Download or read book Genetic Analysis of Hyphal Fusion and Heterokaryon Incompatibility in Neurospora Crassa written by Qijun Xiang and published by . This book was released on 2003 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cellular and Molecular Biology of Filamentous Fungi written by Katherine Borkovich and published by American Society for Microbiology Press. This book was released on 2010-02-02 with total page 1959 pages. Available in PDF, EPUB and Kindle. Book excerpt: An ideal starting point for any research study of filamentous fungi. • Incorporates the latest findings from such disciplines as physiology, taxonomy, genomics, molecular biology and cell biology. • Begins with an historical perspective, cell morphology and taxonomy, and moves on to such topics as cell growth, development, metabolism, and pathogenesis. • Presents the full range of the fungal kingdom and covers important topics as saprophytes, pathogens and endophytes. • Serves as a recommended text for graduate and undergraduate students.

Download or read book Pharmacoepigenetics written by Ramón Cacabelos and published by Academic Press. This book was released on 2019-06-04 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacoepigenetics provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. - Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development - Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry - Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety - Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Download or read book Genetics of Bone Biology and Skeletal Disease written by Rajesh V. Thakker and published by Academic Press. This book was released on 2017-10-31 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. - Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments - Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders - Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Download or read book Oxford Textbook of Medical Mycology written by Christopher C. Kibbler and published by Oxford University Press. This book was released on 2017-12-14 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems based approach to management, fungal disease in specific patient groups, diagnosis, and treatment. The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other 'omics', epidemiology, pathogenesis, and immunology, this textbook is well suited to aid both scientists and clinicians. The extensive illustrations, tables, and in-depth coverage of topics, including discussion of the non-infective aspects of allergic and toxin mediated fungal disease, are designed to aid the understanding of mechanisms and pathology, and extend the usual approach to fungal disease. This textbook is essential reading for microbiologists, research scientists, infectious diseases clinicians, respiratory physicians, and those managing immunocompromised patients. Part of the Oxford Textbook in Infectious Disease and Microbiology series, it is also a useful companion text for students and trainees looking to supplement mycology courses and microbiology training.

Download or read book Fungi written by Kevin Kavanagh and published by John Wiley & Sons. This book was released on 2011-08-04 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi: Biology and Applications, Second Edition provides a comprehensive treatment of fungi, covering biochemistry, genetics and the medical and economic significance of these organisms at introductory level. With no prior knowledge of the subject assumed, the opening chapters offer a broad overview of the basics of fungal biology, in particular the physiology and genetics of fungi and also a new chapter on the application of genomics to fungi. Later chapters move on to include more detailed coverage of topics such as antibiotic and chemical commodities from fungi, new chapters on biotechnological use of fungal enzymes and fungal proteomics, and fungal diseases of humans, antifungal agents for use in human therapy and fungal pathogens of plants.

Download or read book Structure and Dynamics of Fungal Populations written by J. Worrall and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are among the most versatile and diverse groups of organisms in their morphology, life cycles, and ecology. This has provided endless fasci nation and intrigue to those who have studied fungi, but it has also made it difficult to understand fungal biology from the perspective of the broader fields of evolution, ecology, genetics, and population biology. That is changing. Details of fungal biology have been elucidated at an exciting pace, increasingly allowing us to understand fungi on the bases of general biological principles. Moreover, many who study fungi have lately emulated some of the great mycologists and plant pathologists of the early years in applying an insight born of broad perspective. This change has been particularly apparent in fungal population biology. In this book, many of those at the forefront of that change summarize, integrate and comment on recent developments and ideas on populations of fungi. By taking a broad perspective, they show how new information on fungi may contribute to concepts and ideas of biology as a whole. Just as important, they contribute to further invigoration of fungal population research by illuminating mycology with new ideas and concepts, derived in part from other biological fields.

