Download or read book Genetic Control of Malaria and Dengue written by Zach N. Adelman and published by Academic Press. This book was released on 2015-10-15 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission Provides a summary of the concepts of both population suppression and population replacement Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies
Download or read book Global Health Impacts of Vector Borne Diseases written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-10-21 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathogens transmitted among humans, animals, or plants by insects and arthropod vectors have been responsible for significant morbidity and mortality throughout recorded history. Such vector-borne diseases â€" including malaria, dengue, yellow fever, and plague â€" together accounted for more human disease and death in the 17th through early 20th centuries than all other causes combined. Over the past three decades, previously controlled vector-borne diseases have resurged or reemerged in new geographic locations, and several newly identified pathogens and vectors have triggered disease outbreaks in plants and animals, including humans. Domestic and international capabilities to detect, identify, and effectively respond to vector-borne diseases are limited. Few vaccines have been developed against vector-borne pathogens. At the same time, drug resistance has developed in vector-borne pathogens while their vectors are increasingly resistant to insecticide controls. Furthermore, the ranks of scientists trained to conduct research in key fields including medical entomology, vector ecology, and tropical medicine have dwindled, threatening prospects for addressing vector-borne diseases now and in the future. In June 2007, as these circumstances became alarmingly apparent, the Forum on Microbial Threats hosted a workshop to explore the dynamic relationships among host, pathogen(s), vector(s), and ecosystems that characterize vector-borne diseases. Revisiting this topic in September 2014, the Forum organized a workshop to examine trends and patterns in the incidence and prevalence of vector-borne diseases in an increasingly interconnected and ecologically disturbed world, as well as recent developments to meet these dynamic threats. Participants examined the emergence and global movement of vector-borne diseases, research priorities for understanding their biology and ecology, and global preparedness for and progress toward their prevention, control, and mitigation. This report summarizes the presentations and discussions from the workshop.
Download or read book Gene Drives on the Horizon written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-08-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration. Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.
Download or read book Mosquito Gene Drives and the Malaria Eradication Agenda written by Rebeca Carballar-Lejarazú and published by CRC Press. This book was released on 2023-02-24 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is one of most serious infectious diseases today and has afflicted humankind for thousands of years. A significant number of people still die from this mosquito-borne disease, despite the use of various malaria prevention and control methods over hundreds of years and more than a century of coordinated global control efforts using modern tools, together with research into and development of new strategies for prevention, diagnosis, and disease treatment. Genetic approaches that focus on the vector mosquitoes to prevent malaria parasite transmission have been considered for many decades. Genetic control strategies received a significant boost with the successful development of gene drive systems, genetic methods for rapidly spreading beneficial genes and phenotypes through mosquito populations. This book reviews some concepts of gene drive systems and describes pioneering applications to control mosquito populations and prevent parasite transmission.
Download or read book Genetically Modified Mosquitoes for Malaria Control written by Christophe Boete and published by CRC Press. This book was released on 2006-07-15 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a century of research and attempts to control one of the deadliest foes of mankind, the malaria situation remains a major public health problem. Obviously biological explanations (the resistance of parasites and mosquitoes against available drugs and insecticides respectively) are often given, but they remain partial and incomplete. Indeed,
Download or read book Genetically Modified and Other Innovative Vector Control Technologies written by Brij Kishore Tyagi and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.
Download or read book Gene Drives at Tipping Points written by Arnim von Gleich and published by Springer Nature. This book was released on 2020-01-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book reports on a pilot project aiming at collecting information on the socio-ecological risks that could arise in the event of an uncontrolled spread of genetically engineered organisms into the environment. The researchers will, for instance, be taking a closer look at genetically engineered oilseed rape, genetically engineered olive flies as well as plants and animals with so-called gene drives. The book mainly adresses researchers.
