Download or read book Genetics of Antibiotic producing Microorganisms written by Giuseppe Sermonti and published by . This book was released on 1969 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Streptomyces in Nature and Medicine written by David A. Hopwood and published by Oxford University Press. This book was released on 2007-02-03 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an insiders account of 50 years of genetic studies of the soil-inhabiting microbes that produce most of the antibiotics used to treat infections, as well as anti-cancer, anti-parasitic and immunosuppressant drugs. The book begins by describing how these microbes the actinomycetes were discovered in the latter part of the nineteenth century, but remained a Cinderella group until, in the 1940s, they shot to prominence with the discovery of streptomycin, the first effective treatment for tuberculosis and only the second antibiotic, after penicillin, to become a medical marvel. There followed a massive effort over several decades to find further treatments for infectious diseases and cancer, tempered by the rise of antibiotic resistance consequent on antibiotic misuse and over-use. The book goes on to describe the discovery of gene exchange in the actinomycetes in the context of the rise of microbial genetics in the mid-20th century, leading to determination of the complete DNA sequence of a model member of the group at the turn of the millennium. There follow chapters in which the intricate molecular machinery that adapts the organisms metabolism and development to life in the soil, including antibiotic production, is illuminated by the DNA blueprint. Then come an up-to-the minute account of the use of genetic engineering to make novel, hybrid, antibiotics, and a topical description of techniques to learn the roles of the thousands of genes in a genome sequence, throwing a powerful light on the biology of the organisms and their harnessing for increasing antibiotic productivity. In the final chapter we return to the mycobacteria that cause tuberculosis and leprosy, the first actinomycetes to be discovered, and how methodology, in part derived from the study of the streptomycetes, is being applied to understand and control these still deadly pathogens.
Download or read book The Search for Bioactive Compounds from Microorganisms written by Satoshi Omura and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biologically active compounds isolated from microorganisms continue to be vital to the development of new drugs and agricultural chemicals. This book was prepared by current and past members of the laboratory of Dr. Satoshi Omura of the Kitasato Institute in Japan. Dr. Omura and his colleagues have discovered and studied a number of important antibiotics, and in their work they have pioneered new methods for screening microbes for interesting and important compounds. This book presents strategies and methods for identifying novel molecules with several types of biological activity. In addition, the book discusses the identification of microbial compounds of agrochemical importance, presents information on chemical screening methods, and concludes with chapters on microbial strain selection, fermentation technology, and genetic engineering of antibiotic-producing microorganisms. This book will be of great interest to scientists working in the very active and competitive fields of antibiotic and agrochemical discovery.
Download or read book Genetics and Biochemistry of Antibiotic Production written by Colin Stuttard and published by Butterworth-Heinemann. This book was released on 2014-06-28 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: * Emphasizes the molecular genetics of antibiotic production * Provides the latest information on the organization of genes encoding the biosynthetic pathway * Explores the mechanisms governing their expression and regulation * Examines the role of resistance genes in protecting organisms from their own lethal products Genetics and Biochemistry of Antibiotic Production brings together the most up-to-date information on the genetic and biochemical mechanisms involved in antibiotic production. A collection of internationally recognized authors provide the latest information on the organization, function and regulation of genes responsible for antibiotic synthesis in a range of bacteria. This unique book groups antibiotics according to their biosynthetic affiliation, providing a background into evolutionary relationships while raising intriguing questions about the raison d'etre of antibiotics in nature.
Download or read book Evolution of Genetic Mechanisms of Antibiotic Resistance written by Silvia Buroni and published by Frontiers Media SA. This book was released on 2019-12-05 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first introduction of antibiotics into clinical practice, microbial drug resistance has emerged as a major obstacle in the treatment of infections. Recently, the combination of emergence of a complex variety of multidrug resistant strains and the dearth of newly discovered molecules to effectively target and eliminate these strains, has made antibiotic resistance one of the major public health problems of this century. Although different strategies can be adopted to contain the emergence and spread of antibiotic resistance, including (i) antimicrobial stewardship, (ii) infection control, and (iii) tighter control over the use of antibiotics in agriculture and breeding, a better understanding of the dynamics that lead to the evolution of antibiotic resistance remains essential for the development of more efficient strategies to combat this phenomenon. The recent developments in genomics have greatly contributed to expand our knowledge on the mechanisms of microbial resistance, and of the processes by which they emerge, develop and spread. Different approaches and expertise can be used to accelerate advances in this area, ranging from clinical studies on the evolution of resistance in vivo, to theoretical modeling and the study of evolution in the laboratory.
