Download or read book Genetic Analysis of Synaptic Growth and Neurotoxic Effects of Radiation Exposure During Development in Drosophila Melanogaster written by and published by . This book was released on 2015 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drosophila has been used for decades to identify and analyze molecular pathways underlying processes such as neurodevelopment and the innate immune response and for modeling complex diseases. In this thesis, I describe the use of Drosophila in two different projects. The first is characterization of a novel signaling pathway regulating growth of the larval neuromuscular junction. The second is the development of an experimental model to investigate neurotoxic effects of radiation exposure during development. Using the larval neuromuscular junction as a model synapse we have identified the lipocalin GLaz, the ortholog of human Apolipoprotein D (hApoD) as a novel regulator of synaptic growth. We have shown that postsynaptic insulin signaling promotes growth of the presynaptic terminal and that insulin signaling is increased in GLaz mutants. Overexpression of GLaz or hApoD in glia results in NMJ undergrowth, which is suppressed by simultaneously increasing insulin signaling in muscle. These studies uncover a novel role for lipocalins in regulation of synaptic growth and support a model in which GLaz is secreted from glia and antagonizes postsynaptic insulin signaling to restrict NMJ growth. We have also used Drosophila to model the neurotoxic side effects of radiation exposure during development as in the treatment for pediatric central nervous system malignancies. We have shown that many of the side effects observed in human patients treated with radiation during development can be modeled in Drosophila. Adult flies exposed to radiation during larval development display reduced survival to adulthood, early death, impaired locomotor behavior, and neurodegeneration. These phenotypes are consistent with premature aging. One hallmark of premature aging is chronic inflammation. Similarly, we find persistent activation of the innate immune system in adult flies that were exposed to radiation during larval development. We further demonstrate that the innate immune response is protective acutely following radiation exposure. Together these data demonstrate that the innate immune pathway is a potential therapeutic target for reducing the side-effects of CRT. The use of this experimental model in genetic screens should facilitate identification of additional radioprotective or radiosensitizing pathways, which may be of further therapeutic value.
Download or read book A Molecular and Genetic Analysis of Neuromuscular Connectivity and Synaptic Growth in Drosophila Melanogaster written by Hong Iris Wan and published by . This book was released on 2000 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book CSA Neurosciences Abstracts written by and published by . This book was released on 1985 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monthly, with annual subject and author indexes. Worldwide coverage of journal articles, papers presented, and books focused primarily on basic research in vertebrate and invertebrate neurosciences. Arranged under broad topics, e.g., genetics, sleep, and neurophysiology, as well as miscellaneous topics, book notices, and proceedings. Author, subject indexes.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Aerospace Medicine and Biology written by and published by . This book was released on 1992 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: A selection of annotated references to unclassified reports and journal articles that were introduced into the NASA scientific and technical information system and announced in Scientific and technical aerospace reports (STAR) and International aerospace abstracts (IAA).
Download or read book The Nerve Growth Cone written by Paul C. Letourneau and published by Raven Press (ID). This book was released on 1991 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes research on nerve growth cones, (the dynamic cell structure that plays a key role in establishing the specific neuronal interconnections that determine neural circuitry, and thus behaviour), from their individual molecular components to their behaviour within intact living animals.
Download or read book Neonatal Anesthesia written by D. Ryan Cook and published by Davies Publishing. This book was released on 1988 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diagnosis and Treatment of Traumatic Brain Injury written by Rajkumar Rajendram and published by Academic Press. This book was released on 2022-05-10 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnosis and Treatment of Traumatic Brain Injury will improve readers' understanding of the complexities of diagnosis and management of traumatic brain injuries. Featuring chapters on drug delivery, different treatments, and rehabilitation, this volume discusses in detail the impact early diagnosis and effective management has on the long-term prognosis of these injuries and the lives of those affected. This book will be relevant for neuroscientists, neurologists, clinicians, and anyone working to better understand these injuries. - Covers both the diagnosis and treatment of traumatic brain cord injury - Contains chapter abstracts, key facts, dictionary, and summary points to aid in understanding - Features chapters on epidemiology and pain - Includes MRI usage, biomarkers, and stem cell and gene therapy for management of spinal cord injury - Discusses pain reduction, drug delivery, and rehabilitation
Download or read book Impact of Heavy Metals on the Environment written by Jean-Pierre Vernet and published by Elsevier Publishing Company. This book was released on 1992 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighted in this compilation of papers is the role and importance of heavy metals in the environment. It provides up-to-date information in a field of active research and progress, where the focus is on effects and interactions between the environment and organisms, as well as contaminant dynamics. Several papers address the impact of heavy metals on our health. The influence of metals on plants is described in an exhaustive study on lichens, which have been widely used as biomonitors for environmental contamination by heavy metals. Metals are also accumulated by animals, as seen in a chapter which focusses on sediment/benthic organism interactions and biomonitoring in fish. Soil interactions are discussed, as well as regional studies of freshwater sediments and the marine environment. The final part of the book addresses a crucial problem: the management of stabilized municipal waste sludges. As a result, the most important and significant recent trends are included, emphasizing interactions with and impacts of heavy metals on humans, animals, plants and soils.
