Download or read book Functionalized Nanoparticles for Use in Cancer Therapy written by Martin Lafleur and published by . This book was released on 2013 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functionalized Nanoparticles for the Selective Killing of Cancer Cells written by Paul Todd Thevenot and published by ProQuest. This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of nanoparticles for cancer imaging and drug delivery has produced some success in improving the efficacy and safety of cancer chemotherapy. It is generally believed that the efficiency of nanoparticle-based cancer therapy would be greatly improved if such particles could be designed to directly interact with and eradicate tumor. Many recent studies have revealed that surface functionality plays an important role in particle:cell interactions. Using titanium dioxide (TiO2) nanoparticles (21 nm diameter) as test subjects, nanoparticles with different functional groups, hydroxyl ( -OH), amine ( -NH2), and carboxyl ( -COOH) were produced and used in this investigation. An in vitro cell culture system was used to evaluate the interaction of a series of surface functionalized TiO2 nanoparticles with a number of normal animal and cancer cell lines, including B16F10 melanoma, Lewis lung carcinoma (LLC), JHU prostate cancer cells, and 3T3 fibroblasts. It was observed that cell viability following exposure to TiO2 nanoparticles was dependent on particle concentration, cell line, and TiO 2 surface chemistry. Overall, the TiO2 nanoparticles, both functionalized and uncoated, exerted the strongest toxicity effects on LLC cells and least toxicity on B16F10 cells and 3T3 fibroblasts. Cell viability was observed to depend on the specific surface chemistry of the particles. In general, particles with -NH2 or -OH functional groups exhibited significantly higher toxicity than those functionalized with -COOH groups. Microscopy analysis of cell viability as well as spectophotometric analysis of lactate dehydrogenase (LDH) content and arrays of cell proliferation indicated that the TiO 2 nanoparticles disrupt the cell membrane integrity leading to cell death. Overall, the present results suggest that functionalized TiO2 nanoparticles, and presumably other nanoparticles similarly surface modified, may be engineered specifically for targeted cancer therapy. The ability to fully understand how a precisely chemically defined surface interacts with both cell monolayers and body tissues will help scientists and engineers in the design of materials that will perform their desired function while also minimizing unfavorable interactions within the body.
Download or read book Functionalized Nanocarriers for Theranostics written by Stefano Leporatti and published by Frontiers Media SA. This book was released on 2020-12-31 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Functionalized Nanomaterials for Cancer Research written by Hamed Barabadi and published by Elsevier. This book was released on 2024-03-22 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Nanomaterials for Cancer Research: Applications in Treatments, Tools and Devices presents an in-depth and step by step description of knowledge on functionalized nanomaterials for cancer research, including treatment and future developments as well as their impact on patients' overall outcomes. The book discusses the functionalized nanoplatforms for cancer detection and imaging, interactions between nanomaterials and cancer cells, and drug resistant malignancies. The chapters are organized in a manner that can be readily adopted as sources for new and further studies by highlighting the main in vitro and in vivo nano-therapeutic achievements on cancer. Additionally, current trends on functionalized nanomaterials for cancer research and commercial scale opportunities are discussed. It is a valuable resource for researchers, oncologists, students, and members of the biomedical and medical fields who want to learn more about the potential of nanotechnology in cancer research and treatment. - Provides comprehensive coverage on functionalized nanomaterials for cancer therapeutics and future developments - Explores current trends on functionalized nanomaterials for cancer research and commercial scale opportunities - Discusses real-world case studies on functionalized nanomaterials for cancer therapy and research
Download or read book Nanopharmaceuticals Principles and Applications Vol 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
Download or read book Design and Evaluation of Plasmonic Magnetic Au MFe2O4 M Fe Co Mn Core Shell Nanoparticles Functionalized with Doxorubicin for Cancer Therapeutics written by Ravichandran Manisekaran and published by Springer. This book was released on 2017-10-30 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis documents the development of a multifunctional nanoparticle system to enhance the chemotherapeutic efficiency of anti-cancer drugs, and contributes to research that helps decrease the side-effects in cancer patients while simultaneously increasing their survival rates. The work begins with an introduction to nanomedicine and cancer therapy, and contains a literature review on magnetic, gold, and core-shell nanoparticles. It also covers synthesis techniques, properties, various surface modifications, and the importance of magnetic and gold nanoparticles. The author dedicates a chapter to characterization techniques, experimental setup, and cell cultivation techniques for in-vitro studies. Further chapters describe the background, characterizations, and applications of multifunctional magnetite coated gold core-shell nanoparticles, and the doping of cobalt to magnetite and manganese to magnetite nanoparticles. The important highlight of this research was the control of the size, shape, composition, and surface chemistry of nanoparticles.
