Download or read book Gastrointestinal Pathology Classification Diagnosis Emerging Entities An Issue of Surgical Pathology Clinics E Book written by Jason L. Hornick and published by Elsevier Health Sciences. This book was released on 2013-09-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Overall, this book is an excellent update on many important entities..." Reviewed by: Kay Lawson, on behalf of ACP News; Date: Summer 2014. The gastrointestinal tract may be affected by a diverse spectrum of inflammatory and neoplastic disorders, many of which pose problems for practicing surgical pathologists on a daily basis. Pathologists' understanding of these diseases continues to evolve rapidly. The topics in this issue of Surgical Pathology Clinics address a wide range of neoplasms and present ancillary techniques that play an increasingly important role in diagnostic pathology and include prognostic and predictive markers that have become a routine part of gastrointestinal pathology practice. These expert reviews provide surgical pathologists with critical practical updates on many of these challenging areas, with an emphasis on differential diagnosis and diagnostic pitfalls. Some topics include: Lymphomas of the gastrointestinal tract; Mesenchymal tumors of the gastrointestinal tract other than GIST; Barrett's esophagus: evolving concepts in diagnosis and neoplastic progression; Immunohistochemistry in neoplastic gastrointestinal pathology; HER2 testing in adenocarcinomas of the upper gastrointestinal tract; Pediatric inflammatory gastrointestinal pathology; IgG4-related disorders of the gastrointestinal tract. The reader will be interested in cross referencing the first volume on GI pathology presented in this series; its popularity with surgical pathologists has led to this second volume, which covers different topics in GI pathology. Jason Hornick of Brigham and Women's provides his expertise to lead this issue.

Download or read book Gastrointestinal Pathology Classification Diagnosis Emerging Entities an Issue of Surgical Pathology Clinics written by Jason L. Hornick and published by Elsevier Health Sciences. This book was released on 2013-10-02 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The gastrointestinal tract may be affected by a diverse spectrum of inflammatory and neoplastic disorders, many of which pose problems for practicing surgical pathologists on a daily basis. Pathologists' understanding of these diseases continues to evolve rapidly. The topics in this issue of Surgical Pathology Clinics address a wide range of neoplasms and present ancillary techniques that play an increasingly important role in diagnostic pathology and include prognostic and predictive markers that have become a routine part of gastrointestinal pathology practice. These expert reviews provide surgical pathologists with critical practical updates on many of these challenging areas, with an emphasis on differential diagnosis and diagnostic pitfalls. Some topics include: Lymphomas of the gastrointestinal tract; Mesenchymal tumors of the gastrointestinal tract other than GIST; Barrett's esophagus: evolving concepts in diagnosis and neoplastic progression; Immunohistochemistry in neoplastic gastrointestinal pathology; HER2 testing in adenocarcinomas of the upper gastrointestinal tract; Pediatric inflammatory gastrointestinal pathology; IgG4-related disorders of the gastrointestinal tract. The reader will be interested in cross referencing the first volume on GI pathology presented in this series; its popularity with surgical pathologists has led to this second volume, which covers different topics in GI pathology. Jason Hornick of Brigham and Women's provides his expertise to lead this issue.

Download or read book Gastrointestinal Pathology An Issue of Surgical Pathology Clinics E Book written by Rondell P. Graham and published by Elsevier Health Sciences. This book was released on 2023-10-23 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Surgical Pathology Clinics, guest editor Dr. Rondell P. Graham brings his considerable expertise to the topic of Gastrointestinal Pathology. The first half of this issue answers questions from the general pathologist about what new technologies and techniques can confidently be incorporated into daily practice. The second half addresses longstanding riddles and recurring tests, making this issue an excellent resource for practicing pathologists facing new and continuing challenges in GI pathology. Contains 11 practice-oriented topics including artificial intelligence-enabled gastric cancer interpretations: are we there yet?; non-conventional dysplasia in inflammatory bowel disease; a practical approach to small round blue cell tumors involving the GI tract and abdomen infectious disease pathology of the GI tract: diagnosing the challenging cases; and more. Provides in-depth clinical reviews on gastrointestinal pathology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Download or read book Gastrointestinal Pathology Common Questions and Diagnostic Dilemmas An Issue of Surgical Pathology Clinics E Book written by Rhonda K. Yantiss and published by Elsevier Health Sciences. This book was released on 2017-11-13 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Pathology Clinics, edited by Rhonda K. Yantiss, will focus on Gastrointestinal Pathology: Common Questions and Diagnostic Dilemmas. Topics in this issue include, but are not limited to: Other forms of esophagitis; Diagnosis and management of Barrett-related neoplasia in the modern era; Patterns of gastric injury; Practical approach to the flat duodenal biopsy specimen; Chronic colitis in biopsy samples; Mucosal biopsy following bone marrow transplantation; The many faces of medication-related injury in the GI tract; The differential diagnosis of acute colitis: Clues to a specific diagnosis; Problematic colorectal polyps; Persistent problems in colorectal cancer reporting; Emerging concepts in gastric neoplasia; Immunohistochemistry pitfalls; Molecular testing in the modern era, and Lymphoproliferative diseases of the gut.

