Download or read book Genetics of Asthma and Atopy written by I. P. Hall and published by S. Karger AG (Switzerland). This book was released on 1996 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allergic disease is caused by exposure of genetically predisposed individuals to sensitizing agents. Presenting current reviews on the genetics of asthma and atopy, this volume aims to increase the understanding of the mechanisms underlying this predisposition. It includes general reviews on the role of genetic factors as well as articles specifically dealing with candidate genes or candidate loci likely to be important in the etiology of allergic disease. Other chapters deal with the genetics of airway responsiveness in animal models and work examining the linkage between HLA genotypes and allergic disease. Special attention is given to the role of genes on 11q (including the high affinity IgE receptor) in the development of allergic disease and the contribution of genes on 5q (including TH2 cytokine genes and the beta2-adrenoceptor gene) to the asthma phenotype. A compilation of exciting up-to-date information, this book is ideal for clinicians and basic scientists wishing to keep track of the latest findings in this challenging and fast-moving field.

Download or read book Finding a Path to Safety in Food Allergy written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-05-27 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 20 years, public concerns have grown in response to the apparent rising prevalence of food allergy and related atopic conditions, such as eczema. Although evidence on the true prevalence of food allergy is complicated by insufficient or inconsistent data and studies with variable methodologies, many health care experts who care for patients agree that a real increase in food allergy has occurred and that it is unlikely to be due simply to an increase in awareness and better tools for diagnosis. Many stakeholders are concerned about these increases, including the general public, policy makers, regulatory agencies, the food industry, scientists, clinicians, and especially families of children and young people suffering from food allergy. At the present time, however, despite a mounting body of data on the prevalence, health consequences, and associated costs of food allergy, this chronic disease has not garnered the level of societal attention that it warrants. Moreover, for patients and families at risk, recommendations and guidelines have not been clear about preventing exposure or the onset of reactions or for managing this disease. Finding a Path to Safety in Food Allergy examines critical issues related to food allergy, including the prevalence and severity of food allergy and its impact on affected individuals, families, and communities; and current understanding of food allergy as a disease, and in diagnostics, treatments, prevention, and public policy. This report seeks to: clarify the nature of the disease, its causes, and its current management; highlight gaps in knowledge; encourage the implementation of management tools at many levels and among many stakeholders; and delineate a roadmap to safety for those who have, or are at risk of developing, food allergy, as well as for others in society who are responsible for public health.

Download or read book Allergy and Allergic Diseases written by A. Barry Kay and published by Wiley-Blackwell. This book was released on 1997-07-14 with total page 1872 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive and up-to-date allergy textbook in the world. Over 100 chapters written by world leading authorities covering virtually every aspect of basic and clinical allergy fully illustrated throughout with numerous overview diagrams and many colour illustrations. Authors contributing are from UK, Europe, North America and Australia.

Download or read book Severe Asthma written by Kian Fan Chung and published by European Respiratory Society. This book was released on 2019-06-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.

Download or read book Prevention of Allergy and Allergic Asthma written by S. G. O. Johansson and published by Karger Medical and Scientific Publishers. This book was released on 2004-01-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation In the western world, the prevalence of allergy and asthma has increased two- to threefold over the last 40 years and has reached epidemic proportions. This book represents the first complete document containing recommendations on the prevention of allergy and allergic asthma based on the current understanding of the immunological mechanisms of allergic reactions. Prevention of Allergy and Allergic Asthma was a collaborative project between the WAO (World Allergy Organization) and the WHO, launched in 1999. Following two interim reports, this monograph is the final report of the group of international experts involved in the project, ranging from basic immunologists to clinicians. Both theoretical and practical aspects are discussed, and constructive advice is given. Through its network of more than 70 member societies, the WAO will now promote the concept of prevention of allergies and allergic asthma worldwide to benefit patients prone to become allergic, to prevent the worsening of existing allergic diseases, and to reduce their high cost to society. This publication is recommended to specialists in allergy, pediatrics, pneumology and dermatology as well as to general practitioners, health care professionals, journalists, politicians and patients. Only by increasing the knowledge about allergic diseases throughout society can the right steps be taken for their effective prevention.