Download or read book Mosquitoes written by Norbert Becker and published by Springer Nature. This book was released on 2020-09-30 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Mosquitoes – Identification, Ecology and Control” presents a wealth of information on the bionomics, systematics, ecology, research techniques and control of both nuisance and disease vector mosquitoes. It provides practical guidance and important information in an easily readable style, suitable for anyone involved with, or interested in mosquitoes and their management. In this new edition, 102 European species including the most important invasive species and more than 100 globally important vector and nuisance species are described. Most of them, including all European species, are presented in the fully illustrated identification keys, followed by a detailed description of the morphology, biology, distribution and medical importance of each species, including over 700 detailed drawings. “Mosquitoes – Identification, Ecology and Control” includes: · systematics and biology · medical significance · research techniques · morphological characteristics used for identification of larvae and adults · illustrated identification keys for larval and adult mosquito genera · morphology, ecology, and distribution of the species identified in the keys · biological, genetic, physical and chemical control of mosquitoes “Mosquitoes – Identification, Ecology and Control” is a valuable tool for vector ecologists, medical entomologists, students and all those involved with mosquito systematics, biology, ecology, and control world-wide. Society as a whole benefit from the implementation of carefully designed and sustainable programs for the management of mosquitoes, and the diseases they transmit. The third edition of this successful publication has been comprehensively updated and expanded, to provide the foundation of a more enlightened and informed approach to mosquito management.
Download or read book Vector Borne Diseases written by Institute of Medicine and published by National Academies Press. This book was released on 2008-03-18 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vector-borne infectious diseases, such as malaria, dengue fever, yellow fever, and plague, cause a significant fraction of the global infectious disease burden; indeed, nearly half of the world's population is infected with at least one type of vector-borne pathogen (CIESIN, 2007; WHO, 2004a). Vector-borne plant and animal diseases, including several newly recognized pathogens, reduce agricultural productivity and disrupt ecosystems throughout the world. These diseases profoundly restrict socioeconomic status and development in countries with the highest rates of infection, many of which are located in the tropics and subtropics. Although this workshop summary provides an account of the individual presentations, it also reflects an important aspect of the Forum philosophy. The workshop functions as a dialogue among representatives from different sectors and allows them to present their beliefs about which areas may merit further attention. These proceedings summarize only the statements of participants in the workshop and are not intended to be an exhaustive exploration of the subject matter or a representation of consensus evaluation. Vector-Borne Diseases : Understanding the Environmental, Human Health, and Ecological Connections, Workshop Summary (Forum on Microbial Threats) summarizes this workshop.
Download or read book Malaria written by Institute of Medicine and published by National Academies Press. This book was released on 1991-02-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malaria is making a dramatic comeback in the world. The disease is the foremost health challenge in Africa south of the Sahara, and people traveling to malarious areas are at increased risk of malaria-related sickness and death. This book examines the prospects for bringing malaria under control, with specific recommendations for U.S. policy, directions for research and program funding, and appropriate roles for federal and international agencies and the medical and public health communities. The volume reports on the current status of malaria research, prevention, and control efforts worldwide. The authors present study results and commentary on the: Nature, clinical manifestations, diagnosis, and epidemiology of malaria. Biology of the malaria parasite and its vector. Prospects for developing malaria vaccines and improved treatments. Economic, social, and behavioral factors in malaria control.
Download or read book The Resistance Phenomenon in Microbes and Infectious Disease Vectors written by Institute of Medicine and published by National Academies Press. This book was released on 2003-03-26 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: The resistance topic is timely given current events. The emergence of mysterious new diseases, such as SARS, and the looming threat of bioterrorist attacks remind us of how vulnerable we can be to infectious agents. With advances in medical technologies, we have tamed many former microbial foes, yet with few new antimicrobial agents and vaccines in the pipeline, and rapidly increasing drug resistance among infectious microbes, we teeter on the brink of loosing the upperhand in our ongoing struggle against these foes, old and new. The Resistance Phenomenon in Microbes and Infectious Disease Vectors examines our understanding of the relationships among microbes, disease vectors, and human hosts, and explores possible new strategies for meeting the challenge of resistance.