Download or read book Gastrointestinal Pathology an Issue of Surgical Pathology Clinics Volume 16 4 written by Rondell P. Graham and published by Clinics: Surgery. This book was released on 2023-12-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Surgical Pathology Clinics, guest editor Dr. Rondell P. Graham brings his considerable expertise to the topic of Gastrointestinal Pathology. The first half of this issue answers questions from the general pathologist about what new technologies and techniques can confidently be incorporated into daily practice. The second half addresses longstanding riddles and recurring tests, making this issue an excellent resource for practicing pathologists facing new and continuing challenges in GI pathology. Contains 11 practice-oriented topics including artificial intelligence-enabled gastric cancer interpretations: are we there yet?; non-conventional dysplasia in inflammatory bowel disease; a practical approach to small round blue cell tumors involving the GI tract and abdomen infectious disease pathology of the GI tract: diagnosing the challenging cases; and more. Provides in-depth clinical reviews on gastrointestinal pathology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Download or read book Gastrointestinal Pathology an Issue of Surgical Pathology Clinics Volume 13 3 written by Raul S. Gonzalez and published by Elsevier. This book was released on 2020-09-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Pathology Clinics, guest edited by Dr. Raul Gonzalez, will cover key topics in Gastrointestinal Pathology. This issue is one of four selected each year by our series consulting editor, Dr. Jason L. Hornick. Topics discussed in this issue will include: Grossing of Gastrointestinal Specimens: Best Practices and Current Controversies, Subspecialty Signout and Interobserver Variability in Gastrointestinal Pathology, Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms, Daily Dilemmas in Pediatric Gastrointestinal Pathology, Upper Gastrointestinal Tract Manifestations of Inflammatory Bowel Disease, Gastric Polyps, Approaches to Biopsy and Resection Specimens of the Ampulla, Updates in Appendix Pathology, HER2 in Colorectal Carcinoma, Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors, Diagnoses and Difficulties in Mesenteric Pathology, Advances and Annoyances in Anus Pathology, among others.

Download or read book Surgical Pathology of Non neoplastic Gastrointestinal Diseases written by Lizhi Zhang and published by Springer. This book was released on 2019-06-24 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the entire spectrum of non-neoplastic diseases within the gastrointestinal (GI) tract including new entities, recent developments, and questions that arise in the practice of GI pathology. The text is organized by specific organ site, with related disorders of each organ site subgrouped into several chapters based on their common features. Pathologists can quickly find the disorders they are interested and review similar disorders in the same chapter to help them make a correct diagnosis. Each major and common entity is described in detail with its definition, clinical features, pathological features (covering both the gross and microscopic details), differential diagnosis and treatment/prognosis. All chapters also highlight the use of special/immunohistochemical stains and other supporting studies as needed with a focus on providing a practical differential diagnosis rather than just a list of potential associations. This book is extensively illustrated with both gross and microscopic images that act as an integral part of the information provided in the text. Written by practicing GI/liver pathologists and gastroenterologists from the Mayo Clinic, Surgical Pathology of Non-neoplastic Gastrointestinal Diseases serves as a comprehensive yet practical guide for diagnostic surgical pathologists with a passion for GI pathology.

