Download or read book Gastric Cytoprotection written by Daniel Hollander and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastric secretions contain hydrogen ions at a concentration that is more than one million times higher than their intracellular concentration. This phenomenal gradient as well as the demonstrated ability of gastric juice to digest tissues has motivated clinicians and investigators alike to emphasize acid secretion and acid ablation in studying the pathogenesis and therapy of peptic ulcer disease. Conse quently, over the past 150 years, we have made considerable progress in under standing the mechanisms and regulation of acid secretion by the stomach. Not surprisingly, therapy for both peptic disease and mucosal injury has also been predominantly directed at either neutralizing acid or suppressing its production. During the past 10 years, attention has been focused on factors other than acid in the genesis and therapy of ulcer disease. Work done worldwide demon strated that acid hypersecretion is not a common event in peptic ulcer disease. Therefore, we began realizing that factors other than acid secretion may be important in the genesis of ulcer disease or in gastroduodenal mucosal damage. In addition, new physiological information has established that the gas troduodenal mucosa is normally protected by a complex series of events includ ing mucus and bicarbonate secretion, cell renewal, surface mucosal restitution, and preservation of the microvasculature and mucosal proliferative zone.
Download or read book Gastric Cytoprotection written by Daniel Hollander and published by . This book was released on 2014-09-01 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Tissue Injury and Cytoprotection Organoprotection in the Gastrointestinal Tract written by Ludmila P. Filaretova and published by Karger Medical and Scientific Publishers. This book was released on 2012 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date reviews on the mechanisms of gastrointestinal injury and protection In recent years, there have been significant advances both in understanding the mechanisms involved in gastrointestinal mucosal injury and protection, as well as in the development of successful strategies for prevention and treatment of gastrointestinal injury. Nevertheless, many people worldwide still suffer from gastrointestinal damage. This book contains contributions by an international panel of researchers in the form of up-to-date reviews on the mechanisms of gastrointestinal injury and protection. These are complemented by papers discussing how these new findings about cell/tissue injury and cytoprotection/organoprotection can be applied to the prevention and treatment of tissue damage in the gastrointestinal tract. Moreover, the publication includes a special chapter on Andre Robert, who has discovered the phenomenon of gastric cytoprotection. This publication will be of great interest for both basic and clinical researchers in gastroenterology and pharmacology, reviewing the advances made so far and pointing towards future developments.
Download or read book Current Concepts in Gastric Cytoprotection written by Steven P. Mistilis and published by . This book was released on 1985 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gastric Cytoprotection Experimental and Clinical Studies written by FRANCISCO J. MORÓN RODRÍGUEZ and published by . This book was released on 1983 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Mechanisms of Adaptive Cytoprotection Against Ethanol Induced Gastric Mucosal Damage in Rats written by 高加信 and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "The Mechanisms of Adaptive Cytoprotection Against Ethanol-induced Gastric Mucosal Damage in Rats" by 高加信, Ka-shun, Joshua, Ko, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. DOI: 10.5353/th_b3123418 Subjects: Gastric mucosa Cytology Rats - Diseases
Download or read book Current Concepts in Gastric Cytoprotection written by Steven P. Mistilis and published by . This book was released on 1985 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neuroendocrinology of Gastrointestinal Ulceration written by Sandor Szabo and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a meeting held in Esterel, Quebec, Canada, September 13-15, 1989.
Download or read book Gastrointestinal Mucosal Repair and Experimental Therapeutics written by Chi-Hin Cho and published by Karger Medical and Scientific Publishers. This book was released on 2002-01-01 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, considerable progress has been made in understanding cellular and molecular mechanisms involved in gastrointestinal mucosal injury and repair. These findings provide the basis to identify the etiology and pathogenesis of various gut mucosal injury-related diseases and to develop new therapeutic approaches. The publication at hand is divided into three sections: Epithelial restitution, mucosal repair and ulcer healing, and experimental therapeutics. The first part highlights the early rapid mucosal restitution, focussing on the roles of extracellular matrix, cytoskeleton, cytokines, Ca2+ signaling, polyamines, and the protein kinase C/DAG pathways. The next section deals with aspects of chronic mucosal healing, concentrating on the roles of primary response gene expression, angiogenesis and angiogenic growth factors, platelets, and the mechanisms of cell renewal after injury in special circumstances. The last part explores new therapeutic approaches, stressing potential clinical applications of nitric oxide-releasing agents, polysaccharides, nitric oxide synthase modulators, growth factors, prostaglandins, and cyclooxygenase inhibitors. Covering the current state-of-the-art findings relevant to gut mucosal injury and repair as well as providing the underlying conceptual basis and knowledge regarding experimental therapeutics for gastrointestinal mucosal injury-related diseases, this publication will be a timely guide for investigators working in the field.
