenotypes. In Chapter 2, I explored the suitability of lymphoblastoid cell lines (LCLs) for functional genomics studies. I found evidence suggesting that LCLs may be a faithful model for expression quantitative trait loci (eQTL) mapping studies but not for studies of perturbations that affect immune and stress response. In Chapter 3, I studied the main and interactive effects of the genotype at the 17q21 asthma susceptibility locus and HRV wheezing illnesses in early life on inception of asthma in children. I found that variation at the 17q21 locus is associated with the risk and number of HRV wheezing illnesses in the first three years of life. I also showed that 17q21 locus is associated with asthma only in children who had had HRV wheezing illness in early life, suggesting an interaction between a common genetic risk factor (17q21 genotype) and a common environmental risk factor (HRV wheezing illness) with respect to childhood-onset asthma. In Chapter 4, I integrated genome-wide gene expression and genotype data in uninfected and HRV-infected peripheral blood mononuclear cells (PBMCs). I identified local genetic variation that affects gene expression in uninfected and HRV-infected PBMCs. Additionally, I discovered genotype x HRV interactions that influence the expression levels of 32 genes, and showed that HRV-interacting regulatory variations are promising QTLs for pulmonary function phenotypes.

Download or read book Genomic Approach to Asthma written by Xiangdong Wang and published by Springer. This book was released on 2018-06-12 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the series, Translational Bioinformatics, provides an up-to-date overview of genomic approaches to asthma. By applying unbiased “-omics” combined with disease-focused and hypothesis-driven approaches, it enhances readers’ understanding of the asthma endotype. Furthermore, it elucidates how progress in -omics research, such as “genomic,” “transcriptomic,” “protomic,” and “metabolomic,” is applied in asthma, and reports on the related series of important breakthroughs in asthma development, classification, prevention and drug sensitivity. Also covering systems biology knowledge and methodologies, computational models and biostatistical methods to analyze big data, this book provides a valuable resource for scientists and researchers in the field of asthma and respiratory diseases.

Download or read book The Genetics of Asthma written by Stephen B. Liggett and published by Courier Corporation. This book was released on 1996-08-23 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-date resource offers a comprehensive overview of the genetic bases of asthma - examining key pathways, animal models, molecular and genetic techniques, and human genetic studies and furnishing the latest results on genetic analyses involving atopy, human immunoglobulin E (IgE), bronchial hyperresponsiveness, and asthma. Discussing fundamental issues essential in the development of asthma, The Genetics of Asthma describes basic mechanisms that are altered by genetic factors...provides state-of-the-art concepts on the molecular basis of asthma...presents new insights based on traditional animal models and genetically altered mice...explains techniques for conducting genetic studies and statistical approaches for genetic analysis...supplies a critical assessment of issues associated with phenotyping...gives results of human studies on the genetics of asthma...and much more. With over 1900 bibliographic citations and more than 100 explanatory tables, drawings, and photographs, The Genetics of Asthma is an ideal reference for pulmonologists, clinical immunologists, and allergists, physiologists, geneticists, lung biologists, epidemiologists, biochemists, molecular biologists, internists, pediatricians, and graduate and medical school students in these disciplines.