Download or read book Surgical Pathology of the Gastrointestinal System written by Prasenjit Das and published by Springer Nature. This book was released on 2022-03-07 with total page 1037 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume textbook provides a comprehensive review of both adult and pediatric gastrointestinal, hepatobiliary and pancreatic pathology. The 1st volume is dedicated to gastrointestinal tract pathology. The second volume of this book covers liver, biliary system, and pancreatic pathology. This book covers each aspect of gastrointestinal tract pathology in detail, including clinical presentation, endoscopic appearance, disease pathogenesis, gross and microscopic details of each lesion. Ancillary diagnostic methods, molecular subtypes, and prognostic workup have been detailed adequately. The book also covers diseases relevant to South-East Asia, in addition to diseases prevalent worldwide. It contains 24 chapters, categorized into four sections. Section I covers the general aspects of gastrointestinal pathology including normal anatomy of the gastrointestinal tract, endoscopic details relevant for gastrointestinal pathologists and histopathologists, grossing techniques, utility of and details of ancillary tests needed; section II covers all benign diseases in different anatomical parts of the gastrointestinal tract; section III covers preneoplastic lesions and malignancies of the gastrointestinal tract, including a separate chapter on updated molecular classifications of gastrointestinal tract tumors arising from different segments; section IV includes a unique chapter on setting up a gastrointestinal pathology laboratory. This textbook has been written and edited by experts in the field with proven academic and research excellence and include curated contents to provide lucid and updated information to the readers. The book features more than 800 photographs, line diagrams, endoscopic and radiology pictures, gross and microscopic images. It includes 'Chapter Summary' at the end of each chapter and ‘Learning Tips’ summarized after each major segment that helps the readers to reinforce the knowledge gained from each chapter. Chapters also contain case studies and/ or multiple-choice questions to enable readers to self-assess and learn from the explanations added. The textbook includes many unique chapters. It also covers cytological details and techniques relevant to gastrointestinal pathology. This comprehensive review of gastrointestinal pathology is a valuable resource for the faculties, gastrointestinal pathologists, cytologists, histopathologists, practicing pathologists, gastroenterologists, gastrointestinal surgeons, pathology fellows, postgraduates, clinical gastrointestinal fellows, and researchers in related fields.

Download or read book Diagnostic Pathology Gastrointestinal written by Joel K. Greenson and published by Elsevier. This book was released on 2024-09-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of gastrointestinal pathology to help pathologists differentiate between closely related digestive tract disorders, this volume incorporates the most up-to-date scientific and technical knowledge, providing a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the fourth edition of Diagnostic Pathology: Gastrointestinal is a visually stunning, one-stop resource for every practicing pathologist, fellow, resident, or student as an ideal day-to-day reference or as a reliable training resource, and is useful to even the most experienced pathologist for current details on the diagnosis and characterization of neoplastic and nonneoplastic diseases of the digestive tract. Covers all areas of gastrointestinal pathology-from esoteric topics like microsporidia to common issues like serrated colorectal polyps Includes important new material on recently discovered genetic alterations in GI cancers, targeted gene therapies, and the changed approach to GI endocrine neoplasms, as well as numerous new chapters on other timely issues, such as COVID-19's effects on the GI system, drug-induced GI diseases, and more Contains significantly updated information throughout, including new content, images, and references that reflect the most current diagnoses, provide ease for daily case sign-out, and contain details related to the latest WHO Classification of Tumours: Digestive System Tumours Features more than 2,600 print and online-only images, including histology and gross pathology images, full-color medical illustrations, clinical photographs, and radiology images to help practicing and in-training pathologists reach a confident diagnosis Employs consistently templated chapters, bulleted content, key facts, annotated images, and an extensive index for quick, expert reference at the point of care Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud; additional digital ancillary content may publish up to 6 weeks following the publication date . 10-15 new chapters plus image, text, and Reference updates across the book's 200 chapters are in place for the 4th ed. of DP: Gastrointestinal. New chapters are added, and existing contents are updated, to address the newest WHO Classification of Digestive System Tumors. The updated Classification includes a change to how appendiceal neoplasms are classified. Additional new content covers the changed overall approach to gastrointestinal endocrine neoplasms and how to differentiate Grade 3 endocrine tumors from high grade neuroendocrine carcinomas. New 4th ed chapters also include details on targeted gene therapies and important genes now identified which involve primary cancers of the GI tract.

Download or read book Practical Gastrointestinal Pathology written by Hanlin L. Wang and published by Springer Nature. This book was released on 2020-12-05 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses practical issues that reflect the current landscape of GI pathology practice and is organized in such a way that fits the fast-pacing daily life of practicing pathologists. It contains more than 540 questions that address difficult, prevailing and controversial issues in GI pathology that are frequently encountered in daily practice and consult service. For most questions, answers are straightforward with ample literature support. However, true diagnostic controversies and clinical dilemma cannot be easily resolved with current knowledge and available information. To such challenges, an expert approach regarding how to synthesize complicated topics and clearly communicate the thinking process is valuable to readers and can help guide clinicians making optimal treatment plans for their patients. The latter types of answers are highly enriched throughout the book. Distinct from other existing GI pathology textbooks, this book is primarily organized according to disease entities and pathological processes instead of specific organs and anatomic locations. Guided by chapter titles and listed questions, readers should be able to look up a disease or a pathological feature and find the most important and relevant diagnostic criteria and pertinent differential diagnoses. Written by experts in the field, Practical Gastrointestinal Pathology provides easy and quick access to concise, evidence-based and up-to-date information to aid accurate diagnosis and serves as a useful resource for practicing pathologists, pathology trainees and GI clinicians as well as allied health professionals who frequently deal with GI pathology.

