Download or read book Functions of Protein Tyrosine Phosphatases in S Cerevisiae Signal Transduction written by Xiaoli Zhan and published by . This book was released on 2000 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Tyrosine Phosphatases written by Lalima G. Ahuja and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-10-08 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein tyrosine phosphatases remove phosphates from the phosphotyrosine residues of target proteins and reverse the action of various protein tyrosine kinases. This essential interplay between the opposing actions of protein tyrosine phosphatases and protein tyrosine kinases forms the basis of signaling networks that underlie the cellular workings of human physiology. Initially passed-off as housekeeping genes; these proteins were only acknowledged to maintain a steady background of phosphotyrosine levels in the cell. However, recent progress in studying their role in embryonic development and human disease has established their importance as regulators of signal regulation. Convincing evidence shows the role of mutations in these proteins to cause and/or intensify the severity of various diseases including metabolic and neurological disorders and also cancer. Protein tyrosine phosphatases have slowly, yet convincingly become crucial targets for therapeutic intervention of various human pathophysiologies. This book describes these signaling enzymes using the molecular details of their structure and mechanistic function. Various subtypes of cysteine-based Class I, II, III and the Haloacid dehalogenase related Class IV protein tyrosine phosphatases have been illustrated and explained. The superfamily of proteins is also described vis-a-vis its complimentary protein phosphoserine/phosphoserine phosphatases. Membrane bound receptor forms and the cytosolic non-receptor protein tyrosine phosphatases have been described for their biological function. This book serves as a reference for any reader looking to understand the sequence features, structural elements, molecular mechanism and cellular function of this superfamily of signaling enzymes.
Download or read book Protein Tyrosine Phosphatase Interacting Protein 51 in Signal Transduction written by Alexander Martin Brobeil and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Tyrosine Phosphatases written by Damien Thévenin and published by Springer Nature. This book was released on 2024-01-27 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous edition with discussions on the latest advancements in protein tyrosine phosphatases (PTP) research used to investigate these essential enzymes and new inhibitors. The new techniques covered in the chapters of this book include studying enzymes in vitro, in cells, and in animal models through proteomics, genomics, and structural biology. Furthermore, new advances in pharmacology and drug design have contributed to the developing novel therapeutics that target PTPs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Protein Tyrosine Phosphatases: Methods and Protocols, Second Edition is a valuable resource for both experienced and novel researchers in this field, and will lead to discoveries and accelerated progress in the field of PTP, signal transduction, and drug development.
Download or read book Study of the Possible Role of Protein Tyrosine Phosphatase Activity in the Regulation of Insulin s Signal Transduction written by Dalit Hecht and published by . This book was released on 1991 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Role for Protein tyrosine Phosphorylation in Growth Hormone Signal Transduction written by Linda Anne Winston and published by . This book was released on 1991 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Tyrosine Phosphatases written by Teri Hatzihristidis and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Reversible tyrosine phosphorylation is a fundamental regulatory mechanism that is integralfor cellular function. Proper coordination of such signal transduction is crucial since an imbalancecould lead to a disease state. The protein tyrosine phosphatase (PTP) superfamily dephosphorylatesphospho-tyrosine residues to maintain the balance of pathway activation and deactivation withinthe cell. Insight into PTP functions has been predominantly gained from the study of humandiseases and mouse models. However, with over 100 members in mouse and human, functionalredundancy between PTP paralogs often impedes such studies. Examination of less complex modelorganisms is one way of overcoming this, but a lack of proper tools means the tyrosinephosphatomes of most organisms are uncharacterized. Numerous human pathologies can beattributed to perturbations in PTP function, the most common genetic disease associations beingof immune origin. As a mediator of cytokine signaling, T-cell protein tyrosine phosphatase (TCPTP)is implicated in the function of many immune lineages. On the other hand, phosphatase ofregenerating liver 2 (PRL-2) has been extensively studied in the cancer setting but may play novelroles within the immune system. As such, the aim of this thesis is to provide further insight intofunctions of PTPs as immunomodulators while examining a new approach with which to studythis large family.To begin, using a unique method for the systematic prediction of PTPs, the first fullannotation of Drosophila tyrosine phosphatases is described, demonstrating the degree ofconservation across organisms of varying complexity. An integrative analysis is performed toposition Drosophila PTPs within the functional and evolutionary framework and establish thismodel organism as a powerful tool in the study of these enzymes. The subsequent study identifiesa new role for TC-PTP in early T-cell development and describes how PTPs can serve as morethan just an ‘off-switch’ by directing the transcriptome in response to cytokine cues. Lastly, PRL-2 is examined as an emerging player in the immune system, implicated in regulating metabolismto influence T-cell fate. Taken together, the findings presented here demonstrate the value of asimplified model in discerning PTP biology, as highlighted by the complexity of TC-PTP andPRL-2"--
Download or read book Protein Tyrosine Phosphatase Control of Metabolism written by Kendra K. Bence and published by Springer Science & Business Media. This book was released on 2013-08-30 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although phosphorylation of proteins on tyrosine is relatively rare compared to phosphorylation on serine or threonine residues, the past two decades of research into PTP function have led to a great appreciation of the critical role PTPs have in regulating basic cellular processes. Among these important roles is the regulation of cellular signaling pathways related to metabolism. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism. Given the growing obesity and diabetes epidemics in the United States and throughout the world, the desire to identify possible therapeutic targets for treatment of these diseases is a high priority. In many ways, PTPs may be attractive drug targets since they are amenable to targeting with small molecules; however many challenges abound in making PTP inhibitors.
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. - Contains over 350 chapters of comprehensive coverage on cell signaling - Includes discussion on topics from ligand/receptor interactions to organ/organism responses - Provides user-friendly, well-illustrated, reputable content by experts in the field
Download or read book Protein Phosphorylation written by Friedrich Marks and published by Wiley-VCH. This book was released on 1996-04-23 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein phosphorylation is a key mechanism in cellular signaling. This volume presents a state-of-the-art survey of one of the most rapidly developing fields of biochemical research. Written by leading experts, it presents the latest results for some of the most important cellular pathways. Color plates illustrate structural or functional relationships, numerous references provide links to the original literature.
Download or read book Signal Transduction by the SH2 containing Protein Tyrosine Phosphatase SH PTP2 written by Terry L. Tang and published by . This book was released on 1994 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Tyrosine Phosphatases in the Process of Type I Fc epsilon Receptor Signal Transduction written by Christiane Susanne Hampe and published by . This book was released on 1997 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Analysis of the Role Played by the Protein Tyrosine Phosphatase CD45 in Lymphocyte Signal Transduction Processes written by Susanna Fletcher Greer and published by . This book was released on 2000 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Antigen Receptor Signal Transduction by the Protein Tyrosine Phosphatase SHP 1 written by David Robert Plas and published by . This book was released on 1998 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on the Role of Protein tyrosine Phosphorylation in Growth factor Signal Transduction written by In-Soon Kim and published by . This book was released on 1990 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Seeds written by Steve W. Adkins and published by CABI. This book was released on 2007-01-01 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: These proceedings contain 43 papers on the aspects of seed conservation, development, biotechnology, germination, dormancy and ecology.