Download or read book Metal Nanoparticles for Drug Delivery and Diagnostic Applications written by Muhammad Raza Shah and published by Elsevier. This book was released on 2019-11-05 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal Nanoparticles for Drug Delivery and Diagnostic Applications addresses the lifecycle of metal nanoparticles, from synthesis and characterization, to applications in drug delivery and targeting. It is an important resource for those in biomaterials, nanomedicine and pharmaceutical sciences, exploring gold, silver and iron-based drug delivery systems for controlled and targeted delivery of potential drugs and genes for enhanced clinical efficacy. Nanotechnology is widely used in drug delivery due to its ability to reduce plasma fluctuation of drugs, high solubility, and efficiency, the relatively low cost of nanoscale products, and enhancement of patient comfort, hence this resource is a welcome edition to the science. Illustrates the progression of nanoparticle therapeutics from basic research to applications Explores new opportunities and ideas for developing and improving technologies in nanomedicine and nanobiology Discusses the toxicity of different types of metal nanoparticles and how to ensure their safe use
Download or read book Surface Functionalized Magnetic Nanoparticles for Cancer Therapy Applications written by Robert John Wydra and published by . This book was released on 2015 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Peptide functionalized Magnetic Nanoparticles for Cancer Therapy Applications written by Anastasia Kruse Hauser and published by . This book was released on 2016 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nanomaterials for Cancer Therapy written by Challa S. S. R. Kumar and published by Wiley-VCH. This book was released on 2006-07-24 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive overview on nanotechnological approaches to cancer therapy brings together therapeutic oncology and nanotechnology, showing the various strategic approaches to selectively eliminating cancerous cells without damaging the surrounding healthy tissue. The strategies covered include magnetic, optical, microwave and neutron absorption techniques, nanocapsules for active agents, nanoparticles as active agents, and active and passive targeting, while also dealing with fundamental aspects of how nanoparticles cross biological barriers. A valuable single source gathering the many articles published in specialized journals often difficult to locate for members of the other disciplines involved.
Download or read book Nanoparticles in Lung Cancer Therapy Recent Trends written by Abhijit Bandyopadhyay and published by Springer. This book was released on 2014-11-14 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief provides an insight into the present scenario of the role of nanotechnology in the diagnosis and treatment of lung cancer at an early stage. Currently, lung cancer is the subject of major concern owing to the very high mortality rate throughout the world. Most of the conventional treatment methods such as surgery, chemotherapy, radiotherapy, etc., fail to prolong life of the patients. Incidents of recurrence are also very common in case of lung cancer. Researchers have shown that nanoparticles may act as a powerful anti cancer tool, especially for lung cancer. Unique surface properties and easy surface functionalization of nanoparticles enable early detection, diagnosis, imaging and treatment of lung cancer. The authors have elaborately presented how various nanoparticles (natural, semi synthetic and synthetic) may help in the treatment of lung cancer. They have also detailed works of various scientists who succeeded in developing effective nanoparticles and enabled very specific lung cancer therapy without any undesirable side effects and minimized death.
Download or read book Design of Functionalized Nanoparticles as Imaging Agents for Cancer written by José Alejandro Barreto Solano and published by . This book was released on 2012 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the synthesis and characterization of three different generations of iron oxide magnetic nanoparticles derivatized with macrocyclic ligands for application as bi-modal imaging agents in the detection of cancer tumors by Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). The nanoparticles have been modified with polyethyleneglycol (PEG) in order to avoid uptake by the Reticuloendothelial System (RES), whilst the macrocyclic ligands have been introduced for chelation of the radionuclide 64Cu2+, which is detectable by PET. Apart from being a platform for the transport of the radionuclide complexes, the magnetic nanoparticles themselves act as MRI contrast agents and can be used for hyperthermia treatment of cancer due to their super paramagnetic nature. Synthesis of the first generation nanoparticles involved co precipitation of the core nanoparticles from a solution of iron(II) and iron(III) salts through addition of base. The macrocycles 1,4-bis(2-pyridylmethyl)-1,4,7-triazacyclononane (dmptacn), 1,4,7,10-tetraazacyclododecane (cyclen) and 1,4,8,11-tetraazacyclotetradecane (cyclam) were reacted with glycidyloxypropyltriethoxysilane (GPTES) to form the corresponding siloxane derivatives, which were then hydrolyzed over the surface of the nanoparticles to form a stable coating. Macrocycle loadings of the order of 0.2 mmol/g were achieved using this methodology, and the mean diameter of the nanoparticles was found to be ca. 7 nm, respective of the ligand used. Light scattering measurements showed that the particles form aggregates in solution, with a hydrodynamic size of 150-200 nm. The nanoparticles could be rapidly radiolabeled with 64Cu2+. Challenge experiments performed with an excess of cyclam indicated that the nanoparticles derivatized with dmptacn were the most resistant to 64Cu2+ leaching. These particles were also found to be the most stable in rat plasma. A second generation of nanoparticles was synthesized in order to diminish the aggregation of the nanoparticles. This involved synthesis of the core nanoparticles by co precipitation, followed by surface coating with oleic acid, which provided enhanced stability (reduced aggregation) in organic media. Displacement of the oleic acid chains with polyethylene glycol silane (PEG-silane) derivatives was used to produce a stable coating on the nanoparticles and to render them water soluble. Two different PEG-silane molecules, with different PEG chain lengths (Mn 250 and 600), were used to modified the nanoparticles. It was found that the nanoparticles coated with the longer PEG chains (PEG600) were less susceptible to aggregation in aqueous media. The nanoparticles were also functionalized with different macrocycles through amide coupling to the terminal carboxylic acid groups of the PEG chains. The nanoparticles were found to bind 64Cu2+both specifically (via the macrocycles) and nonspecifically, however the weakly boundions could be removed by addition of cyclam. In addition to MRI and PET, these second generation nanoparticles would be suitable for use in hyperthermia treatment as they possess a good specific absorption rate. The third generation nanoparticles consisted of iron oxide particles synthesized by thermal decomposition of iron oleate in the presence of oleic acid. Substitution of the surface oleate molecules by ligand exchange reaction with a PEG 600-silane derivative produced water dispersible nanoparticles with narrower size distribution and smaller hydrodynamic size than the first two generations of nanoparticles. The nanoparticles were found to accumulate in the liver after injection, as revealed by in vivo imaging studies performed on rats. The particles were further functionalized with the 64Cu2+ complex of a new dmptacn derivative, via the free carboxyl groups of the PEG chains, to produce an agent suitable for dual modal MRI-PET imaging.