Download or read book Differential Diagnosis in Surgical Pathology written by Vijaya B. Reddy and published by Elsevier Health Sciences. This book was released on 2014-10-20 with total page 1087 pages. Available in PDF, EPUB and Kindle. Book excerpt: Confidently sign out your most complex and challenging cases with the updated edition of Differential Diagnosis in Surgical Pathology. Widely used by residents and practicing pathologists alike, this comprehensive medical reference provides brief, bulleted descriptions of both common and rare disorders, integrating excellent illustrative examples of the pathology with selected references. It's the perfect go-to resource to have by your microscope! Quickly access essential information through concise, bulleted text; a consistent approach to diagnosis and interpretation; and a comprehensive yet manageable size. Formulate an accurate diagnosis with coverage of all of the relevant ancillary diagnostic techniques, and ensure every diagnostic possibility is explored with help from quick checklists throughout. Make informed decisions when delineating one disease from another with discussions covering all of the major organ systems. Understand what diagnostic criteria to consider or exclude with expert "pearls" and practical tips throughout. Take advantage of extensive updates on tumor classifications and diseases, as well as expanded coverage of medical renal pathology. Stay abreast of the latest developments in molecular testing, including diagnostics, biomarkers, and targeted therapies, for entities such as the breast, lung, gastrointestinal tract, and melanoma. View over 1,350 full-color macro and microphotographs that provide a realistic basis for comparison to what you see under the microscope. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, references, and videos from the book on a variety of devices.

Download or read book Morson and Dawson s Gastrointestinal Pathology written by David W. Day and published by Wiley-Blackwell. This book was released on 2003-02-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morson and Dawson's Gastrointestinal Pathology is one of the 'Gold Standards' of pathology textbooks. It has been completely revised to incorporate the latest advances in this rapidly evolving field including the developments in gastric cancer and Helicobacter pylori and the revised classification of other common gastrointestinal conditions. This new edition features a wealth of new material presented in full colour for the first time.

Download or read book Surgical Pathology of the GI Tract Liver Biliary Tract and Pancreas written by Robert D. Odze and published by Elsevier Health Sciences. This book was released on 2009-01-01 with total page 1387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This one-of-a-kind reference provides a comprehensive and practical guide to help you interpret endoscopic biopsies and resection specimens of all organs related to the digestive system. Plus, thanks to Expert Consult, you'll be able to access the entire contents of this title online and download all images, from anywhere there's an internet connection. The more than 2250 high quality illustrations, 30% more than in the first edition, help you recognize and diagnose any tissue sample under the microscope. Five new chapters, additional expert authors, expanded tables, and coverage of the current clinical approach to management and treatment options, particularly screening and surveillance recommendations for preneoplastic disorders, round out this unique reference. Acts as a one-stop resource for the entire gastrointestinal system, liver, biliary tract, and pancreas. Incorporates over 2250 high quality color illustrations so you can recognize and diagnose any tissue sample under the microscope. Provides all the necessary tools to make a comprehensive diagnostic workup including data from ancillary techniques and molecular findings whenever appropriate. Simplifies complex topics and streamlines decision-making using extensive tables, graphs, and flowcharts. Helps you avoid diagnostic errors thanks to practical advice on pitfalls in differential diagnosis. Uses a new "road map" at the beginning of each chapter, as well as a new, more clinical focus to help you navigate through the book more quickly. Reflects the latest classification and staging systems available so you can provide the clinician with the most accurate and up-to-date diagnostic and prognostic indicators, including key molecular aspects of tumor pathology. Includes access to the entire contents online, from anywhere there's an internet connection. Adds five new chapters including "Screening and Surveillance of the GI Tract", "Congenital and Developmental Disorders of the GI Tract", "Pediatric Enteropathies of the GI Tract", "Vascular Disorders of the GI Tract", and "Fatty Liver Disease". Expands appropriate chapters with new coverage of the normal histology of the GI tract, liver, biliary tract and pancreas. Uses expanded tables to outline specific differential diagnostic points helpful for surgical pathologists. Discusses the key molecular aspects of tumor progression and risk assessment in all chapters that cover neoplastic disorders. Helps you evaluate diagnostically challenging cases using diagnostic algorithms. Increases the number of high quality photographs by at least 30% to include even more normal and abnormal tissue samples. Updates all chapters to include the latest references, concepts, data, and controversies. Incorporates expanded coverage of the pancreas and liver, eliminating the need for a separate text. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Download or read book Gastrointestinal Pathology An Issue of Surgical Pathology Clinics E Book written by Raul S. Gonzalez and published by Elsevier Health Sciences. This book was released on 2020-08-30 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Surgical Pathology Clinics, guest edited by Dr. Raul Gonzalez, will cover key topics in Gastrointestinal Pathology. This issue is one of four selected each year by our series consulting editor, Dr. Jason L. Hornick. Topics discussed in this issue will include: Grossing of Gastrointestinal Specimens: Best Practices and Current Controversies, Subspecialty Signout and Interobserver Variability in Gastrointestinal Pathology, Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms, Daily Dilemmas in Pediatric Gastrointestinal Pathology, Upper Gastrointestinal Tract Manifestations of Inflammatory Bowel Disease, Gastric Polyps, Approaches to Biopsy and Resection Specimens of the Ampulla, Updates in Appendix Pathology, HER2 in Colorectal Carcinoma, Histology of Colorectal Carcinoma: Proven and Purported Prognostic Factors, Diagnoses and Difficulties in Mesenteric Pathology, Advances and Annoyances in Anus Pathology, among others.