Download or read book Morphogenesis and Pathogenicity in Fungi written by José Pérez Martín and published by Springer. This book was released on 2014-02-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious fungal diseases continue to take their toll in terms of human suffering and enormous economic losses. Invasive infections by opportunistic fungal pathogens are a major cause of morbidity and mortality in immuno-compromised individuals. At the same time, plant pathogenic fungi have devastating effects on crop production and human health. New strategies for antifungal control are required to meet the challenges posed by these agents, and such approaches can only be developed through the identification of novel biochemical and molecular targets. However, in contrast to bacterial pathogens, fungi display a wealth of “lifestyles” and modes of infection. This diversity makes it extremely difficult to identify individual, evolutionarily conserved virulence determinants and represents a major stumbling block in the search for common antifungal targets. In order to activate the infection programme, all fungal pathogens must undergo appropriate developmental transitions that involve cellular differentiation and the introduction of a new morphogenetic programme. How growth, cell cycle progression and morphogenesis are co-ordinately regulated during development has been an active area of research in fungal model systems such as budding and fission yeast. By contrast, we have only limited knowledge of how these developmental processes shape fungal pathogenicity, or of the role of the cell cycle and morphogenesis regulators as true virulence factors. This book combines state-of-the-art expertise from diverse pathogen model systems to update our current understanding of the regulation of fungal morphogenesis as a key determinant of pathogenicity in fungi.

Download or read book Fungi written by Ramesh Maheshwari and published by CRC Press. This book was released on 2005-06-23 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today’s accelerated pace of research, aided by new instruments and techniques that combine the approaches of genetics, biochemistry, and cell biology, has changed the character of mycology. A new approach is necessary for the organization and study of fungi. Fungi: Experimental Methods in Biology presents the latest information in fungal biology generated through the application of genetics, molecular biology, and biochemistry. This book analyzes information derived through real experiments, and focuses on unresolved questions in the field. Divided into six sections comprising 14 chapters, the text describes the special features of fungi, interactions of fungi with other organisms, model fungi in research, gene manipulation, adaptations, and natural populations. Each chapter is self-contained and written in a style that enables the reader to progress from elementary concepts to advanced research, benefiting both beginning research workers and experienced professionals. A comprehensive appendix covers the principles in naming fungi and discusses their broad classification.

Download or read book Genetics and Biotechnology written by Ulrich Kück and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycology, the study of fungi, originated as a subdiscipline of botany and was a descriptive discipline, largely neglected as an experimental science until the early years of this century. A seminal paper by Blakeslee in 1904 provided evidence for self incompatibility, termed "heterothallism", and stimulated interest in studies related to the control of sexual reproduction in fungi by mating-type specificities. Soon to follow was the demonstration that sexually reproducing fungi exhibit Mendelian inheritance and that it was possible to conduct formal genetic analysis with fungi. The names Burgeff, Kniep and Lindegren are all associated with this early period of fungal genetics research. These studies and the discovery of penicillin by Fleming, who shared a Nobel Prize in 1945, provided further impetus for experimental research with fungi. Thus began a period of interest in mutation induction and analysis of mutants for bio chemical traits. Such fundamental research, conducted largely with Neurospora crassa, led to the one gene: one enzyme hypothesis and to a second Nobel Prize for fungal research awarded to Beadle and Tatum in 1958. Fundamental research in biochemical genetics was extended to other fungi, especially to Saccharomyces cere visiae, and by the mid-1960s fungal systems were much favored for studies in eukaryotic molecular biology and were soon able to compete with bacterial systems in the molecular arena.

Download or read book Incompatibility in Fungi written by Karl Esser and published by . This book was released on 1965 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sexual reproduction in the fungi is extensively regulated by incom patibility, which determines, in the absence of any morphological differ entiation, the pattern of mating among individual strains. Control of the interactions that comprise the sexual reproductive process resides in specific genetic factors, the incompatibility factors, which occur in several distinct systems in the various groups of fungi and which exert their control in two basically different ways. On the one hand, the system may play the same role as dioecy in higher organisms by restricting or preventing inbreeding amon.

Download or read book Growth Differentiation and Sexuality written by Jürgen Wendland and published by Springer. This book was released on 2016-02-16 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition offers detailed overviews covering a wide area of fungal growth and reproduction on the mechanistic and molecular level. It includes 18 chapters by eminent scientists in the field and is – like the previous edition – divided into the three sections: Vegetative Processes and Growth, Signals in Growth and Development, and Reproductive Processes. Major topics of the first section include dynamic intracellular processes, apical growth, hyphal fusion, and aging. The second section analyses autoregulatory signals, pheromone action, and photomorphogenesis and gravitropism abiotic signals. The third section reveals details of asexual and sexual development in various fungal model systems, culminating in fruit body formation in basidiomycetes, which is a sector of growing economic potential. Since the publication of the first edition of this volume in 1994 and the second edition in 2006, the field of fungal biology has continued to expand thanks to improvements in omics technologies and the application of genetic tools to an increasing variety of fungal models. Several additional chapters by a new generation of fungal biologists discuss this diversity and guarantee lively reading.

