Download or read book Genetic and Developmental Analyses of Cell Fate and Cell Lineage Decisions During the Formation of the Drosophila Nervous System written by Priyadarshini Rath and published by . This book was released on 2001 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Developmental Biology written by Paul Wassarman and published by Elsevier. This book was released on 1996-06-25 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 4 of Advances in Developmental Biology and Biochemistry consists of five chapters that review specific aspects of fly and mammalian development. In Chapter 1, Y. Mishina and R. Behringer discuss various aspects of Müllerian-inhibiting substance (MIS) in mammals, from a brief history of its discovery to recent studies of the MIS gene in transgenic and knock-out animals. In Chapter 2, C. Rushlow and S. Roth discuss the role of the dpp-group genes in dorsoventral patterning of the Drosophila embryo. In Chapter 3, M. Yip and H. Lipshitz discuss the terminal (asegmental termini) gene hierarchy of Drosophila and the genetic control of tissue specification and morphogenesis. In Chapter 4, R. Bachvarova discusses induction of mesoderm and the origin of anterior-posterior polarity in the mouse embryo, using the frog embryo as a paradigm. In Chapter 5, P. Vogt discusses human Y chromosome function in male germ cell development.
Download or read book Neuroblast Lineage and Cell Fate Specification in the Drosophila Central Nervous System written by Xuan Cui and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The generation of cellular diversity during early development of nervous system is poorly understood. In the Drosophila central nervous system, cell diversity is primarily generated by the invariant lineage of neural precursors called neuroblasts. It has been proposed that a class of genes are expressed in neuroblasts and their progeny and control the cell lineage of each neuroblast. I used an enhancer trap screen to identify the ming gene, which is transiently expressed in a subset of neuroblasts at reproducible points in their cell lineage (i.e. in neuroblast sublineages), suggesting that neuroblast identity can be altered during its cell lineage. ming encodes a predicted zinc finger protein within the TFIIIA superfamily. Loss of ming function results in altered CNS expression of the engrailed gene, defects in axonogenesis and embryonic lethality. I propose that ming, as a neuroblast sublineage gene, controls distinct cell fates within neuroblast cell lineages. I investigate the precise temporal regulation of the sublineage gene expression. I show that four genes (ming, even-skipped, unplugged and achaete) are expressed in specific neuroblast sublineages. I show that these neuroblasts can be identified in embryos lacking both neuroblast cytokinesis and cell cycle progression (string mutants) and in embryos lacking only neuroblast cytokinesis (pebble mutants). I find that the unplugged and achaete genes are expressed normally in string and pebble mutant embryos, indicating that temporal control is independent of neuroblast cytokinesis or counting cell cycles. In contrast, neuroblasts require cytokinesis to activate sublineage ming expression, while a single, identified neuroblast requires cell cycle progression to activate even-skipped expression. These results suggest that neuroblasts have an intrinsic gene regulatory hierarchy controlling unplugged and achaete expression, but that cell cycle- or cytokinesis-dependent mechanisms are required for ming and eve CNS expression.
Download or read book Transcriptional Regulation in the Embryonic Central Nervous System of Drosophila written by Robert Graham Franks and published by . This book was released on 1994 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Muscle Development in Drosophilia written by Helen Sink and published by Springer Science & Business Media. This book was released on 2006-02-02 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.
Download or read book Cell Lineages and Specification of Cellular Identity in the Nervous System of Drosophila written by Rachel Melissa Brewster and published by . This book was released on 1996 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Germline Stem Cells written by Steven X. Hou and published by Humana Press. This book was released on 2014-10-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this comprehensive and cutting-edge book, leading experts explore the parameters that define germline stem cells and the mechanisms that regulate the cell behavior in order to better isolate, characterize and maintain them. The volume begins by providing protocols for germline stem cell identification and regulation in model organisms, and concludes with detailed chapters covering current techniques involving in vitro culture and the applications of the cells.
Download or read book The Neural Crest written by Nicole Le Douarin and published by Cambridge University Press. This book was released on 1999-11-28 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 1999 edition of The Neural Crest contains comprehensive information about the neural crest, a structure unique to the vertebrate embryo, which has only a transient existence in early embryonic life. The ontogeny of the neural crest embodies the most important issues in developmental biology, as the neural crest is considered to have played a crucial role in evolution of the vertebrate phylum. Data that analyse neural crest ontogeny in murine and zebrafish embryos have been included in this revision. This revised edition also takes advantage of recent advances in our understanding of markers of neural crest cell subpopulations, and a full chapter is now devoted to cell lineage analysis. The major research breakthrough since the first edition has been the introduction of molecular biology to neural crest research, enabling an elucidation of many molecular mechanisms of neural crest development. This book is essential reading for students and researchers in developmental biology, cell biology, and neuroscience.