Download or read book Graduate Programs in the Biological Sciences 2008 written by Peterson's Guides Staff and published by Peterson Nelnet Company. This book was released on 2007-12 with total page 1642 pages. Available in PDF, EPUB and Kindle. Book excerpt: The six volumes of Peterson's Annual Guides to Graduate Study, the only annually updated reference work of its kind, provide wide-ranging information on the graduate and professional programs offered by accredited colleges and universities in the United States and U.S. territories and those in Canada, Mexico, Europe, and Africa that are accredited by U.S. accrediting bodies. Books 2 through 6 are divided into sections that contain one or more directories devoted to individual programs in a particular field. Book 3 contains more than 4,000 programs of study in 53 disciplines of the biological sciences.
Download or read book Astrocytes in Patho Physiology of the Nervous System written by Vladimir Parpura and published by Springer Science & Business Media. This book was released on 2008-12-11 with total page 701 pages. Available in PDF, EPUB and Kindle. Book excerpt: Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with some ast- cytes surrounding neurons, while the others are intimately associated with vasculature. We start the book by discussing the heterogeneity of astrocytes using contemporary tools and by calling into question the assumption by classical neuroscience that neurons and glia are derived from distinct pools of progenitor cells. Astrocytes have long been neglected as active participants in intercellular communication and information processing in the central nervous system, in part due to their lack of electrical excitability. The follow up chapters review the “nuts and bolts” of ast- cytic physiology; astrocytes possess a diverse assortment of ion channels, neu- transmitter receptors, and transport mechanisms that enable the astrocytes to respond to many of the same signals that act on neurons. Since astrocytes can detect chemical transmitters that are released from neurons and can release their own extracellular signals there is an increasing awareness that they play physiological roles in regulating neuronal activity and synaptic transmission. In addition to these physiological roles, it is becoming increasingly recognized that astrocytes play critical roles during pathophysiological states of the nervous system; these states include gliomas, Alexander disease, and epilepsy to mention a few.
Download or read book Fundamental Neuroscience written by Larry Squire and published by Academic Press. This book was released on 2008-04-02 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness Additional text boxes describing key experiments, disorders, methods, and concepts Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing
Download or read book The Growth Hormone Insulin Like Growth Factor Axis during Development written by Isabel Varela-Nieto and published by Springer Science & Business Media. This book was released on 2005-12-17 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin-like growth factor (IGF)-I is a widely expressed growth factor with diverse effects on many tissues throughout development and in adult life. The purpose of this work is to provide detailed and updated information on the role of the growth hormone (GH)-IGF axis in fetal and postnatal development, as well as its physiological functions and implications in pathology.
Download or read book Toxicological Profile for Aldrin dieldrin written by and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Honeybee Neurobiology and Behavior written by C. Giovanni Galizia and published by Springer Science & Business Media. This book was released on 2011-11-25 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a sequel of a similar book, edited by Randolf Menzel and Alison Mercer, “Neurobiology and Behavior of Honeybees”, published in 1987. It is a “Festschrift” for the 70th birthday of Randolf Menzel, who devoted his life to the topic of the book. The book will include an open commentary for each section written by Randolf Menzel, and discussed with the authors. The written contributions take their inspiration from a symposium on the topic, with all the authors, that was held in Berlin in summer 2010
Download or read book The Perioperative Neurocognitive Disorders written by Roderic G. Eckenhoff and published by Cambridge University Press. This book was released on 2019-03-28 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to perioperative cognitive disorders, the most common complications of anesthesia and surgery in older people.
Download or read book Toxicological Profile for Diazinon written by and published by . This book was released on 1994 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
