Download or read book Gas Uptake Kinetics of Bromotrifluoromethane Halon 1301 and Its Proposed Replacement Iodotrifluoromethane CF3I written by and published by . This book was released on 1994 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: A physiologically based simulation approach was used to estimate in vivo metabolic constants in male Fischer 344 rats for the two chemicals, bromotrifluoromethane (Halon 1301), and its proposed replacement candidate, iodotrifluoromethane (CF3I). A closed recirculating exposure system was used to collect a series of gas uptake curves for both chemicals at equivalent initial exposure concentrations. Additionally, tissue:air partitiOn coefficients were determined experimentally for each chemical and incorporated into a physiologically based pharmacokinetic model, which was then used to simulate the uptake of the chemicals. By iteratively adjusting the constants describing metabolism of the chemical, and optimized fit of the series of uptake curves was obtained for each chemical. This simulation approach adequately described the overall uptake of each chemical from the chamber. Given the relatively low level of partitioning of these chemicals into tissues and their relative inertness, this approach could not be used with certainty to discriminate between metabolism by saturable and/or first-order process and no metabolism at all.
Download or read book Inhalation Uptake and Metabolism of Halon 1301 and Its Proposed Replacements written by Jason Robert Creech and published by . This book was released on 1996 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Government Reports Announcements Index written by and published by . This book was released on 1996 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Effect of Bromotrifluoromethane Halon 1301 on Human Performance written by Medical College of Wisconsin. Department of Environmental Medicine and published by . This book was released on 1973 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organosilicon Materials written by Grish Chandra and published by . This book was released on 2014-01-15 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
