Download or read book Gangliosides in Health and Disease written by and published by Academic Press. This book was released on 2018-04-25 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gangliosides in Health and Disease, Volume 156, presents the latest information on Gangliosides, a class of glycolipids that are found on all vertebrate cell surfaces, and are particularly abundant in the brain. Individual chapters in this new volume cover Gangliosides as Toxin Receptors, Gangliosides in Cancer Cell Signaling, Gangliosides in inflammation and neurodegeneration, Gangliosides as functional galectin receptors, Gangliosides in signal transduction, Gangliosides in brain tumor immunology, and Gangliosides in axon regeneration and stability, amongst other related topics. This book brings together world experts in ganglioside structure and function who have been assembled to contribute to this thorough update of the field. Contains accessible content that is ideal for students and researchers alike Written by leading authorities in the field

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Download or read book Neurobiology of Glycoconjugates written by R.K. Margolis and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised and renamed volume reflects a number of important changes in content and emphasis since this field was first surveyed in Complex carbohydrates of nervous tissue in 1979. A third of the chapters did not appear in the predecessor volume, and more than half have new authors. In this expand

Download or read book Inherited Metabolic Disease in Adults written by Carla E. M. Hollak and published by Oxford University Press. This book was released on 2016 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: As clinical management of inherited metabolic diseases (IMDs) has improved, more patients affected by these conditions are surviving into adulthood. This trend, coupled with the widespread recognition that IMDs can present differently and for the first time during adulthood, makes the need for a working knowledge of these diseases more important than ever. Inherited Metabolic Disease in Adults offers an authoritative clinical guide to the adult manifestations of these challenging and myriad conditions. These include both the classic pediatric-onset conditions and a number of new diseases that can manifest at any age. It is the first book to give a clear and concise overview of how this group of conditions affects adult patients, a that topic will become a growing imperative for physicians across primary and specialized care.

Download or read book GM3 Signaling written by Cheorl-Ho Kim and published by Springer Nature. This book was released on 2020-07-10 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.

Download or read book Handbook of Glycosyltransferases and Related Genes written by Naoyuki Taniguchi and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The so-called postgenomic research era has now been launched, and the field of gly cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl transferases. The regulation of the biosynthesis of sugar chains is under the control of the expression of glycosyltransferases, their substrate specificity, and their local ization in specific tissue sites. There is a growing body of evidence to suggest that these enzymes play pivotal roles in a variety of important cellular differentiation and developmental events, as well as in disease processes. Over 300 glycosyltransferases appear to exist in mammalian tissues. If the genes that have been purified and cloned from various species such as humans, cattle, pigs, rats and mice are counted as one, approximately 110 glycogenes that encode glycosyltransferases and related genes have been cloned at present, and this number continues to grow each day. However, most of the functions of the glycosyltransferase genes and related genes are unknown. This fact has stimulated numerous new and interesting approaches in molecular biologi cal investigations.

Download or read book Inborn Disorders of Sphingolipid Metabolism written by Stanley M. Aronson and published by Elsevier. This book was released on 2017-01-31 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inborn Disorders of Sphingolipid Metabolism is a collection of papers presented at the Third International Symposium on the Cerebral Sphingolipidoses and Allied Diseases, held at the Isaac Albert Research Institute of the Jewish Chronic Disease Hospital and at the State University of New York, Downstate Medical Center, on October 25 and 26, 1965. This book is organized into three parts encompassing 35 chapters. Part I deals first with electron microscopic, histochemical, and morphological investigations of certain sphingolipid metabolism disorders. This part also examines several case reports on the features and symptoms of spongy degeneration of the central nervous system, familial leukodystrophy, adrenal insufficiency, and cutaneous melanosis. Part II surveys the metabolism, biosynthesis, and structure of gangliosides and sialic acids. This part also considers the nature of the lipophilic portions of the brain gangliosides. This part particularly looks into the features and clinical manifestation of Tay-Sachs disease. The third part covers the genetic and clinical aspects of the Tay-Sachs disease. This part also evaluates the genetics of the Hurler-Hunter syndrome, Batten-Spielmeyer-Vogt disease, and lipogranulomatosis syndrome. This book is of value to biochemists, histochemists, geneticists, and researchers in the allied fields of lipidosis.

Download or read book Structure and Function of Gangliosides written by Lars Svennerholm and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume records the proceedings of an International Symposium on The Structure and Function of Gangliosides, held at Le Bischenberg, Alsace, France, in April 23-27, 1979. The meeting was convened to get a comprehensive view of the immense activity that had occurred in the field since the previous conference on gangliosides held at Mont Sainte-Odile, ~lsace, France, in April 1973. At a conference on Enzymes of Lipid Metabolism held at the same place in April, 1977, several of the participants from the first ganglioside conference in 1973 met again. All previous participants agreed that the first meeting with its many frank and stimulating lectures, round tables and informal discussions had been of tremendous importance for the activity in the field and led to many personal contacts and a warm friendship among the ganglioside researchers. The success of the first meeting must be ascribed largely to one single man, PAUL MANDEL. Therefore, we decided to dedicate the next ganglioside conference to hirn and I was given the privilege to arrange the meeting together with him and staff members at Centre de Neurochirnie, Strasbourg. The Symposium on The Structure and Function of Gangliosides was arranged to honour PAUL MANDEL for his unique and never failing efforts to promote and strengthen international col laboration in all fields of neurochemistry.