Download or read book The Hereditary Basis of Allergic Diseases written by Stephen T. Holgate and published by Springer Science & Business Media. This book was released on 2002-07-01 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allergic diseases are complex and involve a range of environmental factors interacting with a susceptible genotype. The familial clustering of diseases, such as asthma and hay fever, has been recognised for over two centuries, but identification of the genetic basis to this had to await the molecular biological revolution. Estimates of the contribution that genetic factors make to asthma susceptibility range from 35% to 70%. For the majority of allergic diseases, segregation analysis has not identified a consistent Mendelian pattern of inheritance, which, when combined with multiple phenotypes and environmental interactions, has made identifying candidate genes especially difficult and, at times, controversial. Part of the difficulty has been lack of agreement over phenotype definitions, reduced power of studies to predict linkage and association, and, importantly, lack of true heterogeneity between populations. Despite these difficulties, the last decade has witnessed enormous progress in this field.

Download or read book Janeway s Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Download or read book Epigenetics in Allergy and Autoimmunity written by Christopher Chang and published by Springer Nature. This book was released on 2020-05-22 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Download or read book Pediatric Allergy Asthma and Immunology written by Arnaldo Cantani and published by Springer Science & Business Media. This book was released on 2008-01-23 with total page 1634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Easy to understand and easy to use, this essential book reflects the rapid progress in one of the most intriguing fields of medicine. It offers state-of-the-art information on basic immunology, fetal-neonatal immunology, and many more fascinating areas.

Download or read book Heterogeneity in Asthma written by Allan R. Brasier and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention. ​

Download or read book Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease written by Ronald Ross Watson and published by Academic Press. This book was released on 2012-10-22 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Food as Dietary Interventions for Liver and Gastrointestinal Disease provides valuable insights for those seeking nutritional treatment options for those suffering from liver and/or related gastrointestinal disease including Crohn’s, allergies, and colitis among others. Information is presented on a variety of foods including herbs, fruits, soy and olive oil. This book serves as a valuable resource for researchers in nutrition, nephrology, and gastroenterology. Addresses the most positive results from dietary interventions using bioactive foods to impact diseases of the liver and gastrointestinal system, including reduction of inflammation, improved function, and nutritional efficiency Presents a wide range of liver and gastrointestinal diseases and provides important information for additional research Associated information can be used to understand other diseases, which share common etiological pathways

Download or read book Practical Insights into Atopic Dermatitis written by Kwang Hoon Lee and published by Springer Nature. This book was released on 2021-04-30 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive, practical guide to the latest developments in the understanding and management of atopic dermatitis. Detailed information is provided on age-specific clinical symptoms, features, and diagnostic methods. Current theories on the pathogenesis of atopic dermatitis are closely examined, with attention to the roles played by genetic, allergic, immunologic, and skin barrier dysfunctions. In the second half of the book, the scientific background to and the practical use of the full range of treatment methods are described, covering topical agents, systemic agents, phototherapy, allergen-specific immunotherapy, and the most recently developed biologics and small molecules. This textbook will be an excellent guide to diagnosis and treatment for not only dermatologists but also practitioners in allergy and general medicine, including pediatricians, allergists, and primary care physicians. In addition, it will be of value for all scientists interested in developing new drugs for atopic dermatitis.

Download or read book Advances in Asthma written by Akihito Yokoyama and published by Springer. This book was released on 2018-12-18 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides discussions on bronchial asthma from a clinical perspective, focusing on the recent studies on its pathophysiology, diagnosis and treatment. It also explores the lastest findings regarding the phenotypes and endotypes of asthmatic patients, making it of particular interest to those involved with non-eosinophilic asthma and eosinophilic asthma. Further, it discusses the importance of ILC 2 in eosinophilic asthma, and the accumulated results from the forced oscilliation technique and periostin that are actively practiced in Japan. As some aspects of diagnosis and treatment are different in Western and Asian countries, it is important that the data is disseminated around the globe. The clinical questions addressed by the authors are critical and thought provoking, while the questions raised by the editors are instructive, informative and provide new perspectives on unresolved issues. This book appeals to wide readership from beginning learners to physicians in clinical practice and scholars engaging in basic research.