Download or read book Disease Control Priorities Third Edition Volume 6 written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Download or read book Genetically Modified and other Innovative Vector Control Technologies written by Brij Kishore Tyagi and published by Springer Nature. This book was released on 2022-01-01 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers the latest development in developing and deploying the genetically modified vectors, particularly Anopheles and Aedes mosquitoes responsible for transmitting malaria parasites and dengue viruses, the most deadly and/or debilitating among all the vector-borne diseases. It is considered timely and commensurate to bring about a book dealing with the various ecological, biological and social as well as regulatory aspects for the deployment of genetically modified vectors in special context with the biosafety of humans, his associates, and the environment. Written by an array of specialists and experts in various subjects of genetically modified organisms, this book centrally addresses the (i) basic principles of the genetic manipulation of vectors and they are potential impact on human and the environment, (ii) ecological, biological, ethical, legal and social implications of the use of genetically modified vectors, (iii) identification of potential hazards; assessment and management of risks for human and environment; risk/benefit analysis, (iv) principles and practices for the assessment and management of biosecurity and biosafety in laboratories (and in the field), (v) guiding principles for creation and management of institutional or national biosafety review boards and ethics review committees, and (vi) development and application of a biosafety regulatory framework and its related legal principles at national levels for securing the development and use of vector control methods based on genetic modification strategies. This publication will be useful to researchers, scientists, and professionals engaged in academic and research institutions, government or non-government, as well as students in universities and medical colleges.
Download or read book Dengue written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is intended to contribute to prevention and control of the morbidity and mortality associated with dengue and to serve as an authoritative reference source for health workers and researchers. These guidelines are not intended to replace national guidelines but to assist in the development of national or regional guidelines. They are expected to remain valid for five years (until 2014), although developments in research could change their validity.--Publisher's description.
Download or read book Biodiversity and Health in the Face of Climate Change written by Melissa R. Marselle and published by Springer. This book was released on 2019-06-11 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book identifies and discusses biodiversity’s contribution to physical, mental and spiritual health and wellbeing. Furthermore, the book identifies the implications of this relationship for nature conservation, public health, landscape architecture and urban planning – and considers the opportunities of nature-based solutions for climate change adaptation. This transdisciplinary book will attract a wide audience interested in biodiversity, ecology, resource management, public health, psychology, urban planning, and landscape architecture. The emphasis is on multiple human health benefits from biodiversity - in particular with respect to the increasing challenge of climate change. This makes the book unique to other books that focus either on biodiversity and physical health or natural environments and mental wellbeing. The book is written as a definitive ‘go-to’ book for those who are new to the field of biodiversity and health.
Download or read book The Ecology of Malaria Vectors written by Jacques Derek Charlwood and published by CRC Press. This book was released on 2019-07-31 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by renowned field entomologist Jacques Derek Charlwood, disseminating his vast experience working on mosquito biology, ecology and the evaluation of new vector control tools across five continents over the past 40 years. It is designed to fill the gap between very specialized texts and undergraduate books on general disease vectors, and is ideal as a textbook for postgraduate courses in entomology and mosquito vectors of disease. It is the first work in this field to concentrate on mosquitoes, rather than covering all disease vectors.
Download or read book Pests and Vector borne Diseases in the Livestock Industry written by Claire Garros and published by Brill Wageningen Academic. This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "How to control economically important vector-borne diseases? What are the best strategies to protect livestock from vector-borne diseases in a changing environment? How to evaluate and assess the acceptability, cost efficiency and cost benefit of the control and surveillance methods? The information in this book will help to answer these questions. It aims at presenting the latest information on vector-borne diseases affecting livestock worldwide, from state-of-the art interventions to the assessment of the impact of these control measures. This book is a valuable tool for entomologists and all those involved in pest and vector control."