Download or read book Cell Injury and Protection in the Gastrointestinal Tract written by Gyula Mózsik and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific main programmes of these series of symposia changed from time to time following the international scientific trends. The main programmes of the First Symposium were: 1. Gastric and intestinal cytoprotection; 2. Hepatoprotection; 3. Pancreatic protection. For the second one: 1. Gastrointestinal mucosal 'cytoprotection'; 2. Liver 'cytoprotection'; 3. Pancreatic 'cytoprotection'; 4. Free radicals and scavangers; 5. Computer approach to cytoprotec tion. For the third one: 1. Basic, central, peripheral and cellular mechanisms of gastrointestinaol cytoprotection; 2. Esophagal protection; 3. Gastric protection; 4. Small intestinal injury and protection; 5. Large bowel injury and protection; 6. Liver injury and protection; 7. Pancreas injury and protection. The main scientific programmes of the Fourth International Symposium on 'Cell Injury and Protection in the Gastrointestinal Tract' are: 1. General mechanisms of gastrointestinal injury and protection; 2. Cell injury and protection in the stomach; 3. Cell injury and protection in the small intestine and in the large bowel; 4. Cell injury and protection in the liver and pancreas; 5. Cell injury and protection of the premalignant status and malignant diseases in the gastrointestinal tract. The presented papers are published in this book. The abstracts of this meeting were published in Digestive Diseases and Sciences, and we record appreciation of the Editor ofthatjoumal for their publication. Some of the papers published here have appeared in Inflammopharmacology 1996;4:331-398.
Download or read book The Mechanisms of Adaptive Cytoprotection Against Ethanol induced Gastric Mucosal Damage in Rats written by Ka-shun Ko (Joshua) and published by . This book was released on 1995 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cytoprotection and Cytobiology written by and published by . This book was released on 1992 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ethnomedicinal Plants written by Mahendra Rai and published by CRC Press. This book was released on 2011-02-01 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting recent discoveries on ethnomedicinal plants around the world, this book focuses on evaluating the progress to date as well as the future potential of drug development in ethnomedicine. Eight reviews examine therapeutic applications including the spasmolitic effects of various plants, the anti-inflammatory activity of plants from Brazil a
Download or read book Alcohol and the Gastrointestinal Tract written by Victor R. Preedy and published by CRC Press. This book was released on 2017-09-08 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of gastrointestinal tract problems caused by alcohol misuse. Opening chapters discuss epidemiology and the metabolism of alcohol and the liver's role in that process. Alcohol and acetaldehyde dehydrogenases, free radicals, and endocrine changes are discussed in detail. Recent advances in the pathophysiology of alcohol-induced disorders are summarized and many chapters detail techniques such as permeability and protein synthesis. Effects on specific organs, including the salivary glands, stomach, pancreas, and small intestine, are also discussed. All contributors and both editors are internationally recognized experts in their fields.
Download or read book Sucralfate written by Daniel Hollander and published by Springer Science & Business Media. This book was released on 2007-07-07 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: International researchers summarize the current understanding of peptic disease and trace the development of a novel new drug for peptic disease therapy-sucralfate. Contributors present laboratory research along side data from clinical trials as well as from the practice of medicine. Articles discuss the history of sucralfate's development, mechanisms of action, clinical efficacy, and future directions for research. This volume will be of interest to scientists and clinicians working in gastroenterology and gastrointestinal physiology.
Download or read book Eicosanoids and the Gastrointestinal Tract written by K. Hillier and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: The original series, Advances in Prostaglandin Research, edited by Sultan M. M. Karim, was published by MTP Press in three volumes in 1975 and 1976. A glance at those books illustrates the progress that has been made since then. The thromboxanes were mentioned twice (first publication 1975) and prostacyclin not once (first publication 1976); leukotrienes were only on the horizon. The amazing generation of research data in the last 10-15 years has given new, broad insights into many areas, including asthma, inflammation, renaL cardiovascular and gastrointestinal diseases and in reproduction, and has led in some instances to real clinical benefit. This series,AdvancesinEicosanoidResearch, reflects the current understanding of prostaglandins, thromboxanes and leukotrienes. The aim is to provide an introductory background to each topic and the most up-to-date information available. Although each book stands alone, the eicosanoids cut across many boundaries in their basic actions; selected chapters from each book in the Series will provide illuminating and productive information for all readers which will advance their education and research. In the production of this series, I must acknowledge with pleasure my collaboration with editors and authors and the patient endeavours of Dr. Michael Brewis and the staff at MTP Press.
Download or read book Prostanoids and Drugs written by B. Samuelson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, the sixth in the series "The Prostaglandin System" assembles most of the lecture notes from the International School of Pharmacology on "Prostanoids and Drugs" that took place in Erice, Sicily, at the "Ettore Majorana Center for Scientific Culture" on Sept 5-15, 1989. The course, which was a NATO Advanced Study Institute, comprised detailed discussion of basic metabolic pathways of arachidonic acid as well as their location in the everyday practice of clinical medicine. The current status of our knowledge on drugs affecting prostanoid metabolic pathways, and/or their functinal effects, together with the use of prostanoids as drugs, has been reviewed in depth by distinguished experts. In certain instances a few chapters might overlap with others to present divergent viewpoints of authors, for a better assessment of the complexity of eicosanoid biology. It is likely that as our knowledge of prostanoids in different diseases increases, new diseases may also be targets for drugs related to these lipid mediators. We hope that this boo~will encourage basic scientists and clinicians to pursue additional biomedical investigations along these lines of inquiry. Moreover we would like to take this opportunity to express our gratitude to all the invited speakers not only for their important contributions before and during the course but also for their ability in creating an atmosphere in which all questions were legitimate and all lines of investigations were encouraged.