Download or read book Recent Advances in Novel Drug Carrier Systems written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2012-10-31 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Download or read book Nano Drug Delivery Strategies for the Treatment of Cancers written by Awesh K. Yadav and published by Academic Press. This book was released on 2020-09-03 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano Drug Delivery Strategies for the Treatment of Cancers discusses several current and promising approaches for the diagnosis and treatment of cancer by using the most recent developments in nanomedical technologies. The book presents introductory information about the biology of different types of cancer in order to provide the reader with knowledge on their specificities. In addition, it discusses various novel drug delivery systems, detailing their functionalities, expected outcomes and future developments in the field, focusing on brain, mouth and throat, breast, lung, liver, pancreas, stomach, colon, bool, skin and prostate cancers. The book is a valuable source for cancer researchers, oncologists, pharmacologists and nanotechnologists who are interested in novel drug delivery systems and devices for treatment of various types of cancer that take advantage of recent advances in this exciting field. - Discusses a wide range of promising approaches for the diagnosis and treatment of cancer using the latest advancement in cutting-edge nanomedical technologies - Provides foundational information on different types of cancer and their biology to help the reader choose the best nano drug delivery system for patients - Presents novel drug delivery systems based on nanoparticles, microparticles, liposomes, self-assembling Micelles and block copolymer micelles
Download or read book Cancer Nanotechnology written by Ângela Maria Almeida de Sousa and published by Springer Nature. This book was released on 2022-12-13 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer nanotechnology is a growing, emerging area of cross-disciplinary research that aims to develop efficient, specific and noninvasive approaches to restore the health and well-being of all cancer patients through more effective diagnosis and treatment. This new volume serves as a fundamental guide to cutting-edge topics in cancer nanotechnology, including advances in therapy, the use of nanoparticles and nanomaterials, future directions for nanocarriers in cancer therapy, and the application of DNA and RNA nanovaccines. Organized into four sections, the volume presents an overview of research and innovation in the emerging field of nanotechnology as a powerful tool in the diagnosis, imaging and treatment of cancer. International experts author chapters addressing targets of cancer therapy, materials for cancer nanotechnology, strategies for cancer therapy using nanotechnology, and innovative nanotechnologies for cancer diagnosis and treatment. The volume will be useful for a broad audience, including cross-disciplinary researchers, trainees, health professionals, and experts in industry.
Download or read book Nanomedicine for Cancer Diagnosis and Therapy written by Arshi Malik and published by Springer Nature. This book was released on 2021-08-01 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current applications and future prospects of nanomaterials in cancer diagnostics and therapy. Nanomaterials have recently emerged as a remarkable and promising tool for cancer therapy and diagnosis, due to their broad range of intrinsic molecular properties. To overcome the current limitations of nanoparticles in drug delivery systems, attempts have been made to synthesize nanoparticles from biological materials for targeted cancer therapy. This book provides concise evaluations of various potential bio-inspired platforms that mimic natural components of the body and offer effective and versatile drug delivery systems for cancer therapy. It also assesses the potential of nanoparticles to enhance the outcomes of cancer immunotherapy via immune cell activation and tumor microenvironment modulation. The book also summarizes in the applications of nanomaterials for the detection, prevention, and treatment of solid tumors and in the treatment of leukemia and lymphomas. In closing, it discusses ethical issues in nanomedicine, including risk assessment, risk management, and risk communication during clinical trials. The book offers offers a valuable source of information for students, academics, researchers, scientists, clinicians, and healthcare professionals working in nanotechnology and cancer research.
Download or read book Nanoparticle Drug Delivery Systems for Cancer Treatment written by Hala Gali-Muhtasib and published by CRC Press. This book was released on 2020-02-19 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.