Download or read book Atlas of Gastrointestinal Pathology A Pattern Based Approach to Neoplastic Biopsies written by Christina Arnold and published by Lippincott Williams & Wilkins. This book was released on 2018-12-11 with total page 2105 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. Closely mirroring the daily sign-out process, Atlas of Gastrointestinal Pathology: A Pattern Based Approach to Neoplastic Biopsies is a highly illustrated, efficient guide to accurate diagnosis. This practical reference uses a proven, pattern-based approach to clearly explain how to interpret challenging cases by highlighting red flags in the clinical chart and locating hidden clues in the slides. Useful as a daily “scope-side guide,” it features numerous clinical and educational features that help you find pertinent information, reach a correct diagnosis, and assemble a thorough and streamlined pathology report.

Download or read book Gastrointestinal pathology written by Basil Clifford Morson and published by . This book was released on 1974 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Greenson Diagnostic Pathology GI written by JOEL K.. OWENS GREENSON (SCOTT R.) and published by Elsevier. This book was released on 2024-09-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of gastrointestinal pathology to help pathologists differentiate between closely related digestive tract disorders, this volume incorporates the most up-to-date scientific and technical knowledge, providing a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the fourth edition of Diagnostic Pathology: Gastrointestinal is a visually stunning, one-stop resource for every practicing pathologist, fellow, resident, or student as an ideal day-to-day reference or as a reliable training resource, and is useful to even the most experienced pathologist for current details on the diagnosis and characterization of neoplastic and nonneoplastic diseases of the digestive tract. Covers all areas of gastrointestinal pathology-from esoteric topics like microsporidia to common issues like serrated colorectal polyps Includes important new material on recently discovered genetic alterations in GI cancers, targeted gene therapies, and the changed approach to GI endocrine neoplasms, as well as numerous new chapters on other timely issues, such as COVID-19's effects on the GI system, drug-induced GI diseases, and more Contains significantly updated information throughout, including new content, images, and references that reflect the most current diagnoses, provide ease for daily case sign-out, and contain details related to the latest WHO Classification of Tumours: Digestive System Tumours Features more than 2,400 print and online-only images, including histology and gross pathology images, full-color medical illustrations, clinical photographs, and radiology images to help practicing and in-training pathologists reach a confident diagnosis Employs consistently templated chapters, bulleted content, key facts, annotated images, and an extensive index for quick, expert reference at the point of care Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud; additional digital ancillary content may publish up to 6 weeks following the publication date . 10-15 new chapters plus image, text, and Reference updates across the book's 200 chapters are in place for the 4th ed. of DP: Gastrointestinal. New chapters are added, and existing contents are updated, to address the newest WHO Classification of Digestive System Tumors. The updated Classification includes a change to how appendiceal neoplasms are classified. Additional new content covers the changed overall approach to gastrointestinal endocrine neoplasms and how to differentiate Grade 3 endocrine tumors from high grade neuroendocrine carcinomas. New 4th ed chapters also include details on targeted gene therapies and important genes now identified which involve primary cancers of the GI tract.