Download or read book Harper s Textbook of Pediatric Dermatology 2 Volume Set written by Peter H. Hoeger and published by John Wiley & Sons. This book was released on 2019-12-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A consummate classic with a fresh approach to pediatric dermatology Children ́s skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment. This fourth edition of the Harper classic provides state-of-the-art information on all aspects of skin disease in children. It covers the diagnosis and treatment of all conditions - both common and rare - with a consistently evidence-based approach. Existing content has been refreshed and fully updated to reflect emerging thinking and to incorporate the latest in research and clinical data - especially at the genetic level. This new fourth edition includes: Greater focus on the genetics behind skin disease, including new genes/genodermatoses, progress in genetic analysis, and stem cell transplants Increased coverage of lasers and other technologies used to treat skin disease More summary tables, learning points, tables of differential diagnosis, and clinical algorithms for diagnosis and management Additional online features, including patient information links and multiple choice questions Harper's Textbook of Pediatric Dermatology delivers crucial clinical insights and up-to-date research information that spans the breadth of the field. As the most comprehensive reference book on this subject available, this revised fourth edition will support and guide the daily practice of both dermatologists and pediatricians across the world.

Download or read book Genetics in Asthma and Allergy written by Deborah A. Meyers and published by W B Saunders Company. This book was released on 2005 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant progress has been made in understanding the pathogenesis of many allergic disorders. In spite of the tremendous complexity, dramatic progress in the past few years has led to an improved understanding of the genetic contributions to allergic and immunoregulatory disorders. This issue is divided into four parts: reviews of positional cloned genes from family studies, gene-environment interactions, gene-by-gene interactions, and future directions.

Download or read book The Parallel March of Asthma and Allergy in Childhood A Multi Perspective Approach written by Luis Garcia-Marcos and published by Frontiers Media SA. This book was released on 2018-07-24 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has not been yet clarified whether allergy and asthma are part of the same condition or they follow a parallel path. This Research Topic aims to try and put some light in this parallel march going through crucial topics: from prenatal events to later risk factors such as obesity; and from basic immunology to immunotherapy, both subcutaneous and sublingual. We hope the readers can infer their own conclusions as what is first: egg or chicken.

Download or read book The Washington Manual of Allergy Asthma and Immunology Subspecialty Consult written by Shirley Joo and published by Lippincott Williams & Wilkins. This book was released on 2012-07-12 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: ­When you need a quick consult, turn to The Washington ManualTM Subspecialty Consult Series Prepared by specialty residents, fellows and staff in the Department of Medicine at Washington University School of Medicine, and reviewed by attending physicians in each field—each volume in this renowned series delivers the on-the-spot help you need to provide quality patient management. Right from the initial chapter, you’ll learn how to take a patient history, how to interpret exam findings, what tests to order, how to complete the workup, and how to formulate an effective management plan. The Second Edition of this dynamic quick reference continues to provide the practical, stepwise guidance you’ve come to trust from The Washington ManualTM and has been fully updated to include the most current diagnostic tests, workup tips, drugs and other therapeutic interventions available. · Coverage of inpatient and outpatient approaches features the same front-line practicality as The Washington ManualTM of Medical Therapeutics · Symptom- and disease-oriented sections address both chronic and acute problems to prepare you for any scenario · Essential clinical information on commonly encountered problems including diagnosis and management of drug allergy, anaphylaxis, asthma, immunotherapy, and immunodeficiency at your fingertips · Useful appendixes provide a hands-on review of drugs commonly used in the treatment of allergy and asthma, as well as lab values for selected immunologic tests and a sample schedule for perennial aqueous therapy · Key points to remember in each chapter deliver vital diagnostic and treatment information NEW to the Second Edition... · Updated content reflects the latest clinical advances and practice standards · New formatting follows consistent subheadings to make key facts easier to find · New chapters detail the latest diagnostic criteria, testing, and treatment options Don’t miss the other titles in this series... Cardiology Endocrinology General Internal Medicine Hematology and Oncology Infectious Diseases Nephrology Pulmonary Medicine Rheumatology The Washington ManualTM is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by LWW under license from Washington University.