Download or read book Ganglioside Biochemistry written by Cheorl-Ho Kim and published by Springer Nature. This book was released on 2020-07-03 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies.

Download or read book Gangliosides written by Sandro Sonnino and published by Humana Press. This book was released on 2018-06-21 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores methods of examining gangliosides, membrane amphiphilic lipids that are deeply involved in the modulation of the overall properties of cellular membranes, as well as of the functions of membrane-associated proteins. The contents take into account the vital availability of new enzymatic approaches, the knowledge of an incredibly extensive number of glyco-enzymes, and the improvement of multi-genetic analyses. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Gangliosides: Methods and Protocols serves as a valuable guidebook for entering in the vast research world of gangliosides.

Download or read book A Treatise on the Chemical Constitution of the Brain written by Johann Ludwig Wilhelm Thudichum and published by . This book was released on 1962 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Neurochemistry written by B. W. Agranoff and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The original premise of the Editors in initiating this series was that there existed a readership ofneurochemists with considerable biochemical back ground who would make use of a series dedicated to both new develop ments and specialized reviews in neurochemistry. Having selected our authors, we have offered them virtually complete freedom to reflect and speculate in a field in which they have achieved prominence. The response to the first two volumes has been rewarding. The present one continues in this tradition. While we have not attempted to publish specialized volumes, the present volume contains two somewhat related chapters (Chapters 4 and 5, on the role of amino acid neurotransmitters). The first three chapters examine three diverse approaches, each of current interest, in neurochemi cal approaches to the molecular bases of neuronal and glial structure. B. W. Agranoff M. H. Aprison vii CONTENTS CHAPTER 1 2',3'-CYCUC NUCLEOTIDE 3'-PHOSPHODIESTERASE NEIL RAYMOND SIMS AND PATRICK ROBERT CARNEGIE 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. Assay of CNPase . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 1. Need for Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2. 2. Comparison of Assays . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3. Association of CNPase with Myelin . . . . . . . . . . . . . . . . . . . . . . . 7 3. 1. Historical. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 3. 2. Subcellular Fractionation. . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 3. Development. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3. 4. Mutant Mice . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. 5. Use as a Myelin Marker . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 3. 6. Myelin-Related Fractions and Peripheral Nerve Myelin. 11 4. CNPase in Nonmyelin Fractions. . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. Activation and Isolation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. 1. Introduction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 5. 2. Activation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 5. 3. Solubilization and Fractionation. . . . . . . . . . . . . . . . . . . . . . 15 6. Properties. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 6. 1. Substrate Specificity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Download or read book Medical Applications of Mass Spectrometry written by Karoly Vekey and published by Elsevier. This book was released on 2011-08-11 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry.* Guides the reader from basic principles and methods to cutting edge applications.* There is NO comparable book on the market to fill this fast growing field.

Download or read book Bioactive Ceramides in Health and Disease written by Johnny Stiban and published by Springer Nature. This book was released on 2019-09-09 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented. Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry. World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings. This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.

Download or read book Adverse Effects of Vaccines written by Institute of Medicine and published by National Academies Press. This book was released on 2012-04-26 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Download or read book Transforming Glycoscience written by National Research Council and published by National Academies Press. This book was released on 2012-10-23 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.

Download or read book Ferri s Differential Diagnosis written by Fred F. Ferri, MD, FACP and published by Elsevier Health Sciences. This book was released on 2010-08-26 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ferri's Differential Diagnosis is a quick reference to the differential diagnosis, etiology, and classification of clinical disorders, signs, and symptoms. Dr. Fred F. Ferri-the respected best-selling author-presents over 1000 signs, symptoms, and clinical disorders. Comprehensive yet small enough to fit in your pocket, this portable guide is a rapid resource for everything you see in daily practice-from abdominal distension to Zenker's Diverticulum. Quickly locate the information you need with an organization that presents differential diagnosis by sign and symptom as well as disorder. Easily identify the likeliest diagnosis through diagnostic possibilities listed in order of incidence. Tap into the authoritative guidance of Dr. Fred Ferri, the respected expert responsible for best-selling titles such as Ferri's Clinical Advisor, Ferri's Fast Facts, and Practical Guide to the Care of the Medical Patient. Apply the differential diagnosis of over 100 new signs, symptoms, and clinical disorders.