Download or read book Genetics of Streptomyces and Other Antibiotic producing Microorganisms written by New York Academy of Sciences and published by . This book was released on 1959 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics of Streptomyces and Other Antibiotic producing Microorganisms written by Waclaw Szybalski and published by . This book was released on 1959 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics of Acquired Antimicrobial Resistance in Animal and Zoonotic Pathogens written by Axel Cloeckaert and published by Frontiers Media SA. This book was released on 2018-01-26 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Development and spread of antimicrobial resistance is the result of an evolutionary process by which microorganisms adapt to antibiotics through several mechanisms including alteration of drug target by mutation and horizontal transfer of resistance genes. The concomitant occurrence of independent antimicrobial resistance mechanisms is a serious threat to human health and has appeared in several emerging epidemic clones over the past decade in humans and also in animals. The increasing prevalence of antimicrobial drug resistance among animal and zoonotic foodborne pathogens is of particular concern for public health. In this Ebook, we gathered a collection of articles which deal with the most important aspects of the genetics of acquired antimicrobial resistance extending from medically-important resistance, emerging epidemic resistant clones, main mobile genetic elements spreading resistance, resistomes, dissemination between animals and humans, to the “One Health” concept.
Download or read book Antibiotic Producing Stetomyces written by Stephen W. Queener and published by Elsevier. This book was released on 1986-03-28 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bacteria: Volume IX: Antibiotic-Producing Streptomyces explores how Streptomyces, including actinomycetes, produce a variety of antibiotics such as aminocyclitols, ansamycins, macrolides, and tetracyclines. Topics covered range from physiology and fermentation to genetic recombination and chromosome mapping in Streptomyces, biomodification of antibiotics by Streptomyces, and biosynthesis of tylosin and erythromycin. The genome structure and evolution of Streptomyces are also discussed. This volume is comprised of 10 chapters and begins with a discussion on the taxonomy of Streptomyces based on morphology, physiological characteristics, the composition of cell constituents such as cell walls, and the presence of characteristic lipids, sugars, and quinones. The discussion then turns to the intraspecific and interspecific recombination in Streptomyces; pathways of DNA repair and mutagenesis in Streptomyces fradiae; strategies for isolation of improved Streptomyces mutants for antibiotic production; and derivation of DNA cloning vectors from Streptomyces phages. The biology and use of Streptomyces plasmids as cloning vectors are also described. The final chapter is devoted to major structural classes of antibiotics produced by Streptomyces, including anthracyclines and other quinones, ß-lactams, macrolides, nucleosides, peptides, polyenes, polyether antibiotics, and tetracyclines. This book will be of value to microbiologists, bacteriologists, biochemists, and biologists.
Download or read book Genetics of Streptomyces and Other Antibiotic producing Microorganisms written by and published by . This book was released on 1959 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Role and prevalence of antibiosis and the related resistance genes in the environment written by Sylvie Nazaret and published by Frontiers Media SA. This book was released on 2015-05-13 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: It becomes increasingly clear that the basis of antibiotic resistance problem among bacterial pathogens is not confined to the borders of clinical microbiology but has broader ecological and evolutionary associations. This Research Topic “Role and prevalence of antibiosis and the related resistance genes in the environment” in Frontiers in Microbiology, section Antimicrobials, Resistance and Chemotherapy, presents the examples of occurrence and diversity of antibiotic resistance genes in the wide range of environments, from the grasslands of the Colombian Andes, to the dairy farms and small animal veterinary hospitals in the United Stated, and to the various environments of Continental Europe and Indochina. Besides, various genetic mechanisms and selection/co-selection factors contributing to the dissemination and maintenance of antibiotic resistance genes are presented. The topic is finalized by the mathematical modeling approach to access the probability of rare horizontal gene transfer events in bacterial populations
Download or read book The Genetics of Antibiotic Production and the Role of Antibiotics in Biological Control of Erwinia Amylovora by Erwinia Herbicola written by Sandra Ann Ingela Wright and published by . This book was released on 1997 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Effects on Human Health of Subtherapeutic Use of Antimicrobials in Animal Feeds written by National Research Council and published by National Academies Press. This book was released on 1980-02-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics of Streptomyces and Other Antibiotic producing Microorganisms written by and published by . This book was released on 1959 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Breeding and Genetics of Applied Microorganisms written by Kenji Sakaguchi and published by Elsevier. This book was released on 2013-10-22 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Breeding and Genetics of Applied Microorganisms provides expert reviews on the developments in the field of applied microbiology in Japan. The book presents areas where further progress in applied microbiology is possible. Articles on these possibilities such as the use of recombinant DNA techniques to link fragments of DNA from unrelated organisms; creation of new strains of microorganisms to control pollution; construction of a ""biological battery"" using a photosynthetic system; and breeding of plant species tolerant to various plant diseases are explored in detail. Microbiologists, biologists, geneticists, biochemists, pharmacologists, and researchers will find the book insightful.
Download or read book Genetics of Streptomyces and other antibiotic producing microorganisms written by Waclaw Szybalski and published by . This book was released on 1959 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics of Industrial Microorganisms written by O. K. Sebek and published by ASM Press. This book was released on 1979 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