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Download or read book Intercellular Signaling in the Developing Nervous System written by Norman Ng and published by . This book was released on 2004 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book How Would I Know that this Could be My Fate written by Steven Walter Miller and published by . This book was released on 2009 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and genetic studies over the past two decades have established that animals ranging from the fruit fly to the human utilize a common "toolkit" of genes to create the myriad cell types during development. For even some of the most well studied developmental paradigms, however, little is known of the transcriptional regulatory networks activated by these core components. Moreover, how these networks manifest the initial cell fate decision remains a rigorous topic of investigation. The Drosophila melanogaster mechanosensory organ lineage has long been a model for binary cell fate specification mechanisms. While it is well-established that the Notch signaling pathway is the dominant cell fate specification mechanism in this lineage, little is known of the battery of genes downstream of the canonical pathway components that enforce the cell fate decision. In this body of work I analyze the Notch signaling events at opposite ends of the lineage with the specification of the mechanosensory organ precursor cell (SOP) at the beginning and the post-mitotic socket and shaft cells at the penultimate of the lineage. These studies focus on the transcriptional regulation of three genes, neuralized, Sox15 and sv. I utilize a number of loss of function mutants, misexpression studies, and transgenic reporter constructs to identify enhancer modules and tease out their regulatory factors. Chapter 2 comprises an analysis of the transcriptional regulation of neuralized during SOP specification where I present evidence that neuralized is both a participant in and a target of Notch signaling, requiring two partially redundant. Chapter 3 focuses on the transcriptional regulation and function of Sox15, a transcription factor specifically expressed in the post-mitotic socket cell. I show that Sox15 is a target of Notch signaling in the socket cell and is required for the proper differentiation of the socket cell as it relates to mechanosensory function. Chapter 4 dovetails off Sox15 and examines regulation of sv in the shaft cell, where I find the dominant theme is auto-regulation. Lastly, Chapter 5 describes the development of a new transgenic reporter system I developed for the rapid screening of genomic fragments for enhancer activity.
Download or read book Development and Neurobiology of Drosophila written by O. Siddiqi and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is no multicellular animal whose genetics is so well understood as Drosophila melanogaster. An increasing number of biologists have, therefore, turned to the fruitfly in pursuit of such diverse areas as the molecular biology of eukaryotic cells, development and neurobiology. Indeed there are signs that Dro sophila may soon become the most central organism in biqlogy for genetic analysis of complex problems. The papers in this collection were presented at a conference on Development and Behavior of Drosophila held at the Tata Insti tute of Fundamental Research from 19th to 22nd December, 1979. The volume reflects the commonly shared belief of the participants that Drosophila has as much to contribute to biology in the future as it has in the past. We hope it will be of interest not merely to Dro sophilists but to all biologists. We thank Chetan Premani, Anil Gupta, K.S. Krishnan, Veronica Rodrigues, Hemant Chikermane and K. Vijay Raghavan for help with recording and transcription of the proceedings and Vrinda Nabar and K.V. Hareesh for editorial assistance. We thank Samuel Richman, Thomas Schmidt-Glenewinkel and T.R. Venkatesh for their valuable assistance in proofreading the manuscripts, and we also thank Patricia Rank for her excellent effort in the preparation of the final manuscripts. The conference was supported by a grant from Sir Dorabji Tata Trust.
Download or read book Brain Development in Drosophila melanogaster written by Gerhard Martin Technau and published by Springer Science & Business Media. This book was released on 2009-01-08 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fruitfly Drosophila melanogaster is an ideal model system to study processes of the central nervous system This book provides an overview of some major facets of recent research on Drosophila brain development.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Nematode Caenorhabditis Elegans written by William Barry Wood and published by . This book was released on 1988 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetic and Molecular Analysis of Hairless and Its Role in Drosophila Adult Peripheral Nervous System Development written by Anne Grete Bang and published by . This book was released on 1993 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mouse Development written by Janet Rossant and published by Gulf Professional Publishing. This book was released on 2002-03 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference. *Broad-based overview of mouse development from fundamental to specialist levels *Extensive coverage of a wide range of developmental mutations of the mouse *Excellent benchmark illustrations of brain, craniofacial, gut and heart development *In-depth experiment-based assessment of concepts in mammalian development *Focus on models of specific relevance to human development *Comprehensive reference to key literature and electronic databases related to mouse development *High-quality full-color production