Download or read book Cell Fusion written by Elizabeth H. Chen and published by Methods in Molecular Biology. This book was released on 2008-07-31 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book a team of leading experts provide a collection of overviews that outline our current understanding of cell fusion. They further provide methods that present classic and state-of-the-art experimental approaches in a variety of systems.

Download or read book Biocommunication of Fungi written by Günther Witzany and published by Springer Science & Business Media. This book was released on 2012-05-31 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are sessile, highly sensitive organisms that actively compete for environmental resources both above and below the ground. They assess their surroundings, estimate how much energy they need for particular goals, and then realise the optimum variant. They take measures to control certain environmental resources. They perceive themselves and can distinguish between ‘self’ and ‘non-self’. They process and evaluate information and then modify their behaviour accordingly. These highly diverse competences show us that this is possible owing to sign(aling)-mediated communication processes within fungal cells (intraorganismic), between the same, related and different fungal species (interorganismic), and between fungi and non-fungal organisms (transorganismic). Intraorganismic communication involves sign-mediated interactions within cells (intracellular) and between cells (intercellular). This is crucial in coordinating growth and development, shape and dynamics. Such communication must function both on the local level and between widely separated mycelium parts. This allows fungi to coordinate appropriate response behaviors in a differentiated manner to their current developmental status and physiological influences.

Download or read book The Fusarium Laboratory Manual written by John F. Leslie and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time in over 20 years, a comprehensive collection of photographs and descriptions of species in the fungal genus Fusarium is available. This laboratory manual provides an overview of the biology of Fusarium and the techniques involved in the isolation, identification and characterization of individual species and the populations in which they occur. It is the first time that genetic, morphological and molecular approaches have been incorporated into a volume devoted to Fusarium identification. The authors include descriptions of species, both new and old, and provide protocols for genetic, morphological and molecular identification techniques. The Fusarium Laboratory Manual also includes some of the evolutionary biology and population genetics thinking that has begun to inform the understanding of agriculturally important fungal pathogens. In addition to practical “how-to” protocols it also provides guidance in formulating questions and obtaining answers about this very important group of fungi. The need for as many different techniques as possible to be used in the identification and characterization process has never been greater. These approaches have applications to fungi other than those in the genus Fusarium. This volume presents an introduction to the genus Fusarium, the toxins these fungi produce and the diseases they can cause. "The Fusarium Laboratory Manual is a milestone in the study of the genus Fusarium and will help bridge the gap between morphological and phylogenetic taxonomy. It will be used by everybody dealing with Fusarium in the Third Millenium." --W.F.O. Marasas, Medical Research Council, South Africa

Download or read book Comparative Ecology of Microorganisms and Macroorganisms written by John H. Andrews and published by Springer. This book was released on 2017-06-27 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition textbook offers an expanded conceptual synthesis of microbial ecology with plant and animal ecology. Drawing on examples from the biology of microorganisms and macroorganisms, this textbook provides a much-needed interdisciplinary approach to ecology. The focus is the individual organism and comparisons are made along six axes: genetic variation, nutritional mode, size, growth, life cycle, and influence of the environment. When it was published in 1991, the first edition of Comparative Ecology of Microorganisms and Macroorganisms was unique in its attempt to clearly compare fundamental ecology across the gamut of size. The explosion of molecular biology and the application of its techniques to microbiology and organismal biology have particularly demonstrated the need for interdisciplinary understanding. This updated and expanded edition remains unique. It treats the same topics at greater depth and includes an exhaustive compilation of both the most recent relevant literature in microbial ecology and plant/animal ecology, as well as the early research papers that shaped the concepts and theories discussed. Among the completely updated topics in the book are phylogenetic systematics, search algorithms and optimal foraging theory, comparative metabolism, the origins of life and evolution of multicellularity, and the evolution of life cycles. From Reviews of the First Edition: "John Andrews has succeeded admirably in building a bridge that is accessible to all ecologists." -Ecology "I recommend this book to all ecologists. It is a thoughtful attempt to integrate ideas from, and develop common themes for, two fields of ecology that should not have become fragmented." -American Scientist "Such a synthesis is long past due, and it is shameful that ecologists (both big and little) have been so parochial." -The Quarterly Review of Biology

Download or read book Trichoderma And Gliocladium written by Gary E. Harman and published by CRC Press. This book was released on 2002-04-12 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gives an account of the morphology and taxonomy of "Trichoderma" and "Gliocladium", before disscusing their ecology and basic biology.